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Structural features and exploration targets of platform margins in Sinian Dengying Formation in Deyang-Anyue Rift, Sichuan Basin, SW China 被引量:1
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作者 ZENG Fuying YANG Wei +12 位作者 WEI Guoqi YI Haiyong ZENG Yunxian ZHOU Gang YI Shiwei WANG Wenzhi ZHANG San JIANG Qingchun HUANG Shipeng HU Mingyi HAO Cuiguo WANG Yuan ZHANG Xuan 《Petroleum Exploration and Development》 SCIE 2023年第2期306-320,共15页
Based on the seismic, logging, drilling and other data, the distribution, structural types and mound-shoal hydrocarbon accumulation characteristics of platform margins of the Sinian Dengying Formation in the Deyang-An... Based on the seismic, logging, drilling and other data, the distribution, structural types and mound-shoal hydrocarbon accumulation characteristics of platform margins of the Sinian Dengying Formation in the Deyang-Anyue Rift and its periphery were analyzed. Four types of platform margins are developed in the Dengying Formation, i.e., single-stage fault-controlled platform margin, multi-stage fault-controlled platform margin, gentle slope platform margin, and overlapping platform margin. In the Gaoshiti West-Weiyuan East area, single-stage fault controlled platform margins are developed in the Deng 2 Member, which trend in nearly NEE direction and are shielded by faults and mudstones, forming fault-controlled–lithologic traps. In the Lezhi-Penglai area, independent and multi-stage fault controlled platform margins are developed in the Deng 2 Member, which trend in NE direction and are controlled by synsedimentary faults;the mound-shoal complexes are aggraded and built on the hanging walls of the faults, and they are shielded by tight intertidal belts and the Lower Cambrian source rocks in multiple directions, forming fault-controlled–lithologic and other composite traps. In the Weiyuan-Ziyang area, gentle slope platform margins are developed in the Deng 2 Member, which trend in NW direction;the mound-shoal complexes are mostly thin interbeds as continuous bands and shielded by tight intertidal belts in the updip direction, forming lithologic traps. In the Gaoshiti-Moxi-Yanting area, overlapping platform margins are developed in the Deng 2 and Deng 4 members;the mound-shoal complexes are aggraded and overlaid to create platform margin buildup with a huge thickness and sealed by tight intertidal belts and the Lower Cambrian mudstones in the updip direction, forming large-scale lithologic traps on the north slope of the Central Sichuan Paleouplift. To summarize, the mound-shoal complexes on the platform margins in the Dengying Formation in the Penglai-Zhongjiang area, Moxi North-Yanting area and Weiyuan-Ziyang area are large in scale, with estimated resources of 1.58×1012 m3, and they will be the key targets for the future exploration of the Dengying Formation in the Sichuan Basin. 展开更多
关键词 Sichuan Basin Deyang-Anyue Rift structural type of platform margin mound-shoal complex on the platform margin lithologic trap Sinian Dengying Formation exploration direction
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Clinical outcomes for men with positive surgical margins after radical prostatectomy—results from the South Australian Prostate Cancer Clinical Outcomes Collaborative community-based registry
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作者 Kerri R.Beckmann Michael E.O'Callaghan +2 位作者 Andrew D.Vincent Kim L.Moretti Nicholas R.Brook 《Asian Journal of Urology》 CSCD 2023年第4期502-511,共10页
Objective Positive surgical margins(PSMs)after radical prostatectomy(RP)indicate failure of surgery to completely clear cancer.PSMs confer an increased risk of biochemical recurrence(BCR),but how more robust outcomes ... Objective Positive surgical margins(PSMs)after radical prostatectomy(RP)indicate failure of surgery to completely clear cancer.PSMs confer an increased risk of biochemical recurrence(BCR),but how more robust outcomes are affected is unclear.This study investigated factors associated with PSMs following RP and determined their impact on clinical outcomes(BCR,second treatment[radiotherapy and/or androgen deprivation therapy],and prostate cancer-specific mortality[PCSM]).Methods The study cohort included men diagnosed with prostate cancer(pT2-3b/N0/M0)between January 1998 and June 2016 who underwent RP from the South Australian Prostate Cancer Clinical Outcomes Collaborative database.Factors associated with risk of PSMs were identified using Poisson regression.The impact of PSMs on clinical outcomes(BCR,second treatment,and PCSM)was assessed using competing risk regression.Results Of the 2827 eligible participants,28%had PSMs—10%apical,6%bladder neck,17%posterolateral,and 5%at multiple locations.Median follow-up was 9.6 years with 81 deaths from prostate cancer recorded.Likelihood of PSM increased with higher pathological grade and pathological tumor stage,and greater tumour volume,but decreased with increasing surgeon volume(odds ratio[OR]:0.93;95%confidence interval[CI]:0.88-0.98,per 100 previous prostatectomies).PSMs were associated with increased risk of BCR(adjusted sub-distribution hazard ratio[sHR]2.5;95%CI 2.1-3.1)and second treatment(sHR 2.9;95%CI 2.4-3.5).Risk of BCR was increased similarly for each PSM location,but was higher for multiple margin sites.We found no association between PSMs and PCSM.Conclusion Our findings support previous research suggesting that PSMs are not independently associated with PCSM despite strong association with BCR.Reducing PSM rates remains an important objective,given the higher likelihood of secondary treatment with associated comorbidities. 展开更多
关键词 Prostate cancer Positive surgical margin Biochemical recurrence RADICAL
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Mechanism of Structure Variations at Rifted Margins in the Central Segment of South Atlantic:Insights from Numerical Modeling
