Bidirectional relationship between diabetes mellitus and depression:Mechanisms and epidemiology

Diabetes mellitus and depression exhibit a complex bidirectional relationship that profoundly impacts patient health and quality of life.This review explores the physiological mechanisms,including inflammation,oxidative stress,and neu-roendocrine dysregulation,that link these conditions.Psychosocial factors such as social support and lifestyle choices also contribute significantly.Epidemiological insights reveal a higher prevalence of depression among diabetics and an in-creased risk of diabetes in depressed individuals,influenced by demographic variables.Integrated management strategies combining mental health asse-ssments and personalized treatments are essential.Future research should focus on longitudinal and multi-omics studies to deepen understanding and improve therapeutic outcomes.

Review on mechanisms and structure-activity relationship of hypoglycemic effects of polysaccharides from natural resources

Diabetes mellitus(DM)is a common multifactorial disease,causing various complications,such as chronic metabolism.The current therapies for diabetes mellitus are commercial diabetic drugs that have different definite side effect.However,polysaccharides mainly extracted from natural resources,have advantages of safety,accessibility,and anti-diabetic potential.We have summarized recent research of natural polysaccharides with hypoglycemic activities,focusing on different pharmacological mechanisms in various cell and animal models.The relationships of structure-hypoglycemic effect are also discussed in detail.This review could provide a comprehensive perspective for better understanding on development and mechanism of natural polysaccharides against diabetes mellitus,which have been required by clinical studies yet.

Food-derived bio-functional peptides for the management of hyperuricemia and associated mechanism

Hyperuricemia,a metabolic disorder related to uric acid metabolism dysregulation,has become a common metabolic disease worldwide,due to changes in lifestyle and dietary structure.In recent years,owing to their high activity and few adverse effects,food-derived active peptides used as functional foods against hyperuricemia have attracted increasing attention.This article aims to focus on the challenge associated with peptide-specific preparation methods development,functional components identification,action mechanism(s)clarification,and bioavailability improvement.The current review proposed recent advances in producing the food-derived peptides with high anti-hyperuricemia activity by protein source screening and matched enzymatic hydrolysis condition adjusting,increased the knowledge about strategies to search antihyperuricemia peptides with definite structure,and emphasized the necessity of combining computer-aided approaches and activity evaluations.In addition,novel action mechanism mediated by gut microbiota was discussed,providing different insights from classical mechanism.Moreover,considering that little attention was paid previously on the structure-activity relationships of anti-hyperuricemia peptides,we collected the sequences from published studies and make a preliminary summary about the structure-activity relationships,which in turn provided guides for enzymatic hydrolysis optimization and bioavailability improvement.Hopefully,this article could promote the development,application and commercialization of food-derived anti-hyperuricemia peptides in the future.

Mass transfer mechanism and relationship of gas–liquid annular flow in a microfluidic cross-junction device

Mass transfer performance of gas–liquid two-phase flow at microscale is the basis of application of microreactor in gas–liquid reaction systems.At present,few researches on the mass transfer property of annular flow have been reported.Therefore,the mass transfer mechanism and relationship of gas–liquid annular flow in a microfluidic cross-junction device are studied in the present study.We find that the main factors,i.e.,flow pattern,liquid film thickness,liquid hydraulic retention time,phase interface fluctuation,and gas flow vorticity,which influence the flow mass transfer property,are directly affected both by gas and liquid flow velocities.But the influences of gas and liquid velocities on different mass transfer influencing factors are different.Thereout,the fitting relationships between gas and liquid flow velocities and mass transfer influencing factors are established.By comparing the results from calculations using fitting equations and simulations,it shows that the fitting equations have relatively high degrees of accuracy.Finally,the Pareto front,namely the Pareto optimal solution set,of gas and liquid velocity conditions for the best flow mass transfer property is obtained using the method of multi-objective particle swarm optimization.It is proved that the mass transfer property of the gas–liquid two-phase flow can be obviously enhanced under the guidance of the obtained Pareto optimal solution set through experimental verification.

Screening hepatoprotective effective components of Lonicerae japonica Flos based on the spectrum-effect relationship and its mechanism exploring

Lonicerae japonicae Flos(LF)is a kind of healthcare food with hepatoprotective function.This study was designed to explore the spectrum-effect relationships between UPLC fingerprints and the hepatoprotective effects of LF.Fingerprints of ten batches of LF were established by UPLC-PDA.The inhibitory levels of AST and ALT were used as pharmacological indexes,and secoxyloganin,isochlorogenic acid A and isochlorogenic acid C were screened as hepatoprotective active compounds by grey relational analysis(GRA)and partial least squares regression analysis(PLSR).Caspase-3 was obtained by network pharmacology as a key target of hepatoprotective active compounds.Molecular docking is used to explore the interaction between small molecules and proteins.This work provided a general model of the combination of UPLC-PDA and hepatoprotective effect to study the spectrum-effect relationship of LF,which can be used to considerable methods and insight for the fundamental research of the material basis of similar healthcare food.

