Two new dibenzofurans, 7,8-dimethoxy-4-methyldibenzofuran-1-carboxaldehyde, named ligumedial (1) and 7,8-dimethoxy-4-methyldibenzofuran-1-carboxylic acid, named ligumediaoic acid (2), have been isolated from the under...Two new dibenzofurans, 7,8-dimethoxy-4-methyldibenzofuran-1-carboxaldehyde, named ligumedial (1) and 7,8-dimethoxy-4-methyldibenzofuran-1-carboxylic acid, named ligumediaoic acid (2), have been isolated from the underground parts of Ligularia intermedia. Their structures were elucidated by spectroscopic methods.展开更多
In order to extend the investigation of the characteristics of desert shrub liquefaction and the structure of liquefied desert shrubs, we studied the liquefaction of Salixpsammophila and Caragana intermedia in the pre...In order to extend the investigation of the characteristics of desert shrub liquefaction and the structure of liquefied desert shrubs, we studied the liquefaction of Salixpsammophila and Caragana intermedia in the presence of phenol and used FTIR analysis on unliquefied and liquefied S. psammophila and C. intermedia. The results showed that the liquefaction effects are enhanced with an increase in temperature, catalyst content and liquid ratio. FTIR analysis proved that more active functional groups appeared after S. psammophila and C. intermedia were liquefied in the presence of phenol. These results can provide a theoretical basis for the further utilization of liquefied S. psammophila and C. intermedia and the development of desert shrubs in a new utilization field.展开更多
Coriaria,the only genus under family Coriariacea,receives a lot interest among botanist due to its controversial taxonomic treatment and unique phytochemistry that could be commercially important.The populations of Co...Coriaria,the only genus under family Coriariacea,receives a lot interest among botanist due to its controversial taxonomic treatment and unique phytochemistry that could be commercially important.The populations of Coriaria japonica subsp.intermedia in Cordillera Central Range(CCR),Philippines had never been studied in detail.With the need for more information on this controversial genus,the study deemed it necessary to present the distribution and morpho-anatomical description of C.japonica subsp.intermedia in CCR.A total of 123 populations were documented,found at an elevation range of 1334 to 2494 m asl and stretched between16°31’37.7"to 17°5’47.8"N and 120°39’40.3"to120°55’48"E.Mapping these populations showed a narrow linear pattern of distribution concentrated at the southern portion of CCR.The plant is a shrub with simple leaves,collateral buds,raceme inflorescence,bisexual flowers with persistent perianth forming an accessory fruit after fertilization.In terms of anatomy,much are of the usual dicot characters such as dorsiventral leaf with stomata concentrated in the lower epidermis,eustele with pith in the stem andpresence of secondary growth both on old stem and old root.Interesting findings of the study include the123 populations,the larger leaf measurements,longer petals and larger fruits than the original description given by Matsumura.Also,the paracytic type of stomata and presence of pith in the primary roots of C.japonica subsp.intermedia are interesting since these are common monocot characters while the plant is dicot.These findings are additional information that could help clear the controversies on the genus Coriaria.More importantly,our results could provide essential information for understanding the plant and for developing conservation strategies not just for this plant but also for the other related plants in the CCR biogeographical zone.展开更多
The public health significance of Yersinia spp. gives a new dimension to the prevailing food chain, wherein the foods do get exposed to heat and cold treatments. In this study, the effect of heat treatment on the nati...The public health significance of Yersinia spp. gives a new dimension to the prevailing food chain, wherein the foods do get exposed to heat and cold treatments. In this study, the effect of heat treatment on the native isolates of Yersinia enterocolitica CFR 2301 and Y. intermedia CFR 2303 revealed the D-values ranging from the lowest of 0.08 min at 65℃ in skim milk/beef gravy to the highest of 18.52 min at 50℃ in beef gravy. The heat sensitivity of both these cultures was in the order of Milli-Q water > 0.85% saline > skim milk > beef gravy. The z-values of the test cultures ranged from 7.55℃ for Y. intermedia to 12.08℃ for Y. enterocolitica. The heat sensitivity in Y. enterocolitica appeared to be related with growth incubation temperatures and also fatty acid profile of cell membrane. The effect of low temperature treatments (–20 ℃, 0℃ and 4℃ for 20 d) in water, saline and skim milk revealed the ability of Y. enterocolitica to survive more efficiently at –20℃, while Y. intermedia was more tolerant at 0℃. In packaged drinking water, Y. enterocolitica could survive and grow at 4℃ and 16℃, while at 30℃, inactivation was rapid. The findings did indicate that heat and cold treatments would not always ensure safety from Y. enterocolitica and Y. intermedia in the food chain.展开更多
