BACKGROUND Urethral stricture is a condition that often develops with trauma and results in narrowing of the urethral lumen.Although endoscopic methods are mostly used in its treatment,it has high recurrence rates.The...BACKGROUND Urethral stricture is a condition that often develops with trauma and results in narrowing of the urethral lumen.Although endoscopic methods are mostly used in its treatment,it has high recurrence rates.Therefore,open urethroplasty is recommended after unsuccessful endoscopic treatments.AIM To investigate the risk factors associated with urethral stricture recurrence.METHODS The data of male patients who underwent internal urethrotomy for urethral stricture between January 2017 and January 2023 were retrospectively analyzed.Demographic data,comorbidities,preoperative haemogram,and biochemical values obtained from peripheral blood and operative data were recorded.Patients were divided into two groups in terms of recurrence development;recurrence and non-recurrence.Initially recorded data were compared between the two groups.RESULTS A total of 303 patients were included in the study.The mean age of the patients was 66.6±13.6 years.The mean duration of recurrence development was 9.63±9.84(min-max:1-39)months in the recurrence group.Recurrence did not occur in non-recurrence group throughout the follow-up period with an average time of 44.15±24.07(min-max:12-84)months.In the comparison of both groups,the presence of diabetes mellitus(DM),hypertension(HT),and multiple comorbidi-ties were significantly higher in the recurrence(+)group(P=0.038,P=0.012,P=0.013).Blood group,postoperative use of non-steroidal anti-inflammatory drugs,preoperative cystostomy,cause of stricture,iatrogenic cause of stricture,location and length of stricture,indwelling urinary cathater size and day of catheter removal did not differ between the two groups.No statistically significant difference was observed between the two groups in terms of age,uroflowmetric maximum flow rate value,hemo-gram parameters,aspartate aminotransferase(AST),alanine aminotransferase(ALT),fasting blood sugar,creati-nine,glomerular filtration rate,neutrophil-lymphocyte ratio,platelet-lymphocyte ratio,lymphocyte-monocyte ratio,monocyte-lymphocyte ratio and AST/ALT ratios.CONCLUSION In patients with urethral stricture recurrence,only the frequency of DM and HT was high,while inflammation marker levels and stricture-related parameters were similar between the groups.展开更多
This work concerns the study of problems relating to the adaptive internal model control of DC motor in both cases conventional and neural. The most important aspects of design building blocks of adaptive internal mod...This work concerns the study of problems relating to the adaptive internal model control of DC motor in both cases conventional and neural. The most important aspects of design building blocks of adaptive internal model control are the choice of architectures, learning algorithms, and examples of learning. The choice of parametric adaptation algorithm for updating elements of the conventional adaptive internal model control shows limitations. To overcome these limitations, we chose the architectures of neural networks deduced from the conventional models and the Levenberg-marquardt during the adjustment of system parameters of the adaptive neural internal model control. The results of this latest control showed compensation for disturbance, good trajectory tracking performance and system stability.展开更多
Objective:To prospectively follow up a cohort of anterior urethral stricture disease patients managed with balloon dilation(BD)for 3 years to evaluate the long-term outcomes and to study factors that contribute to rec...Objective:To prospectively follow up a cohort of anterior urethral stricture disease patients managed with balloon dilation(BD)for 3 years to evaluate the long-term outcomes and to study factors that contribute to recurrence.Methods:This study included men who had urethral BD for significant anterior urethral stricture disease between January 2017 and March 2019.Data about the patient age,stricture characteristics,and