School-based universal screening for behavioral/emotional risk is a necessary first step to providing services in an educational setting for students with emotional and behavioral disorders (EBDs). Psychometric proper...School-based universal screening for behavioral/emotional risk is a necessary first step to providing services in an educational setting for students with emotional and behavioral disorders (EBDs). Psychometric properties are critical to making decisions about choosing a screening instrument. The purpose of the present study was to examine the psychometric properties of the student risk screening scale for internalizing and externalizing behaviors (SRSS-IE). Participants included 3145 students and their teachers. Item-level analyses of the current sample supported the retention of all items. The internal consistency of the SRSS items ranged from 0.83 to 0.85. Convergent validity between the SRSS-IE and a well-established screening tool, the strength and difficulties questionnaire (SDQ), was found for the total score (r = 0.70). Additionally, the results of this study demonstrate strong social validity, suggesting the SRSS-IE to be a useful and functional screening tool. We conclude that the SRSS-IE is a valid and reliable instrument for assessing the level of emotional and behavioral difficulties among elementary students.展开更多
The present paper examines the deterioration of the limestone of Emir Hasan Mosque as a result of internal damage factors. Tests were done and carried to determine the rate of damage to the limestone that was used in ...The present paper examines the deterioration of the limestone of Emir Hasan Mosque as a result of internal damage factors. Tests were done and carried to determine the rate of damage to the limestone that was used in the past in Egypt. Chemical analyses were done to identify soluble salts. The study utilized optical microscopy, scanning electron microscope equipped with EDS unit, and X-ray diffraction analysis to identify the main causes of increased limestone damage rates because of being affected by internal destructive factors. The study discussed different ways to conserve separate parts through the use of one consolidated material through the study of changes to limestone during the period of treatment to determine the appropriate treatment methods.展开更多
Background:Hippocampal damage caused by status epilepticus(SE)can bring about cognitive decline and emotional disorders,which are common clinical comorbidities in patients with epilepsy.It is therefore imperative to d...Background:Hippocampal damage caused by status epilepticus(SE)can bring about cognitive decline and emotional disorders,which are common clinical comorbidities in patients with epilepsy.It is therefore imperative to develop a novel therapeutic strat-egy for protecting hippocampal damage after SE.Mitochondrial dysfunction is one of contributing factors in epilepsy.Given the therapeutic benefits of mitochondrial replenishment by exogenous mitochondria,we hypothesized that transplantation of mitochondria would be capable of ameliorating hippocampal damage following SE.Methods:Pilocarpine was used to induced SE in mice.SE-generated cognitive de-cline and emotional disorders were determined using novel object recognition,the tail suspension test,and the open field test.SE-induced hippocampal pathology was assessed by quantifying loss of neurons and activation of microglia and astrocytes.The metabolites underlying mitochondrial transplantation were determined using metabonomics.Results:The results showed that peripheral administration of isolated mitochon-dria could improve cognitive deficits and depressive and anxiety-like behaviors.Exogenous mitochondria blunted the production of reactive oxygen species,pro-liferation of microglia and astrocytes,and loss of neurons in the hippocampus.The metabonomic profiles showed that mitochondrial transplantation altered multiple metabolic pathways such as sphingolipid signaling pathway and carbon metabolism.Among potential affected metabolites,mitochondrial transplantation decreased levels of sphingolipid(d18:1/18:0)and methylmalonic acid,and elevated levels of D-fructose-1,6-bisphosphate.Conclusion:To the best of our knowledge,these findings provide the first direct ex-perimental evidence that artificial mitochondrial transplantation is capable of amelio-rating hippocampal damage following SE.These new findings support mitochondrial transplantation as a promising therapeutic strategy for epilepsy-associated psychiat-ric and cognitive disorders.展开更多