Recurrent priapism is a rare, serious and difficult to treat complication of some hematological disorders, for which no standard therapy exists. This study reports a case of a 42-year-old man with thalassemia intermed...Recurrent priapism is a rare, serious and difficult to treat complication of some hematological disorders, for which no standard therapy exists. This study reports a case of a 42-year-old man with thalassemia intermedia complicated by recurrent episodes of priapism. To prevent priapism recurrences, a trial of PDE5is use was initiated. One day after initiation of a PDE5i (25 mg sildenafil repeated every 8 hours), priapism was improved. For 3 weeks, the patient reported improvement, without experiencing any episodes of priapism and a normal physiologic erectile function. Four weeks after treatment he experienced priapism reoccurrence and doubling of the Sildenafil was not effective. Gonadotropin-releasing hormone agonist initiated and one week after initiatin of new drug he improved. He was free of priapism episodes for more than 2 years afterward. PDE5 deregulation seems to be an underling pathologic mechanism of recurrent priapism at least in thalassemia intermedia patients. It appears that PDE5is may have a role in the management of such patients and further testing in clinical trials is needed.展开更多
Microbes are good sources of biologically active compounds that can be used as pharmaceuticals and agrochemicals. As part of our continuous efforts in search for biopesticides from natural sources, a fungus is isolate...Microbes are good sources of biologically active compounds that can be used as pharmaceuticals and agrochemicals. As part of our continuous efforts in search for biopesticides from natural sources, a fungus is isolated from leaves of Pandanus amaryllifolius that shows severe necrosis. This fungus is cultured in potato dextrose agar and identified as Curvularia intermedia. The ethyl acetate extract of the liquid culture medium is phytotoxic. Identification and bioassay of αβ-dehydrocurvularin (1) and curvularin (2) from this fungus are described. Monoacetyldehydrocurvularin (3), and diacetyldehydrocurvularin (4) are synthesized from 1. Phytoxicity rankings in a variety of bioassays are 1 > 2 > 4 > 3.展开更多
A benzodioxin derivative was isolated in the phytochemical investigation of Ligularia intermedia Nakai. Its structure was elucidated by high field H-1 NMR, C-13 NMR and DEFT, together with the EI-MS and IR.
BACKGROUNDβ-thalassemia intermedia(βTI)is one of the hemoglobinopathies.It constitutes 10%ofβ-thalassemia cases yet being associated with a better quality of life thanβ-thalassemia major(βTM).CASE SUMMARY We rece...BACKGROUNDβ-thalassemia intermedia(βTI)is one of the hemoglobinopathies.It constitutes 10%ofβ-thalassemia cases yet being associated with a better quality of life thanβ-thalassemia major(βTM).CASE SUMMARY We recently reported the first case of acute lymphoblastic leukemia(ALL)from Egypt in a child withβTM,and we herein report the first case of ALL from Egypt in a child withβTI.In this report,literature was reviewed for cases of malignancies associated withβTI and the possible factors underling the relationship between the two entities.CONCLUSION We stress that physicians should have a high index of suspicion of malignancies in thalassemia patients if they present with any suggestive symptoms or signs.展开更多
文摘利用Gibberella intermedia CA3-1对甾体化合物去氢表雄酮(DHEA)进行C7α-羟基化反应研究。用单因素实验的方法考察接种量、装液量、转速、有机溶剂助溶、投料浓度以及底物投加时间对产物7α-羟基去氢表雄酮(7α-OH-DHEA)生成的影响。最终确定最适工艺条件:接种量6%,装液量30 m L(250 m L三角瓶),转速220 r/min,体积分数6%丙二醇助溶,接种时即添加底物,底物DHEA质量浓度1 g/L,转化时间36 h。采用优化后的转化条件,7α-OH-DHEA摩尔得率为72.34%。
基金This work was financially supported by the National Natural Science Foundation of China for outstanding young scientists to Z. T. Wang (No. 39825129).
文摘Two new dibenzofurans, 7,8-dimethoxy-4-methyldibenzofuran-1-carboxaldehyde, named ligumedial (1) and 7,8-dimethoxy-4-methyldibenzofuran-1-carboxylic acid, named ligumediaoic acid (2), have been isolated from the underground parts of Ligularia intermedia. Their structures were elucidated by spectroscopic methods.
基金This study was financially supported by the Natural Science Foundation of Inner Mongolia(No.200508010603).
文摘In order to extend the investigation of the characteristics of desert shrub liquefaction and the structure of liquefied desert shrubs, we studied the liquefaction of Salixpsammophila and Caragana intermedia in the presence of phenol and used FTIR analysis on unliquefied and liquefied S. psammophila and C. intermedia. The results showed that the liquefaction effects are enhanced with an increase in temperature, catalyst content and liquid ratio. FTIR analysis proved that more active functional groups appeared after S. psammophila and C. intermedia were liquefied in the presence of phenol. These results can provide a theoretical basis for the further utilization of liquefied S. psammophila and C. intermedia and the development of desert shrubs in a new utilization field.
