期刊文献+
共找到2,555篇文章
< 1 2 128 >
每页显示 20 50 100
A clinical evaluation of serum concentrations of intercellular adhesion molecule-1 in patients with gastric cancer 被引量:3
1
作者 LIU Yong Zhong, CHEN Bin and SHE Xi Dian 《World Journal of Gastroenterology》 SCIE CAS CSCD 1998年第3期45-47,共3页
Aclinicalevaluationofserumconcentrationsofintercelularadhesionmolecule1inpatientswithgastriccancerLIUYongZ... Aclinicalevaluationofserumconcentrationsofintercelularadhesionmolecule1inpatientswithgastriccancerLIUYongZhong,CHENBinandSH... 展开更多
关键词 stomach neoplasms/immunology intercellular adhesion molecule 1/blood LYMPHATIC metastasis intercellular adhesion molecule 1/analysis enzyme linked IMMUNOSORBENT assay
下载PDF
High level of intercellular adhesion molecule-1 affects prognosis of patients with hepatocellular carcinoma 被引量:13
2
作者 Peng-Peng Zhu Sheng-Guang Yuan +2 位作者 Yan Liao Li-Ling Qin Wei-Jia Liao 《World Journal of Gastroenterology》 SCIE CAS 2015年第23期7254-7263,共10页
AIM: To determine the cut-off value of intercellular adhesion molecule-1(ICAM-1) and assess the correlation of ICAM-1 with clinicopathological features and the prognosis of hepatocellular carcinoma(HCC)patients who un... AIM: To determine the cut-off value of intercellular adhesion molecule-1(ICAM-1) and assess the correlation of ICAM-1 with clinicopathological features and the prognosis of hepatocellular carcinoma(HCC)patients who underwent surgical resection.METHODS: We prospectively collected clinicopathological data from 236 HCC patients who had undergone successful hepatectomy. Receiver operating characteristic curve analysis was performed to determine the optimal cut-off value of ICAM-1. Enzymelinked immunosorbent assay was used to measure the concentration of ICAM-1 in 236 serum samples isolated from HCC patients and the stratified analysis was used to compare the serum level of ICAM-1 in different HCC subgroups. Immunohistochemistry was performed to test the expression level of the ICAM-1 protein in76 cases of HCC tissues and their adjacent normal liver tissues(ANLT). The survival probability of HCC patients was estimated using Kaplan-Meier plots and differences between the groups were obtained using the log-rank test. Furthermore, independent indicatorsof the prognosis were acquired using a stepwise Cox proportional hazard model to analyze a series of predictors that were associated with disease-free survival(DFS) and overall survival(OS) in HCC patients.RESULTS: Our findings suggested that ICAM-1promotes HCC metastasis and high serum ICAM-1 is significantly associated with alpha-fetoprotein(AFP)(P = 0.022), clinical tumor-node-metastasis stage(P< 0.001), portal vein tumor thrombus(P = 0.005),distant metastasis(P = 0.016) and recurrence(P= 0.034). We further detected the ICAM-1 protein in HCC specimens and found that 56 of 76(73.7%)HCC tissues had ICAM-1 positive staining while only23 of 76(30.3%) ANLT were positively stained(P <0.0001). Survival analysis indicated that HCC patients with increased ICAM-1 concentrations had significantly shorter DFS and OS after resection. A multivariate analysis showed that ICAM-1 > 684 ng/mL was an independent factor for DFS(HR = 1.643; 95%CI:1.125-2.401; P = 0.010) and OS(HR = 1.692; 95%CI:1.152-2.486; P = 0.007).CONCLUSION: ICAM-1 may be a promising serological biomarker for HCC diagnosis and an independent predictor of DFS and OS after surgical resection and may provide a useful reference for the prediction of intra- and extrahepatic metastasis. 展开更多
关键词 HEPATOCELLULAR carcinoma intercellularadhesion molecule-1 PROGNOSIS BIOMARKER METASTASIS
下载PDF
