Efficacy of fexuprazan compared with rebamipide in Korean patients with gastritis:A matching-adjusted indirect comparison

BACKGROUND Gastritis is one of the most frequently diagnosed diseases requiring medical treatment in South Korea.Fexuprazan,a novel potassium-competitive acid blocker,has been approved for treating gastritis and erosive esophagitis.Meanwhile,rebamipide is the most commonly used mucoprotective agent for acute and chronic gastritis in real-world settings in South Korea.However,there have been no studies comparing the efficacy of these two drugs yet.AIM To compare the efficacy of fexuprazan with that of rebamipide for acute and chronic gastritis.METHODS This was a matching-adjusted indirect comparison.Individual patient data from a phase III study of fexuprazan(10 mg BID)were compared with cumulative data from two matching studies of rebamipide(100 mg TID).Erosion improvement and healing rates were compared between two weeks of fexurapan,two weeks of rebamipide,and four weeks of rebamipide.The two main outcome variables were presented as percentages,and the risk differences(RD)and 95%confidence intervals(CI)were calculated for the relative treatment effects.RESULTS In the primary analysis,the erosion improvement and healing rates after a twoweek treatment with fexuprazan were 64.5%and 53.2%,respectively,while a twoweek treatment with rebamipide resulted in erosion improvement and healing rates of 43.6%(RD:21.0%;95%CI:9.6-32.3;P<0.01)and 35.6%(RD:17.6%;95%CI:6.1-29.2;P=0.003),respectively.In the additional analysis,the erosion improvement and healing rates for the two-week fexuprazan treatment(64.2%and 51.2%,respectively)were similar to those obtained during a four-week treatment with rebamipide(60.6%;RD:3.6%;95%CI:-9.8,17.0;P=0.600 and 53.5%;RD:-2.3%;95%CI:-16.1,11.5;P=0.744,respectively).CONCLUSION The two-week fexuprazan treatment was superior to the two-week rebamipide treatment and similar to the fourweek rebamipide treatment for patients with gastritis.

Accuracy comparison and improvement for state of health estimation of lithium-ion battery based on random partial recharges and feature engineering

State of health(SOH)estimation of e-mobilities operated in real and dynamic conditions is essential and challenging.Most of existing estimations are based on a fixed constant current charging and discharging aging profiles,which overlooked the fact that the charging and discharging profiles are random and not complete in real application.This work investigates the influence of feature engineering on the accuracy of different machine learning(ML)-based SOH estimations acting on different recharging sub-profiles where a realistic battery mission profile is considered.Fifteen features were extracted from the battery partial recharging profiles,considering different factors such as starting voltage values,charge amount,and charging sliding windows.Then,features were selected based on a feature selection pipeline consisting of filtering and supervised ML-based subset selection.Multiple linear regression(MLR),Gaussian process regression(GPR),and support vector regression(SVR)were applied to estimate SOH,and root mean square error(RMSE)was used to evaluate and compare the estimation performance.The results showed that the feature selection pipeline can improve SOH estimation accuracy by 55.05%,2.57%,and 2.82%for MLR,GPR and SVR respectively.It was demonstrated that the estimation based on partial charging profiles with lower starting voltage,large charge,and large sliding window size is more likely to achieve higher accuracy.This work hopes to give some insights into the supervised ML-based feature engineering acting on random partial recharges on SOH estimation performance and tries to fill the gap of effective SOH estimation between theoretical study and real dynamic application.

Efficacy comparison of multipoint and single point scanning panretinal laser photocoagulation in non-proliferative diabetic retinopathy treatment

BACKGROUND Non-proliferative diabetic retinopathy(NPDR)poses a significant challenge in diabetes management due to its microvascular changes in the retina.Laser photocoagulation,a conventional therapy,aims to mitigate the risk of progressing to proliferative diabetic retinopathy(PDR).AIM To compare the efficacy and safety of multi-spot vs single-spot scanning panretinal laser photocoagulation in NPDR patients.METHODS Forty-nine NPDR patients(86 eyes)treated between September 2020 and July 2022 were included.They were randomly allocated into single-spot(n=23,40 eyes)and multi-spot(n=26,46 eyes)groups.Treatment outcomes,including bestcorrected visual acuity(BCVA),central macular thickness(CMT),and mean threshold sensitivity,were assessed at predetermined intervals over 12 months.Adverse reactions were also recorded.RESULTS Energy levels did not significantly differ between groups(P>0.05),but the multi-spot group exhibited lower energy density(P<0.05).BCVA and CMT improvements were noted in the multi-spot group at one-month posttreatment(P<0.05).Adverse reaction incidence was similar between groups(P>0.05).CONCLUSION While energy intensity and safety were comparable between modalities,multi-spot scanning demonstrated lower energy density and showed superior short-term improvements in BCVA and CMT for NPDR patients,with reduced laser-induced damage.

