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Safety and Effectiveness of Stent-Assisted Coil Embolization for Ruptured Intracranial Aneurysm
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作者 Bibang Ndong Virginio Shichao Zhang +8 位作者 Wenfeng Feng Mingzhou Li Gang Wang Huibin Kang Yunyu Wen Yu Ye Mesi Ndong Edo Euvaldo Songtao Qi Guozhong Zhang 《Open Journal of Modern Neurosurgery》 2024年第4期275-283,共9页
Background: It has been conclusively established that intracranial aneurysms measuring a diameter below 7 mm pose a minimal risk of rupture. Conversely, those exhibiting irregular morphology or featuring the presence ... Background: It has been conclusively established that intracranial aneurysms measuring a diameter below 7 mm pose a minimal risk of rupture. Conversely, those exhibiting irregular morphology or featuring the presence of a sac necessitate a more stringent and rigorous management approach. Objective: The primary aim of this study is to delve into the morphological features of ruptured aneurysms situated in distinct regions of the brain. Furthermore, we endeavor to assess the degree of safety and efficacy associated with stent-assisted embolization as a treatment modality for these ruptured aneurysms. Methods: This retrospective study encompassed a cohort of 467 patients who presented with intracranial ruptured aneurysms and were diagnosed through a combination of computed tomography (CT) and digital subtraction angiography (DSA) at Nanfang Hospital of Southern Medical University, spanning from January 2009 to December 2019. The following clinical parameters were meticulously recorded: aneurysm height, width, neck measurements, immediate Raymond grade assessments, and any perioperative complications experienced. Results: Within the study population, the average dimensions of ruptured aneurysms were found to be 4.26 ± 2.10 mm (width), 4.86 ± 2.38 mm (height), and 4.04 ± 1.87 mm (neck). Categorically, the most prevalent types of aneurysms were 170 cases of anterior communicating artery aneurysms (accounting for 36.4%), followed by 161 cases of posterior communicating artery aneurysms (34.5%), 56 cases of middle cerebral artery aneurysms (12.0%), 13 cases of anterior cerebral artery aneurysms (2.8%), 45 cases of paraclinoid aneurysms (9.6%), 6 cases of superior pituitary artery aneurysms (1.3%), 7 cases of anterior choroidal artery aneurysms (1.5%), and 9 cases of vertebrobasilar artery aneurysms (2.0%). Notably, 18 patients (3.9%) presented with ruptured aneurysms coexisting with ascus. Regarding treatment approaches, 228 cases (48.8%) underwent stent-assisted embolization, 234 cases (50.1%) received coils embolization, and 5 cases (1.1%) were treated with the dual-catheter technique. Immediately post-treatment, 422 patients (90.4%) attained a Raymond Class I status, with a procedure-related complication rate of 0.9%. Importantly, no statistically significant differences were observed in the incidence of perioperative complications across the three distinct treatment groups (P = 0.505). Conclusion: The outcomes of this study affirm the safety and efficacy of stent-assisted embolization as a treatment modality for ruptured aneurysms. 展开更多
关键词 Ruptured intracranial aneurysm Interventional Therapy stent Assisted embolization
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Mechanical compression management of the right middle cerebral artery inferior trunk using a stent during coil embolization of middle cerebral artery aneurysms:A case report and literature review
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作者 Zhengyu Wang Zhiqing Peng +2 位作者 Liang Chen Wanbin Li Yongli Wang 《Journal of Interventional Medicine》 2023年第3期126-129,共4页