The Value of the Soluable Intercellular Adhesion Molecule-1 Levels in Matermal Serum for Determination of Occult Chorioamnionitis in Premature Rupture of Membranes 被引量:6
3
作者 邹丽 张会军 +1 位作者 祝建芳 朱剑文 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2004年第2期154-157,共4页
To compare the diagnostic value of soluble intercellular adhesion molecule 1 (sICAM-1) with that of c-reactive protein (CRP) for detecting chorioamnionitis (CAM) in serum of women with premature rupture of membranes (... To compare the diagnostic value of soluble intercellular adhesion molecule 1 (sICAM-1) with that of c-reactive protein (CRP) for detecting chorioamnionitis (CAM) in serum of women with premature rupture of membranes (PROM), 55 pregnant women with PROM, including 18 pregnant women with preterm premature rupture of membranes (PPROM) and 20 normal pregnant women at term (TPROM) were studied. Maternal serum were measured by Sandwish enzyme-linked immunoabsorbent assay (ELISA) for sICAM. CAM was histologically confirmed after delivery. The results revealed that (1) maternal serum levels of sICAM-1 and CRP were significantly higher in women with PROM than those without it; (2) maternal serum levels of sICAM-1 and CRP were significantly higher in women with CAM than those without it; (3) serum levels of sICAM-1 in PPROM women were similar to those in TPROM women, whereas serum levels of CRP in PPROM women were significantly higher than those in TPROM women; (4) the sensitivity, specificity, positive predictive value, negative predictive value, Kappa index and area under receiver operating characteristic (ROC) curve of maternal serum sICAM-1 (cutoff 104.7 ng/ml) and CRP(cutoff 1.03 mg/dl) for diagnosing CAM were 100 %, 91.2 %, 87.5 %, 100 %, 0.20, 0.995 and 81.0 %, 73.5 %, 65.4 %, 86.2 %, 0.13, 0.811, respectively; (5) among the mild histological CAM group, severe histological CAM group and clinical CAM group, the difference in maternal serum levels of sICAM-1 were significantly (P<0.001), with the order of concentration from high level to low level corresponding to the severity of CAM. It is concluded that maternal serum level of ICAM-1 is superior to that of CRP as biomarker for diagnosing intraamniotic infection in pregnant women with PROM. 展开更多
关键词 intercellular adhesion molecule-1 chorioamninitis diagnosis
下载PDF
Different expression pattern of serum soluble intercellular adhesion molecules-1 and neutrophilic expression of CD18 in patients with diabetic retinopathy 被引量:5
4
作者 Hua Ai Hu-Ping Song 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2012年第2期202-207,共6页
AIM: To investigate the levels of serum soluble intercellular adhesion molecules-1 (sICAM-1) and neutrophilic expression of CD18 in patients with various stages of diabetic retinopathy and to determine their different... AIM: To investigate the levels of serum soluble intercellular adhesion molecules-1 (sICAM-1) and neutrophilic expression of CD18 in patients with various stages of diabetic retinopathy and to determine their different expression pattern in the development of diabetic retinopathy(DR). METHODS: Levels of serum sICAM-1 and CD18 on the surface of neutrophile were measured in 41 DR patients, they were classified in three subgroups according to the stage of retinopathy as determined by fund's ophthalmoscopy; 10 control subjects were also studied. sICAM-1 were measured by enzyme-linked immunosorbent assay and CD18 by flow cytometry. RESULTS: The neutrophilic CD18 expression and serum sICAM-1 level were all significantly elevated in all diabetic subgroups compared to control subjects (P <0.01). The differences of CD18 and sICAM-1 among