气象观测场在汽车试验场中的应用研究

汽车试验场作为汽车开展道路测试的重要场所,用于验证汽车产品的品质以及可靠性。除了场地道路外,气象条件作为汽车道路测试的重要一环,在《GB/T12534-1990汽车道路试验方法通则》中也有明确要求,如:试验时应是无雨无雾天气,相对湿度小于95%,气温0-40℃,风速不大于3m/s。同时气象条件也作为试验场道路管控的重要依据,实时风速、雨量、能见度等信息为场地管理者发布限速、限行、封场等通知提供必要参考依据,直接影响道路测试安全管控的及时性。因此,文章从气象观测场的建设、气象服务、异常天气道路管控等方面开展气象观测场在汽车试验场中的应用研究。

EXACT SOLUTION FOR RECTANGULAR SLAB WITH THREE EDGES SIMPLY-SUPPORTED AND OTHER FREE

In this paper,we give all-sided pastic analysis of the rectangular slab with three edges simply-supported and other free.Here we discuss the following four cases:(1)The uniformly distributedload over the area a slab.(2).A concentrated load act at midpoint of free edges slab.(3)A concen-trated load act at the center a slab.(4)The line load act along free edge of slab.

Oxidation Kinetics of Aluminum Powders in a Gas Fluidized Bed Reactor in the Potential Application of Surge Arresting Materials

In this technical paper, the oxidation mechanism and kinetics of aluminum powders are discussed in great details. The potential applications of spherical aluminum powders after oxidation to be part of the surging arresting materials are discussed. Theoretical calculations of oxidation of spherical aluminum powders in a typical gas fluidization bed are demonstrated. Computer software written by the author is used to carry out the basic calculations of important parameters of a gas fluidization bed at different temperatures. A mathematical model of the dynamic system in a gas fluidization bed is developed and the analytical solution is obtained. The mathematical model can be used to estimate aluminum oxide thickness at a defined temperature. The mathematical model created in this study is evaluated and confirmed consistently with the experimental results on a gas fluidization bed. Detail technical discussion of the oxidation mechanism of aluminum is carried out. The mathematical deviations of the mathematical modeling have demonstrated in great details. This mathematical model developed in this study and validated with experimental results can bring a great value for the quantitative analysis of a gas fluidization bed in general from a theoretical point of view. It can be applied for the oxidation not only for aluminum spherical powders, but also for other spherical metal powders. The mathematical model developed can further enhance the applications of gas fluidization technology. In addition to the development of mathematical modeling of a gas fluidization bed reactor, the formation of oxide film through diffusion on both planar and spherical aluminum surfaces is analyzed through a thorough mathematical deviation using diffusion theory and Laplace transformation. The dominant defects and their impact to oxidation of aluminum are also discussed in detail. The well-controlled oxidation film on spherical metal powders such as aluminum and other metal spherical powders can potentially become an important part of switch devices of surge arresting materials, in general.

Immunophenotypic signature of primary glioblastoma multiforme: A case of extended progression free survival

Glioblastoma-multiforme(GBM), the most aggressive glial tumor, has a worldwide age-adjusted incidence ranging from 0.59-3.69/100000 persons. Despite current multimodal-treatment approach, median-survival time and progression-free survival(PFS) remains short. Glioblastomas display a variety of molecular alterations, which necessitates determining which of these have a prognostic significance. This is a case of a 45-yearold patient who presented with progressive slurring of speech and features of raised intracranial pressure. Computed tomography(CT) scan revealed a large heterogeneously enhancing lesion in the left front-temporalperisylvian region with solid, cystic areas, suggestive of malignant glioma. Partial tumor-excision was followed by concurrent chemo-radiotherapy. Histopathologically, the tumor was astrocytoma grade-IV. Patient had an extended PFS of 12 mo, with an overall survival of 26 mo. Primary-GBM was confirmed using molecular markers and the immunophenotypic signature was defined by evaluating systemic expression of human telomerase reverse transcriptase, interleukin-6, neutrophil-lymphocyte ratio, tissue inhibitor of metalloproteinases-1, human chitinase-3-like-protein-1(YKL-40) and high mobility group-A1. Current findings suggest that this signature can identify worst outcomes, independent of clinical criteria.

