Technetium-99m-methylene diphosphonate single photon emission computed tomography/computed tomography combined with prostate-specific antigen/free prostate-specific antigen ratio for bone metastasis of prostate cancer

BACKGROUND Prostate cancer(PC)is one of the most common malignant tumors in men,and bone metastasis is one of its common complications,which seriously affects the quality of life and prognosis of patients.AIM To investigate the diagnostic value of technetium-99m-methylene diphosphonate(99mTc-MDP)single photon emission computed tomography(SPECT)/CT imaging combined with the serum prostate-specific antigen(PSA)/free PSA ratio for PC bone metastasis(PCBM).METHODS One hundred patients with PC who visited the Hospital of Chengdu University of Traditional Chinese Medicine from January 2020 to January 2022 were recruited as the experimental(Exp)group,while 30 patients with benign prostatic lesions(BPLs)were recruited as the control(Ctrl)group.All patients underwent 99mTc-MDP SPECT/CT imaging and serum PSA/fPSA testing.The SPECT/CT imaging results and serum PSA/fPSA ratios of patients were analyzed to evaluate their diagnostic values for PCBM.RESULTS The difference in general information of the patients was not obvious,showing comparability.The two methods showed no visible differences in negative predictive value and sensitivity for patients with PCBM,but had great differences in positive predictive value and specificity(P<0.05).The PSA/fPSA ratio of patients with PC in the Exp group was lower than those with BPLs,and patients with PCBM had a much lower PSA/fPSA ratio than those without PC(P<0.05).The results confirmed that the combined use of 99mTc-MDP SPECT/CT imaging and serum PSA/fPSA ratio achieved a detection rate of 95%for PCBM.CONCLUSION The combination of 99mTc-MDP SPECT/CT and PSA/fPSA ratio is accurate and reliable for the diagnosis of PCBM,which provides an important reference for clinical practice.

Single nucleotide polymorphism in DNA methyltransferase 3B promoter and its association with gastric cardiac adenocarcinoma in North China

AIM:To investigate the association between single nucleotide polymorphism (SNP) in promoter of the DNA methyltrans-ferase 3B(DNMT3B) gene and risk for development and lymphatic metastasis of gastric cardiac adenocarcinoma (GCA). METHODS: The hospital based case-control study included 212 GCA patients and 294 control subjects without overt cancer. The DNMT3B SNP was genotyped by PCR and restriction fragment length polymorphism (RFLP) analysis. RESULTS: The C/C genotype was not detected in both GCA patients and controls. In control subjects, the frequency of T/T and C/T genotypes was 94.9% and 5.1% respectively, and that of T and C alleles was 97.4% and 2.6%, respectively. The genotype and allelotype distribution in the GCA patients was not significantly different from that in controls (P=0.34 and 0.33, respectively). When stratified by smoking status and family history of upper gastrointestinal cancer, significant difference in the genotype distribution was not observed between GCA patients and controls. The distribution of DNMT3B genotypes in GCA patents with or without lymphatic metastasis did not show significant difference (P= 0.42). CONCLUSION: The distribution of DNMT3B SNP in North China is distinct from that in Caucasians. Although this SNP has been associated with susceptibility to lung, head, neck and breast cancer, it may not be used as a stratification marker to predict susceptibility and lymphatic metastasis of GCA, at least in the population of North China.

Single-cell analyses of circulating tumor cells

Circulating tumor cells(CTCs) are a population of tumor cells mediating metastasis, which results in most of the cancer related deaths. The number of CTCs in the peripheral blood of patients is rare, and many platforms have been launched for detection and enrichment of CTCs. Enumeration of CTCs has already been used as a prognosis marker predicting the survival rate of cancer patients. Yet CTCs should be more potential. Studies on CTCs at single cell level may help revealing the underlying mechanism of tumorigenesis and metastasis. Though far from developed, this area of study holds much promise in providing new clinical application and deep understanding towards metastasis and cancer development.