Endovascular coil embolization is a minimally invasive,rapid,and effective method for the treatment of intracranial aneurysms.However,complications associated with coil embolization,such as intraoperative aneurysm rup... Endovascular coil embolization is a minimally invasive,rapid,and effective method for the treatment of intracranial aneurysms.However,complications associated with coil embolization,such as intraoperative aneurysm rupture or arterial occlusion,should be promptly managed during the procedure to avoid catastrophic consequences.This study presents a case of mechanical compression management of the right middle cerebral artery(MCA)inferior trunk during coil embolization for bilateral MCA aneurysms.The inferior trunk of the right MCA was abruptly occluded due to mechanical compression during coil embolization of the right MCA bifurcation aneurysm.A Solitaire AB stent(4×20 mm,Covidien/Medtronic,Dublin,Ireland)was implanted in the inferior trunk of the right MCA after tirofiban was injected via a microcatheter,and the right inferior trunk was recanalized.The patient also underwent coil embolization of the left MCA bifurcation aneurysm,without any complications.It is crucial to recognize compressive occlusion of adjacent aneurysm branches to avoid severe complications during intracranial aneurysm embolization.Stent placement is a rescue treatment option for recanalization of an occluded artery. 展开更多
关键词 Endovascular coil embolization intracranial aneurysm Mechanical compression stent
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INITIAL COMPARISON OF INTRACRANIAL ANEURYSM EMBOLIZATION WITH MECHANICAL DETACHABLE SPIRALS AND WITH GUGLIELMI DETACHABLE COILS
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作者 王大明 凌锋 +2 位作者 李萌 王安顺 蔡艺龄 《Chinese Medical Sciences Journal》 CAS CSCD 2003年第1期59-62,共4页
Objective. To compare the embolization effects of intracranial aneurysms with mechanical detachable spirals (MDS) and with Guglielmi detachable coils (GDC).Methods. One hundred and twenty cases with 125 intracranial a... Objective. To compare the embolization effects of intracranial aneurysms with mechanical detachable spirals (MDS) and with Guglielmi detachable coils (GDC).Methods. One hundred and twenty cases with 125 intracranial aneurysms were embolized in Beijing Hospital from March 1995 to July 1999. Sixty - six aneurysms in 64 cases were embolized with MDS, 51 in 48 with GDC, and 8 in 8 with both MDS and GDC. Clinical data including sex, age, subarachnoid hemorrhage (SAH), Hunt & Hess grading, diameter and neck width of aneurysms, number and length of coils used per aneurysm, occlusive ratio, and complications were compared between MDS and GDC groups.Results. MDS and GDC groups were comparable (t-test or x2 -test, all P value > 0. 10) in terms of age, sex, diameter of aneurysms [ (8. 46 ± 3. 42) mm vs. (7. 38 ± 3. 45) mm], neck width [ (3. 49 ± 1. 50) mm vs. (3. 26 ± 1. 52) mm], coils number[ (4. 65 ± 3. 01) vs. (4. 24 ± 2. 65) ] and their length[ (460. 2 ± 398. 5) mm vs. (422. 9 ±387. 1) mm] used per aneurysm, occlusive ratio in aneurysms embolized ≥80% [ (95. 00% ± 6. 32% ) vs. (94. 19% ± 7. 63% ) ], mortality and permanent complications (7. 8% vs. 4. 2% ).Conclusions. MDS and GDC are all materials for embolization of intracranial aneurysms. MDS is less expensive, but more difficult to control and of propensity to complications while GDC is more compliant, easier to be used, safer, and have many alternative types for use as well as more extensive indications. 展开更多
关键词 intracranial aneurysms embolization mechanical detachable spiral Guglielmi detachable coil
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Safety and efficacy of complete versus near-complete coiling in treatment of intracranial aneurysms 被引量:4