Post-disaster very high resolution(VHR) satellite data are potential sources to provide detailed information on damage and geological changes for a large area in a short time.In this paper,we studied landslides trig...Post-disaster very high resolution(VHR) satellite data are potential sources to provide detailed information on damage and geological changes for a large area in a short time.In this paper,we studied landslides triggered by the M_w 6.9 earthquake in Sikkim,India which occurred on 18 September 2011 using VHR data from Cartosat-1,GeoEye-1,QuickBird-2 and WorldView-2 satellites.Since the earthquake-affected area is located in mostly inaccessible Himalayan terrain,VHR data from these satellites provided a unique opportunity for quick and synoptic assessment of the damage.Using visual change analysis technique through comparison of pre- and post-earthquake images,we assessed the damage caused by the event.A total of 123 images acquired from eight satellites,covering an area of4105 km2 were analysed and 1196 new landslides triggered by the earthquake were mapped.Road blockages and severely affected villages were also identified.Geological assessment of the terrain highlighted linear disposition of landslides along existing fault scarps,suggesting a reactivation of fault.The landslide inventory map prepared from VHR images also showed a good correlation with the earthquake shake map.Results showed that several parts of north Sikkim,particularly Mangan and Chungthang,which are close to the epicentre,were severely affected by the earthquake,and that the event-based landslide inventory map can be used in future earthquake-triggered landslide susceptibility assessment studies.展开更多
Spinal cord injury(SCI)is one of the leading causes of disability and is a devastating condition that requires long-term care,reduces social productivity,and gives an immense emotional burden on patients and their fa ...Spinal cord injury(SCI)is one of the leading causes of disability and is a devastating condition that requires long-term care,reduces social productivity,and gives an immense emotional burden on patients and their fa milies.SCI frequently occurs due to traffic accidents,falls,slips,violence,sports,and medical accidents in today's society.The initial mechanical damage triggers a secondary injury cascade that induces more intractable damage(Silva et al.,2014).Secondary injury mechanisms have been postulated,including neuronal apoptosis,inflammation,oxidative stress,and excitotoxicity.展开更多
VIOLENCE IS NOT ONLY WRONG,IT’S DISEASED-it’s always painful and too often fatal-as with Martin Luther King,no less.When emotions run high,doctors have difficulty making progress-calm,dispassionate review of the obv...VIOLENCE IS NOT ONLY WRONG,IT’S DISEASED-it’s always painful and too often fatal-as with Martin Luther King,no less.When emotions run high,doctors have difficulty making progress-calm,dispassionate review of the obvious evidence is vital,if you aim for less pain and fewer deaths.This paper is based on the self-evident precept that violated children unmistakeably predate violent adults.The remedy,highlighted here,is unusual in all psychiatry,in that it is backed by solid,irrefutable,objective,scientific evidence-from brainscans,no less-at least it is,for those willing to look.The paper has 6 parts:1.Introduction;2.Un-memorising Terror;3.Nutritious Emotions;4.Tyrannical Revenge;5.The Way to Cure Nucleargeddon Is Paved With Good Intentions;6.Conclusion.Parenting is a troubled skill,largely because mis-parenting perpetuates itself.As the poet Philip Larkin says of parents-“they fill you with the faults they had,and add some extra just for you”.Larkin moderates his criticism with“they may not mean to,but they do”.Sadly his“solution”-“don’t have any kids yourself”can extinguish the human race as reliably as ever revengeful Emotional Dwarfism will.展开更多
Adverse consequences to the ecological system and human health caused by impacts potentially attributable to climate change have already drawn great and widespread concern of many scientists and international organiza...Adverse consequences to the ecological system and human health caused by impacts potentially attributable to climate change have already drawn great and widespread concern of many scientists and international organizations.However,we still have a hard time determining exactly the impact of climate change on the environment or the damage that climate change inflicts on countries comprising small islands or low-lying lands in light of today's science and technology.The progress for dealing with the issue of loss and damage has been struggling for a long time from the beginning to the present.In this paper,the author begins by summarizing talks on the concept and the positions of commentators.The author is proposing that the development of future climate negotiations and rule-making process be based on global climate justice as a standard for measuring value.Also,the author proposes that a holistic view of climate justice be established.Generally,three aspects of climate justice can be derived.First,the dimension of human rights protection shows that protection of fundamental human rights is a logical precondition if small-island and low-lying countries are able to achieve climate justice.Second,the definite and traditional concepts of distributive justice and corrective justice hold the view that the principle of common but differentiated responsibilities should be upheld as a basic standard of allocating rights