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Pre-Clinical Experimental Studies of Indomethacin-Releasing Copper Intrauterine Device 被引量:1
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作者 曹路敏 周玉玲 +4 位作者 刘子龙 杜庆玲 李万 胡燕群 李玮 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2000年第3期249-252,共4页
Effects of two types of intrauterine device (IUD) on the prostaglandins and endothelin (ET) in uterus and on the endometrial morphology in rats and rabbits, and Cu 2+ releasing amounts of both IUDs in vitro w... Effects of two types of intrauterine device (IUD) on the prostaglandins and endothelin (ET) in uterus and on the endometrial morphology in rats and rabbits, and Cu 2+ releasing amounts of both IUDs in vitro were observed. The results showed that the inhibiting action of the indomethacin releasing copper IUD (FICu IUD) on the PGI 2 was stronger than that on the TXA 2, the ratio of 6 keto PGF 1α /TXB 2 was reduced with the increase of the doses. There were significant differences between the groups. The FICu IUD could inhibit the rising of the ET level and lighten the endometrial impairment caused by the FCu IUD, and promote copper ion release. It was suggested that indomethacin released by FICu IUD could effectively reduce abnormal uterine bleeding. 展开更多
关键词 copper intrauterine device INDOMETHACIN PROSTAGLANDINS ENDOTHELIN ENDOMETRIUM copper ion
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A comparative, randomized study of levonorgestrel Intrauterine System (LNG-IUS) vs Copper T 380 A intrauterine device applied during cesarean section
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作者 José A. López-Farfan Alicia Hernandez-Gonzalez +1 位作者 Irvin J. Vélez-Machorro Leopoldo A. Vázquez-Estrada 《Open Journal of Obstetrics and Gynecology》 2012年第2期151-155,共5页
Objective: To assess levonorgestrel-releasing intrauterine system LNG-IUS (Mirena?) application at caesarean section (CS). Design: Randomized, comparative study. Setting: Department of obstetrics and gynecology in a p... Objective: To assess levonorgestrel-releasing intrauterine system LNG-IUS (Mirena?) application at caesarean section (CS). Design: Randomized, comparative study. Setting: Department of obstetrics and gynecology in a primary reference hospital at Puebla City, Mexico. Sample: 396 women requiring CS signed informed consent and were randomly allocated to the post-placental application of LNG-IUS (198) or Copper T 380 A (198). Methods: Follow up visits at 6 weeks, and 6 and 12 months were performed. Main Outcomes Measures: IUDs expulsion, maternal and babies’ health conditions, breastfeeding and menstrual patterns, adverse effects and pregnancies. Differences between groups were analyzed by Fisher and X2 tests, Odds ratios, relative risk and 95% confidence limits, as appropriate. Results: After one year of follow up, no pregnancies were reported. The IUD expulsion rate was 4.5% in each group. LNG-IUS users had a higher incidence of amenorrhea (OR 2.5 95% CI 2.2 - 3) and menstrual patterns significantly brief and lighter than Copper T 380 A (p < 0.001) with lower incidence of dysmenorrhea (OR 0.1 95% CI 0.04 - 0.2). No detrimental effects of LNG-IUS on breastfeeding was observed and interestingly babies weights of LNG-IUS users was slightly above the average for age compared with Copper T 380 A users. This was probably related with a major proportion of women with normal ferritin serum levels (94% vs 68%) leading to better mother’s general condition. Conclusions: LNG-IUS inserted during CS provides high efficacy contraception with additional benefits, mainly reducing menstrual bleeding and doing so, faster recovery of ferrous homeostasis after CS. 展开更多
关键词 Levonorgestrel-Releasing intrauterine System Medicated IUD copper T IUD CESAREAN Section Postpartum CONTRACEPTION Ferritin Levels
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Using laparoscope to remove an ectopic intrauterine device in the anterior wall of urinary bladder:A case report
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作者 Shi-Xue Liu Xing-You Dong 《World Journal of Clinical Cases》 SCIE 2024年第17期3221-3225,共5页
