Background Genetic variations in the interferon-gamma (IFN-γ) receptor 1 gene (IFNGR1) may contribute to tuberculosis (TB) risk in different populations.Many studies have investigated the relationship between I...Background Genetic variations in the interferon-gamma (IFN-γ) receptor 1 gene (IFNGR1) may contribute to tuberculosis (TB) risk in different populations.Many studies have investigated the relationship between IFNGR1 56C/T polymorphism and the susceptibility to TB,but have yielded conflicting results.A comprehensive meta-analysis is needed to provide a more accurate estimation of the relationship between them.Methods A literature search based on a combination of manual and computer-based methods was conducted on four English databases (PubMed,Science Direct,SpringerLink,and EBSCO) and three Chinese databases (Wanfang,CQVIP,and Chinese National Knowledge Infrastructure databases).Pooled odds ratios (ORs) and 95% confidence intervals (95% Cls) were calculated using either the fixed-effects model or the random-effects model for different genetic models based on the heterogeneity examination.Results A total of six studies comprising 1 497 confirmed TB cases and 1 802 controls were included in this meta-analysis.Overall,no significant association was observed between IFNGR1-56C/T polymorphism and TB susceptibility (C vs.T,OR=0.90,95% Cl 0.69-1.17; CC vs.TT,OR=0.87,95% Cl 0.65-1.18; TC vs.TT,OR=-1.031,95% Cl 0.872-1.219; CC+TC vs.TT,OR=0.89,95% Cl 0.64-1.26; CC vs.TC+TT,OR=0.92,95% Cl 0.66-1.29).In subgroup analysis,a significant association was found in the dominant model (CC+TC vs.TT,OR=1.24,95% Cl 1.02-1.51) in Africans,but not in Asians or Caucasians.Conclusions Our meta-analysis did not provide enough powerful evidence to identify a significant association between IFNGR1-56C/T polymorphism and TB susceptibility in the overall population.In subgroup analysis,it indicates that IFNGR1-56C/T is possibly associated with increased TB risk in Africans,but not in Asians or Caucasians.However,larger sample size and better-designed case-control studies are needed to validate these findings.展开更多
Summary: The inhibitory mechanism of interferon-gamma (IFN-γ) on the fibroblasts from Tenon's capsule was studied. By using immunohistochemical SP method and pathological image system, the inhibitory effects of I...Summary: The inhibitory mechanism of interferon-gamma (IFN-γ) on the fibroblasts from Tenon's capsule was studied. By using immunohistochemical SP method and pathological image system, the inhibitory effects of IFN-γ on the expression of transforming growth factor beta receptor I in the in vitro cultured fibroblasts from Tenon's capsule were quantitatively analyzed. The results showed that IFN-γ could reduce the expression of transforming growth factor beta receptor I in the fibroblasts with the following dose-effect relationship: Y=1937.5-134.2 Igx (r=-0.971, P<0.01). It was concluded that IFN-γ could inhibit the expression of transforming growth factor beta receptor I in the fibroblasts from Tenon's capsule. The modulation of the transforming growth factor beta receptor I expression by IFN-γ may be beneficial to the alleviation of the hyperplasia of scar after trabeculectomy.展开更多
文摘Background Genetic variations in the interferon-gamma (IFN-γ) receptor 1 gene (IFNGR1) may contribute to tuberculosis (TB) risk in different populations.Many studies have investigated the relationship between IFNGR1 56C/T polymorphism and the susceptibility to TB,but have yielded conflicting results.A comprehensive meta-analysis is needed to provide a more accurate estimation of the relationship between them.Methods A literature search based on a combination of manual and computer-based methods was conducted on four English databases (PubMed,Science Direct,SpringerLink,and EBSCO) and three Chinese databases (Wanfang,CQVIP,and Chinese National Knowledge Infrastructure databases).Pooled odds ratios (ORs) and 95% confidence intervals (95% Cls) were calculated using either the fixed-effects model or the random-effects model for different genetic models based on the heterogeneity examination.Results A total of six studies comprising 1 497 confirmed TB cases and 1 802 controls were included in this meta-analysis.Overall,no significant association was observed between IFNGR1-56C/T polymorphism and TB susceptibility (C vs.T,OR=0.90,95% Cl 0.69-1.17; CC vs.TT,OR=0.87,95% Cl 0.65-1.18; TC vs.TT,OR=-1.031,95% Cl 0.872-1.219; CC+TC vs.TT,OR=0.89,95% Cl 0.64-1.26; CC vs.TC+TT,OR=0.92,95% Cl 0.66-1.29).In subgroup analysis,a significant association was found in the dominant model (CC+TC vs.TT,OR=1.24,95% Cl 1.02-1.51) in Africans,but not in Asians or Caucasians.Conclusions Our meta-analysis did not provide enough powerful evidence to identify a significant association between IFNGR1-56C/T polymorphism and TB susceptibility in the overall population.In subgroup analysis,it indicates that IFNGR1-56C/T is possibly associated with increased TB risk in Africans,but not in Asians or Caucasians.However,larger sample size and better-designed case-control studies are needed to validate these findings.
基金ThisprojectwassupportedbyagrantfromHubeiProvincialNaturalSciencesFoundationofChina (No .4 183) .
文摘Summary: The inhibitory mechanism of interferon-gamma (IFN-γ) on the fibroblasts from Tenon's capsule was studied. By using immunohistochemical SP method and pathological image system, the inhibitory effects of IFN-γ on the expression of transforming growth factor beta receptor I in the in vitro cultured fibroblasts from Tenon's capsule were quantitatively analyzed. The results showed that IFN-γ could reduce the expression of transforming growth factor beta receptor I in the fibroblasts with the following dose-effect relationship: Y=1937.5-134.2 Igx (r=-0.971, P<0.01). It was concluded that IFN-γ could inhibit the expression of transforming growth factor beta receptor I in the fibroblasts from Tenon's capsule. The modulation of the transforming growth factor beta receptor I expression by IFN-γ may be beneficial to the alleviation of the hyperplasia of scar after trabeculectomy.
基金supported by National Natural Science Foundation of China(81470250)National Natural Science Foundation of China(81270110)+2 种基金National Natural Science Foundation of China(81473406)Zhejiang Natural Science Foundation(Q16H010010)Science and Technology Project of Wenzhou City(Y20140048)~~
文摘目的:探讨带状疱疹患者的免疫功能状态。方法:采用双抗夹心酶免疫法和酶免疫法检测66例带状疱疹患者血清和水疱的白介素2、游离白介素2受体、r 干扰素和水痘-带状疱疹病毒/IgG 抗体。结果:带状疱疹患者血清白介素2水平高于正常人,水疱中游离白介素2受体、r 干扰素水平高于自身血清,水疱中水痘-带状疱疹病毒/IgG 抗体阳性检出率低于自身血清。结论:带状疱疹患者 T 淋巴细胞功能处于激活状态;白介素2可能是带状疱疹血清中促进病毒消退的主要细胞因子之一;而局部抗病毒的作用 r 干扰素可能强于白介素2。