Poke And Delayed Drink Intertemporal Choice Task(POKE-ADDICT):An open-source behavioral apparatus for intertemporal choice testing in rodents

Advancements in neuroscience research present opportunities and challenges,requiring substantial resources and funding.To address this,we describe here“Poke And Delayed Drink Intertemporal Choice Task(POKE-ADDICT)”,an open-source,versatile,and cost-effective apparatus for intertemporal choice testing in rodents.This allows quantification of delay discounting(DD),a cross-species phenomenon observed in decision making which provides valuable insights into higher-order cognitive functioning.In DD,the subjective value of a delayed reward is reduced as a function of the delay for its receipt.Using our apparatus,we implemented an effective intertemporal choice paradigm for the quantification of DD based on an adjusting delayed amount(ADA)algorithm using mango juice as a reward.Our paradigm requires limited training,a few 3D-printed parts and inexpensive electrical components,including a Raspberry Pi control unit.Furthermore,it is compatible with several in vivo procedures and the use of nose pokes instead of levers allows for faster task learning.Besides the main application described here,the apparatus can be further extended to implement other behavioral tests and protocols,including standard operant conditioning.In conclusion,we describe a versatile and cost-effective design based on Raspberry Pi that can support research in animal behavior,decision making and,more specifically,delay discounting.

A mini-review on how the COVID-19 pandemic affected intertemporal choice

The coronavirus disease(COVID-19)has extremely harmful effects on individual lifestyles,and at present,people must make financial or survival decisions under the profound changes frequently.Although it has been reported that COVID-19 changed decision-making patterns,the underlying mechanisms remained unclear.This mini-review focuses on the impact of the COVID-19 pandemic on in-tertemporal choice,and potential psychological,biological,and social factors that mediate this relationship.A search of the Web of Science electronic database yielded 23 studies.The results showed that under the COVID-19 pandemic,people tended to choose immediate and smaller rewards,and became less patient.In particular,people with negative emotions,in a worse condition of physical health,or who did not comply with their government restriction rules tended to become more"short-sighted"in behavioral terms.Future studies should examine more longitudinal and cross-cultural research to give a broad view about the decision-making change under the COVID-19 pandemic.

Separate Neural Networks for Gains and Losses in Intertemporal Choice

An important and unresolved question is how human brain regions process information and interact with each other in intertemporal choice related to gains and losses. Using psychophysiological interaction and dynamic causal modeling analyses, we investigated the functional interactions between regions involved in the decision- making process while participants performed temporal discounting tasks in both the gains and losses domains. We found two distinct intrinsic valuation systems underlying temporal discounting in the gains and losses domains： gains were specifically evaluated in the medial regions, including the medial prefrontal and orbitofrontal cortices, and losses were evaluated in the lateral dorsolateral prefrontal cortex. In addition, immediate reward or pun- ishment was found to modulate the functional interactions between the dorsolateral prefrontal cortex and distinct regions in both the gains and losses domains： in the gains domain, the mesolimbic regions; in the losses domain, the medial prefrontal cortex, anterior cingulate cortex, and insula. These findings suggest that intertemporal choice of gains and losses might involve distinct valuation systems, and more importantly, separate neural interactions may implement the intertemporal choices of gains and losses. These findings may provide a new biological perspective for understanding the neural mechanisms underlying intertemporal choice of gains and losses.