recurrence date were recorded,along with information on postoperative indwelling catheter use and operative complications.Furthermore,information about the self-calibration procedure was collected and where available,free flow(FF)measurements during the follow-up period were recorded and analyzed.Success was defined as a lack of symptoms and acceptable FF rates(maximum flow rate>12 mL/s).Results:The final analysis was conducted on 187 patients.The mean follow-up period was 37 months.The long-term overall success rate at the end of our study was 66.8%.Our recurrence rate was 7.4%at 12 months,24.7%at 24 months,and reached 33.2%at the end of our study.The time to recurrence ranged from 91 days to 1635 days,with a mean of 670 days.The stricture-free survival was significantly shorter with lengthy peno-bulbar(p=0.031)and multiple strictures(p=0.015),and in the group of patients who were not committed to self-calibration protocol(p<0.011).However,post-procedural self-calibration was the most important factor that may have decreased the incidence of recurrence(odds ratioZ5.85).Adjuvant self-calibration after BD not only reduced the recurrence rate from 85.4%in the non-self-calibration group to 15.1%in the self-calibration one(p<0.001),but also improved the overall stricture-free survival and FF parameters.展开更多
目的探讨复发性鼻咽癌手术治疗前行改良颈内动脉栓塞术的有效性和安全性。方法本研究为回顾性研究。搜集2022年6月—2023年8月于福建中医药大学附属第二人民医院接受改良颈内动脉栓塞术治疗的13例复发性鼻咽癌患者的病例资料。记录围手...目的探讨复发性鼻咽癌手术治疗前行改良颈内动脉栓塞术的有效性和安全性。方法本研究为回顾性研究。搜集2022年6月—2023年8月于福建中医药大学附属第二人民医院接受改良颈内动脉栓塞术治疗的13例复发性鼻咽癌患者的病例资料。记录围手术期并发症,对比患者术前和术后30 d MRS评分,评估改良颈内动脉栓塞术的有效性和安全性。结果13例患者球囊封堵试验均为阴性,且都顺利完成改良颈内动脉栓塞术,完全闭塞颈内动脉。手术时长50.0~110.0 min,平均(63.7±15.3)min;均未出现弹簧圈逃逸。1例术后发生语言不清、肢体无力,给予升压等对症治疗症状消失;1例术后发生头痛、复视,出院前已恢复;1例由于对侧颈内动脉狭窄同期支架植入,术后植入支架侧出现高灌注脑出血表现,术后30 d MRS评分4分。其余患者均未发生围术期并发症,术后30 d MRS评分均为0分。结论针对复发性鼻咽癌侵犯颈内动脉的患者行改良颈内动脉栓塞术,可安全有效闭塞颈内动脉,降低后续鼻咽癌内镜手术中颈动脉出血发生率,提高患者生存预后。展开更多
文摘BACKGROUND Urethral stricture is a condition that often develops with trauma and results in narrowing of the urethral lumen.Although endoscopic methods are mostly used in its treatment,it has high recurrence rates.Therefore,open urethroplasty is recommended after unsuccessful endoscopic treatments.AIM To investigate the risk factors associated with urethral stricture recurrence.METHODS The data of male patients who underwent internal urethrotomy for urethral stricture between January 2017 and January 2023 were retrospectively analyzed.Demographic data,comorbidities,preoperative haemogram,and biochemical values obtained from peripheral blood and operative data were recorded.Patients were divided into two groups in terms of recurrence development;recurrence and non-recurrence.Initially recorded data were compared between the two groups.RESULTS A total of 303 patients were included in the study.The mean age of the patients was 66.6±13.6 years.The mean duration of recurrence development was 9.63±9.84(min-max:1-39)months in the recurrence group.Recurrence did not occur in non-recurrence group throughout the follow-up period with an average time of 44.15±24.07(min-max:12-84)months.In the comparison of both groups,the presence of diabetes mellitus(DM),hypertension(HT),and multiple comorbidi-ties were significantly higher in the recurrence(+)group(P=0.038,P=0.012,P=0.013).Blood group,postoperative use of non-steroidal anti-inflammatory drugs,preoperative cystostomy,cause of stricture,iatrogenic cause of stricture,location and length of stricture,indwelling urinary cathater size and day of catheter removal did not differ between the two groups.No statistically significant difference was observed between the two groups in terms of age,uroflowmetric maximum flow rate value,hemo-gram parameters,aspartate aminotransferase(AST),alanine aminotransferase(ALT),fasting blood sugar,creati-nine,glomerular filtration rate,neutrophil-lymphocyte ratio,platelet-lymphocyte ratio,lymphocyte-monocyte ratio,monocyte-lymphocyte ratio and AST/ALT ratios.CONCLUSION In patients with urethral stricture recurrence,only the frequency of DM and HT was high,while inflammation marker levels and stricture-related parameters were similar between the groups.