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作者 Guogdong Zhang Yongsheng Liu +3 位作者 Yongjian Liu Mingyi Wang Ke Li Feng Wang 《Journal of Interventional Medicine》 2020年第3期136-141,共6页
Objective:This study aimed to evaluate the clinical and angiographic outcomes of aneurysms that were completely or near-completely embolized and ascertain whether complete embolization is important in the stent-assist... Objective:This study aimed to evaluate the clinical and angiographic outcomes of aneurysms that were completely or near-completely embolized and ascertain whether complete embolization is important in the stent-assisted coiling(SAC)of intracranial aneurysms.Methods:This retrospective study enrolled 390 patients(417 aneurysms).Among them,complete(100%)or nearcomplete(>90%)angiographic obliteration of the aneurysms on immediate angiography was accomplished.Baseline characteristics,complications,angiography follow-up results,and clinical outcomes were analyzed.Results:Cumulative adverse events occurred in 30 patients(7.7%),including thromboembolic complications in 17(4.4%),intraoperative rupture in 10(2.6%),and others in 3(0.8%).Statistical analyses revealed an increased intraprocedural rupture rate in the initial completely occluded aneurysms(5.6%compared with 1.0%).The incidence of cumulative adverse events was higher in patients with completely occluded aneurysms(11.1%)than in those with near-completely occluded aneurysms(5.5%).Angiography follow-up was available for 173 aneurysms.Aneurysm occlusion status at follow-up was correlated with stent placement(p?0.000,odds ratio?5.847),size(p?0.000,odds ratio?6.446 for tiny aneurysms;and p?0.001,odds ratio?5.616 for small aneurysms),and initial aneurysm occlusion status(p?0.001,odds ratio?3.436).Complete occlusion at followup was seen in 82.6%of the initial complete occlusion group versus 63.0%of the initial near-complete occlusion group.The incidence of complete occlusion at follow-up was higher in the initial completely occluded aneurysms with SAC(100%)than in the initial completely occluded aneurysms with non-SAC(65.2%).Conclusions:Initial complete treatment may lead to higher complication rates and good clinical outcomes at follow-up.Stent placement may enhance progressive aneurysm occlusion.Initial complete occlusion with SAC can provide durable closure at follow-up. 展开更多
关键词 coil embolization intracranial aneurysm stent
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Effects of Enterprise 2 stent-assisted coil embolization for wide-necked intracranial aneurysms 被引量:1
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作者 Yangyang Zhou Qichen Peng Shiqing Mu 《Chinese Neurosurgical Journal》 CAS CSCD 2023年第1期18-26,共9页
Background:This study analyzed the safety and efficacy of Enterprise 2 stent-assisted coil embolization for wide-necked intracranial aneurysms by examining stent-vessel apposition,operative complications,embolization ... Background:This study analyzed the safety and efficacy of Enterprise 2 stent-assisted coil embolization for wide-necked intracranial aneurysms by examining stent-vessel apposition,operative complications,embolization outcomes,and clinical outcomes.Methods:We retrospectively reviewed the medical records of patients with wide-necked intracranial aneurysms who underwent Enterprise 2 stent-assisted coiling in our hospital from November 2018 to October 2019.Intraoperative VasoCT was performed immediately after stent release in a continuous cohort of patients to observe stent-vessel apposition.Patient demographic,clinical,and imaging data were recorded and analyzed.Results:A total of 106 wide-necked aneurysms in 106 patients were treated.Stent release was