BACKGROUND An intrauterine device(IUD)is a contraceptive device placed in the uterine cavity and is a common contraceptive method for Chinese women.However,an IUD may cause complications due to placement time,intraute... BACKGROUND An intrauterine device(IUD)is a contraceptive device placed in the uterine cavity and is a common contraceptive method for Chinese women.However,an IUD may cause complications due to placement time,intrauterine pressure and other factors.Ectopic IUDs are among the most serious complications.Ectopic IUDs are common in the myometrium and periuterine organs,and there are few reports of ectopic IUDs in the urinary bladder,especially in the anterior wall.CASE SUMMARY A 52-year-old woman was hospitalized due to a urinary bladder foreign body found via abdominal ultrasound and computed tomography(CT)examination.The patient had a 2-year history of recurrent abdominal distension and lower abdominal pain,accompanied by frequent urination,urgency,dysuria and other discomfort.Ultrasound examination revealed foreign bodies in the bladder cavity,with calculus on the surface of the foreign bodies.CT revealed a circular foreign body on the anterior wall of the urinary bladder,suggesting the possibility of an ectopic IUD.After laparoscopic exploration,an annular IUD was found in the anterior wall of urinary bladder,and an oval calculus with a diameter of approximately 2 cm was attached to the surface of the bladder cavity.The IUD and calculus were successfully and completely removed.The patient recovered well after surgery.CONCLUSION Abdominal ultrasound and CT are effective methods for detecting ectopic IUDs.The IUD is located in the urinary bladder and requires early surgical treatment.The choice of surgical method is determined by comprehensively considering the depth of the IUD in the bladder muscle layer,the situation of complicated calculus,the situation of intravesical inflammation and medical technology and equipment. 展开更多
关键词 intrauterine device ECTOPIC Anterior wall of the urinary bladder Calculus LAPAROSCOPE Case report
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Postpartum Intrauterine Device: Use and Follow-Up of Users in the Maternity Ward of the Ratoma Communal Medical Center in Conakry, Guinea
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作者 Daniel W. A. Leno T. M. Millimouno +7 位作者 I. Conté A. Diallo A. F. M. Soumah I. Sylla H. M. Keita D. Lamah A. Delamou T. Sy 《Open Journal of Obstetrics and Gynecology》 2023年第10期1711-1721,共11页
Objective: The aim of this study was to describe the use of the postpartum intrauterine device in the maternity ward of the Ratoma communal medical center in Conakry. Methods: This was a descriptive cross-sectional st... Objective: The aim of this study was to describe the use of the postpartum intrauterine device in the maternity ward of the Ratoma communal medical center in Conakry. Methods: This was a descriptive cross-sectional study carried out between July 1<sup>st</sup> 2015 and June 30 2016, i.e. a duration of one year. Results: A total of 551 patients received advice on various contraceptive methods. Most of this advice was given in the post-partum period (40.2%) and during antenatal care (39.1%). Of the patients advised, 87 (15.8%) used the intrauterine device. The majority of users (93%) were married and uneducated (63.2%), and 39.1% were poor. The majority (56.3%) of intra-uterine devices were inserted in the immediate post-partum period. The majority of women had no adverse events either during the first six weeks (n = 57;65.5%) or at 3<sup>rd</sup> months (n = 75;86.2%) or 6<sup>th</sup> months (n = 76;87.4%) after IUD insertion. Most users remained complication-free throughout the follow-up period (n = 76;87.4% at 6<sup>th</sup> weeks and 3<sup>rd</sup> months, and n = 77;88.5% at 6<sup>th</sup> months). The continuation rate was 89.7% at 6 weeks and 3<sup>rd</sup> months, and 87.4% at 6<sup>th</sup> months after insertion. The majority of users (87.0%) were satisfied with the care they received. Conclusion: This study showed very few complications among intrauterine device users, and high continuation and satisfaction rates. The intrauterine device is a long-acting, effective, reversible and safe contraceptive that can be used by most women for birth spacing in Guinea, where women do not regularly visit health facilities. 展开更多
关键词 Postpartum intrauterine device USE FOLLOW-UP Coronthie Communal Med-ical Center Conakry GUINEA
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Postpartum intrauterine device contraception: A review
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作者 Shadi Rezai Pameela Bisram +2 位作者 Hasan Nezam Ray Mercado Cassandra E Henderson 《World Journal of Obstetrics and Gynecology》 2016年第1期134-139,共6页