Analysis of Orientation Relationships,Carbon Partitioning and Strengthening Mechanism of a Novel Ultrahigh Strength Steel

The orientation relationships,carbon partitioning and strengthening mechanism of a novel ultrahigh strength steel were analyzed in depth during the complex process of heat treatment.The experimental results reveal that the(011)α//()γ,[100]α//[011]γ orientation relationships can be drawn between martensite and retained austenite.The position and angle of martensite and retained austenite are shown more clearly from the stereographic projections.Moreover,the calculated results show that the carbon content near the austenite interface is the highest in the shorter carbon allocation time.With the further increase of time,its carbon content gradually decreases.Furthermore,a model of the relationship between yield strength and strengthening mechanism was established.It was proved that the main strengthening components contributing to the yield strength include Orowan strengthening,grain-size strengthening and dislocation hardening.The main strengthening mechanism of steel in this experiment is dislocation strengthening.

Advances in Research of Biological Activity,Action Mechanism and Structure-Activity Relationship of Lentinan

Lentinula edodes is the second largest edible mushroom in the world and is widely used as food and medicine.Modern research shows that lentinan(LNT)is the main active component of L.edodes.It has anti-cancer,treatment of diabetes,intestinal protection,anti-inflammatory,anti-oxidation,anti-aging,hepatoprotective,immune-regulating effects.In this review,the biological activity,action mechanism and structure-activity relationship of LNT in recent years are reviewed.On this basis,the existing problems were discussed,and the future research and application of LNT were prospected.Finally,it is hoped that this review will promote the in-depth study of LNT and provide a reference for its development as a drug and functional food.

Interaction Relationship Between Corporate Social Responsibility and Corporate Performance:Evidence from 201 Chinese Listed Companies and Preliminary Study of Its Underlying Mechanism

Corporations actively fulfilling corporate social responsibility(CSR)is of more significance to society's sustainable development nowadays.This research discusses the interaction between CSR and corporate performance and then adopts other mediation variables to explain the underlying mechanism.The empirical analyses are performed on a sample of 201 listed Chinese firms.The result shows that CSR has a weak negative impact on corporate perfbnnance while being positively influenced by corporate performance significantly.Further study finds the reason may be CSR requires financial support,but has little to do with increasing shareholder wealth.

Review of collapse triggering mechanism of collapsible soils due towetting

Loess soil deposits are widely distributed in arid and semi-arid regions and constitute about 10% of land area of the world.These soils typically have a loose honeycomb-type meta-stable structure that is susceptible to a large reduction in total volume or collapse upon wetting.Collapse characteristics contribute to various problems to infrastructures that are constructed on loess soils.For this reason,collapse triggering mechanism for loess soils has been of significant interest for researchers and practitioners all over the world.This paper aims at providing a state-of-the-art review on collapse mechanism with special reference to loess soil deposits.The collapse mechanism studies are summarized under three different categories,i.e.traditional approaches,microstructure approach,and soil mechanics-based approaches.The traditional and microstructure approaches for interpreting the collapse behavior are comprehensively summarized and critically reviewed based on the experimental results from the literature.The soil mechanics-based approaches proposed based on the experimental results of both compacted soils and natural loess soils are reviewed highlighting their strengths and limitations for estimating the collapse behavior.Simpler soil mechanics-based approaches with less parameters or parameters that are easy-to-determine from conventional tests are suggested for future research to better understand the collapse behavior of natural loess soils.Such studies would be more valuable for use in conventional geotechnical engineering practice applications.