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作者 WANG Zhichen LI Jianghai +2 位作者 FENG Zhiqiang WANG Lijie LIU Chen 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2023年第4期1229-1242,共14页
Rifted margins in the central South Atlantic portray spatial variability in terms of preserved width and thickness,which relates to complex rift-related fault activities.However,there is still a lack of systematic and... Rifted margins in the central South Atlantic portray spatial variability in terms of preserved width and thickness,which relates to complex rift-related fault activities.However,there is still a lack of systematic and quantitative explanations for the causes of the variations that are observed along the paired rifts.To elucidate this issue,2D viscous-plastic thermomechanical numerical models are applied to capture the behavior of deformation,in which we investigate the effects of extensional rate,crustal strength and thickness on crust-mantle coupling,and timing of transition from rifting to breakup.Our numerical experiments demonstrate that crust-mantle decoupling accounts for crustal hyperextension,and that incorporating moderate-intensity rheology into lower crust may yield insights into the hyper-extended crust and asymmetric architecture observed in the central South Atlantic.The results also suggest that undulations in lithospheric basement cause asymmetric mantle upwelling.The lower crust of fold belts takes priority to be thermally weakened over craton and induces rift migration simultaneously.A new mechanism for the formation of failed rift is described,where the mechanical decoupling derived from thermally weakened lower crust gives access to dual rift migration.These results reinforce the interpretation on how crustal rheology shapes margins architectures and highlight the first-order effects of crust-mantle coupling. 展开更多
关键词 conjugate rifted margins crustal rheology crust-mantle coupling and decoupling rift migration central South Atlantic
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Subducting passive continental margins with crustal (ultra)mafic intrusions: An underappreciated mechanism for recycling water back into the mantle
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作者 CaiCai Pan XiaoBo He 《Earth and Planetary Physics》 CAS CSCD 2023年第5期576-581,共6页
It is well known that outer rise bending-assisted oceanic plate hydration is an important mechanism for transporting substantial amounts of water into the mantle.A key question is:Are there other equally or more impor... It is well known that outer rise bending-assisted oceanic plate hydration is an important mechanism for transporting substantial amounts of water into the mantle.A key question is:Are there other equally or more important water transport mechanisms?Here we propose,for the first time,that subducting passive continental margins,particularly those with crustal(ultra)mafic intrusions,play a critical role in recycling water back into the mantle.Evidence for this mechanism is the exceptionally high outer rise seismicity observed in a subducting passive continental margin(i.e.,the northeastern South China Sea continental margin)near the northern Manila trench,characterized by a high-velocity lower crust that has been attributed to(ultra)mafic intrusions.Our interpretation of this correlation between high outer rise seismicity and lower crust(ultra)mafic intrusions is that(ultra)mafic intrusions alter the crustal rheology and increase brittle deformation in the lower crust in this region,thereby promoting lithospheric fracturing and plate hydration,which is evidenced by increased outer rise seismicity. 展开更多
关键词 (ultra)mafic intrusion passive margin lithospheric fracturing outer rise plate hydration
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A three-dimensional Moho depth model beneath the Yemeni highlands and rifted volcanic margins of the Red Sea and Gulf of Aden, Southwest Arabia
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作者 Amin Noman Al Kadasi 《China Geology》 CAS CSCD 2023年第4期611-622,共12页
Knowing Moho discontinuity undulation is fundamental to understanding mechanisms of lithosphereasthenosphere interaction, extensional tectonism and crustal deformation in volcanic passive margins such as the study are... Knowing Moho discontinuity undulation is fundamental to understanding mechanisms of lithosphereasthenosphere interaction, extensional tectonism and crustal deformation in volcanic passive margins such as the study area, which is located in the southwestern corner of the Arabian Peninsula bounded by the Red Sea and the Gulf of Aden. In this work, a 3D Moho depth model of the study area is constructed for the first time by inverting gravity data from the Earth Gravitational Model(EGM2008) using the ParkerOldenburg algorithm. This model indicates the shallow zone is situated at depths of 20 km to 24 km beneath coastal plains, whereas the deep zone is located below the plateau at depths of 30 km to 35 km and its deepest part coincides mainly with the Dhamar-Rada ’a Quaternary volcanic field. The results also indicate two channels of hot magmatic materials joining both the Sana’a-Amran Quaternary volcanic field and the Late Miocene Jabal An Nar volcanic area with the Dhamar-Rada’a volcanic field. This conclusion is supported by the widespread geothermal activity(of mantle origin) distributed along these channels,isotopic data, and the upper mantle low velocity zones indicated by earlier studies. 展开更多
关键词 Bouguer gravity anomaly Earth gravitational model(EGM2008) Moho discontinuity Mantle upwelling Lithosphere-asthenosphere interaction Volcanic passive margin ISOSTASY Gulf of Aden Red Sea Arabian Peninsula
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Marginal zone lymphoma with severe rashes: A case report