AIM: To review the safety (infection, perforation) and efficacy (expulsion, continuation rates, pregnancy) of intrauterine device (IUD) insertion in the postpartum period. METHODS: MEDLINE, PubMed and Google S... AIM: To review the safety (infection, perforation) and efficacy (expulsion, continuation rates, pregnancy) of intrauterine device (IUD) insertion in the postpartum period. METHODS: MEDLINE, PubMed and Google Scholar were searched for randomized controlled trials and prospective cohort studies of IUD insertions at different times during the postpartum period. Time of insertion during the postpartum period was documented speci-fically, immediate post placenta period (within 10 min), early post placenta period (10 min to 72 h), and de-layed/interval period (greater than 6 wk). Other study variables included mode of delivery, vaginal vs cesarean, manual vs use of ring forceps to insert the IUD. RESULTS: IUD insertion in the immediate postpartum (within 10 min of placental delivery), early postpartum (10 min up to 72 h) and Interval/Delayed (6 wk onward) were found to be safe and effcacious. Expulsion rates were found to be highest in the immediate postpartum groups ranging from 14% to 27%. Immediate post placental insertion found to have expulsion rates that ranged from 3.6% to 16.2%. Expulsion rate was significantly higher after insertion following vaginal vs cesarean delivery. The rates of infection, perforation and unplanned pregnancy following postpartum IUD insertion are low. Method of insertion such as with ring forceps, by hand, or another placement method unique to the type of IUD did not show any signifcant difference in expulsion rates. Uterine perforations are highest in the delayed/interval IUD insertion groups.Breastfeeding duration and infant development are not affected by delayed/interval insertion of the non-hormonal (copper) IUD or the Levonorgestrel IUD. Timing of the Levonorgestrel IUD insertion may affect breastfeeding. CONCLUSION: IUD insertion is safe and efficacious during the immediate postpartum, early postpartum and delayed postpartum periods. Expulsion rates are highest after vaginal delivery and when inserted during the immediate postpartum period. IUD associated infection rates were not increased by insertion during the postpartum period over interval insertion rates. There is no evidence that breastfeeding is negatively affected by postpartum insertion of copper or hormone-secreting IUD. Although perforation rates were higher when inserted after lactation was initiated. Randomized controlled trials are needed to further elucidate the consequence of lactation on postpartum insertion. Despite the concerns regarding expulsion, perforation and breastfeeding, current evidence indicates that a favorable risk beneft ratio in support of postpartum IUD insertion. This may be particularly relevant for women for whom barriers exist in achieving desired pregnancy spacing. 展开更多
关键词 Access to intrauterine devices Contra-ception EXPULSION intrauterine device Long acting reversible contraception Postpartum contraception Postpartum intrauterine device Postpartum intrauterine device placement Post-placental insertion
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Releasing of Cupric Ion of Three types of Copper-bearing Intrauterine Contraceptive Device in Simulated UterineFluid 被引量:3
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作者 Jie GAO Ying LI +1 位作者 Jian-ping LIU Xuan GU 《Journal of Reproduction and Contraception》 CAS 2007年第1期33-39,共7页
Objective To compare the cupric ion releasing in vitro o.f the three IUDs. Methods The stability o.f cupric ion releasing o.f IUDs including TCu 380.4 IUD (TCu 380A), Multiload Cu375 IUD (MCu 375) and Yuangong 365... Objective To compare the cupric ion releasing in vitro o.f the three IUDs. Methods The stability o.f cupric ion releasing o.f IUDs including TCu 380.4 IUD (TCu 380A), Multiload Cu375 IUD (MCu 375) and Yuangong 365 copper-bearing indomethacin-releasing IUD (Yuangong 365) by the determination of cupric ion releasing in simulated uterine fluid. The simulated uterine fluid was used for releasing media. Copper ion was determined by flame atomic absorption spectrometer. Results The cupric ion releasing of three IUDs were instable at the beginning and tend to be stable gradually. In the stable phase, the average level of cupric ion releasing of TCu380A, MCu375 and Yuangong 365 were 4.25±2.71-7.62±6.42 μg, 4.92±1.23 -8.62±3.08 μg and 2.19±0.40-4.68±1.66 μg, respectively. TCu380A had higher instable releasing level than those of Yuangong 365 (P〈0. 05). Conclusion TCu 380.4 and MCu 375 showed a "burst release" during the first few days and the.former was of great significance(P〈0.05). The initial cupric ion releasing of Yuangong 365 appeared to be the lowest, followed by MCu375 and TCu380A in a releasing order 展开更多