The Aharonov-Bohm Effect: An Exploration of Quantum Interference and Electromagnetic Potentials

The AB(Aharonov-Bohm)effect is a pivotal quantum mechanical phenomenon that illustrates the fundamental role of the electromagnetic vector potential A in determining the phase of a charged particle’s wave function,even in regions where the magnetic field B is zero.This effect demonstrates that quantum particles are influenced not only by the fields directly present but also by the potentials associated with those fields.In the AB effect,an electron beam is split into two paths,with one path encircling a solenoid and the other bypassing it.Despite the absence of a magnetic field in the regions traversed by the beams,the vector potential A associated with the magnetic flux Φ through the solenoid induces a phase shift in the electron’s wave function.This phase shift,quantified by △φ=qΦ/hc,manifests as a change in the interference pattern observed in the detection screen.The phenomenon underscores the principle of gauge invariance in QED(quantum electrodynamics),where physical observables remain invariant under local gauge transformations of the vector and scalar potentials.This reinforces the notion that the vector potential A has a profound impact on quantum systems,beyond its classical role.This article outlines the AB effect,including its theoretical framework,experimental observations,and implications.The focus on the role of the vector potential in quantum mechanics provides a comprehensive understanding of this important phenomenon.

A Pragmatic Approach to Coping with Matrix Effects during ICP-MS Analysis of Trace Elements in Silicate Rocks and Calibration of REE Interferences

Operating an Agilent 7700X ICP-MS spectrometer under robust plasma conditions (1550 W) with a He-filled octopole collision cell and analysing solutions (?1 total dissolved solids) still suffered analyte peak suppression due to matrix effects. International reference rocks BCR-1, BHVO-1, AGV-1, G-2 and BCR-2 all showed count rate reductions for 36 elements (mass range 7Li to 238U) averaging ~10% but with no dependence on isotope mass. Use of an internal standard (103Rh) and/or using a ten-fold dilution of sample solutions reduced these effects but problems with reduced count rates combined with larger errors for some elements introduced other problems. The best approach was to normalise the count rates for each element in the other samples against those for BCR-1 as an external standard;thus the count suppression due to the matrix effect is corrected for each individual element. This approach provides standardization “traceability” in line with the ERM ISO/IEC requirement. Experiments are also reported on quantifying the proportions of Ba and selected REE oxide/hydroxide components versus parent isotopes (XO/X and XOH/X). This information is essential for correcting peak interferences on higher mass number REE for the rock samples, and equations are developed to use measured CeO/Ce and CeOH/Ce ratios to predict such values for any other member of the REE suite. Concentrations obtained show excellent agreement with recommended values for the international reference materials especially for the REE. Robust data are also provided for two other standard rocks: nepheline syenite STM-1 and quartz syenite CAAS-1;the latter shows exceptional enrichments of Zr, REE, Th, and U.

Advanced Analysis of HVDC Electrodes Interference on Neighboring Pipelines

This paper focuses on advanced analysis techniques and design considerations of DC interference generated by HVDC electrodes during normal bipolar and temporary monopolar operations on neighboring metallic utilities, with a special emphasis on buried gas and oil pipelines. This study examines the level of pipeline corrosion, the safety status in the vicinity of exposed appurtenances and the impact of DC interference on the integrity of insulating flanges and impressed current cathodic protection (ICCP) systems. Computation results obtained for different soil models show that different soils can lead to completely different DC interference effects. The results and conclusions presented here can be used as a reference to analyze the severity of DC interference on pipelines due to proximate HVDC electrodes.