the diabetic subgroups were significant in CD18 but not in sICAM-1. The progression of retinopathy was associated with an increase both in CD18 and in sICAM-1 levels by simple correlation analysis (beta =0.74, P<0.001; beta =0.38, P<0.01, respectively). But stepwise multiple regression analysis revealed that only CD18 Was independent determinant of retinopathy (beta =1.04, P<0.01). CONCLUSION: Our results confirm the contribution of endothelial and neutrophilic activation in the development of DR as indicated by increased levels of CD18 and sICAM-1. However, a direct implication of CD18 and ICAM-1 in the progression of DR can be supported only in the CD18 but not ICAM-1. CD18 and ICAM-1 may play different role in the development of diabetic retinopathy. 展开更多
关键词 diabetic retinopathy serum soluble intercellular adhesion molecules-1 NEUTROPHILIC CD18
下载PDF
Mild hypothermia effects on intercellular adhesion molecule-1 and serum interleukin-6 expression in brain tissues of a rat focal ischemia model 被引量:1
5
作者 Shengqi Fu Lei Yang +2 位作者 Shuling Zhang Shilong Sun Xingai Mao 《Neural Regeneration Research》 SCIE CAS CSCD 2008年第10期1124-1127,共4页
BACKGROUND: Previous studies have confirmed the neuroprotective effect of mild hypothermia on ischemic brain injury. OBJECTIVE: To investigate the effects of mild hypothermia on intercellular adhesion molecule-1 exp... BACKGROUND: Previous studies have confirmed the neuroprotective effect of mild hypothermia on ischemic brain injury. OBJECTIVE: To investigate the effects of mild hypothermia on intercellular adhesion molecule-1 expression and serum interleukin-6 levels in ischemic brain tissues of focal brain ischemia rats, and to explore the neuroprotective effects of mild hypothermia on ischemic brain injury. DESIGN, TIME AND SETTING: A randomized, controlled, neurobiological experiment was performed at the Central Laboratory, First Affiliated Hospital, Xinxiang Medical College, China from February to July 2006. MATERIALS: Thirty healthy, adult, Sprague Dawley rats were used to establish middle cerebral artery occlusion models using the suture method, The immunohistochemistry (streptavidin-biotin-peroxidase complex method) kit was purchased from Boster, China. Interleukin-6 radioimmunoassay was supplied by Institute of Radioimmunity, Technology Development Center, General Hospital of Chinese PLA. METHODS: The rats were equally and randomly assigned into mild hypothermia and control groups, and middle cerebral artery occlusion models were established. The rectal temperature was maintained at (37 ±0.5)℃ in the control group. In the mild hypothermia group, the rectal temperature was maintained at (33±1)℃. MAIN OUTCOME MEASURES: At 12 hours after model establishment, the ischemic brain hemispheres were coronally sliced at the level of the optic chiasm. The number of intercellular adhesion molecule-1-positive vessels per high-power field was observed with an optical microscope. Serum interleukin-6 levels were measured by radioimmunoassay. RESULTS: Compared with the control group, intercellular adhesion molecule-1 and serum interleukin-6 expressions were significantly decreased in ischemic brain tissues of the mild hypothermia group (P 〈 0.01). CONCLUSION: Mild hypothermia exhibits a neuroprotective effect by reducing serum interleukin-6 and intercellular adhesion molecule-1 expression following cerebral ischemia. 展开更多
关键词 cerebral ischemia intercellular adhesion molecule-1 INTERLEUKIN-6 mild hypothermia
下载PDF
CIRCULATING INTERCELLULAR ADHESION MOLECULE 1 LEVELS IN SERA OF BRONCHIAL ASTHMA
6