关键词 copper-bearing intrauterine contraceptive device CU-IUD the releasing ofcupric ion simulated uterine fluid flame atomic absorption spectrometer
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Giant exophytic cystic adenomyosis with a levonorgestrel containing intrauterine device out of the uterine cavity after uterine myomectomy: A case report 被引量:4
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作者 Yong Zhou Zheng-Yun Chen Xin-Mei Zhang 《World Journal of Clinical Cases》 SCIE 2020年第1期188-193,共6页
BACKGROUND A cystic lesion arising from the myometrium of the uterus, termed as cystic adenomyosis, has chocolate-like, thick viscous contents and contains various amounts of endometrial stroma below the glandular epi... BACKGROUND A cystic lesion arising from the myometrium of the uterus, termed as cystic adenomyosis, has chocolate-like, thick viscous contents and contains various amounts of endometrial stroma below the glandular epithelium. It is an extremely rare type of adenomyosis.CASE SUMMARY Herein, we report an unusual case of a giant cystic mass in the pelvic cavity after uterine myomectomy. The patient complained of abnormal uterine bleeding and severe dysmenorrhea. After a levonorgestrel-containing intrauterine device(LNG-IUD) was inserted, her symptoms were greatly alleviated. However, the LNG-IUD was detected in the cystic cavity during the follow-up. For fear of the intrauterine device migrating into and damaging the surrounding viscera,surgical treatment was proposed. Therefore, laparoscopic resection of the lesion and removal of the LNG-IUD were performed and cystic adenomyosis with an LNG-IUD out of the uterine cavity was diagnosed.CONCLUSION We believe that myomectomy breaking through the endometrial cavity may have been a predisposing factor for the development of cystic adenomyosis in this case. 展开更多
关键词 Cystic adenomyosis Dysmenorrhea Levonorgestrel containing intrauterine device MYOMECTOMY Case report
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Ectopic intrauterine device in the bladder causing cystolithiasis:A case report 被引量:1
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作者 Hai-Tao Yu Yong Chen +2 位作者 Yong-Peng Xie Ting-Bin Gan Xin Gou 《World Journal of Clinical Cases》 SCIE 2022年第10期3194-3199,共6页
BACKGROUND An intrauterine device(IUD)is a commonly used contraceptive among women in China.It is widely used because it is safe,effective,simple,economic,and reversible.Among the possible complications,an ectopic IUD... BACKGROUND An intrauterine device(IUD)is a commonly used contraceptive among women in China.It is widely used because it is safe,effective,simple,economic,and reversible.Among the possible complications,an ectopic IUD in the bladder is rare.It occurs insidiously,has a long course,is associated with a high risk for injury,and is difficult to treat.CASE SUMMARY A 44-year-old woman was admitted for repeated episodes of urinary frequency,urgency,and dysuria over three months.Laboratory tests revealed significantly elevated urine leukocytes and bacteria.Urine culture suggested colonization with Enterococcus faecalis.Abdominal computed tomography images suggested an abnormally positioned IUD that was protruding into the bladder.Cystoscopy revealed a metallic foreign body with multiple stones on its surface in the left posterior bladder wall.The foreign body measured approximately 1 cm.Hysteroscopy revealed the arm of a V-type metal IUD embedded in the middle and upper sections of the anterior wall of the cervical canal.The majority of the IUD was located in the uterine cavity.Cystoscopy was performed,and a holmium laser was utilized to break the stones attached to the portion of the IUD in the bladder.The IUD was then removed through hysteroscopy.CONCLUSION Ectopic IUDs in the bladder can be diagnosed with thorough imaging and safely removed through cystoscopy or hysteroscopy. 展开更多
关键词 Migrated intrauterine device CYSTOSCOPY HYSTEROSCOPY Bladder stones Urinary tract infection Case report
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Effect of Domestically-made Levonorgestrel-releasing Intrauterine Device on the Endocrine System and Mensentruation in Monkeys
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作者 吴昌杰 夏文家 +4 位作者 吴熙瑞 李儒镠 黄秀兰 严以齐 黄达平 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 1996年第2期117-120,共4页