An Unusual Cause of Irritability in a Single Ventricle Patient after Bidirectional Glenn Shunt

The differential diagnosis for irritability in children is broad.In patients with congenital heart disease,one must strongly consider cardiac etiologies such as low cardiac output or elevated central venous pressure(CVP).In patients with single-ventricle physiology,the second stage of palliation includes bidirectional Glenn,which involves anastomosis of the superior vena cava to the pulmonary artery resulting in volume offloading of the single systemic ventricle.Typically,early in the post-operative period,patients may experience a headache due to the acute increase in CVP,and symptoms improve over time.Idiopathic intracranial hypertension(IIH),also known as pseudotumor cerebri,is a rare neurologic disorder in children,characterized by raised intracranial pressure(ICP)in the absence of brain parenchymal lesions or cerebrospinal fluid(CSF)abnormalities.While the pathogenesis of IIH is unknown,early recognition and treatment of IIH are important to prevent permanent vision loss.There are only rare reports of IIH in patients with Fontan circulation.To our knowledge,we report the first case of IIH in a 2-year-old female after bidirectional Glenn.

Incidence of exclusive extrapelvic skeletal metastasis in prostate carcinoma on bone scintigraphy

BACKGROUND Bone is one of the common sites of metastasis from prostate carcinoma.Bone scintigraphy(BS)is one of the most sensitive imaging modalities currently used for bone metastatic work-up.Skeletal metastasis in prostate carcinoma commonly involves pelvic bones but rarely involves extrapelvic-extraspinal sites.AIM To retrospectively analyze the BS data to determine the pattern of skeletal metastases in the prostate carcinoma.METHODS This retrospective observational study involves patients with biopsy-proven prostate carcinoma referred for BS for staging assessment.Patients with abnormal BS were evaluated for the pattern of skeletal involvement and data were pre-sented in descriptive format in the form of percentages.RESULTS A total of 150 patients with biopsy-proven prostate cancer who were referred for staging were included in the study.Thirteen of 150 patients(8.67%)had no abnormal uptake on planar images,ruling out metastatic disease.Twenty-four patients(16%)had heterogeneous uptake in the spine with distribution charac-teristic of degenerative disease and no scan pattern of metastatic disease.Thirty patients(20%)had multifocal uptake involving both pelvic and extra pelvic bones on planar images typical for skeletal metastasis and were considered metastatic.Eighty-three out of 150 patients(55.3%)had increased tracer uptake,which was indeterminate,thus,single photon emission computed tomography-computed tomography(SPECT-CT)was acquired,which showed 51 with metastatic disease,31 benign lesions,and one indeterminate finding.Seven of 150 patients had exclusive pelvic bone uptake,which was found to be metastatic in 4/7 patients in SPECT-CT.Fifty six out of 150 patients showed exclusive extrapelvic tracer uptake,of which only 3 had vertebral metastatic disease.None of the patients with increased uptake exclusively in the extrapelvic-extraspinal location was metastatic.CONCLUSION The incidence of exclusive extrapelvic skeletal metastatic disease in prostate carcinoma is 2%(excluding one patient with indeterminate findings).Further,none of the patients in the current study had exclusive extrapelvic-extraspinal metastasis.Thus,exclusive extrapelvic-extraspinal focal abnormality on planar BS carries a very low probability of metastatic disease and hence,further imaging or SPECT-CT can be safely avoided in such cases.

Production and characterization of a human single-chain Fv to collagenase IV

The over\|expression of collagenase IV in tumor tissues was found to be closely related to tumor metastasis. Collagenase IV has been therefore considered as one of the novel indicative molecules for tumor diagnosis and treatment. Based on phage display antibody library technique, a single\|chain Fv specific for collagenase IV was successfully cloned. This antibody, referred to as hCo4, was mainly composed of variable regions from heavy and light chains, with its molecular weight of 27 ku. The engineered antibody bound to collagenase IV specifically. The affinity of hCo4 was found to be the same as that of a single\|chain antibody constructed from a monoclonal antibody to collagenase IV. Since hCo4 is the smallest among all the antibodies specific for collagenase IV and it is of human origin, it has a potential to be applied for tumor immunotherapy and for the study of the relationship between collagenase IV and tumor metastasis.

Is type Ⅰ alpha 2 collagen gene responsible for intracranial aneurysm in Northeast China?

In this study, we investigated whether a single nucleotide polymorphism （rs42524 G 〉 C） in the type I alpha 2 collagen gene was associated with sporadic ruptured intracranial aneurysm or its clinical characteristics in patients from Northeast China. Genotyping of the rs42524 G 〉 C polymorphism was carried out using a polymerase chain reaction-restriction fragment length polymorphism assay. The data showed that the frequency of the rs42524 GC ＋ CC genotype was significantly higher than the GG genotype among intracranial aneurysm patients whose Hunt and Hess grading scale was 〉 3. In addition, the rs42524 G 〉 C genotype was found to have a statistically significant association with intracranial aneurysm risk. These findings indicate that the type I alpha 2 collagen gene gene may be involved in a predisposition to intracranial aneurysm in the Northeast Chinese population. Crucially, the rs42524 C allele may be an important risk factor for increased severity of the condition in patients with ruptured intracranial aneurysms.