作者 曹国强 杨肇亨 +1 位作者 沈际皋 李天星 《Chinese Medical Sciences Journal》 CAS CSCD 1998年第4期225-227,共3页
Objective The aim of the study was to determine whether bronchial asthma was associated with increased levels of soluble intercellular adhesion molecule 1(sICAM 1) in serum, which might be ... Objective The aim of the study was to determine whether bronchial asthma was associated with increased levels of soluble intercellular adhesion molecule 1(sICAM 1) in serum, which might be valuble data for the effective therapy of these patients Patients and methods The concentrations of sICAM 1 were determined in sera of healthy donors and asthmatic patients using a sensitive enzyme immunoassay Results The mean(±SD) levels of serum sICAM 1 of 26 asthmatic patients (205±72 0 μg/L)was significantly higher than that of the 30 healthy volunteers (154±63 9 μg/L,P<0 01) There was no much difference between the serum levels in 12 patients suffering from atopic asthma and the levels in 14 patients with nonatopic asthma The serum concentrations of sICAM 1 were higher during asthma attacks than that during remissions in the same patients (P<0 05) Conclusion These results suggest that sICAM 1 may play a certain role in the pathophysiology of bronchial asthma,and might be signals for successful treatment 展开更多
关键词 adhesion molecule intercellular adhesion molecule 1 bronchial asthma
下载PDF
Expression of Intercellular Adhesion Molecule-1 in Immune Response of Inner Ear
7
作者 龚树生 曾新力 +1 位作者 严臻 汪吉宝 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 1998年第4期208-211,共4页
To understand the role of intercellular adhesion molecule-1 (ICAM-1) in immune response of the inner ear, inner ear immune response was induced in rats by inoculation of keyhole limpet hemocyanine (KLH) into the scala... To understand the role of intercellular adhesion molecule-1 (ICAM-1) in immune response of the inner ear, inner ear immune response was induced in rats by inoculation of keyhole limpet hemocyanine (KLH) into the scala tympani of the animals who had been systemically sensitized. The expression of ICAM-1 in the inner ear was immunohistochemically examined. ICAM-1 was found in the epithelium of the spiral modiolar vein (SMV) with its collecting venules (CVs) as early as 6 h after challenge. Expression of ICAM-1 was observed on the epithelium of the endolymphatic sac (ES) and perisaccular region at 12 h. The intensity of ICAM-1 staining reached its peak within 24 - 48 h in these sites of the inner ear. By day 28, most specimens were devoid of appreciable staining for ICAM-1. Our study demonstrates that adhesion molecules play an important role in extravasation of inflammatory cells from the systemic circulation in the process of inner ear immune response. It also shows that cytokines that control expression of adhesion molecules may be released by cells outside ES, besides those cells in the ES. 展开更多
关键词 LABYRINTH AUTOIMMUNITY intercellular adhesion molecule-1 en-dolymphatic sac
下载PDF
Changes of soluble intercellular adhesion molecule-1 in the serum from patients with acute cerebral infarction
8
作者 周华东 陈曼娥 颜建华 《Journal of Medical Colleges of PLA(China)》 CAS 1997年第4期328-330,共3页