Effect of domestically-made levonorgestrel-releasing intrauterine device (LNG, release rate: 6 μg/day) on the endocrine system and menstruation in mondeys was investigated. The results showed that the Estradiol (E2) ... Effect of domestically-made levonorgestrel-releasing intrauterine device (LNG, release rate: 6 μg/day) on the endocrine system and menstruation in mondeys was investigated. The results showed that the Estradiol (E2) and progesterone (P) levels were significantly decreased 2 ovulatory cycles after iusertion of the devices as compared with those before insertion in 3 monkeys (P>0. 001) ,suggesting an evident ovulation-suppressing effect. In 1 monkey, the E2 and P levels were the same before and after insertion,and expulsion of device was found in the monkey later. The plasma LNG concentration in 3 animals was 493. 69-454. 60 pg/ml and plasma LNG was not detected in 1 monkey. The hormone level returned to normal level after removal of the devices. 展开更多
关键词 LEVONORGESTREL intrauterine device endocrine system
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Com parison betw een Two Techniques Used in Im m ediatePostplacentalInsertion of TCu 380AIntrauterine Device:36-Month follow-up
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作者 徐晋勋 杨秀兰 +5 位作者 顾兴林 徐素英 周晓波 陈月贞 肖志琴 庄留琪 《Journal of Reproduction and Contraception》 CAS 1999年第3期156-162,共7页
Three hundred and eighty four women in Shanghai who delivered vaginally and chose IUD for contraception received the copper T 380A IUD inserted vaginally within 10 min after delivery of the placenta(i.e.,immediate pos... Three hundred and eighty four women in Shanghai who delivered vaginally and chose IUD for contraception received the copper T 380A IUD inserted vaginally within 10 min after delivery of the placenta(i.e.,immediate postplacental insertion, IPPI). Among them, 98.70% were primipara. The women were randomly divided into two groups: IUD inserted by hand and IUD insreted by ring forceps. Using Life Table Method and χ 2 test, expulsion and other discontinuation rates were compared at 6, 12, 24, and 36 months post insertion between these two different groups. No uterine perforation, infection or prolonged period of lochia occurred in the 384 cases. Expulsions were the main reason for discontinuation. From 6 months to 36 months, the gross cumulative rates of all discontinuation events (expulsion, pregnancy, removal for bleeding/pain, etc.) were not statistically significantly different (P>0.05). The results suggest that these two different insertion techniques do not significantly affect discontinuation rate in vaginal IPPI using the TCu 380 A, which appears to be suitable for postpartum insertion in Chinese women. Other relevant issues, such as breast feeding and IUD position in uterine cavity, are also analyzed and discussed in this paper. 展开更多
关键词 intrauterine device copper T 380A IUD (TCu 380A IUD) Immediate postplacental insertion (IPPI) Vaginal delivery Follow up studies
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Opinions and Perceptions of Gynecologists and Midwives on the Use of the Intrauterine Device in Senegal
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作者 Hadja Maimouna Barro Daff Khalifa Babacar Mansour Fall +7 位作者 Youssoupha Touré Aïssatou Mbodji Moussa Diallo Abdoul Aziz Diouf Magatte Mbaye Khalifa Babacar Gueye Babacar Biaye Alassane Diouf 《Open Journal of Obstetrics and Gynecology》 2021年第11期1484-1493,共10页
<strong>Objective: </strong><span><span><span style="font-family:""><span style="font-family:Verdana;">The purpose of this study was to analyze the opinions... <strong>Objective: </strong><span><span><span style="font-family:""><span style="font-family:Verdana;">The purpose of this study was to analyze the opinions of gynecologists, midwives, and interns/Specialist students practicing in Senegal about the use of IUD, and to assess factors that stand as obstacles to IUD prescribing. </span><b><span style="font-family:Verdana;">Patients and methods: </span></b><span style="font-family:Verdana;">An online questionnaire was developed to assess providers’ IUD practices and attitudes. The questionnaire was based on the one used in a Swiss study on the same topic. The platform used was Google forms. The questionnaire was shared in associative platforms involving gynecologists, midwives and interns/Specialist students. </span><b><span style="font-family:Verdana;">Results and comments: </span></b><span style="font-family:Verdana;">We received 292 feedbacks. Gynecologists represented 13.7% of the sample, interns