Purpose: To investigate the feasibility of partial arc volumetric modulated arc therapy (VMAT) in lung cancer stereotactic body radiotherapy (SBRT), as well the volumetric and dosimetric effects of different internal ...Purpose: To investigate the feasibility of partial arc volumetric modulated arc therapy (VMAT) in lung cancer stereotactic body radiotherapy (SBRT), as well the volumetric and dosimetric effects of different internal target volume (ITV) definitions with 4D CT. Methods: Fourteen patients with primary and metastatic lung cancer underwent SBRT were enrolled. Full and partial arc VMAT plans were generated with four different ITVs: ITVall, ITVMIP, ITVAIP and ITV2phases, representing ITVs generated from all 10 respiratory phases, maximum intensity projection (MIP), average intensity projection (AIP), and 2 extreme respiratory phases. Volumetric and dosimetric differences, as well as MU and delivery time were investigated. Results: Partial arc VMAT irradiated more dose at 2 cm away from planning target volume (PTV) (P = 0.002), however, it achieved better protection on mean lung dose , lung V5, spinal cord, heart and esophagus compared with full arc VMAT. The average MU and delivery time of partial arc VMAT were 240 and 1.6 min less than those of full arc VMAT. There were no significant differences on target coverage and organ at risks (OARs) sparing among four ITVs. The average percent volume differences of ITVMIP, ITVAIP and ITV2phases to ITVall were 8.6%, 13.4%, and 25.2%, respectively. Conclusions: Although partial arc VMAT delivered more dose 2 cm out of PTV, it decreases the dose to lung, spinal cord, and esophagus, as well decreased the total MU and delivery time compared with full arc VMAT without sacrificing target coverage. Partial arc VMAT was feasible and more efficient for lung SBRT.展开更多
Objective: To evaluate the effect of magnetic nanoparticle containing 5-fluorouracil (5-FU) targeting in treating chol- angiocarcinoma based on internal magnetic fields built inside the tumor. Methods: 32 nude mice of...Objective: To evaluate the effect of magnetic nanoparticle containing 5-fluorouracil (5-FU) targeting in treating chol- angiocarcinoma based on internal magnetic fields built inside the tumor. Methods: 32 nude mice of BABL/C bearing ectopic tumor were built by subcutaneouly injecting cholangiocarcinoma cell line QBC 939. Three weeks after tumor inoculation, the animal models were divided equally into four groups at random including: (a) group A, consisting of internal magnetic field built by magnetic biliary stent wires inserted into tumor tissue and receiving magnetic nanoparticles containing 5-FU administered via tail vein injection at 250 mg/kg for consecutive five days; (b) group B, receiving placebo (sodium chloride); (c) group C, receiving pure magnetic biliary stent wires without the applying of magnetic nanoparticles; (d) group D, consisting of external magnetic fields and the same treatment of magnetic nanoparticles containing 5-FU as group A. The tumor volumes were measured every 3 days, totally six times from treatment started. Tumor tissues were observed by transmission electron microscope when the nude mice were killed after the observation period. Results: The experimental group (group A) showed significantly therapeutic efficacy. Moreover, apoptosis of tumor cells could be easily detected in this group. Conclusion: Magnetic particles containing 5-FU combined with internal magnetic field can effectively treat cholangiocarcinoma, and its therapeutic efficacy is better than that of the traditional method based on external magnetic fields.展开更多
Capacitive-load isolation technique[1] was proposed to improve the stability and capacitive load ability of the timing detector system in internal target of CSRe. This technique can solve the overshoot and ringing pro...Capacitive-load isolation technique[1] was proposed to improve the stability and capacitive load ability of the timing detector system in internal target of CSRe. This technique can solve the overshoot and ringing problems of the circuit, without affecting its gain and bandwidth. By constructing the circuit model, the cause of the instability of the circuit is analyzed mathematically, and the rationality of the capacitive-load isolation techniques is proved in experiment.展开更多
The experiments with an internal target at a storage ring have many advantages. However, it is difficult to determine the absolute cross section of a reaction where luminosity cannot be simply established through macr...The experiments with an internal target at a storage ring have many advantages. However, it is difficult to determine the absolute cross section of a reaction where luminosity cannot be simply established through macroscopic measurements. Here we present an experimental determination of the effective target thickness from the beam energy losses at the internal target in HIRFL-CSRe. The measurements here are expected to provide the accurate target thickness and luminosity for the absolute cross-section study on future internal target experiments, and also provide some reference values for the study of beam loss mechanism of the heavy ion at HIRFL-CSRe.展开更多