objective: To observe the changes of soluble intercellular adhesion molecule-1(sICAM-1) in the serum of patients with acute cerebral infarctlon (ACI) and their clinical significance. Methods: The concen-tration of sIC... objective: To observe the changes of soluble intercellular adhesion molecule-1(sICAM-1) in the serum of patients with acute cerebral infarctlon (ACI) and their clinical significance. Methods: The concen-tration of sICAM-1 in the serum of 91 patients with ACI was determined with ELISA and then the results were compared wlth those of 43 patients with cerebral hemorrhage and 30 healthy individuals. Results: In the 24th hour after infarction. the concentration of sICAMu-1 in the serum was significantly higher in patients with ACI than in patients with cerebral hemorrhage and normal controls (P< 0. 01). In the patients with ACI, the concentration exhibited an decreasing tendency in the period from the 24th hour to the 14th day andwas correlated with the focal size of cerebral infarction. During the first 14 days after infarction, the concen-tration was significantly higher in the patients with the complication of infection than in those without. Con-clusion: sICAM-1 is closely correlated with clinical manifestation of ACI. 展开更多
关键词 CEREBRAL INFARCTION SOLUBLE intercellular adhesion molecule-1 (sicam-1)
下载PDF
不同时间窗高压氧治疗对急性脑梗死患者颈动脉血流动力学及血清Hcy、sICAM-1、IL-1β水平的影响 被引量:1
9
作者 韩娟 钟莲梅 +1 位作者 雷春艳 康丽香 《脑与神经疾病杂志》 CAS 2024年第9期576-580,共5页
目的 探讨不同治疗时间窗高压氧治疗对急性脑梗死(ACI)患者颈动脉血流动力学及血清同型半胱氨酸(Hcy)、可溶性细胞间黏附分子-1 (sICAM-1)、白细胞介素-1β (IL-1β)水平的影响。方法 选取2022年10月至2023年12月昆明医科大学第一附属... 目的 探讨不同治疗时间窗高压氧治疗对急性脑梗死(ACI)患者颈动脉血流动力学及血清同型半胱氨酸(Hcy)、可溶性细胞间黏附分子-1 (sICAM-1)、白细胞介素-1β (IL-1β)水平的影响。方法 选取2022年10月至2023年12月昆明医科大学第一附属医院神经内科收治的180例ACI患者,根据随机数字表法分为4组,各45例。对照组不接受高压氧治疗,早期组在发病72h内接受高压氧治疗,中期组在发病3~7d内接受高压氧治疗,晚期组在发病7d后接受高压氧治疗。对比各组临床疗效、颈动脉血流动力学状况及血清Hcy、sICAM-1、IL-1 β水平变化。结果 治疗后,早期组总有效率显著高于中期组、晚期组及对照组(^(均)P<0.05)。治疗后,早期组美国国立卫生院卒中量表(NIHSS)评分、改良Rankin量表(mRS)评分均低于中期组、晚期组及对照组,中期组低于晚期组及对照组(^(均)P<0.05);早期组治疗后颈动脉平均血流速(Vm)、搏动指数(PI)、阻力指数(RI)优于中期组、晚期组和对照组,中期组颈动脉Vm、PI、RI又优于晚期组和对照组(^(均)P<0.05);早期组治疗后血清Hcy、sICAM-1及IL-1 β水平低于中期组、晚期组和对照组,中期组血清Hey、sICAM-1及IL-1 β水平又低于晚期组和对照组(^(均)P <0.05)。结论 ACI患者在发病72 h内接受高压氧治疗效果显著,可有效改善颈动脉血流状况,降低血管损害和炎症反应程度,具有较高安全性。 展开更多
关键词 急性脑梗死 高压氧 血流动力学 同型半胱氨酸 可溶性细胞间黏附分子-1 白细胞介素-1β
下载PDF
升阳除湿防风汤联合化疗治疗晚期胃癌疗效及对患者血清CA72-4、sICAM-1的影响
10
作者 慈书俊 梁惠 +1 位作者 吴宁波 耿亚迪 《陕西中医》 CAS 2024年第6期775-779,共5页
目的:观察升阳除湿防风汤联合化疗治疗晚期胃癌患者的临床疗效及血清糖类抗原72-4(CA72-4)、可溶性细胞间黏附分子-1(sICAM-1)变化。方法:选择86例晚期胃癌患者,根据治疗方法将其分为两组,各43例,化疗组给予常规化疗治疗,观察组在化疗... 目的:观察升阳除湿防风汤联合化疗治疗晚期胃癌患者的临床疗效及血清糖类抗原72-4(CA72-4)、可溶性细胞间黏附分子-1(sICAM-1)变化。方法:选择86例晚期胃癌患者,根据治疗方法将其分为两组,各43例,化疗组给予常规化疗治疗,观察组在化疗组基础上给予升阳除湿防风汤治疗,比较两组客观缓解率(ORR)、疾病控制率(DCR)、中医症状积分、血清CA72-4、sICAM-1水平、T淋巴细胞亚群指标(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))、不良反应总发生率。结果:观察组ORR、DCR均较化疗组更高(P<0.05)。观察组治疗后畏寒肢冷、脘腹胀满、恶心呕吐、神疲乏力积分均较化疗组更低(P<0.05)。观察组治疗后血清CA72-4、sICAM-1水平均较化疗组更低(P<0.05)。观察组治疗后CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均较化疗组更高(P<0.05),CD8^(+)较化疗组更低(P<0.05)。观察组血小板减少、贫血、脱发、恶心、呕吐总发生率与化疗组比较,差异无统计学意义(P>0.05)。结论:升阳除湿防风汤联合化疗可有效提高晚期胃癌客观缓解率、疾病控制率,缓解脘腹胀满等症状,改善免疫功能,纠正免疫失衡,降低血清CA72-4、sICAM-1表达量,且未增加不良反应发生率。 展开更多
关键词 胃癌 升阳除湿防风汤 多西他赛 顺铂 5-氟尿嘧啶 糖类抗原72-4 可溶性细胞间黏附分子-1
下载PDF
血清ICAM-1、IL-6水平与系统性红斑狼疮患者疾病活动度的关系及评估颈动脉粥样硬化的价值
11
作者 杨有国 李小芬 +2 位作者 张炜 曾邕萍 刘媛 《临床和实验医学杂志》 2024年第18期1953-1957,共5页
目的 研究血清细胞间黏附分子(ICAM-1)、白细胞介素-6(IL-6)与系统性红斑狼疮(SLE)患者疾病活动性的相关性,并探讨其评估颈动脉粥样硬化(CA)的临床价值。方法 回顾性选取2021年1月至2023年12月广西医科大学附属柳州市人民医院收治的SLE... 目的 研究血清细胞间黏附分子(ICAM-1)、白细胞介素-6(IL-6)与系统性红斑狼疮(SLE)患者疾病活动性的相关性,并探讨其评估颈动脉粥样硬化(CA)的临床价值。方法 回顾性选取2021年1月至2023年12月广西医科大学附属柳州市人民医院收治的SLE患者98例作为研究对象,设为SLE组。按SLE疾病活动指数(SLEDAI)-2000将其分为中重度活动(SLEDAI≥10分)组(n=53)与轻度活动(SLEDAI<10分)组(n=45);并按是否合并CA将患者分为CA组(n=29)与非CA组(n=69)。另选取同期健康体检者50名作为对照组。比较各组血清ICAM-1、IL-6水平,比较CA组与非CA组的临床资料[性别、年龄、体重指数、吸烟史、饮酒史、高血压、高脂血症、SLEDAI评分、C反应蛋白(CRP)、红细胞沉降率(ESR)、补体(C3、C4)],并使用多因素Logistic回归分析影响SLE并发CA的相关因素;用受试者操作特征(ROC)曲线评价血清ICAM-1、IL-6对SLE并发CA的评估能力。结果 SLE组血清ICAM-1、IL-6水平分别为(150.47±46.39)ng/mL、(21.54±5.49) pg/mL,均显著高于对照组[(65.52±19.46)ng/mL、(9.31±2.35) pg/mL],差异均有统计学意义(P<0.05)。