文摘This work concerns the study of problems relating to the adaptive internal model control of DC motor in both cases conventional and neural. The most important aspects of design building blocks of adaptive internal model control are the choice of architectures, learning algorithms, and examples of learning. The choice of parametric adaptation algorithm for updating elements of the conventional adaptive internal model control shows limitations. To overcome these limitations, we chose the architectures of neural networks deduced from the conventional models and the Levenberg-marquardt during the adjustment of system parameters of the adaptive neural internal model control. The results of this latest control showed compensation for disturbance, good trajectory tracking performance and system stability.
文摘Objective:To prospectively follow up a cohort of anterior urethral stricture disease patients managed with balloon dilation(BD)for 3 years to evaluate the long-term outcomes and to study factors that contribute to recurrence.Methods:This study included men who had urethral BD for significant anterior urethral stricture disease between January 2017 and March 2019.Data about the patient age,stricture characteristics,and recurrence date were recorded,along with information on postoperative indwelling catheter use and operative complications.Furthermore,information about the self-calibration procedure was collected and where available,free flow(FF)measurements during the follow-up period were recorded and analyzed.Success was defined as a lack of symptoms and acceptable FF rates(maximum flow rate>12 mL/s).Results:The final analysis was conducted on 187 patients.The mean follow-up period was 37 months.The long-term overall success rate at the end of our study was 66.8%.Our recurrence rate was 7.4%at 12 months,24.7%at 24 months,and reached 33.2%at the end of our study.The time to recurrence ranged from 91 days to 1635 days,with a mean of 670 days.The stricture-free survival was significantly shorter with lengthy peno-bulbar(p=0.031)and multiple strictures(p=0.015),and in the group of patients who were not committed to self-calibration protocol(p<0.011).However,post-procedural self-calibration was the most important factor that may have decreased the incidence of recurrence(odds ratioZ5.85).Adjuvant self-calibration after BD not only reduced the recurrence rate from 85.4%in the non-self-calibration group to 15.1%in the self-calibration one(p<0.001),but also improved the overall stricture-free survival and FF parameters.
文摘目的探讨复发性鼻咽癌手术治疗前行改良颈内动脉栓塞术的有效性和安全性。方法本研究为回顾性研究。搜集2022年6月—2023年8月于福建中医药大学附属第二人民医院接受改良颈内动脉栓塞术治疗的13例复发性鼻咽癌患者的病例资料。记录围手术期并发症,对比患者术前和术后30 d MRS评分,评估改良颈内动脉栓塞术的有效性和安全性。结果13例患者球囊封堵试验均为阴性,且都顺利完成改良颈内动脉栓塞术,完全闭塞颈内动脉。手术时长50.0~110.0 min,平均(63.7±15.3)min;均未出现弹簧圈逃逸。1例术后发生语言不清、肢体无力,给予升压等对症治疗症状消失;1例术后发生头痛、复视,出院前已恢复;1例由于对侧颈内动脉狭窄同期支架植入,术后植入支架侧出现高灌注脑出血表现,术后30 d MRS评分4分。其余患者均未发生围术期并发症,术后30 d MRS评分均为0分。结论针对复发性鼻咽癌侵犯颈内动脉的患者行改良颈内动脉栓塞术,可安全有效闭塞颈内动脉,降低后续鼻咽癌内镜手术中颈动脉出血发生率,提高患者生存预后。
