Fetal growth restriction(FGR),or intrauterine growth restriction(IUGR),is a complication of pregnancy where the fetus does not achieve its genetic growth potential.FGR is characterized by a pathological retardation of...Fetal growth restriction(FGR),or intrauterine growth restriction(IUGR),is a complication of pregnancy where the fetus does not achieve its genetic growth potential.FGR is characterized by a pathological retardation of intrauterine growth velocity in the curve of intrauterine growth.However,the FGR definition is still debated,and there is a lack of a uniform definition in the literature.True IUGR,compared to constitutional smallness,is a pathological condition in which the placenta fails to deliver an adequate supply of oxygen and nutrients to the developing fetus.Infants with IUGR,compared to appropriately grown gestational age infants,have a significantly higher risk of mortality and neonatal complications with long-term consequences.Several studies have demonstrated how suboptimal fetal growth leads to long-lasting physiological alterations for the developing fetus as well as for the newborn and adult in the future.The long-term effects of fetal growth retardation may be adaptations to poor oxygen and nutrient supply that are effective in the fetal period but deleterious in the long term through structural or functional alterations.Epidemiologic studies showed that FGR could be a contributing factor for adult chronic diseases including cardiovascular disease,metabolic syndrome,diabetes,respiratory diseases and impaired lung function,and chronic kidney disease.In this review we discussed pathophysiologic mechanisms of FGR-related complications and potential preventive measures for FGR.展开更多
目的探讨超声检查在胎儿大脑中动脉及脐动脉血流在胎儿宫内缺氧及分娩结局诊断中的应用价值。方法选取2020年8月—2022年2月广东省中山市东凤人民医院收治的孕妇60例,根据是否出现宫内缺氧分为缺氧组(31例)与正常组(29例),再根据围产儿...目的探讨超声检查在胎儿大脑中动脉及脐动脉血流在胎儿宫内缺氧及分娩结局诊断中的应用价值。方法选取2020年8月—2022年2月广东省中山市东凤人民医院收治的孕妇60例,根据是否出现宫内缺氧分为缺氧组(31例)与正常组(29例),再根据围产儿是否出现不良妊娠结局分为正常结局组(32例)与不良结局组(28例)。比较超声检查大脑中动脉(middle cerebral artery,MCA)及脐动脉(umbilical artery,UmA)血流情况,并对脉动指数(pulsatility index,PI)、阻力指数(resistance index,RI)、收缩期峰值/舒张末期流速(systolic peak value and the end-diastolic velocity of blood flow,S/D)指标。结果孕30周时正常组MCA的PI、RI、S/D高于缺氧组,UmA的PI、RI、S/D低于缺氧组(P<0.05);正常结局组MCA的PI、RI、S/D高于不良结局组,UmA的PI、RI、S/D低于不良结局组(P<0.05)。结论应用超声检查可有效诊断胎儿大脑中动脉及脐动脉血流宫内缺氧和分娩结局,为胎儿宫内缺氧情况采取早期预防措施提供可靠依据,可有效避免围产儿出现不良结局,临床上可借鉴及推广。展开更多
目的探讨应用彩色多普勒超声血流检测及生物物理评分(BPS)诊断胎儿宫内缺氧的价值。方法将2015年3月至2017年3月宝鸡市中医医院妇产科收治的60例胎儿宫内窘迫孕妇为研究组,并选择60例正常孕妇为对照组,均采用彩色多普勒超声检测大脑中动...目的探讨应用彩色多普勒超声血流检测及生物物理评分(BPS)诊断胎儿宫内缺氧的价值。方法将2015年3月至2017年3月宝鸡市中医医院妇产科收治的60例胎儿宫内窘迫孕妇为研究组,并选择60例正常孕妇为对照组,均采用彩色多普勒超声检测大脑中动脉(MCA)、静脉导管(DV)、脐动脉(UA)血流指数,采用B超获得胎儿BPS评分,比较两组孕妇MCA、DV、UA血流指数和BPS评分的差异,并分析超声血流检测、BPS、联合检测诊断胎儿宫内窘迫的价值。结果研究组孕妇BPS评分低于对照组[(4.02±1.92)分vs (6.32±2.59)分],MCAPI、MCAR1、MCAS/D低于对照组[(1.12±0.23) vs (1.85±0.45)、(0.63±0.04) vs (0.79±0.06)、(3.02±0.25) vs (4.97±0.28)],UAPI、UARI、UAS/D、DVPIV、DVPVIV高于对照组[(1.28±0.26) vs (0.81±0.21)、(0.76±0.09) vs (0.52±0.03)、(4.03±0.18) vss (2.06±0.22)、(0.85±0.03) vs (0.60±0.03)、(0.78±0.06) vs (0.50±0.04)],差异均有统计学意义(P<0.05);研究组孕妇BPS、超声血流检测胎儿宫内窘迫的阳性率高于对照组[58.33%vs 20.00%、70.00%vs 25.00%],差异均有统计学意义(P<0.05);研究组联合检测阳性率为88.33%,高于BPS单独检测的58.33%和超声血流检测的70.00%,差异均有统计学意义(P<0.05)。BPS、超声血流检测、联合检测诊断胎儿宫内窘迫的曲线下面积(AUC)分别为0.761 (95%CI:0.364～0.951)、0.803 (95%CI:0.271～0.806)、0.902 (95%CI:0.135～0.947),灵敏度和特异度分别为73.16%、54.61%;81.64%、71.52%;92.34%、95.37%。结论彩色多普勒超声血流检测诊断胎儿宫内窘迫的价值高于生物物理评分,联合检测可提高胎儿宫内窘迫的诊断价值。展开更多