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作者 Si-Jun Bai Ye Geng +7 位作者 Yi-Nan Gao Cai-Xia Zhang Qian Mi Chen Zhang Jia-Ling Yang Si-Jie He Zhen-YingYan Jian-Xia He 《World Journal of Clinical Cases》 SCIE 2024年第3期565-574,共10页
BACKGROUND Marginal zone lymphoma(MZL)is an indolent subtype of non-Hodgkin lymphoma(NHL),which is rare clinically with severe rashes as the initial symptom.CASE SUMMARY This study reports a case of MZL with generaliz... BACKGROUND Marginal zone lymphoma(MZL)is an indolent subtype of non-Hodgkin lymphoma(NHL),which is rare clinically with severe rashes as the initial symptom.CASE SUMMARY This study reports a case of MZL with generalized skin rashes accompanied by pruritus and purulent discharge.First-line treatment with rituximab combined with zanubrutinib had poor effects.However,after switching to obinutuzumab combined with zanubrutinib,the case was alleviated,and the rashes disappeared.CONCLUSION For patients with advanced stage MZL not benefiting from type I anti-CD20 monoclonal antibody(mAb)combination therapy,switching to a type II anti-CD20 mAb combination regimen may be considered.This approach may provide a new perspective in the treatment of MZL. 展开更多
关键词 marginal zone lymphoma Mucosa-associated lymphoid tissue Extranodal marginal zone lymphoma Primary cutaneous marginal zone lymphoma Rituximab Obinutuzumab Zanubrutinib Case report
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The largest CPIES array in the marginal sea:abundant dynamics in the northeast South China Sea
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作者 Hua Zheng Xiao-Hua Zhu +4 位作者 Min Wang Ruixiang Zhao Chuanzheng Zhang Feng Nan Fei Yu 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2024年第1期135-137,共3页
The South China Sea(SCS)is a marginal sea connecting the Pacific and Indian oceans and has gained much attention in recent decades.The dynamics in the northeast SCS are considerably influenced by topography,monsoons,t... The South China Sea(SCS)is a marginal sea connecting the Pacific and Indian oceans and has gained much attention in recent decades.The dynamics in the northeast SCS are considerably influenced by topography,monsoons,tropical cyclones,the Kuroshio intrusion,and water exchange through the Luzon Strait(LS). 展开更多
关键词 NORTHEAST marginAL abundant
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Distal margin distance in radical resection of locally advanced rectal cancer after neoadjuvant therapy
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作者 Jun Luo Mingxuan Zhu +6 位作者 Long Zhao Meiwen He Bei Li Yifan Liu Yuhan Sun Guoqing Lyu Zhanlong Shen 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2024年第2期226-232,共7页
Colorectal cancer has a high incidence and mortality rate in China, with the majority of cases being middle and low rectal cancer. Surgical intervention is currently the main treatment modality for locally advanced re... Colorectal cancer has a high incidence and mortality rate in China, with the majority of cases being middle and low rectal cancer. Surgical intervention is currently the main treatment modality for locally advanced rectal cancer, with the common goal of improving oncological outcomes while preserving function. The controversy regarding the circumferential resection margin distance in rectal cancer surgery has been resolved. With the promotion of neoadjuvant therapy concepts and advancements in technology, treatment strategies have become more diverse.Following tumor downstaging, there is an increasing trend towards extending the safe distance of distal rectal margin. This provides more opportunities for patients with low rectal cancer to preserve their anal function.However, there is currently no consensus on the specific distance of distal resection margin. 展开更多
关键词 Colorectal cancer distal resection margin neoadjuvant therapy
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Bendamustine and rituximab as frontline therapy in extranodal marginal zone lymphoma:a single-institution experience
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作者 CONSTANTINE N.LOGOTHETIS NATHAN P.HORVAT +8 位作者 TONY KURIAN CELESTE BELLO JULIO CHAVEZ LEIDY ISENALUMHE BIJAL SHAH LUBOMIR SOKOL HAYDER SAEED JAVIER PINILLA SAMEH GABALLA 《Oncology Research》 SCIE 2024年第6期1031-1036,共6页
Extranodal marginal zone lymphoma(EMZL)encompasses 70%of cases of marginal zone lymphoma.Frontline bendamustine and rituximab(BR)were derived from trials involving other indolent non-Hodgkin’s lymphomas.Only one tria... Extranodal marginal zone lymphoma(EMZL)encompasses 70%of cases of marginal zone lymphoma.Frontline bendamustine and rituximab(BR)were derived from trials involving other indolent non-Hodgkin’s lymphomas.Only one trial has evaluated frontline BR prospectively in EMZL.This retrospective study reports outcomes among EMZL patients receiving frontline BR.Twenty-five patients were included with a median age of 69 years(40–81).Five(20.0%)patients had stage Ⅰ/Ⅱ disease,and 20(80.0%)had stage Ⅲ/Ⅳ disease.The median number of cycles was 6.0(3.0–6.0).Maintenance rituximab was administered to 10(41.7%)individuals.Overall response rate(ORR)was 100.0%(60.0%complete response,40.0%partial response).Medians of overall survival and progression-free survival were not reached.The estimated 2-year progression-free survival was 85.2%and overall survival was 100.0%.Four(16.6%)patients had infections related to treatment;3(12.0%)transformed to diffuse large B-cell lymphoma;5(20.8%)had a relapse or progression of EMZL;and 3(12.0%)died unrelated to BR.BR is an efficacious and well-tolerated front-line regimen for EMZL with response data consistent with existing literature. 展开更多
关键词 Extranodal marginal zone lymphoma BENDAMUSTINE RITUXIMAB Front-line therapy
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Depositional model of the Member Deng-2 marginal microbial mound-bank complex of the Dengying Formation in the southwestern Sichuan Basin, SW China: Implications for the Ediacaran microbial mound construction and hydrocarbon exploration