and specialist students 11.3% and midwives 76%. Parity is a determining factor in IUD selection. The care-providers were concerned about the followings, which might have prevented the use of IUD, even </span><span style="font-family:Verdana;">though it </span></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">was</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> indicated: infections (75.7%), pelvic pain (61.3%), expulsion (48.3%), increased risk of perforation (46.9%), women’s appreciation </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">(45.2%), ectopic pregnancy (33.9%) and sexual behavior (28.4%). </span><b><span style="font-family:Verdana;">Conclusion: </span></b><span style="font-family:Verdana;">Our study reveals that providers’ apprehensions and concerns severely limit the availability of IUDs. These concerns are often unfounded, based on personal experiences and not on official recommendations. Parity is a major obstacle.</span></span></span></span> 展开更多
关键词 intrauterine device IUD PARITY Gynecologists MIDWIVES Interns
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Effects of Copper-Containing Intrauterine Devices on the Endometrium
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作者 Jia-Hui Che Xiao-Ying Yao 《Reproductive and Developmental Medicine》 CSCD 2021年第1期38-43,共6页
The use of copper-containing intrauterine devices(Cu-IUDs)is a safe,effective,and long-term contraceptive method.Here,we review the effects of Cu-IUDs on subsequent pregnancy and the morphology,local coagulation funct... The use of copper-containing intrauterine devices(Cu-IUDs)is a safe,effective,and long-term contraceptive method.Here,we review the effects of Cu-IUDs on subsequent pregnancy and the morphology,local coagulation function,sensitivity to estrogen and progesterone,cell proliferation,and immune response of the endometrium.Studies on the morphology of endometrium indicate that the use of Cu-IUDs can affect the number and binding capacity of estrogen and progesterone receptors in the endometrium and reduce the response of the endometrium to estrogen and progesterone.The use of Cu-IUDs can also affect the proliferation of endometrial cells,suggesting that the aseptic inflammation caused by Cu-IUDs may differ from chronic infectious or noninfectious inflammation;this highlights that the use of Cu-IUDs provides protection against endometrial proliferative diseases.The use of Cu-IUDs increases local endometrial angiogenesis,bleeding tendency,and fibrinolytic activity,which can result in prolonged menstruation or abnormal uterine bleeding.Additionally,the use of Cu-IUDs can cause the infiltration of numerous lymphocytes,monocytes,macrophages,and other inflammatory cells around the endometrial gland and changes in endometrial immune function,immune cell function,and the number and type of immune molecules.Cu-IUD-induced decidual injury significantly increases the invasiveness of trophoblasts,further affecting the aberrant expression of their growth-,angiogenesis-,and invasion-related factors and improving the formation of the placenta.Moreover,the endometrial damage caused by Cu-IUD placement before embryo transfer can improve both clinical pregnancy and live birth rates;however,specific changes in the immune system after Cu-IUD use as well as its effects on future pregnancies require further investigation. 展开更多
关键词 CONTRACEPTION copper ENDOMETRIUM intrauterine Contraception intrauterine device
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Cytotoxicity of six copper-bearing intrauterine devices on Chinese hamster ovary cells: the influence of frame, shape and copper surface area
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作者 Tong CHEN Ying LI +3 位作者 Wen-li ZHANG Wei-sai ZHOU Shuang-shuang ZHANG Jian-ping LIU 《Journal of Reproduction and Contraception》 CAS CSCD 2015年第3期160-172,共13页