successful in all patients.Twenty-one patients were enrolled consecutively for VasoCT scanning,and incomplete stent apposition was observed in 5(23.8%).Perioperative complications occurred in 10 patients(9.4%):cerebral infarction in 6,intraoperative coil prolapse in 1,puncture site pseudoaneurysm in 1,deep vein thrombosis at multiple sites in 1,and transient brainstem mass effect in 1.Among the 95 aneurysms with angiographic follow-up,embolization was satisfactory(Raymond-Roy classifications I and II)in 89(93.7%).Hyperlipidemia was an independent risk factor for incomplete aneurysm occlusion.At the last clinical follow-up,seven patients had a poor clinical outcome(modified Rankin Scale score≥3).Independent risk factors for poor outcomes were preoperative subarachnoid hemorrhage at presentation and cerebral infarction.Conclusion:Enterprise 2 stent-assisted coiling for treatment of wide-necked intracranial aneurysms showed good safety and efficacy;however,incomplete stent apposition can still occur in vessels with a large curvature.Preoperative subarachnoid hemorrhage at presentation and cerebral infarction are the main reasons for poor clinical outcomes after stent-assisted coil embolization. 展开更多
关键词 intracranial aneurysm Enterprise 2 stent coilING stent malposition Treatment outcome
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Regenerative material for aneurysm embolizationA 3-dimensional culture system of fibroblasts and calcium alginate gel
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作者 Jingdong Zhang Kan Xu Jinlu Yu Jun Wang Qi Luo 《Neural Regeneration Research》 SCIE CAS CSCD 2011年第10期762-766,共5页
Calcium alginate gel(CAG) has been shown to successfully model aneurysm embolization within a short period of time.However,gradually degrading CAG potentially results in aneurysm recanaliza-tion.In the present study... Calcium alginate gel(CAG) has been shown to successfully model aneurysm embolization within a short period of time.However,gradually degrading CAG potentially results in aneurysm recanaliza-tion.In the present study,a regenerative embolic material was designed by seeding rat fibroblasts in a CAG.The study investigated the feasibility of constructing a 3-dimensional culture system.The fibroblasts grew well and firmly attached to the CAG.CAG was conducive for fibroblast growth,and resulted in a 3-dimensional culture system.Results show that CAG can be used theoretically as a vascular,regenerative,embolic material. 展开更多
关键词 intracranial aneurysm embolic material detachable coil FIBROBLAST ALGINATE neural regeneration
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COMPARISON OF CELLULOSE ACETATE POLYMER AND ELECTROLYTIC DETACHABLE COILS FOR TREATMENT OF CANINE ANEURYSMAL MODELS
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作者 杨新健 吴中学 +2 位作者 李佑祥 孙异临 尹可 《Chinese Medical Sciences Journal》 CAS CSCD 2002年第1期47-51,共5页
Electrolytic detachable coils (EDC) have been the main embolic materi als for intracranial aneurysms. Liquid aneurysmal embolic materials represented by cellulose acetate polymer (CAP) are still in controversy. In thi... Electrolytic detachable coils (EDC) have been the main embolic materi als for intracranial aneurysms. Liquid aneurysmal embolic materials represented by cellulose acetate polymer (CAP) are still in controversy. In this research, t he embolization results and pathological reactions after embolization of canine aneurysmal models with EDC or CAP were observed and compared. Methods. The canine aneurysmal models constructed by anastomosis of venous pouch es were randomly grouped. The aneurysms were respectively occluded with CAP and electrolytic detachable coils that was named by Wu electrolytic detachable coil (WEDC) and