Global Research Progress on Municipal Waste and Future Prospect Based on the Cross-national Comparisons

Due to the acceleration of urbanization,the municipal waste(MW)problem has transformed into a global challenge for urb-an sustainability.To elucidate historical trends,current focal points,and future directions in MW research,we conducted a bibliometric analysis and employed knowledge graph visualization to scrutinize a total of 34212 articles,which were published between 1991 and 2021 in the Web of Science(WoS)core database.The results indicated that current major research themes encompass waste classifica-tion and recycling,waste management and public behavior,waste disposal methods and technologies,as well as environmental impact and evaluation.There has been a shift in the research focus from the environmental impacts of waste incineration to sustainable manage-ment related issues.A comparison of research from six typical countries revealed the differences in research priorities and techniques advantages.Scholars from the USA and Britain initiated MW research earlier than other countries and investigated management issues in depth,such as public behavior and willingness to pay.Meanwhile,Japanese,German,and Swedish scholars conducted extensive studies on advanced waste treatment technologies,such as disposal and recycling,risk assessment,and waste-to-energy techniques.Chinese scholars placed particular emphasis on end-of-pipe treatments and their associated environmental impacts.Hotspots and poten-tial future frontiers were identified by burst detection analysis.Keywords with high value of burst index(BI)worldwide are food waste and circular economy.Chinese scholars have put great efforts on waste environmental impact and its recycling technologies,while we’re expecting to further investigating vulnerable population.Furthermore,this study contributes to bridging the regional gap of scientific research among different countries and fostering international collaboration.

Comparison and Selection of Water Restoration Techniques for Artificial Landscape Lakes in Nantong City

As an important part of urban infrastructure,urban water system is of great and far-reaching significance for ensuring urban flood control and waterlogging safety,protecting ecological environment and building livable homes.Taking the urban water system of Nantong as an example,Nantong Water Resources Bureau issued R evision of Nantong Urban Water System Planning in 2017,and put forward the construction of the"two circles,eight lakes and nine veins"water system layout,giving new vitality to the urban water system.In view of problems existing in newly excavated artificial landscape lakes,such as fragile water ecosystem,strong eutrophication trend,poor environmental sensory effect and unsatisfactory water landscape effect,it is urgent to study the in-situ water ecological restoration technique of"algae-controlling zooplankton+submerged plant community"to build a"grass-type clear water"ecosystem for artificial landscape lakes,so as to improve the water sensory index and self-purification ability and finally realize the double improvement of"sensory effect and water quality"of artificial landscape lakes.

Direct Pointwise Comparison of FE Predictions to StereoDIC Measurements:Developments and Validation Using Double Edge-Notched Tensile Specimen

To compare finite element analysis(FEA)predictions and stereovision digital image correlation(StereoDIC)strain measurements at the same spatial positions throughout a region of interest,a field comparison procedure is developed.The procedure includes(a)conversion of the finite element data into a triangular mesh,(b)selection of a common coordinate system,(c)determination of the rigid body transformation to place both measurements and FEA data in the same system and(d)interpolation of the FEA nodal information to the same spatial locations as the StereoDIC measurements using barycentric coordinates.For an aluminum Al-6061 double edge notched tensile specimen,FEA results are obtained using both the von Mises isotropic yield criterion and Hill’s quadratic anisotropic yield criterion,with the unknown Hill model parameters determined using full-field specimen strain measurements for the nominally plane stress specimen.Using Hill’s quadratic anisotropic yield criterion,the point-by-point comparison of experimentally based full-field strains and stresses to finite element predictions are shown to be in excellent agreement,confirming the effectiveness of the field comparison process.