中重度活动患者血清ICAM-1、IL-6水平分别为(177.41±42.36) ng/mL、(25.31±4.78) pg/mL,均显著高于轻度活动患者[(118.74±38.21) ng/mL、(17.10±4.23) pg/mL],差异均有统计学意义(P<0.05)。CA组合并高血压比例、SLEDAI评分、血清CRP、ICAM-1和IL-6水平分别为48.28%、(13.96±2.04)分、(4.36±1.42) mg/L、(171.58±38.41) ng/mL、(24.31±4.27) pg/mL,均高于非CA组[17.39%、(7.41±2.13)分、(3.72±1.19) mg/L、(141.60±42.34) ng/mL、(20.38±5.11) pg/mL],而补体C3、C4水平分别为(0.38±0.11)、(0.09±0.02)g/L,均低于非CA组[(0.57±0.16)、(0.14±0.04)g/L],差异均有统计学意义(P<0.05)。经Logistic回归分析得出,高血压、血清较高ICAM-1水平、较高IL-6水平均是患者并发CA的危险因素(OR=1.110,95%CI:1.016~1.212;OR=1.239,95%CI:1.078~1.424;OR=1.217,95%CI:1.079~1.371;P<0.05)。ROC曲线分析得出,血清ICAM-1、IL-6评估SLE并发CA的曲线下面积(AUC)分别为0.735、0.722,二者联合的AUC为0.810,相比单项指标显著增大(P<0.05)。结论 SLE患者血清ICAM-1、IL-6水平增高与疾病活动度相关,且对SLE并发CA有评估价值。 展开更多
关键词 系统性红斑狼疮 细胞间黏附分子1 白细胞介素-6 颈动脉粥样硬化 疾病活动度
下载PDF
温胆汤加减治疗气虚血瘀痰阻型缺血性脑卒中急性期的疗效及对NT-proBNP、ICAM-1和MCP-1的影响研究
12
作者 金海涛 张雯 王非 《中国医院用药评价与分析》 2024年第6期681-684,共4页
目的:探讨温胆汤加减治疗气虚血瘀痰阻型缺血性脑卒中急性期患者的疗效,以及对N末端脑钠肽前体(NT-proBNP)、细胞间黏附分子-1(ICAM-1)和单核细胞趋化蛋白-1(MCP-1)水平的影响。方法:以2021年5月至2022年5月该院收治的气虚血瘀痰阻型缺... 目的:探讨温胆汤加减治疗气虚血瘀痰阻型缺血性脑卒中急性期患者的疗效,以及对N末端脑钠肽前体(NT-proBNP)、细胞间黏附分子-1(ICAM-1)和单核细胞趋化蛋白-1(MCP-1)水平的影响。方法:以2021年5月至2022年5月该院收治的气虚血瘀痰阻型缺血性脑卒中急性期患者100例为研究对象,根据随机数字表法分为对照组和观察组,每组50例。对照组患者给予常规治疗,观察组患者在对照组的基础上给予温胆汤加减治疗。比较两组患者的临床疗效,NT-proBNP、ICAM-1和MCP-1水平,美国国立卫生院卒中神经功能缺损评分量表(NIHSS)评分、改良Rankin量表(mRS)评分及中医证候积分。结果:治疗1个月后,观察组患者的总有效率为94.00%(47/50),显著高于对照组的80.00%(40/50),差异有统计学意义(P<0.05)。治疗1个月后,观察组患者NT-proBNP、ICAM-1和MCP-1水平显著低于对照组,血液流变学各指标(血浆黏度、血低切黏度、血高切黏度、纤维蛋白原和红细胞压积)水平显著低于对照组,差异均有统计学意义(P<0.05)。治疗7 d、1个月后,观察组患者的NIHSS评分低于对照组;治疗1个月后,观察组患者的mRS评分、中医证候积分低于对照组,差异均有统计学意义(P<0.05)。结论:温胆汤加减治疗气虚血瘀痰阻型缺血性脑卒中急性期患者的效果较好,可显著降低NT-proBNP、ICAM-1和MCP-1水平,促进血液流通和疾病的恢复,提高患者的生活质量。 展开更多
关键词 缺血性脑卒中 气虚血瘀痰阻证 温胆汤 N末端脑钠肽前体 细胞间黏附分子-1 单核细胞趋化蛋白-1
下载PDF
血清SIRT1、sICAM-1及PD-L1联合检测对难治性弥漫性大B细胞淋巴瘤患者预后的评估效能
13
作者 刘帅 宋海容 段昱 《河南医学研究》 CAS 2024年第16期2922-2926,共5页
目的探讨血清沉默信息调节因子1(SIRT1)、可溶性细胞间黏附分子-1(sICAM-1)及细胞程序性死亡-配体1(PD-L1)联合检测对难治性弥漫性大B细胞淋巴瘤(DLBCL)患者预后的评估效能。方法选取2022年1月至2023年10月在郑州大学第一附属医院诊治... 目的探讨血清沉默信息调节因子1(SIRT1)、可溶性细胞间黏附分子-1(sICAM-1)及细胞程序性死亡-配体1(PD-L1)联合检测对难治性弥漫性大B细胞淋巴瘤(DLBCL)患者预后的评估效能。方法选取2022年1月至2023年10月在郑州大学第一附属医院诊治的84例难治DLBCL患者作为研究对象,根据治疗后1个月的疾病状态将患者分为预后良好组(57例)和预后不良组(27例),收集患者的一般临床资料;采用酶联免疫吸附法(ELISA)检测患者血清SIRT1、sICAM-1及PD-L1水平;分析血清SIRT1、sICAM-1及PD-L1水平与患者临床特征、治疗效果及预后的关系;采用多因素logistic回归分析,筛选出患者预后不良的影响因素。绘制受试者工作特征(ROC)曲线,计算曲线下面积(AUC),评价血清SIRT1、sICAM-1及PD-L1水平对难治DLBCL患者预后的预测能力。结果预后不良组血清SIRT1、sICAM-1及PD-L1水平均高于预后良好组(P<0.05)。多因素logistic回归分析显示,血清SIRT1、sICAM-1及PD-L1水平是影响难治性DLBCL患者预后不良的独立危险因素(P<0.05);ROC结果显示,血清SIRT1、sICAM-1及PD-L1单独及三者联合预测难治性DLBCL患者预后不良的AUC分别为0.851、0.843、0.924、0.980,且三者联合的预测价值高于单独预测(P<0.05)。结论血清SIRT1、sICAM-1及PD-L1水平可作为难治DLBCL患者预后评估的重要指标,且三者联合检测的效能优于单项检测,对指导临床治疗及监测疾病进展有重要意义。 展开更多
关键词 沉默信息调节因子1 可溶性细胞间黏附分子-1 细胞程序性死亡-配体1 难治性弥漫性大B细胞淋巴瘤 预后
下载PDF
Expression of intercellular adhesive molecule-1 in liver cancer tissues and liver cancer metastasis 被引量:12
14
作者 SUN Jing Jing, ZHOU Xin Da, ZHOU Ge and LIU Yin Kun 《World Journal of Gastroenterology》 SCIE CAS CSCD 1998年第3期22-25,共4页
AIM To study the relationship between intercellular adhesive molecule 1 (ICAM 1) and liver cancer metastasis and to search for factors to predict metastasis of liver cancer. METHODS ICAM 1 expression in fresh ti... AIM To study the relationship between intercellular adhesive molecule 1 (ICAM 1) and liver cancer metastasis and to search for factors to predict metastasis of liver cancer. METHODS ICAM 1 expression in fresh tissues of normal liver and hepatocellular cancer (HCC) was examined by immunoperoxidase staining. The expression of ICAM 1 in human hepatoma, tumor surrounding tissues and normal livers were semiquantitatively analyzed by Dot immuno blot. Tissue ICAM 1 expression at mRNA level was detected