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作者 Jin-Min Song Xin Jin +10 位作者 Zhong Luo Shu-Gen Liu Shao-Bo Liu Xing-Zhi Ma Zhi-Wu Li Xue-Song Lu Ling-Li Zhao Ke-Ran Li Jia-Xin Ren Li-Zhou Tian Hao-Shuang Deng 《Petroleum Science》 SCIE EI CAS CSCD 2024年第2期806-822,共17页
Recent advances in hydrocarbon exploration have been made in the Member Deng-2 marginal microbial mound-bank complex reservoirs of the Dengying Formation in the western Sichuan Basin, SW China,where the depositional p... Recent advances in hydrocarbon exploration have been made in the Member Deng-2 marginal microbial mound-bank complex reservoirs of the Dengying Formation in the western Sichuan Basin, SW China,where the depositional process is regarded confusing. The microfacies, construction types, and depositional model of the Member Deng-2 marginal microbial mound-bank complex have been investigated using unmanned aerial vehicle photography, outcrop section investigation, thin section identification,and seismic reflections in the southwestern Sichuan Basin. The microbialite lithologic textures in this region include thrombolite, dendrolite, stromatolite, fenestral stromatolite, spongiostromata stone,oncolite, aggregated grainstone, and botryoidal grapestone. Based on the comprehensive analysis of“depositional fabrics-lithology-microfacies”, an association between a fore mound, mound framework,and back mound subfacies has been proposed based on water depth, current direction, energy level and lithologic assemblages. The microfacies of the mound base, mound core, mound flank, mound cap, and mound flat could be recognized among the mound framework subfacies. Two construction types of marginal microbial mound-bank complex have been determined based on deposition location, mound scale, migration direction, and sedimentary facies association. Type Jinkouhe microbial mound constructions(TJMMCs) develop along the windward margin owing to their proximity to the seaward subfacies fore mound, with a northeastwardly migrated microbial mound on top of the mud mound,exhibiting the characteristics of large-sized mounds and small-sized banks in the surrounding area. Type E'bian microbial mound constructions(TEMMCs) primarily occur on the leeward margin, resulting from the presence of onshore back mound subfacies, with the smaller southwestward migrated microbial mounds existing on a thicker microbial flat. The platform margin microbial mound depositional model can be correlated with certain lateral comparison profile and seismic reflection structures in the 2D seismic section, which can provide references for future worldwide exploration. Microbial mounds with larger buildups and thicker vertical reservoirs are typically targeted on the windward margin, while small-sized microbial mounds and flats with better lateral connections are typically focused on the leeward margin. 展开更多
关键词 Sichuan Basin The Member Deng-2 marginal microbial mound-bank complex Depositional model Exploration implications
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Three-dimensional constrained gravity inversion of Moho depth and crustal structural characteristics at Mozambique continental margin
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作者 Shihao Yang Zhaocai Wu +3 位作者 Yinxia Fang Mingju Xu Jialing Zhang Fanlin Yang 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2024年第2期120-129,共10页
Mozambique's continental margin in East Africa was formed during the break-off stage of the east and west Gondwana lands. Studying the geological structure and division of continent-ocean boundary(COB) in Mozambiq... Mozambique's continental margin in East Africa was formed during the break-off stage of the east and west Gondwana lands. Studying the geological structure and division of continent-ocean boundary(COB) in Mozambique's continental margin is considered of great significance to rebuild Gondwana land and understand its movement mode. Along these lines, in this work, the initial Moho was fit using the known Moho depth from reflection seismic profiles, and a 3D multi-point constrained gravity inversion was carried out. Thus, highaccuracy Moho depth and crustal thickness in the study area were acquired. According to the crustal structure distribution based on the inversion results, the continental crust at the narrowest position of the Mozambique Channel was detected. According to the analysis of the crustal thickness, the Mozambique ridge is generally oceanic crust and the COB of the whole Mozambique continental margin is divided. 展开更多
关键词 3D constrained gravity inversion continent-ocean boundary Mozambique continental margin Moho depth
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Linkage between precipitation isotopes and water vapor sources in the monsoon margin:Evidence from arid areas of Northwest China
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作者 CHEN Fenli ZHANG Qiuyan +3 位作者 WANG Shengjie CHEN Jufan GAO Minyan Mohd Aadil BHAT 《Journal of Arid Land》 SCIE CSCD 2024年第3期355-372,共18页