Eliminating poverty is the essential requirement of socialism. Since the 18th National Congress of the Communist Party of China, targeted poverty alleviation has become a major strategy for poverty alleviation and dev...Eliminating poverty is the essential requirement of socialism. Since the 18th National Congress of the Communist Party of China, targeted poverty alleviation has become a major strategy for poverty alleviation and development in China. Xi Jinping s important exposition of poverty alleviation is the theoretical basis and practical guide to direct the effective implementation of China s targeted poverty alleviation strategy. It has gradually developed into an innovative theoretical system for poverty alleviation and development in the new era, with meticulous internal logic and a reputation for the significance of the times at home and abroad. Xi Jinping s thought of targeted poverty alleviation is the development and innovation of the theory and practice of poverty alleviation and development with Chinese characteristics. It is an important guarantee for China to win the battle to get rid of poverty and build a well-off society in an all-round way, and has contributed China s wisdom and China s plan to reducing poverty in the world.展开更多
The supersonic gas-jet target is an important experimental target for laser wakefield acceleration(LWFA),which has great potential for driving novel radiation sources such as betatron radiation and Compton scattering ...The supersonic gas-jet target is an important experimental target for laser wakefield acceleration(LWFA),which has great potential for driving novel radiation sources such as betatron radiation and Compton scattering gamma rays.According to different electron acceleration requirements,it is necessary to provide specific supersonic gas jets with different density profiles to generate electron beams with high quality and high repetition rates.In this study,the interference images and density profiles of different gas-jet targets were obtained through a modified Nomarski interference diagnosis system.The relationships between the gas density and back pressure,nozzle structure,and other key parameters were studied.Targets with different characteristics are conducive to meeting the various requirements of LWFA.展开更多
Follicle stimulating hormone (FSH) is a kind of glycoprotein gonadotropin, and plays an important role in the diagnosis and treatment of infertility. Follicle stimulating hormone receptor (FSHR) is a kind of G protein...Follicle stimulating hormone (FSH) is a kind of glycoprotein gonadotropin, and plays an important role in the diagnosis and treatment of infertility. Follicle stimulating hormone receptor (FSHR) is a kind of G protein coupled receptor (GPCR), found in the ovary and testes, and its activation is required for the hormonal operation during the breeding period. In this study, an experimental model of FSHR mediated FSH into cell membrane, which exhibited a phenomenon of fluorescent localized on cell surfaces internalized into cell interior, was established to verify biological activity of FSH.展开更多
The Jiangsu Hubao Group, now very active in the garment sector, used to be a small shirt factory with a loaned capital of only a few hundred thousand yuan(RMB). Since its founding in 1989, the group has been aiming at...The Jiangsu Hubao Group, now very active in the garment sector, used to be a small shirt factory with a loaned capital of only a few hundred thousand yuan(RMB). Since its founding in 1989, the group has been aiming at the international first-class level, and has formulated and implemented international famous brand strategy, with quality products occupying the market. After展开更多
The implications brought about by the present international status of English for English language teaching （ELT） are enormous; however, the aim of this paper is to bring to light the shifting notion of target cultu...The implications brought about by the present international status of English for English language teaching （ELT） are enormous; however, the aim of this paper is to bring to light the shifting notion of target cultures and elaborate on the possible reasons based on the characteristics of English as an international language （EIL） and its use in a global sense for international communication. Suggestions are then provided with regard to the teaching of ＂language-and-culture＂ for Chinese college students from a realistic perspective of current world uses of English.展开更多
Pellet target with a close to 4π detector configuration is an optional effective internal target in the storage ring CSRm. Thermodynamic simulations are carried out to describe the hydrogen microsphere behaviors in t...Pellet target with a close to 4π detector configuration is an optional effective internal target in the storage ring CSRm. Thermodynamic simulations are carried out to describe the hydrogen microsphere behaviors in the whole moving path, and the temperature and mass changes of hydrogen microspheres are clearly indicated. The achievable experimental luminosity by pellet target in CSRm is calculated to be 1×1033 cm?2·s?1 at most.展开更多
The target thickness for nitrogen was determined from the beam energy loss in HIRFL-CSRe during the experimental study of the K-REC process in 197 MeV/u Xe54＋-N2 collisions. Furthermore, the corresponding integrated ...The target thickness for nitrogen was determined from the beam energy loss in HIRFL-CSRe during the experimental study of the K-REC process in 197 MeV/u Xe54＋-N2 collisions. Furthermore, the corresponding integrated luminosity of （1.15±0.06） x 10^30 cm-2 was obtained. As an independent check on the energy-loss method, we have also determined the integrated luminosity by measuring the produced X-rays from the K-REC process with a known differential cross section. The values of （1.12±0.06） x 10^30 and （1.09±0.06） x 1030 cm-2 were obtained by using two high-purity germanium （HPGe） detectors which were oriented at 90% and 120%with respect to the beam path, respectively. The consistent results confirmed the feasibility of the energy-loss method, which may have an important impact on future internal target experiments at HIRFL-CSRe.展开更多