and duties associated with climate change.Third,climate justice requires that any state follow the "no-harm principle," which is regarded as an international customary rule.According to the principle,the obligation of states to prevent the use of their territory for causing trans-boundary harm to the environment shall be a violation of state responsibility,which incurs international punishment.Then we put forward three remedial approaches in light of climate justice,including the approach of State Responsibility(SR) based on the principles and rules of international human rights law and international environmental law.Based on clear rules,the judge can determine whether the damaging behavior or the damage perpetrated by a state party constitutes a state responsibility.The International Environmental Regulation(IEB),which means solving the problems within the framework established by the Conventions on Climate Change,takes advantage of the market mechanisms and incentives such as fund and insurance support system to relieve or compensate the loss and damage.International Environmental Dispute Settlement Mechanism(IEDSM),which includes the means such as consultations,negotiations,nonmandatory ways and international arbitration,international judicial ways to solve these disputes,functions as a procedural safeguard.As an active promoter of global climate governance,China should no doubt stand by the principle of Common But Differentiated Responsibility(CBDR) and take it as a basis for negotiations,actively strengthen the work of South-South cooperation,fulfill her international climate commitments without reservation,vigorously develop a low-carbon economy,and actively promote international negotiations on the subject of loss and damage.展开更多
With the aid of non-contact measurements of vibrating surfaces through laser scanning,operating deflection shapes(ODSs)with high spatial resolutions can be used to graphically characterize damage in plane structures.A...With the aid of non-contact measurements of vibrating surfaces through laser scanning,operating deflection shapes(ODSs)with high spatial resolutions can be used to graphically characterize damage in plane structures.Although numerous damage identification approaches relying on laser-measured ODSs have been developed for plate-type structures,they cannot be directly applied to circular cylinders due to the gap between equations of motions of plates and circular cylinders.To fill this gap,a novel approach is proposed in this study for damage identification of circular cylinders.Damage-induced discontinuities of the derivatives of ODSs can be used to gra-phically manifest the occurrence of the damage,and characterize the location and size of the damage.The approach is experimentally validated on a specimen of the circular cylinder component,whose out-of-plane ODSs in an inspection region are acquired through laser scanning using a scanning laser vibrometer.The results suggest that the occurrence,location,and size of the internal damage of the circular cylinder can be identified.展开更多
文摘School-based universal screening for behavioral/emotional risk is a necessary first step to providing services in an educational setting for students with emotional and behavioral disorders (EBDs). Psychometric properties are critical to making decisions about choosing a screening instrument. The purpose of the present study was to examine the psychometric properties of the student risk screening scale for internalizing and externalizing behaviors (SRSS-IE). Participants included 3145 students and their teachers. Item-level analyses of the current sample supported the retention of all items. The internal consistency of the SRSS items ranged from 0.83 to 0.85. Convergent validity between the SRSS-IE and a well-established screening tool, the strength and difficulties questionnaire (SDQ), was found for the total score (r = 0.70). Additionally, the results of this study demonstrate strong social validity, suggesting the SRSS-IE to be a useful and functional screening tool. We conclude that the SRSS-IE is a valid and reliable instrument for assessing the level of emotional and behavioral difficulties among elementary students.
文摘The present paper examines the deterioration of the limestone of Emir Hasan Mosque as a result of internal damage factors. Tests were done and carried to determine the rate of damage to the limestone that was used in the past in Egypt. Chemical analyses were done to identify soluble salts. The study utilized optical microscopy, scanning electron microscope equipped with EDS unit, and X-ray diffraction analysis to identify the main causes of increased limestone damage rates because of being affected by internal destructive factors. The study discussed different ways to conserve separate parts through the use of one consolidated material through the study of changes to limestone during the period of treatment to determine the appropriate treatment methods.
基金the National Natural Science Foundation of China(Grant No.82173803,81872847).