The isotope composition in precipitation has been widely considered as a tracer of monsoon activity.Compared with the coastal region,the monsoon margin usually has limited precipitation with large fluctuation and is u... The isotope composition in precipitation has been widely considered as a tracer of monsoon activity.Compared with the coastal region,the monsoon margin usually has limited precipitation with large fluctuation and is usually sensitive to climate change.The water resource management in the monsoon margin should be better planned by understanding the composition of precipitation isotope and its influencing factors.In this study,the precipitation samples were collected at five sampling sites(Baiyin City,Kongtong District,Maqu County,Wudu District,and Yinchuan City)of the monsoon margin in the northwest of China in 2022 to analyze the characteristics of stable hydrogen(δD)and oxygen(δ18O)isotopes.We analyzed the impact of meteorological factors(temperature,precipitation,and relative humidity)on the composition of precipitation isotope at daily level by regression analysis,utilized the Hybrid Single-Particle Lagrangian Integrated Trajectory(HYSPLIT)-based backward trajectory model to simulate the air mass trajectory of precipitation events,and adopted the potential source contribution function(PSCF)and concentration weighted trajectory(CWT)to analyze the water vapor sources.The results showed that compared with the global meteoric water line(GMWL),the slope of the local meteoric water line(LMWL;δD=7.34δ^(18)O-1.16)was lower,indicating the existence of strong regional evaporation in the study area.Temperature significantly contributed toδ18O value,while relative humidity had a significant negative effect onδ18O value.Through the backward trajectory analysis,we found eight primary locations that were responsible for the water vapor sources of precipitation in the study area,of which moisture from the Indian Ocean to South China Sea(ITSC)and the western continental(CW)had the greatest influence on precipitation in the study area.The hydrogen and oxygen isotopes in precipitation are significantly influenced by the sources and transportation paths of air mass.In addition,the results of PSCF and CWT analysis showed that the water vapor source areas were primarily distributed in the south and northwest direction of the study area. 展开更多
关键词 water vapor monsoon margin stable water isotope transport trajectory air mass d-excess Δ18O δD
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Influences of burial process on diagenesis and high-quality reservoir development of deep-ultra-deep clastic rocks:A case study of Lower Cretaceous Qingshuihe Formation in southern margin of Junggar Basin,NW China
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作者 CHEN Sirui XIAN Benzhong +4 位作者 JI Youliang LI Jiaqi TIAN Rongheng WANG Pengyu TANG Heyuan 《Petroleum Exploration and Development》 SCIE 2024年第2期364-379,共16页
Taking the Lower Cretaceous Qingshuihe Formation in the southern margin of Junggar Basin as an example,the influences of the burial process in a foreland basin on the diagenesis and the development of high-quality res... Taking the Lower Cretaceous Qingshuihe Formation in the southern margin of Junggar Basin as an example,the influences of the burial process in a foreland basin on the diagenesis and the development of high-quality reservoirs of deep and ultra-deep clastic rocks were investigated using thin section,scanning electron microscope,electron probe,stable isotopic composition and fluid inclusion data.The Qingshuihe Formation went through four burial stages of slow shallow burial,tectonic uplift,progressive deep burial and rapid deep burial successively.The stages of slow shallow burial and tectonic uplift not only can alleviate the mechanical compaction of grains,but also can maintain an open diagenetic system in the reservoirs for a long time,which promotes the dissolution of soluble components by meteoric freshwater and inhibits the precipitation of dissolution products in the reservoirs.The late rapid deep burial process contributed to the development of fluid overpressure,which effectively inhibits the destruction of primary pores by compaction and cementation.The fluid overpressure promotes the development of microfractures in the reservoir,which enhances the dissolution effect of organic acids.Based on the quantitative reconstruction of porosity evolution history,it is found that the long-term slow shallow burial and tectonic uplift processes make the greatest contribution to the development of deep-ultra-deep high-quality clastic rock reservoirs,followed by the late rapid deep burial process,and the progressive deep burial process has little contribution. 展开更多
关键词 deep-ultra-deep layer clastic rock reservoir DIAGENESIS burial process Lower Cretaceous Qingshuihe Formation southern margin of Junggar Basin
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Transformation of marginal zone lymphoma into high-grade B-cell lymphoma expressing terminal deoxynucleotidyl transferase:A case report
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作者 Zhi-Min Fan Dao-Lei Wu +4 位作者 Neng-Wen Xu Li Ye Li-Ping Yan Lin-Jie Li Jun-Yu Zhang 《World Journal of Clinical Cases》 SCIE 2024年第15期2655-2663,共9页
BACKGROUND High-grade B-cell lymphoma(HGBL)is an unusual malignancy that includes myelocytomatosis viral oncogene(MYC),B-cell lymphoma-2(BCL-2),and/or BCL-6 rearrangements,termed double-hit or triple-hit lymphomas,and... BACKGROUND High-grade B-cell lymphoma(HGBL)is an unusual malignancy that includes myelocytomatosis viral oncogene(MYC),B-cell lymphoma-2(BCL-2),and/or BCL-6 rearrangements,termed double-hit or triple-hit lymphomas,and HGBL-not otherwise specific(HGBL-NOS),which are morphologically characteristic of HGBL but lack MYC,BCL-2,or BCL-6 rearrangements.HGBL is partially transformed by follicular lymphoma and other indolent lymphoma,with few cases of marginal zone lymphoma(MZL)transformation.HGBL often has a poor prognosis and intensive therapy is currently mainly advocated,but there is no good treatment for these patients who cannot tolerate chemotherapy.CASE SUMMARY We reported a case of MZL transformed into HGBL-NOS with TP53 mutation and terminal deoxynucleotidyl transferase expression.Gene analysis revealed the gene expression profile was identical in the pre-and post-transformed tissues,suggesting that the two diseases are homologous,not secondary tumors.The chemotherapy was ineffective and the side effect was severe,so we tried combination therapy including venetoclax and obinutuzumab.The patient tolerated treatment well,and reached partial response.The patient had recurrence of hepatocellular carcinoma and died of multifunctional organ failure.He survived for 12 months after diagnosis.CONCLUSION Venetoclax combined with obinutuzumab might improve the survival in some HGBL patients,who are unsuitable for chemotherapy. 展开更多