Failure mechanism and influencing factors of cement sheath integrity under alternating pressure

The failure of cement sheath integrity can be easily caused by alternating pressure during large-scale multistage hydraulic fracturing in shale-gas well.An elastic-plastic mechanical model of casing-cement sheath-formation(CSF)system under alternating pressure is established based on the Mohr-Coulomb criterion and thick-walled cylinder theory,and it has been solved by MATLAB programming combining global optimization algorithm with Global Search.The failure mechanism of cement sheath integrity is investigated,by which it can be seen that the formation of interface debonding is mainly related to the plastic strain accumulation,and there is a risk of interface debonding under alternating pressure,once the cement sheath enters plasticity whether in shallow or deep well sections.The matching relationship between the mechanical parameters(elastic modulus and Poisson's ratio)of cement sheath and its integrity failure under alternating pressure in whole well sections is studied,by which it has been found there is a“critical range”in the Poisson's ratio of cement sheath.When the Poisson's ratio is below the“critical range”,there is a positive correlation between the yield internal pressure of cement sheath(SYP)and its elastic modulus.However,when the Poisson's ratio is above the“critical range”,there is a negative correlation.The elastic modulus of cement sheath is closely related to its Poisson's ratio,and restricts each other.Scientific and reasonable matching between mechanical parameters of cement sheath and CSF system under different working conditions can not only reduce the cost,but also protect the cement sheath integrity.

Mechanical Properties and Constitutive Relationship of the High-Durable Parallel Strand Bamboo

Engineered bamboo has recently received lots of attention of civil engineers and professional researchers due to its better mechanical performance than that of softwood timber.Parallel strand bamboo is one important part of engineered bamboo for its excellent durable performance compared to the laminated veneer bamboo.The required curing temperature in hot-pressing process is usually higher than 120°C to reduce the content of nutri-tional ingredients and hemy cellulose,and to avoid the decay from the environment and insects.Nonetheless,the appearance of engineered bamboo gets darker with the increase of temperature during the hot-pressing process.In order to minimize the color deepening while maintaining the durability,a high-durable parallel strand bamboo(HPSB)with relative high hot-pressing temperature(140°C)was produced and tested.The present study inves-tigates the mechanical performance through tension,compression,shear and bending tests.The experimental behavior of the specimens was identified,including the failure mode and load-displacement relationship.It was demonstrated that the HPSB material had better mechanical performance parallel to grain,making it as a considerable structural material.The average elastic modulus parallel to grain was 14.1 GPa,and the tensile and compressive strengths were 120.7 MPa and 121.0 MPa,respectively.The tension perpendicular to grain should be avoided in the practical application due to the lower strength and elastic modulus.Two stress-strain relationships of tension and compression parallel to grain,including three-linear and quadratic function models,were proposed and compared with the experimental results.The three-linear model was then applied to the finite element model.The finite element analysis using ANSYS software was conducted to validate the feasibility of the constitutive relationship.The quadratic function model showed better agreement with the experimental results,but the three-linear relationship was also precise enough to analyze the bending tests of HPSB material,whereas being less accurate to describe the elastic-plastic compression behavior.

Tension-compression asymmetry and corresponding deformation mechanism in ZA21 magnesium bars with bimodal structure

We investigated the asymmetric tension-compression(T-C)behavior of ZA21 bars with bimodal and uniform structures through axial tension and compression tests.The results show that the yield strengths of bars having bimodal structure are 206.42 and 140.28 MPa under tension and compression,respectively,which are higher than those of bars having uniform structure with tensile and compressive yield strength of 183.71 and 102.86 MPa,respectively.Prismatic slip and extension twinning under tension and basal slip and extension twinning under compression dominate the yield behavior and induce the T-C asymmetry.However,due to the basal slip activated in fine grains under tension and the inhibition of extension twinning by fine grains under compression,the bimodal structure possesses a lower T-C asymmetry(0.68)compared to the uniform structure(0.56).Multiple extension twins occur during deformation,and the selection of twin variants depends on the Schmid factor of the six variants activated by parent grains.Furthermore,the strengthening effect of the bimodal structure depends on the grain size and the ratio of coarse and fine grains.

Design and Dynamic Analysis of the Recirculating Planetary Roller Screw Mechanism

The recirculating planetary roller screw mechanism(RPRSM)is a transmission mechanism that engages the screw and nut threaded by multiple grooved rollers.In this paper,frstly,the design method of RPRSM nut threadless area is proposed,and the equations related to the structural parameters of nut threadless area are derived.On this basis,the cross-section design method of roller,screw and nut is constructed according to the actual situation of engagements between the screw/nut and the roller.By adjusting the gap between the two beveled edges and that between the arc and the beveled edge,the accuracy of the thread engagements between the screw/nut and the roller can be improved.Secondly,to ensure the engagements of the screw/nut and the roller,the distance equation from the center surface of the diferent rollers to the end surface of cam ring is given.Thirdly,combined with the working principle and structural composition of RPRSM,the component model is established according to its relevant structural parameters,and the virtual assembly is completed.Finally,the 3D model is imported into the ADAMS simulation software for multi-rigid body dynamics.The dynamic characteristic is analyzed,and the simulated values are compared with the theoretical values.The results show that the contact forces between the screw/nut and the roller are sinusoidal,mainly due to the existence of a small gap between the roller and the carrier.The maximum collision forces between the roller and cam ring are independent from load magnitude.Normally,the collision force between the roller and the carrier increases as the load increases.When RPRSM is in the transmission process,the roller angular speed in nut threadless area begins to appear abruptly,and the position of the maximum change is at the contact between the roller and the convex platform of cam ring.The design of the nut threadless area and the proposed virtual assembly method can provide a theoretical guidance for RPRSM research,as well as a reference for overall performance optimization.