文摘Background:Hippocampal damage caused by status epilepticus(SE)can bring about cognitive decline and emotional disorders,which are common clinical comorbidities in patients with epilepsy.It is therefore imperative to develop a novel therapeutic strat-egy for protecting hippocampal damage after SE.Mitochondrial dysfunction is one of contributing factors in epilepsy.Given the therapeutic benefits of mitochondrial replenishment by exogenous mitochondria,we hypothesized that transplantation of mitochondria would be capable of ameliorating hippocampal damage following SE.Methods:Pilocarpine was used to induced SE in mice.SE-generated cognitive de-cline and emotional disorders were determined using novel object recognition,the tail suspension test,and the open field test.SE-induced hippocampal pathology was assessed by quantifying loss of neurons and activation of microglia and astrocytes.The metabolites underlying mitochondrial transplantation were determined using metabonomics.Results:The results showed that peripheral administration of isolated mitochon-dria could improve cognitive deficits and depressive and anxiety-like behaviors.Exogenous mitochondria blunted the production of reactive oxygen species,pro-liferation of microglia and astrocytes,and loss of neurons in the hippocampus.The metabonomic profiles showed that mitochondrial transplantation altered multiple metabolic pathways such as sphingolipid signaling pathway and carbon metabolism.Among potential affected metabolites,mitochondrial transplantation decreased levels of sphingolipid(d18:1/18:0)and methylmalonic acid,and elevated levels of D-fructose-1,6-bisphosphate.Conclusion:To the best of our knowledge,these findings provide the first direct ex-perimental evidence that artificial mitochondrial transplantation is capable of amelio-rating hippocampal damage following SE.These new findings support mitochondrial transplantation as a promising therapeutic strategy for epilepsy-associated psychiat-ric and cognitive disorders.
基金support work carried out under the Decision Support Centre(DSC) activities of NRSC
文摘Post-disaster very high resolution(VHR) satellite data are potential sources to provide detailed information on damage and geological changes for a large area in a short time.In this paper,we studied landslides triggered by the M_w 6.9 earthquake in Sikkim,India which occurred on 18 September 2011 using VHR data from Cartosat-1,GeoEye-1,QuickBird-2 and WorldView-2 satellites.Since the earthquake-affected area is located in mostly inaccessible Himalayan terrain,VHR data from these satellites provided a unique opportunity for quick and synoptic assessment of the damage.Using visual change analysis technique through comparison of pre- and post-earthquake images,we assessed the damage caused by the event.A total of 123 images acquired from eight satellites,covering an area of4105 km2 were analysed and 1196 new landslides triggered by the earthquake were mapped.Road blockages and severely affected villages were also identified.Geological assessment of the terrain highlighted linear disposition of landslides along existing fault scarps,suggesting a reactivation of fault.The landslide inventory map prepared from VHR images also showed a good correlation with the earthquake shake map.Results showed that several parts of north Sikkim,particularly Mangan and Chungthang,which are close to the epicentre,were severely affected by the earthquake,and that the event-based landslide inventory map can be used in future earthquake-triggered landslide susceptibility assessment studies.
基金supported solely by the Department of Anesthesiology and Intensive Care Medicine(Akita University Graduate School of Medicine)。
文摘Spinal cord injury(SCI)is one of the leading causes of disability and is a devastating condition that requires long-term care,reduces social productivity,and gives an immense emotional burden on patients and their fa milies.SCI frequently occurs due to traffic accidents,falls,slips,violence,sports,and medical accidents in today's society.The initial mechanical damage triggers a secondary injury cascade that induces more intractable damage(Silva et al.,2014).Secondary injury mechanisms have been postulated,including neuronal apoptosis,inflammation,oxidative stress,and excitotoxicity.