Implications of the autophagy core gene variations on brain metastasis risk in non-small cell lung cancer treated with EGFR-TKI

Objective The brain is the main site of failure in cancer patients with epidermal growth factor receptor(EGFR)mutations undergoing treatment.However,identifying patients who may develop brain metastases(BM)is difficult.Autophagy is critical for cancer initiation and progression.We hypothesized that genetic variants in autophagy core genes might contribute to BM risk of non-small cell lung cancer(NSCLC)following treatment with EGFR tyrosine kinase inhibitor(EGFR-TKIs).Methods We systematically examined 16 potentially functional genetic polymorphisms in seven autophagy core genes among 105 TKI-treated NSCLC patients.Kaplan-Meier curves were plotted to assess the cumulative BM probability.Univariate and multivariate Cox proportional hazard regression analyses were utilized to calculate hazard ratios(HRs)and 95%confidence intervals(CIs).We evaluated the potential associations of these genes with subsequent BM development.Results We found that ATG16L1:rs2241880,ATG10:rs10036653,rs3734114,and ATG3:rs7652377 are significantly associated with NSCLC treated with EGFR-TKIs(all P<0.05).BM developed more often in patients with ATG3 rs7652377 CC genotype(33%),ATG10 rs10036653 AA genotype(43%),ATG10:rs3734114 CT/CC genotype(46%),and ATG16L1 rs2241880 AA genotype(37%)compared to patients with AA genotypes at rs7652377(12%),AT/TT genotypes at rs10036653(16%),the TT genotype at rs3734114(13%),or AG/GG genotypes at rs2241880(17%).Conclusion These associations may be critical for understanding the role of autophagy in BM risk.Future prospective studies are needed to determine if prophylactic cranial irradiation(PCI)could offer a survival benefit in this group of patients.

Evaluation of changes of intracranial blood flow after carotid artery stenting using digital subtraction angiography flow assessment

AIM: To evaluate the changes of intracranial blood flow after carotid artery stenting(CAS), using the flow assessment application "Flow-Insight", which was developed in our department.METHODS: Twenty patients treated by CAS participated in this study. We analyzed the change in concentration of the contrast media at the anterior-posterior and profile view image with the flow assessment application "Flow-Insight". And we compared the results with N-isopropyl-p-[123I] iodoamphetamine-single-photon emission computed tomography(IMP SPECT) performed before and after the treatment. RESULTS: From this study, 200% of the parameter "blood flow" change in the post/pre-treatment is suggested as the critical line of the hyperperfusion syndrome arise. Although the observed blood flow increase in the digital subtraction angiography system did not strongly correlate with the rate of increase of SPECT, the "Flow-Insight" reflected the rate of change of the vessels well. However, for patients with reduced reserve blood flow before CAS, a highly elevated site was in agreement with the site analysis results. CONCLUSION: We concluded that the cerebral angiography flow assessment application was able to more finely reveal hyperperfusion regions in the brain after CAS compared to SPECT.

Correlation of tumor necrosis factor receptor superfamily 13B variation with sporadic intracranial aneurysm and clinical characteristics in Han Chinese populations