Does US Dollar Supply Trigger House Price Fluctuations?An International Comparison

Cyclical fluctuations in asset prices are closely related to the overall stability of the macroeconomy and have thus become a significant topic in academic and professional exploration.Among these fluctuations,changes in the supply of the U.S.dollar,the global reserve,and primary settlement currency have a broad and far-reaching impact on international financial markets.Since COVID-19,asset prices across various countries have shown differing trends due to fluctuations in the U.S.dollar supply.Housing prices,a key focus in asset pricing research,have been affected to varying degrees.This thesis utilizes seven house price indices from representative cities worldwide from 2020 to 2023 to compare the differential impacts across various countries using an empirical approach.The results indicate that the impact of the U.S.dollar money supply(M2)diminishes in a gradient from the U.S.to East Asia,and then to Europe.

Comparison of the Development of CDMO at Home and Abroad and Its Enlightment to China

Objective To analyze the development status of contract development manufacturing organization(CDMO)at home and abroad,and to make some suggestions for the development of CDMO in China.Methods The relevant literature was searched and reviewed,and the development status of CDMOs in the United States,France,Japan and China was compared from the aspects of market scale,development process,development focus,advantages and disadvantages,and policy support.Then,some suggestions for the development of CDMO enterprises in China were summarized.Results and Conclusion Through the comparison of CDMO development at home and abroad,it can be seen that China started CDMO late,there were many technical barriers and its globalization layout were not sufficient.However,the development trend was good and it focused on the field of chemical drugs and biological drugs to constantly develop innovative drugs.China needs to continuously improve its own technical capabilities to carry out innovative research.Therefore,cost reduction and efficiency increase will be the key elements for the development of CDMOs,and they are expected to have a rapid and comprehensive development in the future.

Inter-provincial Differences in Rice Multi-cropping Changes in Main Double-cropping Rice Area in China: Evidence from Provinces and Households

Since the early 1980 s, the multi-cropping index for rice has decreased significantly in main double-cropping rice area in China, which is the primary double-cropping rice(DCR) production area. This decline may bring challenges to food security in China because rice is the staple food for more than 60% of the Chinese population. It has been generally recognized that rapidly rising labor costs due to economic growth and urbanization in China is the key driving force of the ‘double-to-single' rice cropping system adaption. However, not all provinces have shown a dramatic decline in DCR area, and labor costs alone cannot explain this difference. To elucidate the reasons for these inter-provincial distinctions and the dynamics of rice cropping system adaption, we evaluated the influencing factors using provincial panel data from 1980 to 2015. We also used household survey data for empirical analysis to explore the mechanisms driving differences in rice multi-cropping changes. Our results indicated that the eight provinces in the study can be divided into three spatial groups based on the extent of DCR area decline, the rapidly-declining marginal, core, and stable zones. Increasing labor cost due to rapid urbanization was the key driving force of rice cropping system adaption, but the land use dynamic vary hugely among different provinces. These differences between zones were due to the interaction between labor price and accumulated temperature conditions. Therefore, increasing labor costs had the greatest impact in Zhejiang, Anhui, and Hubei, where the accumulated temperature is relatively low and rice multi-cropping index declined dramaticly. However, labor costs had little impact in Guangdong and Guangxi. Differences in accumulated temperature conditions resulted in spatially different labor demands and pressure on households during the busy season. As a result, there have been different profits and rice multi-cropping changes between provinces and zones. Because of these spatial differences, regionally appropriate policies that provide appropriate subsidies for early rice in rapidly-declining marginal zone such as Zhejiang and Hubei should be implemented. In addition, agricultural mechanization and the number of agricultural workers have facilitated double-cropping; therefore, small machinery and agricultural infrastructure construction should be further supported.

平“语”近人中课程思政元素comparison的应用及分析

文章的研究目的是理解平“语”近人中comparison(比喻)的用法,平“语”近人中课程思政的内容和其背后的真实含义具有重要的教育意义。文章以话语中课程思政元素的comparison主要例子作为研究对象,来探讨和研究平“语”近人话语中的关于comparison的应用并且加以分析。

Rural migrants' participation in old-age insurance: a case study of the inter-provincial migrant workers from Sichuan, China

Old-age pension, a fundamental part of the Chinese social security system, is perceived by the Chinese government as the last support for rural-to-urban migrant workers upon retreating from the labor market. Using survey data collected by the authors, this paper examines a host of factors which influence migrant workers' participation in the old-age scheme. The result shows that individual characteristics, employment status, attitudes toward old-age support and perception of the old-age pension system significantly differentiate two groups of migrant workers between those that have participated in and their counterparts who have not participated in the old-age pension schemes. Among a number of factors, age, educational attainment, holding labor contract, etc. are found to be significant factors influencing migrants' behavior participating(or not participating) the available age-pension schemes. Policy implications for how to improve the rate of participation in existing old-age pension schemes among migrant workers are drawn from the findings.