by Northern blot. RESULTS All 6 cases of normal liver samples were negative in anti ICAM 1 immunohistochemical staining, 80 0% (36/45) of HCC presented various ICAM 1 expression. The number of positive cells was a little higher in large tumors, tumors with intact capsule and metastasis, but there was no significant difference. Two cases with cancer embolus also had high ICAM 1 expression. ICAM 1 concentration in HCC (13 43±0 09) was higher than that in tumor surrounding tissues (5 89±0 17, P <0 01) and normal livers (4 27±0 21, P <0 01). It was also higher in metastasis group (20 24±0 30) than in nonmetastasis group (10 23±0 12, P <0 05). Northern blot analysis revealed that ICAM 1 expression at mRNA level was also higher in HCC and cancer embolus than that in tumor surrounding tissues and normal livers. CONCLUSION Tissue ICAM 1 could indicate the growth and metastasis of HCC, and may be an index that can predict liver cancer metastasis. 展开更多
关键词 LIVER CANCER tumor METASTASIS intercellular adhesion molecule 1
下载PDF
血清FOXO3a、NLRP3、sICAM-1水平在冠心病合并高尿酸血症患者中的意义
15
作者 闫国伟 刘雯 贾青霞 《河南医学研究》 CAS 2024年第21期3900-3904,共5页
目的探讨冠心病合并高尿酸血症(HUA)患者叉头转录因子O亚家族成员3a(FOXO3a)、核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)、可溶性细胞间黏附分子1(sICAM-1)水平变化的意义。方法选取河南科技大学第一附属医院2021年1月至2022年8月收治... 目的探讨冠心病合并高尿酸血症(HUA)患者叉头转录因子O亚家族成员3a(FOXO3a)、核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)、可溶性细胞间黏附分子1(sICAM-1)水平变化的意义。方法选取河南科技大学第一附属医院2021年1月至2022年8月收治的156例冠心病患者为研究对象,根据尿酸水平分为HUA组(62例)和UA正常组(94例)。比较两组一般临床资料及FOXO3a、NLRP3、sICAM-1水平,分析FOXO3a、NLRP3、sICAM-1水平与临床资料中有统计学差异指标及UA水平相关性,采用logistic回归分析影响冠心病合并HUA的危险因素,以受试者工作特征(ROC)曲线分析FOXO3a、NLRP3、sICAM-1水平联合检测对冠心病合并HUA的诊断价值。结果HUA组总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平高于UA正常组(P<0.05);HUA组FOXO3a、NLRP3、sICAM-1水平高于UA正常组(P<0.05);相关性分析发现,FOXO3a、NLRP3、sICAM-1水平与TC、TG、LDL-C、UA水平均呈正相关(P<0.05);logistic回归分析发现,TC(>5.04 mmol·L^(-1))、TG(>1.88 mmol·L^(-1))、LDL-C(>2.53 mmol·L^(-1))、FOXO3a(>4.65μg·L^(-1))、sICAM-1(>195.73μg·L^(-1))、NLRP3(>1322.12 ng·L^(-1))水平是冠心病患者合并HUA的危险因素(P<0.05);ROC分析发现,FOXO3a、sICAM-1、NLRP3水平联合诊断冠心病合并HUA的曲线下面积(AUC)为0.811,敏感度、特异度分别为95.16%、67.02%,优于各指标单一指标诊断,具有较高诊断效能(P<0.05)。结论FOXO3a、NLRP3、sICAM-1参与冠心病合并HUA发生过程,且在临床诊断冠心病合并HUA方面具有较高效能。 展开更多
关键词 冠心病 高尿酸血症 叉头转录因子O亚家族成员3a 核苷酸结合寡聚化结构域样受体蛋白3 可溶性细胞间黏附分子1
下载PDF
Clinical significance of serum intercellular adhesion molecule-i detection in patients with hepatocellular carcinoma 被引量:20
16
作者 Ming Hui Mei Jing Xu Qin Fen Shi Jing Hong Yang Qian CHen Li Ling Qin Department of Hepatobiliary Surgery, Institute of Hepatobiliary Surgery,Guilin Medical College,Guilin 541001,Guangxi Province,China 《World Journal of Gastroenterology》 SCIE CAS CSCD 2000年第3期408-410,共3页
INTRODUCTION Since the late 1980s,studies on the expression ofintercellular adhesion molecule-1(ICAM-1)inpatients with malignancies have demonstrated thatICAM-1 may strongly express in two forms in suchdiseases:membra... INTRODUCTION Since the late 1980s,studies on the expression ofintercellular adhesion molecule-1(ICAM-1)inpatients with malignancies have demonstrated thatICAM-1 may strongly express in two forms in suchdiseases:membranous one on the surface of tumorcells(membrane-bound ICAM-1)and soluble one incirculation(soluble ICAM-1,sICAM-1). 展开更多
关键词 carcinoma hepatocellular/diagnosis intercellular adhesion molecule-1 liverneoplasms/diagnosis ALPHA-FETOPROTEIN
下载PDF
开窍活血汤联合阿替普酶对急性脑梗死患者认知功能及血清NT-proBNP和sICAM-1的影响 被引量:3
17
作者 朱智恒 罗凯 +2 位作者 刘用 王璐 李春辉 《中国药业》 CAS 2024年第5期54-58,共5页
