Peyronie’s disease(PD)is a condition of penile connective tissue affecting up to 10%of men worldwide.In the complexity ofits management,nonsurgical treatments,such as intraplaque injections,are gaining attention.The ...Peyronie’s disease(PD)is a condition of penile connective tissue affecting up to 10%of men worldwide.In the complexity ofits management,nonsurgical treatments,such as intraplaque injections,are gaining attention.The current literature shows dataon the efficacy of intraplaque injections of hyaluronic acid(HA)mainly in acute-phase PD.However,data on injections of HA instable-phase PD are lacking.Data for this retrospective study were derived from a prospectively maintained database of privatepatients presenting at a private medical practice affiliated to the University of Naples“Federico II”(Naples,Italy)with stable-phasePD between January 2020 and March 2023.Patients underwent a standard protocol of three injections,each administered at atwo-week interval.During the intervals,patients performed vacuum device therapy,penile stretching,and modeling exercises.Allpatients compiled the Peyronie’s Disease Questionnaire(PDQ)and Global Assessment of Peyronie’s Disease(GAPD)at baselineand 2 weeks after the third injection.A penile Doppler ultrasound was performed 2 weeks after the last injection to record thefinal curvature.Overall,we recruited 62 patients with stable-phase PD and a mean(±standard deviation[s.d.])curvature of52.7°(±9.7°).After 6 weeks,eight(12.9%)patients did not experience any curvature improvement.The remaining 54 patientshad a final mean(±s.d.)curvature of 40.3°(±9.1°)with P<0.001,compared to that before treatment.We found improvement inall PDQ domains(all P≤0.01),and 50(80.6%)patients reported subjective improvement of the penile curvature according to theGAPD.In conclusion,we demonstrated that after three injections of HA administered according to the adopted protocol,patientswith stable-phase PD could experience significant improvements in penile curvature,and physical and psychological consequencesof the disease without significantly relevant side effects.展开更多
Two petrochemical types of doleritic dykes have been distinguished in Bafoussam area: 1) the olivine-bearing dolerites which are the most representative are dark green, showing characteristics of alkaline basalts and,...Two petrochemical types of doleritic dykes have been distinguished in Bafoussam area: 1) the olivine-bearing dolerites which are the most representative are dark green, showing characteristics of alkaline basalts and, 2) the calcite-bearing dolerites are grayish green, showing characteristics of tholeiitic basalts. The studied dolerites are less differentiated (1 FeOt/MgO 2);they present the evolution of a subalkaline magma following a calc-alkaline series (alkaline dolerites) and the tholeiitic series (tholeitiic dolerite). The chondrite normalized multielement spider diagrams of all the dolerites show a pronounced depletion in Ba, Th, and enrichment in Rb. Their geotectonic context is inferred to be intraplate and the contrast between the two types is probably due to a diverse source: crustal source for calcite-bearing dolerites and mantle source for olivine-bearing dolerites.展开更多
文摘Peyronie’s disease(PD)is a condition of penile connective tissue affecting up to 10%of men worldwide.In the complexity ofits management,nonsurgical treatments,such as intraplaque injections,are gaining attention.The current literature shows dataon the efficacy of intraplaque injections of hyaluronic acid(HA)mainly in acute-phase PD.However,data on injections of HA instable-phase PD are lacking.Data for this retrospective study were derived from a prospectively maintained database of privatepatients presenting at a private medical practice affiliated to the University of Naples“Federico II”(Naples,Italy)with stable-phasePD between January 2020 and March 2023.Patients underwent a standard protocol of three injections,each administered at atwo-week interval.During the intervals,patients performed vacuum device therapy,penile stretching,and modeling exercises.Allpatients compiled the Peyronie’s Disease Questionnaire(PDQ)and Global Assessment of Peyronie’s Disease(GAPD)at baselineand 2 weeks after the third injection.A penile Doppler ultrasound was performed 2 weeks after the last injection to record thefinal curvature.Overall,we recruited 62 patients with stable-phase PD and a mean(±standard deviation[s.d.])curvature of52.7°(±9.7°).After 6 weeks,eight(12.9%)patients did not experience any curvature improvement.The remaining 54 patientshad a final mean(±s.d.)curvature of 40.3°(±9.1°)with P<0.001,compared to that before treatment.We found improvement inall PDQ domains(all P≤0.01),and 50(80.6%)patients reported subjective improvement of the penile curvature according to theGAPD.In conclusion,we demonstrated that after three injections of HA administered according to the adopted protocol,patientswith stable-phase PD could experience significant improvements in penile curvature,and physical and psychological consequencesof the disease without significantly relevant side effects.
文摘Two petrochemical types of doleritic dykes have been distinguished in Bafoussam area: 1) the olivine-bearing dolerites which are the most representative are dark green, showing characteristics of alkaline basalts and, 2) the calcite-bearing dolerites are grayish green, showing characteristics of tholeiitic basalts. The studied dolerites are less differentiated (1 FeOt/MgO 2);they present the evolution of a subalkaline magma following a calc-alkaline series (alkaline dolerites) and the tholeiitic series (tholeitiic dolerite). The chondrite normalized multielement spider diagrams of all the dolerites show a pronounced depletion in Ba, Th, and enrichment in Rb. Their geotectonic context is inferred to be intraplate and the contrast between the two types is probably due to a diverse source: crustal source for calcite-bearing dolerites and mantle source for olivine-bearing dolerites.