关键词 marginal zone lymphoma High-grade B-cell lymphoma Terminal deoxynucleotidyl transferase Venetoclax TP53 mutation Case report
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Deep tectonics and seismogenic mechanisms of the seismic source zone of the Jishishan M_(s)6.2 earthquake on December 18,2023,at the northeast margin of the Tibetan Plateau
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作者 Qiong Wang ShuYu Li +3 位作者 XinYi Li Yue Wu PanPan Zhao Yuan Gao 《Earth and Planetary Physics》 EI CAS CSCD 2024年第3期514-521,共8页
On December 18,2023,an M_(s)6.2 earthquake occurred in Jishishan,Gansu Province,China.This earthquake happened in the eastern region of the Qilian Orogenic Belt,which is situated at the forefront of the NE margin of t... On December 18,2023,an M_(s)6.2 earthquake occurred in Jishishan,Gansu Province,China.This earthquake happened in the eastern region of the Qilian Orogenic Belt,which is situated at the forefront of the NE margin of the Tibetan Plateau(i.e.,Qinghai-Tibet Plateau),encompassing a rhombic-shaped area that intersects the Qilian-Qaidam Basin,Alxa Block,Ordos Block,and South China Block.In this study,we analyzed the deep tectonic pattern of the Jishishan earthquake by incorporating data on the crustal thickness,velocity structure,global navigation satellite system(GNSS)strain field,and anisotropy.We discovered that the location of the earthquake was related to changes in the crustal structure.The results showed that the Jishishan M_(s)6.2 earthquake occurred in a unique position,with rapid changes in the crustal thickness,Vp/Vs,phase velocity,and S-wave velocity.The epicenter of the earthquake was situated at the transition zone between high and low velocities and was in proximity to a low-velocity region.Additionally,the source area is flanked by two high-velocity anomalies from the east and west.The principal compressive strain orientation near the Lajishan Fault is primarily in the NNE and NE directions,which align with the principal compressive stress direction in this region.In some areas of the Lajishan Fault,the principal compressive strain orientations show the NNW direction,consistent with the direction of the upper crustal fast-wave polarization from local earthquakes and the phase velocity azimuthal anisotropy.These features underscore the relationship between the occurrence of the Jishishan M_(s)6.2 earthquake and the deep inhomogeneous structure and deep tectonic characteristics.The NE margin of the Tibetan Plateau was thickened by crustal extension in the process of northeastward expansion,and the middle and lower crustal materials underwent structural deformation and may have been filled with salt-containing fluids during the extension process.The presence of this weak layer makes it easier for strong earthquakes to occur through the release of overlying rigid crustal stresses.However,it is unlikely that an earthquake of comparable or larger magnitude would occur in the short term(e.g.,in one year)at the Jishishan east margin fault. 展开更多
关键词 Jishishan M_(s)6.2 earthquake crustal structure anisotropy stress and strain seismogenic mechanism northeast margin of the Tibetan Plateau
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Hydrothermal Mineralization on the Mesoproterozoic Passive Continental Margins of China: A Case Study of the Langshan-Zha'ertaishan Belt,Inner Mongolia, China 被引量:20
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作者 PENGRunmin ZHAIYusheng 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2004年第2期534-547,共14页
Most ore-forming characteristics of the Langshan-Zha'ertaishan hydrothermal exhalation belt, which consists of the Dongshengmiao, Huogeqi, Tanyaokou and Jiashengpan large-superlarge Zn-Pb-Cu-Fe sulfide deposits, a... Most ore-forming characteristics of the Langshan-Zha'ertaishan hydrothermal exhalation belt, which consists of the Dongshengmiao, Huogeqi, Tanyaokou and Jiashengpan large-superlarge Zn-Pb-Cu-Fe sulfide deposits, are most similar to those of Mesoproterozoic SEDEX-type provinces of the world. The characteristics include: (1) All deposits of this type in the belt occur in third-order fault-basins in the Langshan-Zha'ertaishan aulacogen along the northern margin of the North China Platform; (2) these deposits with all their orebodies hosted in the Mesoproterozoic impure dolomite-marble and carbonaceous phyllite (or schists) have an apparent stratabound nature; ores display laminated and banded structures, showing clear depositional features; (3) there is some evidence of syn-sedimentary faulting, which to a certain extent accounts for the temporal and spatial distribution and the size of the orebodies in all deposits and the formation of intrabed conglomerates and breccias; (4) they show lateral and vertical zonation of sulfides; (5) The Cu/(Pb+Zn+Cu) ratio of the large and thick Pb+Zn+Cu orebodies gradually decreases from bottom to top; and (6) barite is interbedded with pyrites and sometimes with sphalerite. However, some characteristics such as the Co/Ni radio of the pyrites, the volcanism, for example, of the Langshan-Zha'ertaishan metallogenic belt, are different from those of the typical SEDEX deposits of the world. The meta-basic volcanic rock in Huogeqi, the sodic bimodal volcanic rocks in the Dongshengmiao and potassic bimodal-volcanic rocks with blastoporphyritic and blasto-glomeroporphyritic texture as well as blasto-amygdaloidal structure in the Tanyaokou deposits have been discovered in the only ore-bearing second formation of the Langshan Group in the past 10 years. The metallogeny of some deposits hosted in the Langshan Group is closely related to syn-sedimentary volcanism based on the following facts: most of the lead isotopes in sphalerite, galena, pyrite, pyrrhotite