Neuroimmune actions in the brain and interactions with the effects of alcohol

The neuroimmune system of the brain:Early studies(1990’s)on the neurological consequences of human immunodeficiency virus-1(HIV-1)infection in the brain were instrumental in establishing that specific brain cell types can function as an innate immune system within the brain and in that role influence cognitive function(Kaul et al.,2005).

ORA59 and EIN3 interaction couples jasmonate-ethylene synergistic action to antagonistic salicylic acid regulation of PDF expression

Hormonal crosstalk is central for tailoring plant responses to the nature of challenges encountered. The role of antagonism between the two major defense hormones, salicylic acid （SA） and jasmonic acid （JA）, and modulation of this interplay by ethylene （ET） in favor of JA signaling pathway in plant stress responses is well recognized, but the underlying mechanism is not fully understood. Here, we show the opposing function of two transcription factors, ethylene insensitive3 （EIN3） and EIN3-Like1 （EIL1）, in SA-mediated suppression and JA- mediated activation of PLANT DEFENSINI.2 （PDFI.2）. This functional duality is mediated via their effect on protein, not transcript levels of the PDF1.2 transcriptional activator octadecanoid-responsive Arabidopsis59 （ORA59）. Specifically, JA induces ORA59 protein levels independently of EIN3/EIL1, whereas SA reduces the protein levels dependently of EIN3/EIL1. Co-infiltration assays revealed nuclear co-localization of ORA59 and EIN3, and split- luciferase together with yeast-two-hybrid assays established their physical interaction. The functional ramification of the physical interaction is EIN3-dependent degradation of ORA59 by the 26S proteasome. These findings allude to SA-responsive reduction of ORA59 levels mediated by EIN3 binding to and targeting of ORA59 for degrada4tion, thus nominating ORA59 pool as a coordination node for the antagonistic function of ET/JA and SA.

DATA: Digital Archiving and Transformed Analytics

As cloud service becomes more and more capable, available and powerful, wiseCIO has emerged from an innovative roadmap toward archival Content Management Service (aCMS) and massive Content Delivery Service (mCDS) in support of Anything-as-a-Service (XaaS) via Digital Archiving and Transformed Analytics (DATA);DATA aims to automate UBC with FAST solutions throughout a feasible, analytical, scalable and testable approach. This paper, based on the novel wiseCIO (web-based intelligent service engaging Cloud Intelligence Outlet), presents digital archiving and transformed analytics via machine learning automata for intelligent UBC processes to liaise with Universal interface for human-computer interaction, enable Brewing aggregation (differing from traditional web browsing), and engage Centered user experience. As one of the most practical aspects of artificial intelligence, machine learning is applied to analytical model building and massive and/or multidimensional Online Analytical Processing (mOLAP) for more intelligent cloud service with little explicit coding required. DATA is central to useful information via archival transformation and analytics, and utilizable intelligence for Business, Education and Entertainment (iBEE) in support of decision-making. As a result, DATA orchestrates wiseCIO to promote ACTiVE XaaS that enables accessibility, contextuality and traceability of information for vast engagement with various cloud services, such as aCMS (archival Content Management Service), COSA (Context-Oriented Screening Aggregation), DASH (Deliveries Assembled for fast Search and Hits), OLAS (Online Learning via Analytical Synthesis), REAP (Rapid Extension and Active Presentation), and SPOT (Special Points On Top) with great ease.