Water-cut rising mechanism and optimized water injection technology for deepwater turbidite sandstone oilfield: A case study of AKPO Oilfield in Niger Delta Basin, West Africa

Through the analysis of the reservoir connection relationship and the water-cut rising rules after water breakthrough in the highly volatile oil AKPO oilfield, a new model of water-cut rising was established, and the timing and strategy of water injection were put forward. The water-cut rising shapes of producers after water breakthrough can be divided into three types, and their water-cut rising mechanism is mainly controlled by reservoir connectivity. For the producers which directly connect with injectors in the single-phase sand body of the single-phase channel or lobe with good reservoir connectivity, the water-cut rising curve is "sub-convex". For the producers which connect with injectors through sand bodies developed in multi-phases with good inner sand connectivity but poorer physical property and connectivity at the overlapping parts of sands, the response to water injection is slow and the water-cut rising curve is "sub-concave". For the producers which connect with injectors through multi-phase sand bodies with reservoir physical properties, connectivity in between the former two and characteristics of both direct connection and overlapping connection, the response to water injection is slightly slower and the water-cut rising curve is "sub-S". Based on ratio relationship of oil and water relative permeability, a new model of water cut rising was established. Through the fitting analysis of actual production data, the optimal timing and corresponding technology for water injection after water breakthrough were put forward. Composite channel and lobe reservoirs can adopt water injection strategies concentrating on improving the vertical sweep efficiency and areal sweep efficiency respectively. This technology has worked well in the AKPO oilfield and can guide the development of similar oilfields.

Study on the effect of focal position change on the expansion velocity and propagation mechanism of plasma generated by millisecond pulsed laser-induced fused silica

In this work, by controlling the positional relationship between the target and the focal point, the surface damage, shock wave phenomenon and propagation mechanism involved in the plasma generation of fused silica by millisecond pulsed laser irradiation at different focal positions were studied. Laser energy is an important experimental variable. The dynamic process of plasma was detected by optical shadow method, and the influence of surface film damage on plasma propagation and the propagation mechanism at different focal positions were discussed. The study found that the plasma induced by the pulsed laser at the focus position within 0–20 μs exploded, the micro-droplets formed around 20 μs. At the same time, a shock wave is formed by the compressed air, the micro-droplets are compressed under the action of the shock wave recoil pressure, and the micro-droplets channel phenomenon is observed in the micro-droplets. The peak velocities of plasma and combustion wave appear earlier in the pre-focus position than in the post-focus position. This research provides a reference for the field of laser processing using fused silica as the substrate.

A Large-Scale Group Decision Making Model Based on Trust Relationship and Social Network Updating

With the development of big data and social computing,large-scale group decisionmaking(LGDM)is nowmerging with social networks.Using social network analysis(SNA),this study proposes an LGDM consensus model that considers the trust relationship among decisionmakers(DMs).In the process of consensusmeasurement:the social network is constructed according to the social relationship among DMs,and the Louvain method is introduced to classify social networks to form subgroups.In this study,the weights of each decision maker and each subgroup are computed by comprehensive network weights and trust weights.In the process of consensus improvement:A feedback mechanism with four identification and two direction rules is designed to guide the consensus of the improvement process.Based on the trust relationship among DMs,the preferences are modified,and the corresponding social network is updated to accelerate the consensus.Compared with the previous research,the proposedmodel not only allows the subgroups to be reconstructed and updated during the adjustment process,but also improves the accuracy of the adjustment by the feedbackmechanism.Finally,an example analysis is conducted to verify the effectiveness and flexibility of the proposed method.Moreover,compared with previous studies,the superiority of the proposed method in solving the LGDM problem is highlighted.