BACKGROUND： Inflammatory reaction correlates with sporadic intracranial aneurysm （IA）. Variation of tumor necrosis factor receptor superfamily 13B （TNFRSF13B）, an inflammatory mediator receptor, may associate with IA. OBJECTIVE： To explore the relationship between TNFRSF13B gene and sporadic IA, as well as the clinical characteristics of sporadic IA. DESIGN, TIME AND SETTING： Case-control study of genetic association was performed at the Experimental Technology Center of China Medical University from November 2006 to January 2008. PARTICIPANTS： A total of 367 patients with IA, confirmed by three-dimensional computed tomography angiography, magnetic resonance angiography, digital subtraction angiography, and neuro surgery, were admitted to the Department of Neurosurgery, First Affiliated Hospital of China Medical University from 2006 to 2007, and were selected as the case group. All patients were Han, with no family history of IA. In addition, a total of 396 non-lA patients were selected as control subjects. METHODS： Peripheral vein blood was harvested to extract whole blood genomic DNA. Genotyping and TNFRSF13B single nucleotide polymorphism （SNP） rs11078355 G〉A allele polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism. The relationship of TNFRSF13B SNP rs11078355 G〉A polymorphisms to IA and IA clinical characteristics were analyzed using the chi-square and two-sided test. MAIN OUTCOME MEASURES： TNFRSF13B SNP rs11078355 G〉A genotype distribution. RESULTS： In the IA patients, TNFRSF13B SNP rs11078355 G〉A genotype frequency was significantly increased （X2 = 16.306, odds ratio = 1.881,95% confidence interval = 1.382 2.560, P 〈 0.001）. In IA patients aged 〉 65 years, the frequency of TNFRSF13B SNP rs11078355 GA ＋ AA genotype was significantly greater than the GG genotype （X2 = 26.604, odds ratio = 5.248, 95% confidence interval = 2.662 10.345, P 〈 0.001）. CONCLUSION： The TNFRSF13B gene may associate with sporadic IA in Han Chinese populations In elderly patients, allele A may be an independent risk factor for IA, in addition to senile diseases, such as hypertension and diabetes mellitus.

Meningeal Hemangiopericytoma: A Rare Intracranial Tumor—About a Case

Introduction: Hemangiopericytoma is a very rare vascular tumor, difficult to diagnose, often confused with a meningioma. Imaging is not very specific and the diagnostic certainty remains histological. Observation: We report a case of meningeal hemangiopericytoma in a 48-year-old patient with a history of active smoking and whose sister died of glioblastoma. He was brought to the emergency room for a fall, confusion, and tonic-clonic seizures. The diagnosis was suspected on imaging (CT and MRI, in front of a syndrome of right temporal intraventricular mass measured at 37 mm in diameter, centered on the choroid plexus, with perilesional vasogenic edema and posterior white commissure. There was homogeneous enhancement of the lesion after gadolinium injection. The diagnosis was confirmed by immunohistochemical study, which showed diffuse expression of STAT6 and partial labeling for CD34, without significant expression of SSTR2. Expression of neurofilament protein was also found in the brain parenchyma. Conclusion: Hemangiopericytoma is a rare tumor, characterized by its malignant potential, its high rate of recurrence and distant metastasis. The management is based on a total microsurgical resection followed by radiotherapy.

基于MRI影像组学鉴别胶质瘤及单发脑转移瘤的应用研究

目的分析基于多模态磁共振成像(Magnetic Resonance Imaging,MRI)影像组学鉴别胶质瘤及单发脑转移瘤的研究进展,得出提升鉴别准确性的要素。方法通过检索PubMed、Web of Science及FMRS外文医学信息资源检索平台3个数据库,根据纳入排除标准,对纳入的文章提取数据来源、患者数量、MRI设备、MRI序列、肿瘤分割软件、分割方式、分割范围、分割类型、特征提取方法、筛选方法、机器学习分类器、最优的机器学习分类器等数据进行综合分析。结果最终纳入12篇文献进行分析,大多数研究选择MRI传统结构序列,特征筛选方法选择最多的是最小绝对收缩和选择算子,使用最多且表现最佳的机器学习分类器为随机森林。结论MRI影像组学方法在鉴别胶质瘤及单发脑转移瘤方面展现出了较高的准确性,为临床决策提高了较大帮助。

Surgical Reconstruction of a Large Defect after Excision of Infiltrative Squamous Cell Carcinoma in the Scalp and Occipital Region: A Case Report

Squamous cell carcinoma(SCC)of the scalp is the second most prevalent skin cancer,following basal cell carcinoma.Notably,it has the capability to infiltrate the skull,dura mater,and even brain tissue.The cornerstone of treatment is the surgical removal of the lesion,with a particular focus on the depth of invasion,which is directly correlated with recurrence rates.Post-surgical strategies may involve immediate or delayed cranial bone reconstruction and repair of scalp defects using either artificial dermis or skin grafts.In the case presented,a substantial defect necessitated more than a single flap for primary repair.Hence,a single pedicle double-island flap was designed for reconstructing the occipital area.Due to increased tension on the flap following cranial bone repair,the bone repair was temporarily deferred.Postoperative care included adjuvant chemotherapy and radiotherapy to mitigate the risk of SCC recurrence.