Thermodynamic Equilibrium of the Saturated Fluid with a Free Surface Area and the Internal Energy as a Function of the Phase-Specific Volumes and Vapor Pressure

This study is concerned with describing the thermodynamic equilibrium of the saturated fluid with and without a free surface area A. Discussion of the role of A as system variable of the interface phase and an estimate of the ratio of the respective free energies of systems with and without A show that the system variables given by Gibbs suffice to describe the volumetric properties of the fluid. The well-known Gibbsian expressions for the internal energies of the two-phase fluid, namely for the vapor and for the condensate (liquid or solid), only differ with respect to the phase-specific volumes and . The saturation temperature T, vapor presssure p, and chemical potential are intensive parameters, each of which has the same value everywhere within the fluid, and hence are phase-independent quantities. If one succeeds in representing as a function of and , then the internal energies can also be described by expressions that only differ from one another with respect to their dependence on and . Here it is shown that can be uniquely expressed by the volume function . Therefore, the internal energies can be represented explicitly as functions of the vapor pressure and volumes of the saturated vapor and condensate and are absolutely determined. The hitherto existing problem of applied thermodynamics, calculating the internal energy from the measurable quantities T, p, , and , is thus solved. The same method applies to the calculation of the entropy, chemical potential, and heat capacity.

An Inquiry into the Approach to Asian Regional Trade Integration Under the Belt and Road Initiative——The Case of the Alignment of a China-Japan-South Korea Free Trade Area

It has been five years since the Belt and Road Initiative (BRI) was first introduced. Though there has been a growing body of literature on regional cooperation between covered countries, Japan and South Korea have been barely discussed. This paper starts with the consensus-based mechanism of a China-Japan-South Korea Free Trade Area (FTA) to probe the approach of its alignment with the BRI in terms of the sequence of “master plans,”“viability of cooperation,” and “embedding of rules.” This inquiry found that the three countries have a shared interest in cooperation in Central Asia to which China prefers a pragmatic approach, while Japan and South Korea an approach combining idealism with pragmatism. Given the huge potential of cooperation between the trio, it is suggested that a “Central Asia chapter” be incorporated in the negotiation framework of this trilateral FTA, and that the design feature three aspects;fundamental principles, specific rules, and an executive body with a view to functionally contributing to regional trade integration in Asia. This approach may also be applied to the alignment of other Asian areas with the BRI.

2023年东风岚图FREE混动版无法充电和上电

故障现象一辆2023年生产的东风岚图FREE混动版,搭载DAM15NTDE型东风自研1.5T发动机和360kW双电机,VIN码为LDP95H96XPE31****;行驶里程为4101km。据车主反映:该车由于长时间停放,在需要用车的时候发现车辆无法启动,仪表台上显示的电池电量为0;接上充电枪,发现无法充电。我店技术负责人通过观察仪表台上的故障指示灯,初步判断是由于电池过度亏电导致车辆无法充电和上电,只好协助车主将故障车拖回店内做全面的检查和诊断。

基于组增长的小世界Scale-free网络模型

小世界和Scale-free是很多大规模复杂网络的重要特征,建立体现这些特征的网络模型是研究网络结构和行为的重要基础。针对现有模型不能全面地反映实际网络所具有的特征属性,提出了基于组增长的小世界 Scale-free网络模型。该模型在小世界和 Scale-free模型的基础上,结合了节点的本地强连接性、新增连接的度相关性和网络动态的增长方式,把小世界和 Scale-free联系了起来。仿真结果表明,该模型生成的网络图同时具有小世界和 Scale-free特征。

High-throughput RNA interference screens integrative analysis: Towards a comprehensive understanding of the virus-host interplay

Viruses are extremely heterogeneous entities; the size and the nature of their genetic information, as well as the strategies employed to amplify and propagate their genomes, are highly variable. However, as obligatory intracellular parasites, replication of all viruses relies on the host cell. Having co-evolved with their host for several million years, viruses have developed very sophisticated strategies to hijack cellular factors that promote virus uptake, replication, and spread. Identification of host cell factors(HCFs) required for these processes is a major challenge for researchers, but it enables the identification of new, highly selective targets for anti viral therapeutics. To this end, the establishment of platforms enabling genome-wide high-throughput RNA interference(HT-RNAi) screens has led to the identification of several key factors involved in the viral lifecycle. A number of genome-wide HT-RNAi screens have been performed for major human pathogens. These studies enable first inter-viral comparisons related to HCF requirements. Although several cellular functions appear to be uniformly required for the life cycle of most viruses tested(such as the proteasome and the Golgi-mediated secretory pathways), some factors, like the lipid kinase Phosphatidylinositol 4-kinase Ⅲα in the case of hepatitis C virus, are selectively required for individual viruses. However, despite the amount of data available, we are still far away from a comprehensive understanding of the interplay between viruses and host factors. Major limitations towards this goal are the low sensitivity and specificity of such screens, resulting in limited overlap between different screens performed with the same virus. This review focuses on how statistical and bioinformatic analysis methods applied to HTRNAi screens can help overcoming these issues thus increasing the reliability and impact of such studies.