文摘VIOLENCE IS NOT ONLY WRONG,IT’S DISEASED-it’s always painful and too often fatal-as with Martin Luther King,no less.When emotions run high,doctors have difficulty making progress-calm,dispassionate review of the obvious evidence is vital,if you aim for less pain and fewer deaths.This paper is based on the self-evident precept that violated children unmistakeably predate violent adults.The remedy,highlighted here,is unusual in all psychiatry,in that it is backed by solid,irrefutable,objective,scientific evidence-from brainscans,no less-at least it is,for those willing to look.The paper has 6 parts:1.Introduction;2.Un-memorising Terror;3.Nutritious Emotions;4.Tyrannical Revenge;5.The Way to Cure Nucleargeddon Is Paved With Good Intentions;6.Conclusion.Parenting is a troubled skill,largely because mis-parenting perpetuates itself.As the poet Philip Larkin says of parents-“they fill you with the faults they had,and add some extra just for you”.Larkin moderates his criticism with“they may not mean to,but they do”.Sadly his“solution”-“don’t have any kids yourself”can extinguish the human race as reliably as ever revengeful Emotional Dwarfism will.
文摘Adverse consequences to the ecological system and human health caused by impacts potentially attributable to climate change have already drawn great and widespread concern of many scientists and international organizations.However,we still have a hard time determining exactly the impact of climate change on the environment or the damage that climate change inflicts on countries comprising small islands or low-lying lands in light of today's science and technology.The progress for dealing with the issue of loss and damage has been struggling for a long time from the beginning to the present.In this paper,the author begins by summarizing talks on the concept and the positions of commentators.The author is proposing that the development of future climate negotiations and rule-making process be based on global climate justice as a standard for measuring value.Also,the author proposes that a holistic view of climate justice be established.Generally,three aspects of climate justice can be derived.First,the dimension of human rights protection shows that protection of fundamental human rights is a logical precondition if small-island and low-lying countries are able to achieve climate justice.Second,the definite and traditional concepts of distributive justice and corrective justice hold the view that the principle of common but differentiated responsibilities should be upheld as a basic standard of allocating rights and duties associated with climate change.Third,climate justice requires that any state follow the "no-harm principle," which is regarded as an international customary rule.According to the principle,the obligation of states to prevent the use of their territory for causing trans-boundary harm to the environment shall be a violation of state responsibility,which incurs international punishment.Then we put forward three remedial approaches in light of climate justice,including the approach of State Responsibility(SR) based on the principles and rules of international human rights law and international environmental law.Based on clear rules,the judge can determine whether the damaging behavior or the damage perpetrated by a state party constitutes a state responsibility.The International Environmental Regulation(IEB),which means solving the problems within the framework established by the Conventions on Climate Change,takes advantage of the market mechanisms and incentives such as fund and insurance support system to relieve or compensate the loss and damage.International Environmental Dispute Settlement Mechanism(IEDSM),which includes the means such as consultations,negotiations,nonmandatory ways and international arbitration,international judicial ways to solve these disputes,functions as a procedural safeguard.As an active promoter of global climate governance,China should no doubt stand by the principle of Common But Differentiated Responsibility(CBDR) and take it as a basis for negotiations,actively strengthen the work of South-South cooperation,fulfill her international climate commitments without reservation,vigorously develop a low-carbon economy,and actively promote international negotiations on the subject of loss and damage.
基金The authors are grateful for the supports from the Changzhou Policy Guidance Plan-International Science and Technology Cooperation(No.CZ20200003)the Anhui International Joint Research Center of Data Diagnosis and Smart Maintenance on Bridge Structures(No.2021AHGHYB01)+1 种基金the Nantong Science and Technology Opening Cooperation Project in 2021(No.BW2021001)the Key R&D Project of Anhui Science and Technology Department(202004b11020026).
文摘With the aid of non-contact measurements of vibrating surfaces through laser scanning,operating deflection shapes(ODSs)with high spatial resolutions can be used to graphically characterize damage in plane structures.Although numerous damage identification approaches relying on laser-measured ODSs have been developed for plate-type structures,they cannot be directly applied to circular cylinders due to the gap between equations of motions of plates and circular cylinders.To fill this gap,a novel approach is proposed in this study for damage identification of circular cylinders.Damage-induced discontinuities of the derivatives of ODSs can be used to gra-phically manifest the occurrence of the damage,and characterize the location and size of the damage.The approach is experimentally validated on a specimen of the circular cylinder component,whose out-of-plane ODSs in an inspection region are acquired through laser scanning using a scanning laser vibrometer.The results suggest that the occurrence,location,and size of the internal damage of the circular cylinder can be identified.