Inter-provincial pattern of the coupled and coordinated relationship between touristization and urbanization

The coordinated development between touristization and urbanization is the key to optimizing regional industrial structure and building a long-term dynamic mechanism for urbanization. Based on constructing the measurement index system of touristization and urbanization level, the evaluation model on the coupled and coordinated degree is used in this paper to measure the inter-provincial pattern of the coupled and coordinated relationship between touristization and urbanization in 31 provinces and autonomous regions in China. The results show that the coupled and coordinated relationship between touristization and urbanization is significantly different in different regions, which presents a gradient decline pattern of the highest in the east, the lower in the middle and the lowest in the west. In the future, measures should be taken to promote the coordinated development between touristization and urbanization in accordance with the regional differences and actual development needs.

Multiomics comparison among populations of three plant sources of Amomi Fructus

Amomi Fructus(Sharen,AF)is a traditional Chinese medicine(TCM)from three source species(or varieties),including Wurfbainia villosa var.villosa(WVV),W.villosa var.xanthioides(WVX),or W.longiligularis(WL).Among them,WVV has been transplanted from its top-geoherb region,Guangdong,to its current main production area,Yunnan,for>50 years in China.However,the genetic and transcriptomic differentiation among multiple AF source species(or varieties)and between the origin and transplanted populations of WVV is unknown.In our study,the observed overall higher expression of terpenoid biosynthesis genes in WVV than in WVX provided possible evidence for the better pharmacological effect of WVV.We also screened six candidate borneol dehydrogenases(BDHs)that potentially catalyzed borneol into camphor in WVV and functionally verified them.Highly expressed genes at the P2 stage of WVV,Wv05G1424 and Wv05G1438,were capable of catalyzing the formation of camphor from(+)-borneol,(-)-borneol and DL-isoborneol.Moreover,the BDH genes may experience independent evolution after acquiring the ancestral copies,and the following tandem duplications might account for the abundant camphor content in WVV.Furthermore,four populations of WVV,WVX,and WL are genetically differentiated,and the gene flow from WVX to WVV in Yunnan contributed to the greater genetic diversity in the introduced population(WVV-JH)than in its top-geoherb region(WVV-YC),which showed the lowest genetic diversity and might undergo genetic degradation.In addition,terpene synthesis(TPS)and BDH genes were selected among populations of multiple AF source species(or varieties)and between the top-and non-top-geoherb regions,which might explain the difference in metabolites between these populations.Our findings provide important guidance for the conservation,genetic improvement,and industrial development of the three source species(or varieties)and for identifying top-geoherbalism with molecular markers,and proper clinical application of AF.

Inter-Provincial Development Difference in Information & Telecom Industry in China

This article measures the development difference in the information and telecommunication industry among provinces in China quantitatively by Gini coefficient.According to the calculation results,the article concludes that the development levels are between "highly equal"and "relatively equal".Further more,the research also shows that the difference gap has been narrowing down gradually in recent years.Compared with the inter-provincial economic difference,the difference in the information and telecommunication industry among provinces is small.

First acceptance testing of multiple A10 absolute gravimeters in China and analysis of the comparison results

Three A10 absolute gravimeters(AGs) were first acquired in China by the Hubei Earthquake Agency under the Belt and Road Seismic Monitoring Network Project. Although AG measuring and testing technique is not new, the purchase and simultaneous testing of 3 A10 absolute gravimeters is unprecedented in China. This study conducted the first acceptance testing of the AGs at 3 locations(the Jiufengshan Gravity Observation Station, the Global Navigation Satellite System Observation Station in Wuhan, and the Jiugongshan Observation Station in Xianning). The results were compared using a method based on expert validation, and the acceptance testing scheme was formulated by referring to the Technical Regulations for Tectonic Environment Monitoring Networks in China and Specifications for Gravimetry Control. Based on the repeatability, precision, and consistency of the measured g values, the results from each instrument were evaluated using the air pressure precision test. Comparing the instrument reference values, the final test results can identify the indicator parameters for 3 A10 AGs, the effects of the surrounding environment, and the related parameters on measurement precision. The precision of A10-059, A10-058, and A10-057 exceeded 0.78 μGal, 0.79 μGal, and 0.42 μGal, respectively.This testing scheme can be used as a reference for conducting acceptance testing of AGs in the future and obtaining absolute gravimetric measurements.