慢性氟中毒大鼠肾脏自由基含量与形态学变化

目的研究慢性氟中毒大鼠肾脏自由基含量与形态学变化的关系。方法Wistar大鼠随机分为三组。正常对照组,未作任何处理;染氟组,自由饮用含氟化钠132.6mg/L的含氟水;抗氧化中药—染氟组,自由饮用含氟化钠132.6mg/L的含氟水,同时每日经腹腔内注射抗氧化中药丹参绞股蓝复方3.125毫克/公斤/天,实验6个月时检查动物。用电子自旋共振的方法检测肾组织内自由基的含量,并观察肾脏的形态学变化。结果与正常对照组动物相比,染氟组自由基明显升高,电镜下见肾小管上皮细胞有巨大线粒体及髓鞘样结构形成,内质网扩张,粗面内质网上核糖体脱落,细胞浆内游离核糖体增加,胞核内异染色质有向核膜下聚集的趋势;光镜下呈颗粒性变,偶见坏死。抗氧化中药一染氟组肾组织中自由基含量不增高,光镜及电镜下均未见明显病变。结论慢性氟中毒时肾脏病变与自由基含量增多有密切关系。

QPSK DS-CDMA System over Rayleigh Channel with a Randomly-Varying Frequency Narrow-Band Interference: Frequency Tracking Analysis

This paper analyses frequency tracking characteristics of a complex-coefficient adaptive infinite-impulse response (IIR) notch filter used for suppression of narrow-band interference (NBI) with a randomly-varying frequency in a quadriphase shift keying (QPSK) modulated direct-sequence code-division multiple-access (DS-CDMA) communication system. The QPSK DS-CDMA signals are transmitted over a frequency non-selective Rayleigh fading channel. The analysis is based on a first-order real-coefficient difference equation with respect to steady-state instantaneous frequency tracking error from which a closed-form expression that relates frequency tracking mean square error (MSE) with number of DS-CDMA active users and NBI power is obtained. Closed-form expressions for optimum notch bandwidth coefficient and step size constant that minimize the frequency tracking MSE are also derived. Computer simulations are included to substantiate the accuracy of the analyses.

糖尿病大鼠心肌损伤的观察及机制初探

目的:探讨不同病程、不同血糖浓度对糖尿病(diabetesmellitus,DM)大鼠的心肌损伤及其机制。方法:SD大鼠64只,随机分为2组:对照组(NC组)32只,实验组(DM组)32只。DM组腹腔注射链脲佐菌素(streptozotocin,STZ)55mg/kg诱发DM模型。实验组和对照组又随机分为4组,每组8只。分别观察病程2周、4周、6周、8周大鼠心功能及心肌组织生化指标的变化。另取SD大鼠40只,随机分出8只作为对照组(NC),其余用上述方法造模,并按最后一次血糖浓度分为3组:16.7～21.6mmol/L(DM1组),21.7～26.6mmol/L(DM2组),26.7mmol/L以上(DM3组)。比较各组大鼠心功能及心肌组织生化指标的变化。结果:与NC组比,DM大鼠第4周心肌LVEDP、-dp/dtmax、MDA含量,第6周除CK外各项指标、第8周心肌各项指标差异均有显著性(P<0.01～0.05)。不同血糖浓度DM大鼠各项指标与NC组差异均有显著性(P<0.01～0.05)。与DM1组比,DM2组LVEDP、-dp/dtmax、t-dp/dt、CK、SOD、MDA差异均有显著性(P<0.01～0.05),DM3组各项指标除LDH外差异均有显著性(P<0.01～0.05);与DM2组比,DM3组LVSP、LVEDP、+dp/dtmax、SOD差异有显著性(P<0.01～0.05)。结论:DM大鼠从第4周开始出现心肌舒张受限,第6周开始出现心肌收缩障碍,心肌组织酶明显改变,随病程延长、血糖浓度升高而逐渐加重。