目的探讨开窍活血汤联合阿替普酶(rt-PA)对急性脑梗死(ACI)患者认知功能及血清N-末端B型脑钠肽前体(NT-proBNP)、可溶性细胞间黏附分子-1(sICAM-1)水平的影响。方法选取湖南中医药大学第一附属医院2022年1月至12月收治的ACI患者100例,... 目的探讨开窍活血汤联合阿替普酶(rt-PA)对急性脑梗死(ACI)患者认知功能及血清N-末端B型脑钠肽前体(NT-proBNP)、可溶性细胞间黏附分子-1(sICAM-1)水平的影响。方法选取湖南中医药大学第一附属医院2022年1月至12月收治的ACI患者100例,按随机数字表法分为观察组和对照组,各50例。两组患者均予rt-PA溶栓治疗联合常规治疗,观察组患者加用开窍活血汤,两组患者均治疗2周。结果观察组总有效率为96.00%,显著高于对照组的82.00%(P<0.05)。治疗后,两组患者的口舌歪斜、半身不遂、言语謇涩、面色皎白、舌质暗淡、脉沉细等中医证候积分均显著降低,且观察组显著低于对照组(P<0.05);两组患者美国国立卫生研究院卒中量表(NIHSS)评分显著降低,简易智能精神状态评估量表(MMSE)评分显著升高,且观察组显著优于对照组(P<0.05);两组患者NT-proBNP和sICAM-1水平均显著降低(P<0.05),且观察组显著低于对照组(P<0.05)。观察组患者治疗期间不良反应发生率为6.00%,显著低于对照组的20.00%(P<0.05)。结论开窍活血汤联合rt-PA治疗ACI的临床疗效显著,可有效缓解患者的临床症状和体征,改善其神经功能及认知功能,降低血清NT-proBNP和sICAM-1水平,且安全性良好。 展开更多
关键词 开窍活血汤 阿替普酶 急性脑梗死 N-末端B型脑钠肽前体 可溶性细胞间黏附分子-1
下载PDF
miR-92a、sICAM-1、VEGF在乳腺癌组织中的表达及其与超声血流参数的相关性研究 被引量:1
18
作者 常正江 陈小龙 《实用癌症杂志》 2024年第2期300-303,共4页
目的探讨微小核糖核酸-92a(miR-92a)、可溶性细胞间黏附分子-1(sICAM-1)、血管内皮生长因子(VEGF)在乳腺癌组织中的表达差异,并分析其与患者超声血流参数的相关性。方法选取乳腺癌患者102例作为乳腺癌组,同期收集乳腺良性肿瘤患者100例... 目的探讨微小核糖核酸-92a(miR-92a)、可溶性细胞间黏附分子-1(sICAM-1)、血管内皮生长因子(VEGF)在乳腺癌组织中的表达差异,并分析其与患者超声血流参数的相关性。方法选取乳腺癌患者102例作为乳腺癌组,同期收集乳腺良性肿瘤患者100例作为对照组。比较miR-92a、sICAM-1、VEGF在两组间的表达,分析其诊断价值。采用多普勒超声检测患者病变部位的血流参数,主要包括动脉血流峰值速度(PSV)、舒张末期血流速度(EDV)、脉动指数(PI)、阻力指数(RI),分析miR-92a、sICAM-1、VEGF与乳腺超声血流参数的相关性。结果乳腺癌组患者miR-92a、sICAM-1、VEGF水平明显高于对照组,差异具有统计学意义(P<0.05),三项联合检测诊断乳腺癌的曲线下面积(AUC)为0.897,灵敏度为89.3%,特异度为90.0%。Logistic回归分析显示miR-92a、sICAM-1、VEGF是乳腺癌发生的重要危险因素(P<0.05)。乳腺癌组患者的PSV、EDV明显高于对照组,PI、RI明显低于对照组,差异具有统计学意义(P<0.05)。Spearman相关性分析结果显示miR-92a、sICAM-1、VEGF水平与PSV、EDV呈正相关,与PI、RI呈负相关(P<0.05)。结论miR-92a、sICAM-1、VEGF在乳腺癌患者中明显升高,且与患者超声血流参数密切相关,是乳腺癌发生的重要危险因素,三项联合检测有助于乳腺癌的早期诊断及病情评估。 展开更多
关键词 乳腺癌 微小核糖核酸-92a 可溶性细胞间黏附分子-1 血管内皮生长因子 血流 超声
下载PDF
血浆ET-1、D-D、sVCAM-1、ICAM-1水平预测突发性耳聋患者预后的价值
19
作者 谢书华 杨竹梅 +3 位作者 刘慧茹 董晶 刘冰 李华超 《徐州医科大学学报》 CAS 2024年第1期32-36,共5页
目的探讨血浆内皮素-1(ET-1)、D-二聚体(D-D)、血浆可溶性血管细胞黏附分子-1(sVCAM-1)、细胞间黏附因子-1(ICAM-1)在预测突发性耳聋患者预后方面的价值。方法选取2020年6月—2022年6月上海市杨浦区控江医院收治的老年突发性耳聋患者130... 目的探讨血浆内皮素-1(ET-1)、D-二聚体(D-D)、血浆可溶性血管细胞黏附分子-1(sVCAM-1)、细胞间黏附因子-1(ICAM-1)在预测突发性耳聋患者预后方面的价值。方法选取2020年6月—2022年6月上海市杨浦区控江医院收治的老年突发性耳聋患者130例,作为观察组。选取同期检查的健康体检者120例,作为对照组。采用酶联免疫法(ELISA)测量2组患者血浆ET-1、D-D、sVCAM-1、ICAM-1水平。采用受试者工作特征(ROC)曲线评估血浆ET-1、D-D、sVCAM-1、ICAM-1水平预测突发性耳聋患者预后的价值。结果观察组血浆ET-1、D-D、sVCAM-1、ICAM-1水平显著高于对照组,差异有统计学意义(P<0.05)。与高频突发性耳聋相比,低频突发性耳聋患者血浆ET-1、D-D、sVCAM-1、ICAM-1水平更高,差异有统计学意义(P<0.05)。随着突发性耳聋患者听力损失的加重,血浆ET-1、D-D、sVCAM-1、ICAM-1水平显著升高,差异有统计学意义(P<0.05)。与治疗有效组相比,治疗无效组血浆ET-1、D-D、sVCAM-1、ICAM-1水平显著提升,差异有统计学意义(P<0.05)。血浆ET-1、D-D、sVCAM-1和ICAM-1联合应用时预测治疗有效的灵敏度、特异度高于单一指标预测(P<0.05)。结论血浆ET-1、D-D、sVCAM-1、ICAM-1水平升高与突发性耳聋的发生及预后有一定的关系。上述治疗联合检测将有助于临床更好地评价突发性耳聋患者的预后。 展开更多
关键词 内皮素-1 D-二聚体 血清可溶性血管细胞黏附分子-1 细胞间黏附因子-1 突发性耳聋 预后
下载PDF
急性大血管闭塞性脑卒中桥接治疗后再灌注损伤sCD40L、ET-1、ICAM-1因子相关性研究
20
作者 李峥嵘 袁波 +1 位作者 刘坤 付舒冉 《脑与神经疾病杂志》 CAS 2024年第5期302-306,共5页
目的探讨血清细胞间黏附分子(ICAM-1)、内皮素-1(ET-1)、血浆可溶性CD40配体(sCD40L)与急性大血管闭塞性脑卒中桥接治疗后再灌注损伤的关系。方法选取湖南省脑科医院2021年12月至2022年12月间接受桥接治疗的急性大血管闭塞性脑卒中患者9... 目的探讨血清细胞间黏附分子(ICAM-1)、内皮素-1(ET-1)、血浆可溶性CD40配体(sCD40L)与急性大血管闭塞性脑卒中桥接治疗后再灌注损伤的关系。方法选取湖南省脑科医院2021年12月至2022年12月间接受桥接治疗的急性大血管闭塞性脑卒中患者90例。按照术后是否出现再灌注损伤并发症进行分组,分为再灌注损伤组和未再灌注损伤组:运用ELISA法检测桥接治疗前和治疗开始后30 min、1h、2h、6h、24 h、5d的患者血清sCD40L、ICAM-1、ET-1的水平,并分析两组之间的差异以及治疗前后这3种因子水平的变化。结果治疗前再灌注损伤组和未再灌注损伤组患者血清中sCD40L、ICAM-1、ET-1水平比较差异无统计学意义(P>0.05)。未再灌注损伤组患者的治疗前及治疗后30 min、1 h、2h、6h、24 h、5d的血清中sCD40L、ICAM-1、ET-1水平随时间推移的变化急性大血管闭塞性脑卒中桥接治疗后再灌注损伤组患者的血清sCD40L、ICAM-1、ET-1水平增高,并且随时间推移逐渐升高。均不显著(P>0.05),各指标间无差异:再灌注损伤组患者治疗后各时间点血清中sCD40L、ICAM-1、ET-1水平均显著高于治疗前(均P<0.05),且在治疗后30 min、1h、2h、6 h、24 h、5d的时间点,患者血清中sCD40L、ICAM-1、ET-1水平均随时间变化而升高,不同时间亚组间比较差异均有统计学意义(~均P<0.05)。再灌注损伤组患者治疗后各时间点血清中sCD40L、ICAM-1、ET-1水平均高于未再灌注损伤组相同时间点(~均P<0.05)。结论急性大血管闭塞性脑卒中桥接治疗后再灌注损伤组患者的血清sCD40L、ICAM-1、ET-1水平增高,并且5d内随时间推移逐渐升高。 展开更多
关键词 桥接治疗 再灌注损伤 血清细胞间黏附分子 内皮素-1 血浆可溶性CD40配体
下载PDF
上一页 1 2 128 下一页 到第
使用帮助 返回顶部