Pellet target is one of the main candidate targets in CSRm (cooler storage ring’s main ring) for hadron physics studies. Pellet speed is an important physical parameter for the target. Larger pellet speed could short...Pellet target is one of the main candidate targets in CSRm (cooler storage ring’s main ring) for hadron physics studies. Pellet speed is an important physical parameter for the target. Larger pellet speed could shorten the interacting time interval between the pellet and the cyclotron beam, and thus results in a small temperature variation for the pellet. This could make the pellet facility work in a stable condition. A fluid dynamic simulation was carried out for the pellet speed, and it was found that the maximum speed for the target pellet may be restricted to about 100 m/s even if all working parameters were set to their optimal values.展开更多
文摘Purpose: To investigate the feasibility of partial arc volumetric modulated arc therapy (VMAT) in lung cancer stereotactic body radiotherapy (SBRT), as well the volumetric and dosimetric effects of different internal target volume (ITV) definitions with 4D CT. Methods: Fourteen patients with primary and metastatic lung cancer underwent SBRT were enrolled. Full and partial arc VMAT plans were generated with four different ITVs: ITVall, ITVMIP, ITVAIP and ITV2phases, representing ITVs generated from all 10 respiratory phases, maximum intensity projection (MIP), average intensity projection (AIP), and 2 extreme respiratory phases. Volumetric and dosimetric differences, as well as MU and delivery time were investigated. Results: Partial arc VMAT irradiated more dose at 2 cm away from planning target volume (PTV) (P = 0.002), however, it achieved better protection on mean lung dose , lung V5, spinal cord, heart and esophagus compared with full arc VMAT. The average MU and delivery time of partial arc VMAT were 240 and 1.6 min less than those of full arc VMAT. There were no significant differences on target coverage and organ at risks (OARs) sparing among four ITVs. The average percent volume differences of ITVMIP, ITVAIP and ITV2phases to ITVall were 8.6%, 13.4%, and 25.2%, respectively. Conclusions: Although partial arc VMAT delivered more dose 2 cm out of PTV, it decreases the dose to lung, spinal cord, and esophagus, as well decreased the total MU and delivery time compared with full arc VMAT without sacrificing target coverage. Partial arc VMAT was feasible and more efficient for lung SBRT.
基金Supported by a grant from the National High-Tech Research and Development Program (863 Program) of China (No: 2002AA214061).
文摘Objective: To evaluate the effect of magnetic nanoparticle containing 5-fluorouracil (5-FU) targeting in treating chol- angiocarcinoma based on internal magnetic fields built inside the tumor. Methods: 32 nude mice of BABL/C bearing ectopic tumor were built by subcutaneouly injecting cholangiocarcinoma cell line QBC 939. Three weeks after tumor inoculation, the animal models were divided equally into four groups at random including: (a) group A, consisting of internal magnetic field built by magnetic biliary stent wires inserted into tumor tissue and receiving magnetic nanoparticles containing 5-FU administered via tail vein injection at 250 mg/kg for consecutive five days; (b) group B, receiving placebo (sodium chloride); (c) group C, receiving pure magnetic biliary stent wires without the applying of magnetic nanoparticles; (d) group D, consisting of external magnetic fields and the same treatment of magnetic nanoparticles containing 5-FU as group A. The tumor volumes were measured every 3 days, totally six times from treatment started. Tumor tissues were observed by transmission electron microscope when the nude mice were killed after the observation period. Results: The experimental group (group A) showed significantly therapeutic efficacy. Moreover, apoptosis of tumor cells could be easily detected in this group. Conclusion: Magnetic particles containing 5-FU combined with internal magnetic field can effectively treat cholangiocarcinoma, and its therapeutic efficacy is better than that of the traditional method based on external magnetic fields.
文摘Capacitive-load isolation technique[1] was proposed to improve the stability and capacitive load ability of the timing detector system in internal target of CSRe. This technique can solve the overshoot and ringing problems of the circuit, without affecting its gain and bandwidth. By constructing the circuit model, the cause of the instability of the circuit is analyzed mathematically, and the rationality of the capacitive-load isolation techniques is proved in experiment.
基金National Natural Science Foundation of China (11105201, U1532130, U1332206)
文摘The experiments with an internal target at a storage ring have many advantages. However, it is difficult to determine the absolute cross section of a reaction where luminosity cannot be simply established through macroscopic measurements. Here we present an experimental determination of the effective target thickness from the beam energy losses at the internal target in HIRFL-CSRe. The measurements here are expected to provide the accurate target thickness and luminosity for the absolute cross-section study on future internal target experiments, and also provide some reference values for the study of beam loss mechanism of the heavy ion at HIRFL-CSRe.
