AIM:To assess the repeatability,interocular correlation,and agreement of quantitative swept-source optical coherence tomography angiography(OCTA)optic nerve head(ONH)parameters in healthy subjects.METHODS:Thir ty-thre...AIM:To assess the repeatability,interocular correlation,and agreement of quantitative swept-source optical coherence tomography angiography(OCTA)optic nerve head(ONH)parameters in healthy subjects.METHODS:Thir ty-three healthy subjects were enrolled.The ONH of both eyes were imaged four times by a swept-source-OCTA using a 3 mm×3 mm scanning protocol.Images of the radial peripapillary capillary were analyzed by a customized Matlab program,and the vessel density,fractal dimension,and vessel diameter index were measured.The repeatability of the four scans was determined by the intraclass correlation coefficient(ICC).The most well-centered optic disc from the four repeated scans was then selected for the interocular correlation and agreement analysis using the Pearson correlation coefficient,ICC and Bland-Altman plots.RESULTS:All swept-source-OCTA ONH parameters exhibited certain repeatability,with ICC>0.760 and coefficient of variation(CoV)≤7.301%.The obvious interocular correlation was observed for papillary vessel density(ICC=0.857),vessel diameter index(ICC=0.857)and fractal dimension(ICC=0.906),while circumpapillary vessel density exhibited moderate interocular correlation(ICC=0.687).Bland-Altman plots revealed an agreement range of-5.26%to 6.21%for circumpapillary vessel density.CONCLUSION:OCTA ONH parameters demonstrate good repeatability in healthy subjects.The interocular correlations of papillary vessel density,fractal dimension and vessel diameter index are high,but the correlation for circumpapillary vessel density is moderate.展开更多
Background:Stereoscopic Vision uses the disparity between the two images received by the two eyes in order to create a tridimensional representation.With this study,we aimed at providing an estimate of binocular visio...Background:Stereoscopic Vision uses the disparity between the two images received by the two eyes in order to create a tridimensional representation.With this study,we aimed at providing an estimate of binocular vision at a level prior to disparity processing.In particular,we wanted to assess the spatial properties of the visual system for detecting interocular correlations(IOC).Methods:We developed dichoptic stimuli,made of textures which IOC is sinusoidally modulated at various correlation spatial frequencies.Then,we compared the sensitivity to these stimuli to the sensitivity to analogous stimuli with disparity modulation.Results:We observed that IOC sensitivity presents a low-pass/band-pass profile and increases as a function of presentation duration and contrast,in a similar way as disparity sensitivity.Conclusions:IOC sensitivity is weakly-though significantly-correlated with disparity sensitivity in the general population,which suggests that it could provide a marker for binocular vision,prior to disparity processing.展开更多
基金Natural Science Foundation of Guangdong Province(No.2018A0303130306)Shantou Science and Technology Program(No.190917085269835,No.200629165261641).
文摘AIM:To assess the repeatability,interocular correlation,and agreement of quantitative swept-source optical coherence tomography angiography(OCTA)optic nerve head(ONH)parameters in healthy subjects.METHODS:Thir ty-three healthy subjects were enrolled.The ONH of both eyes were imaged four times by a swept-source-OCTA using a 3 mm×3 mm scanning protocol.Images of the radial peripapillary capillary were analyzed by a customized Matlab program,and the vessel density,fractal dimension,and vessel diameter index were measured.The repeatability of the four scans was determined by the intraclass correlation coefficient(ICC).The most well-centered optic disc from the four repeated scans was then selected for the interocular correlation and agreement analysis using the Pearson correlation coefficient,ICC and Bland-Altman plots.RESULTS:All swept-source-OCTA ONH parameters exhibited certain repeatability,with ICC>0.760 and coefficient of variation(CoV)≤7.301%.The obvious interocular correlation was observed for papillary vessel density(ICC=0.857),vessel diameter index(ICC=0.857)and fractal dimension(ICC=0.906),while circumpapillary vessel density exhibited moderate interocular correlation(ICC=0.687).Bland-Altman plots revealed an agreement range of-5.26%to 6.21%for circumpapillary vessel density.CONCLUSION:OCTA ONH parameters demonstrate good repeatability in healthy subjects.The interocular correlations of papillary vessel density,fractal dimension and vessel diameter index are high,but the correlation for circumpapillary vessel density is moderate.
文摘Background:Stereoscopic Vision uses the disparity between the two images received by the two eyes in order to create a tridimensional representation.With this study,we aimed at providing an estimate of binocular vision at a level prior to disparity processing.In particular,we wanted to assess the spatial properties of the visual system for detecting interocular correlations(IOC).Methods:We developed dichoptic stimuli,made of textures which IOC is sinusoidally modulated at various correlation spatial frequencies.Then,we compared the sensitivity to these stimuli to the sensitivity to analogous stimuli with disparity modulation.Results:We observed that IOC sensitivity presents a low-pass/band-pass profile and increases as a function of presentation duration and contrast,in a similar way as disparity sensitivity.Conclusions:IOC sensitivity is weakly-though significantly-correlated with disparity sensitivity in the general population,which suggests that it could provide a marker for binocular vision,prior to disparity processing.