文摘Fetal growth restriction(FGR),or intrauterine growth restriction(IUGR),is a complication of pregnancy where the fetus does not achieve its genetic growth potential.FGR is characterized by a pathological retardation of intrauterine growth velocity in the curve of intrauterine growth.However,the FGR definition is still debated,and there is a lack of a uniform definition in the literature.True IUGR,compared to constitutional smallness,is a pathological condition in which the placenta fails to deliver an adequate supply of oxygen and nutrients to the developing fetus.Infants with IUGR,compared to appropriately grown gestational age infants,have a significantly higher risk of mortality and neonatal complications with long-term consequences.Several studies have demonstrated how suboptimal fetal growth leads to long-lasting physiological alterations for the developing fetus as well as for the newborn and adult in the future.The long-term effects of fetal growth retardation may be adaptations to poor oxygen and nutrient supply that are effective in the fetal period but deleterious in the long term through structural or functional alterations.Epidemiologic studies showed that FGR could be a contributing factor for adult chronic diseases including cardiovascular disease,metabolic syndrome,diabetes,respiratory diseases and impaired lung function,and chronic kidney disease.In this review we discussed pathophysiologic mechanisms of FGR-related complications and potential preventive measures for FGR.
文摘目的探讨超声检查在胎儿大脑中动脉及脐动脉血流在胎儿宫内缺氧及分娩结局诊断中的应用价值。方法选取2020年8月—2022年2月广东省中山市东凤人民医院收治的孕妇60例,根据是否出现宫内缺氧分为缺氧组(31例)与正常组(29例),再根据围产儿是否出现不良妊娠结局分为正常结局组(32例)与不良结局组(28例)。比较超声检查大脑中动脉(middle cerebral artery,MCA)及脐动脉(umbilical artery,UmA)血流情况,并对脉动指数(pulsatility index,PI)、阻力指数(resistance index,RI)、收缩期峰值/舒张末期流速(systolic peak value and the end-diastolic velocity of blood flow,S/D)指标。结果孕30周时正常组MCA的PI、RI、S/D高于缺氧组,UmA的PI、RI、S/D低于缺氧组(P<0.05);正常结局组MCA的PI、RI、S/D高于不良结局组,UmA的PI、RI、S/D低于不良结局组(P<0.05)。结论应用超声检查可有效诊断胎儿大脑中动脉及脐动脉血流宫内缺氧和分娩结局,为胎儿宫内缺氧情况采取早期预防措施提供可靠依据,可有效避免围产儿出现不良结局,临床上可借鉴及推广。
文摘目的探讨应用彩色多普勒超声血流检测及生物物理评分(BPS)诊断胎儿宫内缺氧的价值。方法将2015年3月至2017年3月宝鸡市中医医院妇产科收治的60例胎儿宫内窘迫孕妇为研究组,并选择60例正常孕妇为对照组,均采用彩色多普勒超声检测大脑中动脉(MCA)、静脉导管(DV)、脐动脉(UA)血流指数,采用B超获得胎儿BPS评分,比较两组孕妇MCA、DV、UA血流指数和BPS评分的差异,并分析超声血流检测、BPS、联合检测诊断胎儿宫内窘迫的价值。结果研究组孕妇BPS评分低于对照组[(4.02±1.92)分vs (6.32±2.59)分],MCAPI、MCAR1、MCAS/D低于对照组[(1.12±0.23) vs (1.85±0.45)、(0.63±0.04) vs (0.79±0.06)、(3.02±0.25) vs (4.97±0.28)],UAPI、UARI、UAS/D、DVPIV、DVPVIV高于对照组[(1.28±0.26) vs (0.81±0.21)、(0.76±0.09) vs (0.52±0.03)、(4.03±0.18) vss (2.06±0.22)、(0.85±0.03) vs (0.60±0.03)、(0.78±0.06) vs (0.50±0.04)],差异均有统计学意义(P<0.05);研究组孕妇BPS、超声血流检测胎儿宫内窘迫的阳性率高于对照组[58.33%vs 20.00%、70.00%vs 25.00%],差异均有统计学意义(P<0.05);研究组联合检测阳性率为88.33%,高于BPS单独检测的58.33%和超声血流检测的70.00%,差异均有统计学意义(P<0.05)。BPS、超声血流检测、联合检测诊断胎儿宫内窘迫的曲线下面积(AUC)分别为0.761 (95%CI:0.364～0.951)、0.803 (95%CI:0.271～0.806)、0.902 (95%CI:0.135～0.947),灵敏度和特异度分别为73.16%、54.61%;81.64%、71.52%;92.34%、95.37%。结论彩色多普勒超声血流检测诊断胎儿宫内窘迫的价值高于生物物理评分,联合检测可提高胎儿宫内窘迫的诊断价值。