Spatial Interactions of China's Steel Output: An Empirical Analysis Based on Chinese Inter-provincial Panel Data

In view of the extensive growth of China's steel production in recent years, this paper analyzed the industrial development background and economic geography theory, and discussed the possible spatial interaction mechanism. Based on panel data of China's inter-provincial steel output from 2001 to 2015, using spatial econometric model, this paper also explored whether China's provincial steel production shows material orientation, market orientation and traffic orientation, and isolated spatial interactions of interprovincial steel output. The results showed that the inter-provincial steel production in China did show both material orientation, market orientation and traffic orientation and that there was a significant negative spatial interaction, indicating that there might be strong competition and a crowing-out effect between neighboring provinces, and that the smaller the spatial scope, the more significant the spatial interactions of steel production.

Measurement of Grain Production Efficiency in Main Grain-producing Areas and Analysis of Inter-provincial Differences--A Study Based on Super-SBM Model and Malmquist Index

China's food security mainly depends on the core areas of food production.Under the dual constraints of resource scarcity and environmental degradation,improving the grain production efficiency of the main grain-producing areas has become the fundamental way to strengthen the grain production capacity and improve the national food security capability,and to improve the efficiency of grain production in major grain-producing areas requires empirical support.This paper used the Super SBM model and the Malmquist index to measure the grain production efficiency of the main grain-producing areas from 2001 to 2020 from both static and dynamic perspectives,and compared the differences in grain production efficiency among different soil types and different provinces(autonomous regions)in the main grain-producing areas.The results showed that from 2001 to 2020,the grain production in the main grain-producing areas was in a relatively ineffective state,and the differences in grain production efficiency among different soil types and different provinces(autonomous regions)in the main grain-producing areas were obvious.The order of grain production efficiency in different soil types was black soil region>red-yellow soil region>paddy soil region>fluvo-aquic soil region,and the order of grain production efficiency of the provinces(autonomous regions)in the main grain-producing areas was Jilin>Heilongjiang>Inner Mongolia>Jiangxi>Hunan>Sichuan>Hubei>Jiangsu>Liaoning>Henan>Anhui>Shandong>Hebei.From 2001 to 2020,the total factor productivity of grain in the main grain-producing areas increased,but due to the trade-off between the technological progress and the growth of technical efficiency,the increase in the total factor productivity of grain in the main grain-producing areas was small,and the growth mainly came from the increase of input factors in this period.The total factor productivity of grain in Hebei,Heilongjiang,Liaoning,Jilin,Inner Mongolia,Shandong,Jiangsu,Henan and Anhui increased,but the increase was small,while the total factor productivity of grain in Jiangxi,Sichuan,Hunan and Hubei provinces declined.

Natural gas characteristics and gas-source comparisons of the Lower Triassic Feixianguan Formation,Eastern Sichuan Basin,China