单支架与双支架辅助弹簧圈栓塞颅内分叉处宽颈动脉瘤的临床价值对比分析

目的:探讨单支架辅助弹簧圈(SSAC)和双支架辅助弹簧圈(DSAC)栓塞颅内分叉处宽颈动脉瘤(WNBA)的临床价值。方法:选取2013年1月至8月郑州大学第一附属医院收治的颅内分叉处WNBA患者109例,其中SSAC栓塞68例和DSAC栓塞41例。比较两组术中支架内血栓形成、替罗非班或依替巴肽应用情况,手术时间、费用,术后即刻Raymond-Roy闭塞分级(RROC)以及出院时改良Rankin(mRS)评分;术后3~6个月随访,比较两组支架内狭窄情况、RROC和mRS评分。结果:SSAC组术中支架内血栓形成率、手术时间、手术费用和替罗非班或依替巴肽应用率,出院时和术后3~6个月的mRS评分以及术后支架内狭窄率均低于DSAC组(P<0.05)。结论:SSAC治疗颅内分叉处WNBA支架内血栓形成和支架内狭窄率低、并发症少,且手术耗时短、费用低,更值得临床推广。

鼻咽癌颅底骨转移瘤SPECT/CT影像特征变化及诊断价值分析

目的分析单光子发射计算机体层成像CT(SPECT/CT)在诊断鼻咽癌(NPC)颅底骨转移瘤中的应用价值。方法选取2019年1月-2021年6月期间于我院拟接受手术治疗的60例NPC患者,全部患者术前均接受SPECT/CT及核磁共振成像(MRI)检查,以随访作为“金标准”,对比分析患者SPECT/CT、MRI检查影像特征以及SPECT/CT、MRI检查对NPC颅底骨转移的诊断结果和诊断效能。结果经SPECT/CT检查评估NPC的准确度、灵敏度、特异度、阳性预测值、阴性预测值分别为81.66%、86.04%、70.58%、88.09%、66.66%,经MRI检查准确度、灵敏度、特异度、阳性预测值、阴性预测值分别为63.33%、67.44%、52.94%、78.37%、39.13%(P<0.05);经SPECT/CT检查评估NPC颅底骨转移的准确度、灵敏度、特异度、阳性预测值、阴性预测值分别为76.66%、73.60%、81.81%、87.50%、64.28%,经MRI检查准确度、灵敏度、特异度、阳性预测值、阴性预测值分别为56.66%、50.00%、68.18%、73.07%、44.11%(P<0.05)。结论SPECT/CT在NPC颅底骨转移瘤中有较高的诊断价值,临床在放射治疗前参照SPECT/CT影像特征,可全面掌握病灶情况,提高诊断的准确率。

多模态磁共振在颅脑单发转移瘤与高级别胶质瘤鉴别诊断中的价值

目的探讨多模态磁共振在颅脑单发转移瘤与高级别胶质瘤鉴别诊断中的价值。方法选取2019年1月至2022年12月新余市人民医院收治的24例手术病理诊断为颅脑单发转移瘤患者作为颅脑转移瘤组,36例高级别胶质瘤患者作为高级别胶质瘤组,两组均接受多模态磁共振检查。比较两组多模态磁共振影像学特征、多模态磁共振参数[瘤体最大直径、瘤体与瘤周表观弥散系数(apparent diffusion coefficient,ADC)值、脑血流量(cerebral blood flow,CBF)、肿瘤实质区相对脑血流量值(relative cerebral blood flow,rCBF)、瘤周水肿区rCBF、胆碱(choline,Cho)/肌酸(creatinine,Cr)、N-乙酰天门冬氨酸(N-acetyl aspartate,NAA)/Cr、Cho/NAA],采用受试者工作特征(receiver operating characteristic,ROC)曲线分析多模态磁共振对颅脑单发转移瘤与高级别胶质瘤的鉴别诊断价值。结果高级别胶质瘤组瘤灶形态不规则、强化方式为花环样占比均高于脑转移瘤组,差异有统计学意义(P<0.05)。高级别胶质瘤组肿瘤实质区rCBF、Cho/Cr、Cho/NAA均高于脑转移瘤组,瘤体ADC值、瘤体rADC、NAA/Cr均低于脑转移瘤组,差异有统计学意义(P<0.05)。ROC曲线分析显示,多模态磁共振参数指标中瘤体ADC值、肿瘤实质区rCBF、Cho/NAA三者联合检测诊断高级别胶质瘤的曲线下面积(area under the curve,AUC)高于单项检测(P<0.05)。结论多模态磁共振对颅脑单发转移瘤与高级别胶质瘤具有较高的诊断价值。