and chalcopyrite plot on both sides of the line for the mantle or between the lines for the mantle and lower crust in the lead isotope composition diagram; cobalt content of some pyrites samples is much higher than the nickel content (Co/Ni=11.91-12.19). Some volcanic blocks and debris have been picked out from some pyritic and pyrrhotitic ores. All Zn-Pb-Cu-Fe sulfide orebodies in these deposits occur in the strata overlying metamorphic volcanic rocks in the only ore-bearing second formation. In the Jiashengpan deposit that lacks syn-sedimentary volcanic rocks in the host succession only Pb and Zn ores occur without Cu ore, but in the Dongshengmiao, Tanyaokou and Huogeqi deposits with syn-sedimentary volcanic rocks in the host succession Cu ores occur. This indicates a relatively higher ore-forming temperature. The process of syn-sedimentary volcanic eruption directly supplied some ore-forming elements, and resulted in secular geothermal anomaly favorable for the circulation of a submarine convective hydrothermal system, which accounts for the precipitation of deep mineralizing fluids exhaling into anoxidic basins along the syn-sedimentary fault system in the Langshan-Zha'ertai rift. The Dongshengmiao, Tanyaokou, and Huogeqi deposits hosted in the Langshan Group appear to be a transitional type of mineral deposit between SEDEX and VMS-types but with a bias towards SEDEX, while the Jiashengpan deposit hosted in the Zha'ertai Group is of a characteristic SEDEX type. This evidence, together with other new discoveries of Mesoproterozoic volcanic rocks and the features of lithogeny and metallogeny of the Bayun Obo deposit in the neighborhood emphasize the diversity, complexity and uniqueness of the Mesoproterozoic Langshan-Zha'ertai-Bayun Obo ore belt. 展开更多
关键词 passive continental margin stratabound and rock-controlled character VOLCANISM transitional SEDEX and VMS-type deposits MESOPROTEROZOIC northern margin of the North China Platform
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Tectonic Setting and Metallogenic System of North China Block Margins 被引量:6
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作者 Zhai Yusheng Deng Jun Xiao Rongge Peng Runmin Department of Geology and Mineral Resources, China University of Geosciences, Beijing 100083 《Journal of Earth Science》 SCIE CAS CSCD 1999年第1期34-37,共4页
The paleocontinental margins have frequent and intensive tectonic movement and various ore forming processes. According to their tectono dynamic characteristics, the paleocontinental margins can be classified into t... The paleocontinental margins have frequent and intensive tectonic movement and various ore forming processes. According to their tectono dynamic characteristics, the paleocontinental margins can be classified into three types: the divergent, the convergent and the transformational. Each type has its specific geological geochemical processes and metallogenic system. The paper discusses the tectonic evolution and ore forming features of the North China block margins, puts forward conceptions such as complexity, variety and multi stage development of metallogenic evolution in the paleocontinental margins, and expounds five factors controlling the formation of large superlarge ore deposits in the paleocontinental margins: (1) channelway, (2) rendezvous of fluids, (3) abundance of ore source, (4) thermo dynamic anomaly, (5) long duration of structural activities. 展开更多
关键词 paleocontinental margin metallogenic system North China block tectonic evolution superlarge ore deposit.
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The trade margins of Chinese agricultural exports to ASEAN and their determinants 被引量:3
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作者 SUN Zhi-lu LI Xian-de 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2018年第10期2356-2367,共12页
How do Chinese agricultural exports to ASEAN(Association of Southeast Asian Nations) evolve? And what factors affected the evolution pattern? This study measures the trade margins of Chinese agricultural exports t... How do Chinese agricultural exports to ASEAN(Association of Southeast Asian Nations) evolve? And what factors affected the evolution pattern? This study measures the trade margins of Chinese agricultural exports to ASEAN by utilizing the 2000-2015 Harmonized System's six-digit agricultural trade data, and further analyzes their determinants by developing an augmented gravity model of international trade. The results indicate that, the main growth source of Chinese agricultural exports to ASEAN has shifted from the extensive margin before the formal establishment of CAFTA(China-ASEAN Free Trade Area) in 2010 to the intensive margin since the formal establishment of CAFTA, but changes in Chinese agricultural exports to ASEAN have always mainly depended on the intensive margin. Since the formal establishment of CAFTA, the evolution pattern of Chinese agricultural exports to ASEAN has shifted from "more varieties, low price, and small quantity" to "less varieties, high price, and large quantity". Relative economic scale, relative population scale, capacity of agricultural export, trade integration, global financial crisis, and common border significantly affect the trade margins of Chinese agricultural exports to ASEAN. 展开更多
关键词 China agricultural product ASEAN trade margins
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Tectonic Development of the Proterozoic Continental Margins in East Qinling and Adjacent Regions 被引量:2
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作者 Wang HongzhenDepartment of Geology , China University of Geosciences, Beijing 100083 《Journal of Earth Science》 SCIE CAS CSCD 1990年第1期5-16,共12页