made by us. Angiogram follow ups were performed at 24 hour, 2 week , and 2 month after embolization. The occluded aneurysms were dissected in each stage for light microscopic, electron microscopic, and histochemical research. Results. The effect of embolization was significantly better with WEDC than that with CAP . Post embolized complications such as aneurysm rupture and stenosis of parent arteries could only be found in CAP group. Pathol ogical research showed that CAP mass could packed the aneurysms more densely tha n coils. Acute chemical damage of aneurysmal wall and inflammatory cell infiltra tion was prominently found in early stage after CAP embolization. Organization of thrombus inside aneurysms and formation of endothelial tissue over the orific es of aneurysmal necks could be found in both groups 2 months after embolization . But parts of coils might be exposed outside endothelial layer. Conclusions. EDC are still the most safe, efficient, and reliable instruments to embolize aneurysm. CAP should be improved further to solve the problem of stron g chemical corrosion and difficulty in control before it is widely used. 展开更多
关键词 intracranial aneurysm embolISM cellulose acetate polymer electrol ytic detachable coils
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Combined stent and coil in endovascular treatment of intracranial wide-necked and fusiform aneurysms 被引量:3
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作者 刘建民 黄清海 +3 位作者 许奕 洪波 张珑 张鑫 《Chinese Medical Journal》 SCIE CAS CSCD 2004年第1期54-57,共4页
Background Wide-necked and fusiform aneurysms are challenges for interventional neuroradiologists and neurosurgeons since they may involve entire vessels or be irregular in shape,making is possible for Guglielmi det... Background Wide-necked and fusiform aneurysms are challenges for interventional neuroradiologists and neurosurgeons since they may involve entire vessels or be irregular in shape,making is possible for Guglielmi detachable coil to protrude into the parent arteries. This study was to evaluate the endovascular treatment of intracranial wide-necked and fusiform aneurysms by using a combination of stents and coils. Methods From October 2000 to July 2001,eighteen patients with intracranial wide-necked or fusiform aneurysms were treated with intraluminal stenting in combination with endosaccular coiling. Results Stent placement and coil packing were technically successful in all patients. There were no complications related to the procedure except for the migration of the stent in four cases. The aneurysms were embolized with the coils after precise stenting,and total occlusion was obtained in 13 cases,neck remnants in 3,and loose occlusion in 2. All the patients recovered well. Short-term follow-up angiograms suggested patency of the parent arteries without recanalization. Conclusions A combination of endovascular stenting and coil packing may be a favorable alternative for the treatment of intracranial aneurysms that are unsuitable for surgical clipping or coil embolization. Further study is necessary to assess the long-term outcome. 展开更多
关键词 intracranial aneurysm·embolization·coil·stent
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Giant Coronary Artery Pseudoaneurysm after Drug-Eluting Stent Implantation
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作者 Ashok Bhupali Amit Joshi +5 位作者 Sachin Patil Prithiviraj Jadhav Sayi Prasad Tanmay Vora Nirlep Gajiwala Ashok Thakkar 《International Journal of Clinical Medicine》 2015年第8期554-560,共7页