基金Project Commissioned by the Office of Rural Work Leading Group of Kunming Municipal Party CommitteeConstruction Project of Studio for Party Branch Secretaries of"Double Leaders"Teachers in Colleges and Universities.
文摘Eliminating poverty is the essential requirement of socialism. Since the 18th National Congress of the Communist Party of China, targeted poverty alleviation has become a major strategy for poverty alleviation and development in China. Xi Jinping s important exposition of poverty alleviation is the theoretical basis and practical guide to direct the effective implementation of China s targeted poverty alleviation strategy. It has gradually developed into an innovative theoretical system for poverty alleviation and development in the new era, with meticulous internal logic and a reputation for the significance of the times at home and abroad. Xi Jinping s thought of targeted poverty alleviation is the development and innovation of the theory and practice of poverty alleviation and development with Chinese characteristics. It is an important guarantee for China to win the battle to get rid of poverty and build a well-off society in an all-round way, and has contributed China s wisdom and China s plan to reducing poverty in the world.
基金This work was supported by the Programs for the National Natural Science Foundation of China(Nos.11975316,11775312,12005305 and 61905287)the Continue Basic Scientific Research Project(Nos.WDJC-2019-02 and BJ20002501).
文摘The supersonic gas-jet target is an important experimental target for laser wakefield acceleration(LWFA),which has great potential for driving novel radiation sources such as betatron radiation and Compton scattering gamma rays.According to different electron acceleration requirements,it is necessary to provide specific supersonic gas jets with different density profiles to generate electron beams with high quality and high repetition rates.In this study,the interference images and density profiles of different gas-jet targets were obtained through a modified Nomarski interference diagnosis system.The relationships between the gas density and back pressure,nozzle structure,and other key parameters were studied.Targets with different characteristics are conducive to meeting the various requirements of LWFA.
文摘Follicle stimulating hormone (FSH) is a kind of glycoprotein gonadotropin, and plays an important role in the diagnosis and treatment of infertility. Follicle stimulating hormone receptor (FSHR) is a kind of G protein coupled receptor (GPCR), found in the ovary and testes, and its activation is required for the hormonal operation during the breeding period. In this study, an experimental model of FSHR mediated FSH into cell membrane, which exhibited a phenomenon of fluorescent localized on cell surfaces internalized into cell interior, was established to verify biological activity of FSH.
文摘The Jiangsu Hubao Group, now very active in the garment sector, used to be a small shirt factory with a loaned capital of only a few hundred thousand yuan(RMB). Since its founding in 1989, the group has been aiming at the international first-class level, and has formulated and implemented international famous brand strategy, with quality products occupying the market. After
文摘The implications brought about by the present international status of English for English language teaching （ELT） are enormous; however, the aim of this paper is to bring to light the shifting notion of target cultures and elaborate on the possible reasons based on the characteristics of English as an international language （EIL） and its use in a global sense for international communication. Suggestions are then provided with regard to the teaching of ＂language-and-culture＂ for Chinese college students from a realistic perspective of current world uses of English.
文摘Pellet target with a close to 4π detector configuration is an optional effective internal target in the storage ring CSRm. Thermodynamic simulations are carried out to describe the hydrogen microsphere behaviors in the whole moving path, and the temperature and mass changes of hydrogen microspheres are clearly indicated. The achievable experimental luminosity by pellet target in CSRm is calculated to be 1×1033 cm?2·s?1 at most.
基金Supported by National Natural Science Foundation of China(11179017,11105201,U1532130,and U1332206)
文摘The target thickness for nitrogen was determined from the beam energy loss in HIRFL-CSRe during the experimental study of the K-REC process in 197 MeV/u Xe54＋-N2 collisions. Furthermore, the corresponding integrated luminosity of （1.15±0.06） x 10^30 cm-2 was obtained. As an independent check on the energy-loss method, we have also determined the integrated luminosity by measuring the produced X-rays from the K-REC process with a known differential cross section. The values of （1.12±0.06） x 10^30 and （1.09±0.06） x 1030 cm-2 were obtained by using two high-purity germanium （HPGe） detectors which were oriented at 90% and 120%with respect to the beam path, respectively. The consistent results confirmed the feasibility of the energy-loss method, which may have an important impact on future internal target experiments at HIRFL-CSRe.
基金Supported by the National Natural Science Foundation of China (Grant Nos 10635080 and 10575120)
文摘Pellet target is one of the main candidate targets in CSRm (cooler storage ring’s main ring) for hadron physics studies. Pellet speed is an important physical parameter for the target. Larger pellet speed could shorten the interacting time interval between the pellet and the cyclotron beam, and thus results in a small temperature variation for the pellet. This could make the pellet facility work in a stable condition. A fluid dynamic simulation was carried out for the pellet speed, and it was found that the maximum speed for the target pellet may be restricted to about 100 m/s even if all working parameters were set to their optimal values.