MR增强后液体衰减反转恢复序列对脑转移瘤的诊断价值

目的分析MR增强后液体衰减反转恢复(fluid-attenuated inversion recovery,FLAIR)序列对脑转移瘤的诊断价值。资料与方法确诊恶性肿瘤可疑有脑转移患者159例。MR检查除常规平扫和增强外,在增强后加扫FLAIR序列,图像由3名有经验的放射科医师评估。结果58例有脑内转移,6例增强后FLAIR脑实质病灶数目显示较增强T1WI多,11例病灶强化较T1WI明显;在11例柔脑膜转移者中,7例病灶强化程度优于增强后T1WI。结论增强后FLAIR是增强后T1WI的有效补充,对脑内小病灶和脑膜病灶更敏感。

脑转移瘤的磁共振诊断

目的 评价核磁共振成像在脑转移瘤中的诊断价值。方法 经临床证实的脑转移瘤34例，行MRI平扫及增强扫描，分析其影像表现。结果 MRI平扫1例正常，33例共发现病灶178个，呈略长T1长T2信号，约半数有囊变，少数合并出血；GdDTPA增强扫描，34例共发现病灶245个，呈结节状或环形明显强化。结论 磁共振增强扫描是诊断脑转移瘤的最佳方法。

分子影像SPECT/CT对乳腺癌骨转移的临床应用价值

目的:探讨分子影像SPECT/CT对乳腺癌骨转移的临床应用价值。方法 :回顾性分析多层螺旋CT与SPECT/CT融合显像对68个疑似乳腺癌骨转移病灶的检查结果,进行统计学检验。结果:经临床确诊乳腺癌骨转移的55个病灶中:MSCT诊断的敏感度为78.2%(43/55),特异性为92.3%(12/13),准确性为80.9%(55/68);SPECT/CT融合显像诊断敏感度为96.4%(53/55),特异性为76.9%(10/13),准确性为92.6%(63/68)。2种检查方法的敏感度、准确性差异有统计学意义(P<0.05),特异性差异无统计意义。结论:SPECT/CT融合显像相对于MSCT检查,可提高对乳腺癌骨转移的诊断敏感性和准确性,具有较好的临床应用价值。

白介素18基因启动子区-607C/A多态性与颅内动脉瘤的发病和破裂的关系

目的分析白介素18(IL-18)基因启动子区-607C/A单核苷酸多态性(SNP)与颅内动脉瘤(IAs)发病和破裂的关系。方法采用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)及DNA直接测序方法检测我院和唐山工人医院收治的98例IAs患者(动脉瘤组)和97例非脑血管病患者(对照组)的IL-18基因启动子区SNP位点-607 C/A(rs1946518)的基因型频率和等位基因频率,其中动脉瘤组患者分为破裂组和未破裂组,并分析IL-18基因多态性与IAs发病、破裂的相关关系。结果 -607C/A位点的基因型分布的测量值(171 bp、99 bp、72 bp)与预期值(171 bp)比较,差异无统计学意义(χ2=1.662,P>0.05),符合Hardy-Weinberg遗传平衡规律。动脉瘤组-607位点基因型及等位基因与对照组比较,差异均有统计学意义(P<0.05),其中基因型以CC型最多,其次为AA型和CA型;等位基因以C型多见,动脉瘤组C等位基因的频率高于对照组,差异有统计学意义(P<0.05);CC+CA基因型增加了IAs发生的风险性〔χ2=10.662,P<0.05,OR=0.357,95%CI(0.191,0.669)〕。破裂组-607位点基因型及等位基因与未破裂组比较,差异均有统计学意义(P<0.05),其中基因型以CC型多见,其次为AA和CA型;等位基因以C型多见,破裂组C等位基因的频率高于未破裂组,差异有统计学意义(P<0.05);CC+CA基因型增加了动脉瘤发生破裂的风险性〔χ2=7.286,P<0.05,OR=0.024,95%CI(0.096,0.717)〕。结论 IL-18基因启动子区-607C/A多态性与IAs的发病和破裂显著相关。