Formation of coronary artery pseudoaneurysm after percutaneous coronary intervention is rarely reported. A close review of available literature indicates a trend of growing incidence in recent times. Here, we present ... Formation of coronary artery pseudoaneurysm after percutaneous coronary intervention is rarely reported. A close review of available literature indicates a trend of growing incidence in recent times. Here, we present a case of coronary pseudoaneurysm developing in the left circumflex artery within 50 days of sirolimus-eluting stent implantation in a 47-year-old man who was treated for triple-vessel coronary artery disease. Initially, the patient refused any further treatment. However, considering the rapid growth of pseudoaneurysm and increased severity of symptoms at subsequent follow-up, we decided to treat giant pseudoaneurysm with embolization coils. The procedure was successful and the patient remained asymptomatic thereafter. 展开更多
关键词 Coronary aneurysm DRUG-ELUTING stent embolization coil INTERVENTIONAL CARDIOLOGY PSEUDOaneurysm SIROLIMUS
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血管内治疗小脑后下动脉瘤24例临床经验
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作者 刘飞 罗靖 +5 位作者 王晓健 胡阳春 程宝春 赵亮 江敏 程宏伟 《安徽医药》 CAS 2024年第3期564-567,共4页
目的 探讨血管内治疗小脑后下动脉(PICA)瘤的治疗策略、安全性及临床疗效。方法 回顾性分析安徽医科大学第一附属医院2017年7月至2022年1月行血管内治疗的24例PICA动脉瘤病人的临床资料(其中,PICA近端13例、过渡段1例、远端10例;以蛛网... 目的 探讨血管内治疗小脑后下动脉(PICA)瘤的治疗策略、安全性及临床疗效。方法 回顾性分析安徽医科大学第一附属医院2017年7月至2022年1月行血管内治疗的24例PICA动脉瘤病人的临床资料(其中,PICA近端13例、过渡段1例、远端10例;以蛛网膜下腔出血首诊的21例、未破裂动脉瘤3例),单纯栓塞12例、动脉瘤及载瘤动脉闭塞7例(闭塞材料使用弹簧圈3例、Onyx胶4例)、支架辅助弹簧圈栓塞5例。术后随访3~24个月。结果 24例PICA动脉瘤病人术中动脉瘤均栓塞顺利。23例病人无近期并发症,1例出血病人合并严重脑血管痉挛自动出院(临床预估死亡)。随访结果:19病人远期随访无复发;4例复发,其中2例二期行支架辅助栓塞,后期随访良好、未再复发;1例首次支架辅助栓塞病人再次行穿支架网孔弹簧圈单纯栓塞,后期随访良好、未再复发;1例首次单纯栓塞病人再次行弹簧圈栓塞,后期随访良好、未再复发。结论 血管内治疗PICA动脉瘤安全、可行,疗效可靠。根据动脉瘤血管解剖位置,对于破裂出血的PICA动脉瘤首次治疗倾向单纯栓塞或载瘤动脉闭塞术。首次单栓病例术后复发,可二期行支架辅助栓塞能取得满意效果。对于复发动脉瘤经再次血管内治疗可获得满意效果。 展开更多
关键词 颅内动脉瘤 栓塞 治疗性 椎动脉 夹层 血管内治疗 载瘤动脉闭塞 弹簧圈 支架
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超早期介入栓塞破裂颅内动脉瘤治疗体会
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作者 徐亮 王根 +2 位作者 汤德刚 王维东 马骏 《临床神经外科杂志》 2024年第1期82-85,共4页
目的 研究在破裂出血急性期的颅内动脉瘤患者中,超早期(24 h内)采取介入栓塞治疗的临床疗效。方法 回顾性分析安徽医科大学附属滁州医院(滁州市第一人民医院)神经外科2020年4月—2022年7月收治的51例急诊破裂颅内动脉瘤患者,所有患者均... 目的 研究在破裂出血急性期的颅内动脉瘤患者中,超早期(24 h内)采取介入栓塞治疗的临床疗效。方法 回顾性分析安徽医科大学附属滁州医院(滁州市第一人民医院)神经外科2020年4月—2022年7月收治的51例急诊破裂颅内动脉瘤患者,所有患者均在24 h内采取介入栓塞治疗,对患者临床资料、治疗效果、术后并发症等情况进行总结。结合Raymond分级标准,对术中及术后栓塞情况进行分析,以格拉斯哥预后评分(GOS)为基础,对患者预后情况进行评估。结果 所有患者介入栓塞手术均成功完成,其中RaymondⅠ级栓塞35例,Ⅱ级及Ⅲ级栓塞分别有10例、6例,其中动脉瘤术中破裂3例,予以快速填塞弹簧圈等急救措施后完全栓塞;4例患者发生血栓事件,给予替罗非班溶栓等措施后血流恢复。患者预后情况用GOS评分进行评估,其中良好、轻度残疾、重度残疾、死亡患者数量分别为36例、8例、4例、3例,死亡率为5.88%,总体预后良好。结论 急诊超早期对破裂的颅内动脉瘤患者采取栓塞方法治疗,可以减少动脉瘤二次破裂出血的机会,提高患者生存率及生存质量。 展开更多
关键词 颅内动脉瘤 弹簧圈栓塞 手术时机 并发症
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支架辅助栓塞治疗颅内破裂宽颈动脉瘤的安全性和有效性:Solitaire支架和Neuroform支架的比较
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作者 朱云中 周庆 +3 位作者 陈锐 周海静 韦展亮 卢双宏 《中国临床神经外科杂志》 2024年第4期204-208,共5页
目的比较Solitaire支架和Neuroform支架辅助弹簧圈栓塞治疗颅内破裂宽颈动脉瘤的安全性和有效性。方法回顾性分析2017年9月至2022年10月支架辅助栓塞治疗的118例颅内破裂宽颈动脉瘤的临床资料,其中采用Solitaire支架45例,Neuroform支架7... 目的比较Solitaire支架和Neuroform支架辅助弹簧圈栓塞治疗颅内破裂宽颈动脉瘤的安全性和有效性。方法回顾性分析2017年9月至2022年10月支架辅助栓塞治疗的118例颅内破裂宽颈动脉瘤的临床资料,其中采用Solitaire支架45例,Neuroform支架73例。结果术中所有支架均成功展开,无支架打开不良或移位,无弹簧圈突入载瘤动脉瘤。术后即刻造影显示,Solitaire支架组动脉瘤完全闭塞率(84.4%,38/48)与Neuroform支架组(86.3%,65/73)无统计学差异(P=0.683)。Solitaire支架组1例术中出现动脉瘤破裂出血,Neuroform支架组1例术后出现局部脑缺血;两例病人出院时均无明显神经功能受损。出院时,Solitaire支架组预后良好率(86.7%,39/45)与Neuroform支架组(87.7%,64/73)无统计学差异(P=0.874)。107例(90.7%,107/118)获得临床随访(102~458 d;平均145 d),Solitaire支架组末次随访预后良好率(86.0%,37/43)与Neuroform支架组(85.9%,55/64)无统计学差异(P=0.323)。88例(74.8%,88/118)接受影像学随访(213~817 d;平均264 d),Solitaire支架组末次随访动脉瘤完全闭塞率(92.1%,35/38)与Neuroform支架组(90.0%,45/50)无统计学差异(P=0.670)。随访期间未发生出血或缺血事件。结论对于颅内破裂宽颈动脉瘤,采用Solitaire支架和Neuroform支架辅助栓塞治疗是安全的、有效的,二者的安全性和有效性相当。 展开更多
关键词 颅内破裂动脉瘤 宽颈动脉瘤 血管内治疗 Solitaire支架 NEUROFORM支架 安全性 有效性
