Background Airway remodeling is the specific pathological characteristics of asthma, which is related to the clinical symptoms, pulmonary function, and airway hyperreactivity. This study aimed at exploring the effects...Background Airway remodeling is the specific pathological characteristics of asthma, which is related to the clinical symptoms, pulmonary function, and airway hyperreactivity. This study aimed at exploring the effects of dermatophagoides pteronyssinus allergen-specific immunotherapy （SIT） on the serum interleukin （IL）-13 and pulmonary functions in asthmatic children. Methods Fifty-eight pediatric asthma patients allergic to dust mite participated in this study. Thirty-five children received SIT with a standardized dermatophgoides pteronyssinus extract for one year （SIT group）, and the other 23 children treated with inhaled corticosteroids （ICS group） according to the Global Initiative for Asthma （GINA） for one year. Serum levels of IL-13, IL-4 and interferon （IFN）-γ were examined and the pulmonary functions were checked before and after the treatment. Results After the treatment, the number of emergency visiting for asthma attack in SIT group was significantly less than that in ICS group. The serum levels of IL-4 and IL-13 were clearly reduced, IFN-γ and the ratio of IFN-γ/IL-4 were significantly increased, the pulmonary functions （forced vital capacity （FVC）, forced expiratory volume in one second percentage （FEV1%） and peak expiratory flow percentage （PEF%） were significantly improved in the SIT group. Meanwhile, IFN-γ and the ratio of IFN-γ/IL-4 were greatly increased, but serum levels of IL-4 and IL-13 had less changes, the pulmonary functions （FVC, FEV1% and PEF%） were poorly improved in ICS group. The basic pulmonary functions in both groups were at the same level, which had made more improvement in SIT group than in ICS group one year later. Conclusions One year of dermatophagoides pteronyssinus SIT can significantly reduce the frequencies of emergency visiting for asthma attack and improve the pulmonary functions of children with allergic asthma, and that is attributed to SIT, which can reduce the levels of IL-4 and IL-13 and regulate the imbalance of the Th1/Th2 cells in asthmatic children. All of these might be effective in preventing the asthmatic airway from remodeling.展开更多
Bronchial asthma is a reversible obstructive airway disease characterized by persistent airway inflammation and airway remodeling, with eosinophil infiltration of the airway walls as the predominant feature. However, ...Bronchial asthma is a reversible obstructive airway disease characterized by persistent airway inflammation and airway remodeling, with eosinophil infiltration of the airway walls as the predominant feature. However, our previous work and other reports have demonstrated that neutrophil predominant inflammation is present in a subgroup of asthmatics, particularly severe asthmatics, and patients with airway neutrophilia are less responsive to glucocorticoid therapy. The mechanisms underlying airway neutrophilia in asthma are still under investigation, but interleukin （IL）-8 as an important neutrophil chemokine may play an important role.展开更多
Objective: To observe the therapeutic effect of composite Xinyi ae rosol (复方辛夷雾化剂, XYA) in treating asthma and its influence on asthma relat ed cytokines in serum and sputum of patients with mild or moderate br...Objective: To observe the therapeutic effect of composite Xinyi ae rosol (复方辛夷雾化剂, XYA) in treating asthma and its influence on asthma relat ed cytokines in serum and sputum of patients with mild or moderate bronchial ast hma.Methods: Sixty patients were divided randomly into the treated gr oup and the control group, 30 in each group. They were treated with XYA and Salb utamol aerosol (SA) respectively by spray inhalation once a day for seven days a s one therapeutic course to observe the antiasthmatic effect of the treatment. Changes of lung function and the levels of tumor necrosis factor α (TNF-α) , interleukine-2 receptor (IL-2R) and interleukine-8 (IL-8) in serum and sputum were observed before and after treatment using enzyme linked immunos orbent assay (ELISA). Levels of TNF-α, IL-2R andIL-8 in the sputum of part of the patients in the treatment group were also observed.Results: In the treated group, 6 patients had the asthma clinica lly controlled after treatment, 12 were markedly alleviated, 9 alleviated and 3 remained unchanged, while in the control group, the respective numbers were 4, 6 , 15 and 5. The controlled-markedly effective rate of XYA was 60.0%, which wa s significantly better than that of SA (33.3%, P <0.05). The one second forc ed expiratory volume percent (FEV1%) and peek expiratory flow rate (PEFR) improv ed significantly and the levels of TNF-α, IL-2R and IL-8 in serum decr eased noticeably in both groups after treatment ( P <0.05 or P <0.01), but the improvement in the treated group was more significant as compared with tho se in the control group ( P <0.05). The levels of TNF-α, IL-2R and IL -8 in sputum considerably lowered also after XYA treatment ( P <0.01).Conclusion: XYA could regulate the related cytokines in patient s with mild or moderate bronchial asthma, and reduce the releasing of inflammato ry factors, which is consistent with the improvement of lung functions, so as to ease the airway inflammation chiefly exhibited as cell infiltration in bron chi.展开更多