Overexpression of heme oxygenase-1 protects smooth muscle cells against oxidative injury and inhibits cell proliferation

To investigate whether the expression of exogenous heme oxygenase-1 (HO-1) gene within vascular smooth muscle cells (VSMC) could protect the cells from free radical attack and inhibit cell proliferation, we established an in vitro transfection of human HO-1 gene into rat VSMC mediated by a retroviral vector. The results showed that the profound expression of HO-1 protein as well as HO activity was 1.8- and 2.0-fold increased respectively in the transfected cells compared to the non-transfected ones. The treatment of VSMC with different concentrations of H2O2 led to the remarkable cell damage as indicated by survival rate and LDH leakage. However, the resistance of the HO-1 transfected VSMC against H2O2 was significantly raised. This protective effect was dramatically diminished when the transfected VSMC were pretreated with ZnPP-IX, a specific inhibitor of HO, for 24 h. In addition, we found that the growth potential of the transfected cells was significantly inhibited directly by increased activity of HO-1, and this effect might be related to decreased phosphorylation of MAPK. These results suggest that the overexpression of introduced hHO-1 is potentially able to reduce the risk factors of atherosclerosis, partially due to its cellular protection against oxidative injury and to its inhibitory effect on cellular proliferation.

Element Free Gelerkin Method for 2-D Potential Problems

A meshfree method namely, element free Gelerkin (EFG) method, is presented in this paper for the solution of governing equations of 2-D potential problems. The EFG method is a numerical method which uses nodal points in order to discretize the computational domain, but where the use of connectivity is absent. The unknowns in the problems are approximated by means of connectivity-free technique known as moving least squares (MLS) approximation. The effect of irregular distribution of nodal points on the accuracy of the EFG method is the main goal of this paper as a complement to the precedent researches investigated by proposing an irregularity index (II) in order to analyze some 2-D benchmark examples and the results of sensitivity analysis on the parameters of the method are presented.

Wide-Area Delay-Dependent Adaptive Supervisory Control of Multi-machine Power System Based on Improve Free Weighting Matrix Approach

The paper demonstrates the possibility to enhance the damping of inter-area oscillations using Wide Area Measurement (WAM) based adaptive supervisory controller (ASC) which considers the wide-area signal transmission delays. The paper uses an LMI-based iterative nonlinear optimization algorithm to establish a method of designing state-feedback controllers for power systems with a time-varying delay. This method is based on the delay-dependent stabilization conditions obtained by the improved free weighting matrix (IFWM) approach. In the stabilization conditions, the upper bound of feedback signal’s transmission delays is taken into consideration. Combining theoriesof state feedback control and state observer, the ASC is designed and time-delay output feedback robust controller is realized for power system. The ASC uses the input information from Phase Measurement Units (PMUs) in the system and dispatches supplementary control signals to the available local controllers. The design of the ASC is explained in detail and its performance validated by time domain simulations on a New England test power system (NETPS).

柑橘果实发育成熟中果肉游离糖、肌肌醇及钾含量的变化

以龟井(无籽)温州蜜柑和鄂柑1号(有籽)橘为试材,对果实发育成熟过程中果肉游离糖(果糖、葡萄糖和蔗糖)、肌肌醇及钾含量变化进行了测定。结果表明:(1)果实增大初期鄂柑1号果肉果糖和葡萄糖含量明显上升,蔗糖变化小,肌肌醇却趋下降,进入果实增大中后期,蔗糖含量显著上升,其它变化小;而龟井的果糖、葡萄糖和蔗糖均于果实增大初期和中期出现明显积累,肌肌醇除在增大中期出现一峰值外趋于平稳;采前果实发育期两品种总糖含量变化趋势均与各自的蔗糖较一致;(2)采后贮藏期内两品种果肉总糖和肌肌醇含量均趋于稳定,而二者的果糖、葡萄糖和蔗糖含量变化趋势却均趋相反;(3)两品种果肉钾含量均在果实增大期内出现明显上升并居相对较高水平。