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三种不同支架置入辅助弹簧圈栓塞治疗颅内动脉瘤的疗效及安全性比较 被引量:1
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作者 卞立松 何远东 +2 位作者 齐佳伟 甄宇航 柳江 《川北医学院学报》 CAS 2024年第4期457-460,共4页
目的:比较Solitaire AB、Neuroform、Lvis/Lvis jr支架分别置入辅助弹簧圈栓塞治疗颅内动脉瘤的疗效及安全性。方法:回顾性分析接受弹簧圈栓塞治疗的103例颅内动脉瘤患者的临床资料,根据治疗方案将其分为Solitaire AB组(n=37),Neuroform... 目的:比较Solitaire AB、Neuroform、Lvis/Lvis jr支架分别置入辅助弹簧圈栓塞治疗颅内动脉瘤的疗效及安全性。方法:回顾性分析接受弹簧圈栓塞治疗的103例颅内动脉瘤患者的临床资料,根据治疗方案将其分为Solitaire AB组(n=37),Neuroform组(n=34)及Lvis/Lvis jr组(n=32),比较各组患者的治疗效果及安全性。结果:各组患者支架均定位满意,且成功释放,技术成功率均为100%。术后即刻、术后6个月,Lvis/Lvis jr组Raymond分级优于Solitaire AB组和Neuroform组(P<0.05)。治疗后,各组患者血清神经生长因子(NGF)、S-100B蛋白表达水平均降低(P<0.05),且Lvis/Lvis jr组低于Solitaire AB组和Neurofor组(P<0.05)。术后6个月,各组患者屏气前动脉平均血流流速(Vm)、屏气后Vm、屏气指数(BHI)及改良Rankin量表(mRs)评分比较,差异均无统计学意义(P>0.05)。各组患者并发症总发生率比较:Lvis/Lvis jr组低于Solitaire AB组和Neuroform组(P<0.05)。结论:Lvis/Lvis jr支架置入辅助弹簧圈栓塞治疗颅内动脉瘤的短期疗效及安全性优于Solitaire AB、Neuroform支架。 展开更多
关键词 Solitaire AB支架 NEUROFORM支架 Lvis/Lvis jr支架 弹簧圈栓塞 颅内动脉瘤
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低剂量替罗非班用于急性颅内破裂动脉瘤支架置入结合弹簧圈栓塞治疗的有效性和安全性分析
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作者 莫仡 曹洁 +4 位作者 朱旭成 陈荣华 邵华明 宣井岗 彭亚 《中国脑血管病杂志》 CAS CSCD 北大核心 2024年第9期587-594,共8页
目的探讨低剂量替罗非班用于支架置入结合弹簧圈栓塞治疗急性颅内破裂动脉瘤的有效性和安全性。方法回顾性连续纳入2011年4月至2020年9月常州市第一人民医院神经外科收治的颅内动脉瘤破裂伴蛛网膜下腔出血并于入院24~48 h内行支架置入... 目的探讨低剂量替罗非班用于支架置入结合弹簧圈栓塞治疗急性颅内破裂动脉瘤的有效性和安全性。方法回顾性连续纳入2011年4月至2020年9月常州市第一人民医院神经外科收治的颅内动脉瘤破裂伴蛛网膜下腔出血并于入院24~48 h内行支架置入结合弹簧圈栓塞且使用抗血小板聚集药物治疗患者335例,根据抗血小板聚集药物治疗方案的不同,将患者分为双抗组(89例)和替罗非班组(246例)。收集所有患者的基线及临床资料并进行组间比较,包括年龄、性别、高血压病、糖尿病、入院Hunt-Hess分级、入院改良Fisher量表评分、动脉瘤直径(>5 mm、≤5 mm)、动脉瘤位置(前循环、后循环)及术后急性脑积水或脑室积血、术后即刻动脉瘤栓塞情况。所有患者颅内动脉瘤破裂伴蛛网膜下腔出血均为入院后急诊头部CT平扫确认。术后即刻采用Raymond分级标准评估栓塞效果:Ⅰ级指完全不显影(完全栓塞),Ⅱ级指仅瘤颈显影(不完全栓塞),Ⅲ级指瘤体显影,其中Raymond分级Ⅰ~Ⅱ级为有效栓塞。替罗非班组:在动脉瘤瘤腔内填入弹簧圈后、支架释放时,给予4.2μg/kg替罗非班静脉注射后以0.07μg/(kg·min)静脉滴注维持6~8 h,并在停止静脉滴注2 h前予序贯阿司匹林100 mg与氯吡格雷75 mg双联抗血小板聚集药物治疗。双抗组:至少于支架置入前2 h给予顿服负荷剂量阿司匹林300 mg+氯吡格雷300 mg,术后第2天给予阿司匹林100 mg+氯吡格雷75 mg。所有患者均接受术后持续口服6个月阿司匹林(100 mg/d)和术后持续口服3个月氯吡格雷(75 mg/d)治疗。观察并比较两组有效性指标、安全性指标、不良事件及其他并发症发生情况,其中有效性指标为术中及术后72 h内血栓事件发生率,安全性指标为术中及术后早期(术后48 h以内)颅内出血事件发生率、术后晚期(术后48 h及以后)颅内出血事件发生率和脑室外引流相关颅内出血事件(症状性、无症状性)发生率,不良事件为药物相关血小板减少症发生情况,其他并发症指延迟性脑缺血事件发生情况。采用改良Rankin量表(mRS)评分评估患者术后180 d临床预后,将mRS评分≤2分定义为预后良好,mRS评分>2分为预后不良,其中6分为死亡。结果(1)替罗非班组与双抗组的基线及临床资料的组间差异均无统计学意义(均P>0.05)。(2)替罗非班组与双抗组术后180 d良好预后[75.2%(185/246)比74.2%(66/89),P=0.845]及死亡[10.2%(25/246)比12.4%(11/89),P=0.566]患者比例差异均无统计学意义。(3)抗血小板聚集方案有效性比较结果显示,替罗非班组与双抗组术中[0.8%(2/246)比4.5%(4/89),P=0.075]、术后72 h血栓事件[11.0%(27/246)比13.5%(12/89),P=0.527]发生比例差异均无统计学意义。(4)抗血小板聚集方案安全性比较结果显示,替罗非班组术后早期颅内出血事件发生率低于双抗组[2.8%(7/246)比10.1%(9/89),P=0.014],接受脑室外引流术发生症状性脑室外引流相关颅内出血事件患者比例组间差异无统计学意义(0比2/15,P=0.050)。两组术中颅内出血事件(1.6%比3.4%,P=0.580)、术后晚期颅内出血事件(3.3%比4.5%,P=0.836)、药物相关血小板减少症(0.4%比1.1%,P=0.461)发生比例差异均无统计学意义。结论低剂量替罗非班方案用于支架置入结合弹簧圈栓塞治疗颅内急性破裂动脉瘤在预防血栓事件方面与双抗效果类似,且不增加早期出血事件发生率。 展开更多
关键词 破裂颅内动脉瘤 蛛网膜下腔出血 替罗非班 低剂量 支架结合弹簧圈栓塞术
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单支架与双支架辅助弹簧圈栓塞颅内分叉处宽颈动脉瘤的临床价值对比分析
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作者 张化彪 张本骏 +3 位作者 李亚华 张庆辉 徐苗 韩新巍 《郑州大学学报(医学版)》 CAS 北大核心 2024年第4期556-559,共4页
目的:探讨单支架辅助弹簧圈(SSAC)和双支架辅助弹簧圈(DSAC)栓塞颅内分叉处宽颈动脉瘤(WNBA)的临床价值。方法:选取2013年1月至8月郑州大学第一附属医院收治的颅内分叉处WNBA患者109例,其中SSAC栓塞68例和DSAC栓塞41例。比较两组术中支... 目的:探讨单支架辅助弹簧圈(SSAC)和双支架辅助弹簧圈(DSAC)栓塞颅内分叉处宽颈动脉瘤(WNBA)的临床价值。方法:选取2013年1月至8月郑州大学第一附属医院收治的颅内分叉处WNBA患者109例,其中SSAC栓塞68例和DSAC栓塞41例。比较两组术中支架内血栓形成、替罗非班或依替巴肽应用情况,手术时间、费用,术后即刻Raymond-Roy闭塞分级(RROC)以及出院时改良Rankin(mRS)评分;术后3~6个月随访,比较两组支架内狭窄情况、RROC和mRS评分。结果:SSAC组术中支架内血栓形成率、手术时间、手术费用和替罗非班或依替巴肽应用率,出院时和术后3~6个月的mRS评分以及术后支架内狭窄率均低于DSAC组(P<0.05)。结论:SSAC治疗颅内分叉处WNBA支架内血栓形成和支架内狭窄率低、并发症少,且手术耗时短、费用低,更值得临床推广。 展开更多
关键词 单支架辅助弹簧圈 双支架辅助弹簧圈 颅内分叉处宽颈动脉瘤
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Neuroform Atlas支架在宽颈颅内动脉瘤的应用价值