文摘Background Airway remodeling is the specific pathological characteristics of asthma, which is related to the clinical symptoms, pulmonary function, and airway hyperreactivity. This study aimed at exploring the effects of dermatophagoides pteronyssinus allergen-specific immunotherapy （SIT） on the serum interleukin （IL）-13 and pulmonary functions in asthmatic children. Methods Fifty-eight pediatric asthma patients allergic to dust mite participated in this study. Thirty-five children received SIT with a standardized dermatophgoides pteronyssinus extract for one year （SIT group）, and the other 23 children treated with inhaled corticosteroids （ICS group） according to the Global Initiative for Asthma （GINA） for one year. Serum levels of IL-13, IL-4 and interferon （IFN）-γ were examined and the pulmonary functions were checked before and after the treatment. Results After the treatment, the number of emergency visiting for asthma attack in SIT group was significantly less than that in ICS group. The serum levels of IL-4 and IL-13 were clearly reduced, IFN-γ and the ratio of IFN-γ/IL-4 were significantly increased, the pulmonary functions （forced vital capacity （FVC）, forced expiratory volume in one second percentage （FEV1%） and peak expiratory flow percentage （PEF%） were significantly improved in the SIT group. Meanwhile, IFN-γ and the ratio of IFN-γ/IL-4 were greatly increased, but serum levels of IL-4 and IL-13 had less changes, the pulmonary functions （FVC, FEV1% and PEF%） were poorly improved in ICS group. The basic pulmonary functions in both groups were at the same level, which had made more improvement in SIT group than in ICS group one year later. Conclusions One year of dermatophagoides pteronyssinus SIT can significantly reduce the frequencies of emergency visiting for asthma attack and improve the pulmonary functions of children with allergic asthma, and that is attributed to SIT, which can reduce the levels of IL-4 and IL-13 and regulate the imbalance of the Th1/Th2 cells in asthmatic children. All of these might be effective in preventing the asthmatic airway from remodeling.
文摘Bronchial asthma is a reversible obstructive airway disease characterized by persistent airway inflammation and airway remodeling, with eosinophil infiltration of the airway walls as the predominant feature. However, our previous work and other reports have demonstrated that neutrophil predominant inflammation is present in a subgroup of asthmatics, particularly severe asthmatics, and patients with airway neutrophilia are less responsive to glucocorticoid therapy. The mechanisms underlying airway neutrophilia in asthma are still under investigation, but interleukin （IL）-8 as an important neutrophil chemokine may play an important role.
文摘Objective: To observe the therapeutic effect of composite Xinyi ae rosol (复方辛夷雾化剂, XYA) in treating asthma and its influence on asthma relat ed cytokines in serum and sputum of patients with mild or moderate bronchial ast hma.Methods: Sixty patients were divided randomly into the treated gr oup and the control group, 30 in each group. They were treated with XYA and Salb utamol aerosol (SA) respectively by spray inhalation once a day for seven days a s one therapeutic course to observe the antiasthmatic effect of the treatment. Changes of lung function and the levels of tumor necrosis factor α (TNF-α) , interleukine-2 receptor (IL-2R) and interleukine-8 (IL-8) in serum and sputum were observed before and after treatment using enzyme linked immunos orbent assay (ELISA). Levels of TNF-α, IL-2R andIL-8 in the sputum of part of the patients in the treatment group were also observed.Results: In the treated group, 6 patients had the asthma clinica lly controlled after treatment, 12 were markedly alleviated, 9 alleviated and 3 remained unchanged, while in the control group, the respective numbers were 4, 6 , 15 and 5. The controlled-markedly effective rate of XYA was 60.0%, which wa s significantly better than that of SA (33.3%, P <0.05). The one second forc ed expiratory volume percent (FEV1%) and peek expiratory flow rate (PEFR) improv ed significantly and the levels of TNF-α, IL-2R and IL-8 in serum decr eased noticeably in both groups after treatment ( P <0.05 or P <0.01), but the improvement in the treated group was more significant as compared with tho se in the control group ( P <0.05). The levels of TNF-α, IL-2R and IL -8 in sputum considerably lowered also after XYA treatment ( P <0.01).Conclusion: XYA could regulate the related cytokines in patient s with mild or moderate bronchial asthma, and reduce the releasing of inflammato ry factors, which is consistent with the improvement of lung functions, so as to ease the airway inflammation chiefly exhibited as cell infiltration in bron chi.