There is great controversy regarding the origin and source of natural gas in the Lower Triassic Feix-ianguan Formation in the Eastern Sichuan Basin.This seriously restricts the study of natural gas dy-namics in the Feixianguan Formation and thus hampers natural gas exploration in the region,so further study is urgently required.Using experimental tests of natural gas composition,stable isotopes,and noble gas isotopes with gas chromatography(GC)and mass spectrometry(MS)studies of source rock and reservoir asphalt saturated hydrocarbons,the natural gas geochemical characteristics,the genetic identification and a gas-source comparison of the Feixianguan Formation were studied.Then,con-strained by the thermal history,the histories of gas generation and expulsion were restored by basin simulation technology.Finally,a gas accumulation model was established for the Feixianguan Formation.The results showed that(1)the H_(2)S-rich and H2S-poor gas reservoirs of the Feixianguan Formation are distributed on the east and west sides of the Kaijiang-Liangping trough in the Eastern Sichuan Basin,respectively.The carbon and hydrogen isotope compositions of the natural gas in the gas reservoirs are generally heavy and have typical characteristics of high-maturity dry gas reservoirs.(2)The natural gas of the Feixianguan Formation is organic thermogenic gas,which is mainly oil-type gas generated by the secondary cracking of crude oil.The gas-generating parent material is mainly type II kerogen.(3)The natural gas of the Feixianguan Formation in the Eastern Sichuan Basin was mainly generated by argil-laceous source rocks of the Upper Permian Longtan Formation.(4)Natural gas accumulation occurred as follows:the paleo-structure heights were filled with crude oil in the Early Jurassic,and paleo-oil res-ervoirs were formed in the Feixianguan Formation;during the Middle-Late Jurassic,the paleo-oil res-ervoirs were cracked when the reservoir temperatures rose above 160 C,and paleo-gas reservoirs were formed.Since the end of the Late Jurassic,the paleo-gas reservoirs have been adjusted and reformed to form the present-day natural gas reservoirs.These results provide a basis for studying natural gas accumulation dynamics of the Feixianguan Formation in the Eastern Sichuan Basin.

Trends and Features of China's Inter-Provincial Trade:1987-2007

With today's economic globalization,inter-provincial trade plays an important role in a country's economy.This paper is the first to adopt the input-output tables of 30 Chinese provinces and to summarize the evolution of China's inter-provincial trade from1987 to 2007.This paper reaches the following conclusions.First,China's inter-provincial trade has sustained a period of rapid growth.In 2007,the total volume of inter-provincial trade was twice the amount of international trade,with the eastern region accounting for the majority of the inter-provincial trade volume.GDP may have a greater effect on interprovincial trade than geographic distance does.Second,inter-provincial trade maintains a high level of concentration and overlaps with the high concentration of GDP.Third,the inter-provincial trade dependence of Chinese provinces tends to increase,an indication of the growing domestic market integration.Moreover,the eastern region's dependence on inter-provincial trade is higher than the central and western regions'.Fourth,the share of inter-provincial trade in the overall external trade of Chinese provinces has a declining tendency,which indicates a slower process of China's domestic market integration compared with international market integration.However,in terms of proportion,the external trade of most Chinese provinces is still dominated by inter-provincial trade.Fifth,most provinces with longstanding inter-provincial trade deficits are in the central and western regions.

Influencing Factors of Long-Term Residence Intention of Highly Educated Inter-Provincial and Intra-Provincial Floating Population From the Perspective of Social Integration:Take Guangdong Province for Example

Floating population plays an important role in the development of cities,regions,and countries.The economic growth path with Guangdong characteristics is inseparable from the support of highly educated groups.Studying the long-term residence intention of the highly educated floating population is helpful for the city to attract and retain talents.From the perspective of social integration,using CMDS 2017 data and taking Guangdong Province for example,this paper studies the influencing factors of long-term residence intention through SPSS logistic regression,taking intra-provincial and inter-provincial floating population with a bachelor’s degree or above as sample.The main conclusions are:(1)Marital and childbearing status is the primitive influencing factor of long-term residence intention among intra-provincial and inter-provincial floating population.Samples with high income,under social insurance system,being female and having non-agricultural hukou,are tend to prefer long-term residence.Samples who connect with the locals and participate in social public welfare are more likely to stay.(2)Personal age and city livability have a significant positive impact on the long-term residence intention of the inter-provincial highly educated floating population,but agricultural hukou and self-employed laborer status will weaken the long-term residence intention of this group.(3)Participation in townsmen/alumni association has a positive effect on the long-term residence intention of the intra-provincial highly educated floating population,and connection with outlanders also promotes the long-term residence intention of this group.(4)The long-term residence intention of inter-provincial highly educated floating population is usually based on reality,therefore they pay more attention to the development,changes,and livability of the destination city.However,the long-term residence intention of intra-provincial highly educated floating population is usually based on perception,so they pay more attention to whether they like the city.Compared with intra-provincial flows,inter-provincial flows have higher economic and emotional migration costs,more institutional barriers,and more life adaptation problems.Therefore,the government should introduce targeted measures to promote social integration and improve long-term residence intention.