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作者 杜安东 张学兵 +4 位作者 刘带林 蒯涛 白雅林 马东明 许世辉 《中国微侵袭神经外科杂志》 CAS 2024年第8期449-452,共4页
目的探讨颅内宽颈动脉瘤栓塞治疗中Neuroform Atlas支架的临床应用价值。方法回顾性分析52例宽颈动脉瘤患者的临床资料,均在Neuroform Atlas支架的辅助下成功完成介入栓塞手术治疗。采用Raymond Roy分级评估动脉瘤栓塞情况,改良Rankin量... 目的探讨颅内宽颈动脉瘤栓塞治疗中Neuroform Atlas支架的临床应用价值。方法回顾性分析52例宽颈动脉瘤患者的临床资料,均在Neuroform Atlas支架的辅助下成功完成介入栓塞手术治疗。采用Raymond Roy分级评估动脉瘤栓塞情况,改良Rankin量表(Modified Rankin Scale,mRS)评分评估患者预后,对术后并发症与动脉瘤复发进行总结结果在52例宽颈动脉瘤患者中,动脉瘤位于大脑中动脉6例,前交通动脉14例,后交通动脉22例,大脑前动脉2例,基底动脉尖2例,椎动脉V4段2例,眼动脉段4例。40例破裂动脉瘤,12例未破裂动脉瘤。术后脑梗死2例,脑梗死合并出血2例,围手术期未见其他明显的介入相关并发症。术后即刻造影显示动脉瘤完全闭塞40例、瘤颈残留6例、瘤体小部分残瘤6例;随访6~12个月,动脉瘤完全闭塞46例,瘤颈残留4例,瘤体小部分残留2例。mRS评分在出院时:0分38例,1分10例,2分2例,3分2例;随访6~12个月,mRS评分0分46例,1分4例,2分2例。结论宽颈动脉瘤患者使用Neuroform Atlas支架辅助弹簧圈栓塞,具有手术成功率高、并发症低等优点,但需进一步跟踪观察其远期效果。 展开更多
关键词 颅内动脉瘤 宽颈 弹簧圈栓塞术 Neuroform Atlas支架
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血管内弹簧圈栓塞术后不同MRRC分级颅内动脉瘤患者近期及远期疗效的比较
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作者 程吉斌 方宪清 胡英明 《中南医学科学杂志》 CAS 2024年第2期265-267,285,共4页
目的比较血管内弹簧圈栓塞术后不同改良的Raymond-Roy分级(MRRC)颅内动脉瘤患者近期及远期疗效。方法纳入接受血管内弹簧圈栓塞术的颅内动脉瘤患者248例,按术后MRRC分级分为Ⅰ级、Ⅱ级、Ⅲa级和Ⅲb级,比较各组近期及远期疗效。结果各组... 目的比较血管内弹簧圈栓塞术后不同改良的Raymond-Roy分级(MRRC)颅内动脉瘤患者近期及远期疗效。方法纳入接受血管内弹簧圈栓塞术的颅内动脉瘤患者248例,按术后MRRC分级分为Ⅰ级、Ⅱ级、Ⅲa级和Ⅲb级,比较各组近期及远期疗效。结果各组瘤体直径、瘤颈长度、动脉瘤位置、术前Hunt-Hess分级、手术方法和手术时长比较,差异均无显著性(P>0.05)。随MRRC分级提高,各组患者近期疗效改善率逐渐提高,恶化率逐渐降低(P<0.05)。248例患者中有53例出现复发,复发率为21.37%,MRRC分级Ⅰ、Ⅱ级患者远期复发率明显低于Ⅲa级和Ⅲb级患者(P<0.05)。结论随MRRC分级提高,颅内动脉瘤患者近期疗效逐渐提高,远期复发率逐渐提高。 展开更多
关键词 颅内动脉瘤 血管内弹簧圈栓塞术 改良Raymond-Roy分级
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法舒地尔与尼莫地平在颅内宽颈动脉瘤破裂弹簧圈栓塞术后患者中的应用效果比较
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作者 苗统 周国平 +2 位作者 王飞 翟书鹏 魏康康 《中国民康医学》 2024年第13期142-144,共3页
目的:比较法舒地尔与尼莫地平在颅内宽颈动脉瘤破裂弹簧圈栓塞术后患者中的应用效果。方法:选取2021年1月至2023年3月该院收治的80例颅内宽颈动脉瘤破裂患者进行前瞻性研究,按照随机数字法将其分为对照组和研究组各40例。两组均接受支... 目的:比较法舒地尔与尼莫地平在颅内宽颈动脉瘤破裂弹簧圈栓塞术后患者中的应用效果。方法:选取2021年1月至2023年3月该院收治的80例颅内宽颈动脉瘤破裂患者进行前瞻性研究,按照随机数字法将其分为对照组和研究组各40例。两组均接受支架辅助弹簧圈栓塞术治疗,在此基础上,对照组采用尼莫地平注射液治疗,研究组采用盐酸法舒地尔注射液治疗。比较两组预后情况[改良Rankin量表(mRS)]、治疗前后神经功能缺损程度[美国国立卫生研究院卒中量表(NIHSS)]评分、脑血管痉挛发生率及不良反应发生率。结果:研究组mRS、NIHSS评分均低于对照组,差异有统计学意义(P<0.05);研究组脑血管痉挛发生率为0,低于对照组的15.00%(7/40),差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:法舒地尔用于颅内宽颈动脉瘤破裂弹簧圈栓塞术后患者可有效降低脑血管痉挛发生率,减轻患者神经功能缺损,改善预后,效果优于尼莫地平。 展开更多
关键词 颅内动脉瘤 破裂 法舒地尔 尼莫地平 支架辅助弹簧圈栓塞术 脑血管痉挛 神经功能
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脑动脉瘤夹闭术与支架植入弹簧圈栓塞术治疗颅内动脉瘤的疗效与安全性分析
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作者 罗轶 朱春伟 +2 位作者 陈圣攀 舒航 谢强 《吉林医学》 CAS 2024年第10期2343-2346,共4页
目的:探究脑动脉瘤夹闭术与支架植入弹簧圈栓塞术治疗颅内动脉瘤(IA)的疗效与安全性。方法:选取广东省人民医院珠海医院2020年8月~2022年9月接受治疗的100例颅内动脉瘤患者进行研究,按照随机数字表法分组,分为对照组(n=50,脑动脉瘤夹闭... 目的:探究脑动脉瘤夹闭术与支架植入弹簧圈栓塞术治疗颅内动脉瘤(IA)的疗效与安全性。方法:选取广东省人民医院珠海医院2020年8月~2022年9月接受治疗的100例颅内动脉瘤患者进行研究,按照随机数字表法分组,分为对照组(n=50,脑动脉瘤夹闭术)与观察组(n=50,支架植入弹簧圈栓塞术),观察研究对象的临床疗效、围术期指标及术后并发症的情况。结果:观察组治疗有效率(84.00%)显著高于对照组(66.00%),差异有统计学意义(P<0.05);观察组手术时间及术后住院时间均短于对照组,且术中出血量较少,差异有统计学意义(P<0.05);观察组并发症发生率(2.00%)显著低于对照组(14.00%),差异有统计学意义(P<0.05)。结论:对于IA患者采用支架植入弹簧圈栓塞术进行治疗效果较好,相比于传统的夹闭术,能够有效改善患者围术期指标,且术后不良反应发生情况较少。 展开更多
关键词 脑动脉瘤夹闭术 支架植入弹簧圈栓塞术 颅内动脉瘤 围术期指标
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血管内介入治疗颅内分叉部宽颈动脉瘤的现状与进展
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作者 吴文凯 杨堃 《中国医药导报》 CAS 2024年第1期43-46,55,共5页
目前血管内介入治疗颅内动脉瘤已广泛应用于临床。相较于开颅夹闭手术,血管内介入治疗具有创伤小、恢复快、风险低的优点。但颅内复杂性动脉瘤,尤其是分叉部宽颈动脉瘤(WNBA)的血管内介入治疗仍是目前的治疗难点之一。由于WNBA特殊的解... 目前血管内介入治疗颅内动脉瘤已广泛应用于临床。相较于开颅夹闭手术,血管内介入治疗具有创伤小、恢复快、风险低的优点。但颅内复杂性动脉瘤,尤其是分叉部宽颈动脉瘤(WNBA)的血管内介入治疗仍是目前的治疗难点之一。由于WNBA特殊的解剖结构,传统的血管内栓塞治疗难以充分填塞瘤腔与保障流出道的通畅。随着介入技术的发展,以及设备如类支架装置、血管内置物和囊内扰流装置等的开发与更新,使WNBA也能得到有效治疗。本文通过介绍新的介入技术和设备等内容,阐述血管内介入治疗WNBA的现状与进展。 展开更多
关键词 颅内分叉部宽颈动脉瘤 血管内介入栓塞治疗 支架辅助栓塞 囊内扰流装置 综述
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