基金financial support provided by Benguet State University though the Office of the Vice-President for Research and Extension headed by Dr.Carlito P.Laurean。
文摘Coriaria,the only genus under family Coriariacea,receives a lot interest among botanist due to its controversial taxonomic treatment and unique phytochemistry that could be commercially important.The populations of Coriaria japonica subsp.intermedia in Cordillera Central Range(CCR),Philippines had never been studied in detail.With the need for more information on this controversial genus,the study deemed it necessary to present the distribution and morpho-anatomical description of C.japonica subsp.intermedia in CCR.A total of 123 populations were documented,found at an elevation range of 1334 to 2494 m asl and stretched between16°31’37.7"to 17°5’47.8"N and 120°39’40.3"to120°55’48"E.Mapping these populations showed a narrow linear pattern of distribution concentrated at the southern portion of CCR.The plant is a shrub with simple leaves,collateral buds,raceme inflorescence,bisexual flowers with persistent perianth forming an accessory fruit after fertilization.In terms of anatomy,much are of the usual dicot characters such as dorsiventral leaf with stomata concentrated in the lower epidermis,eustele with pith in the stem andpresence of secondary growth both on old stem and old root.Interesting findings of the study include the123 populations,the larger leaf measurements,longer petals and larger fruits than the original description given by Matsumura.Also,the paracytic type of stomata and presence of pith in the primary roots of C.japonica subsp.intermedia are interesting since these are common monocot characters while the plant is dicot.These findings are additional information that could help clear the controversies on the genus Coriaria.More importantly,our results could provide essential information for understanding the plant and for developing conservation strategies not just for this plant but also for the other related plants in the CCR biogeographical zone.
文摘The public health significance of Yersinia spp. gives a new dimension to the prevailing food chain, wherein the foods do get exposed to heat and cold treatments. In this study, the effect of heat treatment on the native isolates of Yersinia enterocolitica CFR 2301 and Y. intermedia CFR 2303 revealed the D-values ranging from the lowest of 0.08 min at 65℃ in skim milk/beef gravy to the highest of 18.52 min at 50℃ in beef gravy. The heat sensitivity of both these cultures was in the order of Milli-Q water > 0.85% saline > skim milk > beef gravy. The z-values of the test cultures ranged from 7.55℃ for Y. intermedia to 12.08℃ for Y. enterocolitica. The heat sensitivity in Y. enterocolitica appeared to be related with growth incubation temperatures and also fatty acid profile of cell membrane. The effect of low temperature treatments (–20 ℃, 0℃ and 4℃ for 20 d) in water, saline and skim milk revealed the ability of Y. enterocolitica to survive more efficiently at –20℃, while Y. intermedia was more tolerant at 0℃. In packaged drinking water, Y. enterocolitica could survive and grow at 4℃ and 16℃, while at 30℃, inactivation was rapid. The findings did indicate that heat and cold treatments would not always ensure safety from Y. enterocolitica and Y. intermedia in the food chain.
文摘Recurrent priapism is a rare, serious and difficult to treat complication of some hematological disorders, for which no standard therapy exists. This study reports a case of a 42-year-old man with thalassemia intermedia complicated by recurrent episodes of priapism. To prevent priapism recurrences, a trial of PDE5is use was initiated. One day after initiation of a PDE5i (25 mg sildenafil repeated every 8 hours), priapism was improved. For 3 weeks, the patient reported improvement, without experiencing any episodes of priapism and a normal physiologic erectile function. Four weeks after treatment he experienced priapism reoccurrence and doubling of the Sildenafil was not effective. Gonadotropin-releasing hormone agonist initiated and one week after initiatin of new drug he improved. He was free of priapism episodes for more than 2 years afterward. PDE5 deregulation seems to be an underling pathologic mechanism of recurrent priapism at least in thalassemia intermedia patients. It appears that PDE5is may have a role in the management of such patients and further testing in clinical trials is needed.
文摘Microbes are good sources of biologically active compounds that can be used as pharmaceuticals and agrochemicals. As part of our continuous efforts in search for biopesticides from natural sources, a fungus is isolated from leaves of Pandanus amaryllifolius that shows severe necrosis. This fungus is cultured in potato dextrose agar and identified as Curvularia intermedia. The ethyl acetate extract of the liquid culture medium is phytotoxic. Identification and bioassay of αβ-dehydrocurvularin (1) and curvularin (2) from this fungus are described. Monoacetyldehydrocurvularin (3), and diacetyldehydrocurvularin (4) are synthesized from 1. Phytoxicity rankings in a variety of bioassays are 1 > 2 > 4 > 3.
文摘A benzodioxin derivative was isolated in the phytochemical investigation of Ligularia intermedia Nakai. Its structure was elucidated by high field H-1 NMR, C-13 NMR and DEFT, together with the EI-MS and IR.
文摘BACKGROUNDβ-thalassemia intermedia(βTI)is one of the hemoglobinopathies.It constitutes 10%ofβ-thalassemia cases yet being associated with a better quality of life thanβ-thalassemia major(βTM).CASE SUMMARY We recently reported the first case of acute lymphoblastic leukemia(ALL)from Egypt in a child withβTM,and we herein report the first case of ALL from Egypt in a child withβTI.In this report,literature was reviewed for cases of malignancies associated withβTI and the possible factors underling the relationship between the two entities.CONCLUSION We stress that physicians should have a high index of suspicion of malignancies in thalassemia patients if they present with any suggestive symptoms or signs.