The East Qinling and adjacent cratonic regions belong to two geotectonic units, the Sinokorean Subdomain including the Sinokorean Platform and its southern continental margin the North Qinling Belt, and the Yangtzean ... The East Qinling and adjacent cratonic regions belong to two geotectonic units, the Sinokorean Subdomain including the Sinokorean Platform and its southern continental margin the North Qinling Belt, and the Yangtzean Subdomain comprising the Yangtze Platform and its northern continental margin the South Qinling Belt .The Qinling region may thus be subdivided into two continental margin belts separated from each other by the Proterozoic Qinling marine realm , which did not disappear until Late Triassic . The convergent crustal consumption zone ,the megasuture between the two belts ,lies between the Fengxian Shangnan line in the north and the Shanyang Xijia line in the south and was much deformed and displaced through Mesozoic intracratonic collision and compression.In the northern subdomain the Lower Proterozoic is represented by protoaulacogen volcano-sediments , the inner Tiedonggou Group and the outer marginal Qinling Group , which were folded and metamorphosed in the Luliangian orogeny ,a general process of aggregation and stabilization of the Early Proterozoic mobile belts between and around the Archaean nuclei. Genuine aulacogen occurred in the Middle Proterozoic and was represented by the Xionger rift volcanics . The Middle and Upper Proterozoic comprise the inner Guandaokou shelf sediments and the outer extensional' back- arc' Kuanping Group behind the Qinling island chain . Oceanic subduction from the south of the Qinling arc representing the Jinningian orogeny caused the folding of the Mid dle and Upper Proterozoic and emplacement of island arc-continent collision type of granite . After the Jinningian orogeny Late Sinian glacigene deposits formed the platform cover and the Erlangping back arc basin began to develop on the northern slope of the Qinling arc .In South Qinling the Lower Proterozoic Tongbe Group was probably an original marginal part of the Yangtze Platform . The passive margin began rifting in Middle Proterozoic with the formation of the inner Shennongjia aulacogen and the outer marginal Wudang aulacogen. Deformation of the Wudang and Douling groups indicating Jinningian Movement seemed to have been caused by a southward compression of the Tongbe Massif. Resumed rifting in the Sinian evidenced by the sedimentary facies pattern caused the northward separation of the Douling Massif, which formed part of the Fuping-Zhenan island chain , the northern boundary of the South Qinling Belt. In the western part of South Qinling , in the Hanzhong region , the Middle and Upper Proterozoic are represented by the Huodiya shelf sediments and the Xixiang marginal volcano sedimentaries , The Jinningian orogeny is well represented by the deformed Xixiang Group and the subduction pattern of magmatism from north to south in the Beiba area . It seems that the genuine arc-basin system in the continental margin and the aulacogen in the inner part of the platform began in the Middle Proterozoic (1800 Ma), which marks the beginning of a new tectonic megastage in lithosphere evolution. 展开更多
关键词 PROTEROZOIC East Qinling continental margin .
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Metallogenic‘factories’and resultant highly anomalous mineral endowment on the craton margins of China 被引量:6
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作者 Li-Qiang Yang Jun Deng +6 位作者 David I.Groves M.Santosh Wen-Yan He Nan Li Liang Zhang Rui-Rui Zhang Hong-Rui Zhang 《Geoscience Frontiers》 SCIE CAS CSCD 2022年第2期1-20,共20页
The current margins of the North China and Yangtze Cratons provide arguably the best examples globally of anomalously high mineral endowment within a 100 km buffer zone,hosting 66 diverse world-class to giant ore syst... The current margins of the North China and Yangtze Cratons provide arguably the best examples globally of anomalously high mineral endowment within a 100 km buffer zone,hosting 66 diverse world-class to giant ore systems that help explain China’s premier position as a producer of multiple metal and mineral commodities.After the cratonization of these crustal blocks during the Neoarchean-Paleoproterozoic,with incorporation of iron ores on assembled micro-block margins,the margins of the cratons experienced multiple convergence and rifting events leading to metasomatism and fertilization of their underlying sub-continental lithospheric mantle.The rifted margins with trans-lithosphere faults provided pathways for Cu-Au(Mo-W-Sn)-bearing felsic to Ni-Cu-bearing ultrabasic intrusions and REE-rich carbonatite magmas,and for the development of marginal sedimentary basins with both Cu-Pb-Zn-rich source units and reactive carbonate or carbonaceous host rocks.There was diachronous formation of hydrothermal orogenic gold,antimony,and bismuth systems in the narrow orogenic belts between the cratons.Complexity in the Mesozoic Paleo-Pacific subduction systems resulted in asthenosphere upwelling and lithosphere extension and thinning in the North China Craton,leading to anomalous heat flow and formation of orogenic gold deposits,including those of the giant Jiaodong gold province on its north-eastern margin.These gold deposits,many of which formed from fluids liberated by devolatilization of previously metasomatized sub-continental lithospheric mantle,helped propel China to be the premier gold producer globally.The thick sub-continental lithospheric mantle of the cold buoyant cratons helped the preservation of some of the world’s oldest porphyry-skarn and epithermal mineral systems.Although craton margins globally control the formation and preservation of a diverse range of mineral deposits,China represents the premier example in terms of metal endowment due to the anomalous length of its craton margins combined with their abnormally complex tectonic history. 展开更多
关键词 Craton margin Ore deposits Geodynamic setting Fertile mantle lithosphere Mineral exploration
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