An experimental investigation is performed to assess the relation of interference performance on the total resistance of a pentamaran model advancing in calm water. For this motivation, the total drag of the ship is ...An experimental investigation is performed to assess the relation of interference performance on the total resistance of a pentamaran model advancing in calm water. For this motivation, the total drag of the ship is performed for several values of asymmetric outrigger configuration and hull separation, altering the Froude number in the range 0.3–0.9. Our results indicate that remarkable changes in resistance require notable changes in transverse distance values （hull separation） when wave interference may occur. In addition, there is no single configuration that consistently outperforms the other configurations across the entire speed range and the optimum interference factor -0.2 appears at a Froude number of 0.45 in S/L=0.33 with the outrigger outer position： asymmetric outboard for A3 configuration.展开更多
Photodynamic therapy(PDT)is a treatment that uses light-sensitive drugs and a light source to destroy cancer cells.Methylene blue(MB)is an efficient photosensitizing agent that has been widely used in PDT.However,MB s...Photodynamic therapy(PDT)is a treatment that uses light-sensitive drugs and a light source to destroy cancer cells.Methylene blue(MB)is an efficient photosensitizing agent that has been widely used in PDT.However,MB suffers from the hypochromic effect that is caused by self-aggregation and DNA binding in vivo.It is also easily reduced to ineffective leucomethylene blue in the hypoxic environments surrounding solid tumors.In this work,we prepared MB carbon dots(MB-CDs)using MB as the carbon source.The MB-CDs not only inherit the PDT capabilities of MB,but also demonstrate good biocompatibility and low toxicity.Importantly,MB-CDs demonstrate excellent resistance to interference from reduction,aggregation,and DNA interactions.The MB-CDs exhibited satisfactory PDT activities both in vitro and in vivo.The tumor sizes were reduced to below 20%of their original volumes when irradiated by a 590-nm lightemitting diode source.展开更多
文摘An experimental investigation is performed to assess the relation of interference performance on the total resistance of a pentamaran model advancing in calm water. For this motivation, the total drag of the ship is performed for several values of asymmetric outrigger configuration and hull separation, altering the Froude number in the range 0.3–0.9. Our results indicate that remarkable changes in resistance require notable changes in transverse distance values （hull separation） when wave interference may occur. In addition, there is no single configuration that consistently outperforms the other configurations across the entire speed range and the optimum interference factor -0.2 appears at a Froude number of 0.45 in S/L=0.33 with the outrigger outer position： asymmetric outboard for A3 configuration.
基金financially supported by the National Natural Science Foundation of China (NSFC, 21822804,21676047, 21421005, 21878039, and 21925802)NSFC-Liaoning United Fund (U1908202 and U1608222)
文摘Photodynamic therapy(PDT)is a treatment that uses light-sensitive drugs and a light source to destroy cancer cells.Methylene blue(MB)is an efficient photosensitizing agent that has been widely used in PDT.However,MB suffers from the hypochromic effect that is caused by self-aggregation and DNA binding in vivo.It is also easily reduced to ineffective leucomethylene blue in the hypoxic environments surrounding solid tumors.In this work,we prepared MB carbon dots(MB-CDs)using MB as the carbon source.The MB-CDs not only inherit the PDT capabilities of MB,but also demonstrate good biocompatibility and low toxicity.Importantly,MB-CDs demonstrate excellent resistance to interference from reduction,aggregation,and DNA interactions.The MB-CDs exhibited satisfactory PDT activities both in vitro and in vivo.The tumor sizes were reduced to below 20%of their original volumes when irradiated by a 590-nm lightemitting diode source.