基于分量感知动态图Transformer的短期电力负荷预测

准确的短期负荷预测对于电力系统的稳定运行和有效调度至关重要。电力负荷数据因存在非线性、非平稳性而导致预测精度低。分解可以降低序列非平稳性的影响从而有效地提高预测精度,但现有分解预测方法缺乏对分解分量间关系的捕获且显著增加了预测时间。为此,提出分量感知动态图Transformer(component-aware dynamic graph Transformer,CDGT)模型。首先,引入联合对立选择(joint opposite selection,JOS)算子和随机扰动改进雪消融优化算法(snow ablation optimizer,SAO),使用联合搜索和随机扰动的SAO(jointly searched and stochastic perturbed SAO,JSSAO)对变分模态分解(variational mode decomposition,VMD)进行参数寻优。VMD对原始的负荷数据进行分解得到不同频率的分量序列,然后使用图神经网络(graph neural network,GNN)来识别和建模分量之间的复杂关系。同时,使用引入频域指数滑动平均(exponential moving average,EMA)注意力的Transformer来学习分量内部的依赖关系。一次输出所有分量结果,线性相加后得到负荷预测值。通过两个公开负荷数据集的实验表明,CDGT优于一系列先进的基线以及分解预测方法,在澳大利亚数据集和摩洛哥数据集上,MAE分别降低了5.51%~31.08%和15.02%~75.49%。

碳纤维复合材料与极地环境因素交互关系研究

目的揭示低温环境对碳纤维复合材料静态力学性能的影响,探讨极地环境因素的交互关系及其性能敏感性。方法采用正交试验设计,并通过极值与方差分析法探究各因素对材料性能影响的显著性与主次顺序。基于响应面法,建立力学性能指标与各环境因素间的二次回归模型,分析各因素之间的交互作用。结果碳纤维复合材料的硬度、抗拉强度和弹性模量对环境因素的敏感性存在差异。材料硬度和抗拉强度主要受辐照影响,其次为温度和覆冰厚度;弹性模量则受温度影响显著。响应面分析结果表明,温度、覆冰厚度与辐照之间存在明显的交互效应,尤其是对抗拉强度和弹性模量的影响更为显著,而对硬度的交互影响较弱。结论碳纤维复合材料在极地环境下表现出良好的稳定性与环境适应性,该研究将为碳纤维复合材料的极地应用提供一定的数据支持与理论基础。

免疫细胞与膝骨关节炎之间因果作用:一项两样本双向孟德尔随机化分析

背景:膝骨关节炎是一种常见的关节软骨及周围组织损伤的慢性炎症性疾病,而免疫细胞在膝骨关节炎免疫炎症反应中起到重要作用,但其中的具体机制仍有待深入研究。目的:采用孟德尔随机化方法来评估731种免疫细胞表型与膝骨关节炎风险之间的潜在因果关系。方法:使用全基因组关联分析(GWAS)目录中公开获取731种免疫细胞表型的全基因组关联分析统计数据(从GCST0001391到GCST0002121)和IEUGWAS数据库中膝骨关节炎的全基因组关联分析数据(ebi-a-GCST007090)。采用逆方差加权法、MR-Egger回归法、加权中位数法、加权模型法和简单模型法来研究免疫细胞与膝骨关节炎之间的因果关系。敏感性分析用于检验孟德尔随机化分析结果是否可靠,然后以同样方法进行反向孟德尔随机化分析。结果与结论:①正向分析结果表明,共有4种免疫细胞表型与膝骨关节炎有显著的因果关系(FDR<0.20),其中B细胞中的CD27 on CD24+CD27+(OR=1.026,P=0.00026,Pfdr=0.18)、髓系细胞中的CD33 on CD33dim HLA DR-(OR=1.014,P=0.00050,Pfdr=0.18)以及Treg细胞中的CD45RA+CD28-CD8br%CD8br(OR=1.001,P=0.00078,Pfdr=0.18)与膝骨关节炎风险呈直接的正向因果关联;单核细胞中PDL-1 on monocyte(OR=0.952,P=0.00098,Pfdr=0.18)与膝骨关节炎风险呈直接的负向因果关联。②反向分析结果表明,当膝骨关节炎作为暴露数据时,与731种免疫细胞表型均不具有显著因果关系(FDR<0.20)。③敏感性分析结果显示:双向孟德尔随机化的Cochran’s Q检验和MR-Egger回归法结果P值均大于0.05,表明免疫细胞表型与膝骨关节炎之间的因果效应分析不存在显著的异质性和多效性。④上述结果证实,CD27 on CD24+CD27+,CD33 on CD33dim HLA DR-,CD45RA+CD28-CD8br%CD8br以及PDL-1 on monocyte免疫细胞表型与膝骨关节炎之间可能具有较为显著的潜在因果关系,这为研究膝骨关节炎的生物学机制及探索膝骨关节炎的早期防治提供有价值的线索,也为干预性药物的开发提供了新的方向。