Objective To evaluate the cytotoxicity of six commonly used copper-bearing intrauterine devices (Cu-IUDs) on Chinese hamster ovary (CHO-K1) cells and to investigate the influence of frame, shape and copper surface... Objective To evaluate the cytotoxicity of six commonly used copper-bearing intrauterine devices (Cu-IUDs) on Chinese hamster ovary (CHO-K1) cells and to investigate the influence of frame, shape and copper surface area of Cu-IUDs on cell toxicity.Methods Cu-IUDs were incubated in 10% FBS-DMEM/F12 culture medium at 37 ℃ for 24 h. The extracts were analyzed by flame atomic absorption spectrometer and were then diluted into different concentrations with culture medium. Finally, cytotoxicity of these original and diluted extracts on CHO-K1 cells was detected by cell counting kit-8 (CCK-8) assay.Results The viabilities of cells treated with the original extracts of six Cu-IUDs (TCu220C bulb, TCu220C, GCu220, GCu300, Yuangong Cu270 and Yuangong Ⅱ- 300) were all below 10% and the cupric ion concentrations in these extracts were 28.22 mg/L, 31.80 mg/L, 92.80 mg/L, 99.74 mg/L, 114.90 mg/L and 119.20 mg/L, respectively. After these original extracts were diluted, significant differences in cytotoxicity were exhibited. IUDs with larger copper surface areas (GCu300 and Yuangong Ⅱ-300) showed more cytotoxicity than those with smaller areas (GCu220 and Yuangong Cu270) respectively; When different shapes of Cu-IUDs were compared, TCu220C bulb showed lower cytotoxicity than TCu220C, and GCu300 exhibited higher toxicity than Yuangong Ⅱ-300; TCu220C displayed significantly lower cytotoxicity than GCu220 due to their differences in frames.Conclusion We presented evidence on the cytotoxic effects of copper ions released from Cu-IUDs on CHO-K1 cells and found that shape, frame together with copper surface area of Cu-IUDs had obvious influence on the cytotoxicity. 展开更多
关键词 copper-bearing intrauterine device (Cu-IUD) Chinese hamster ovary (CHO-K1) cell counting kit-8 (CCK-8) CYTOTOXICITY extract concentration influential factor
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Barriers to Intrauterine Device Use at an University-Based Women’s Clinic
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作者 Denise Ragland Nalin Paykachat Nafisa Dajani 《Open Journal of Obstetrics and Gynecology》 2014年第16期1058-1064,共7页
Objective: The purpose of this study was to determine the barriers to intrauterine device (IUD) use at a University-Based Women’s Clinic. Methods: This study is a cross-sectional survey of a convenience sample of sub... Objective: The purpose of this study was to determine the barriers to intrauterine device (IUD) use at a University-Based Women’s Clinic. Methods: This study is a cross-sectional survey of a convenience sample of subjects receiving obstetrical care at a University-Based Women’s Clinic. Eligible women who consented to participate self-administered a 16-question survey during a routine prenatal visit. Descriptive statistics were used to report participants’ demographics and history of contraception use. Additionally, subjects were asked if they would consider IUD use in the future. Results: A total of 160 women participated in this study. The average age of this sample was 24.9 (SD = 6.3). The majority were in low income and low education categories. Only 5% of women reported previous IUD use. 27% of women surveyed desired more information regarding IUD contraception. 19% of participants would consider using an IUD in the future and 25% would consider?IUD in the future if they knew more about them. Insurance and financial constraints were cited as barriers to IUD use. 4% of the sample reported that they had used an IUD previously and were unhappy with it due to pain and discomfort. 18% would not consider an IUD because they had heard about side effects. 68%?of the surveyed sample reported unintended pregnancies. Conclusion: The two most common barriers to IUD use in this patient population was lack of knowledge?and concern about side effects. Increasing patients’ knowledge of IUDs has the potential to increase IUD utilization in this clinic population which reported a 68% rate of unintended pregnancy. 展开更多
关键词 intrauterine device intrauterine CONTRACEPTION IUD Utilization Barriers Unintended PREGNANCIES Component Formatting Style STYLING
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Intravesical Migration of Intrauterine Device and Calculi Formation 12 Years Post Missing: A Case Report
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作者 Ahmad Rezaee Azandaryani Pezhman Ghaderzadeh Leili Ebrahimi Farsangi 《Case Reports in Clinical Medicine》 2017年第1期24-30,共7页
Intraunterine device (IUD) is a safe, effective and feasible method used for reversible contraception worldwide. Transvesical migration of an Intrauterine device (IUD) is a rare complication. We describe a case in who... Intraunterine device (IUD) is a safe, effective and feasible method used for reversible contraception worldwide. Transvesical migration of an Intrauterine device (IUD) is a rare complication. We describe a case in whom initially a plain abdominopelvic radiography demonstrated calcified string of an IUD in a 42-year-old woman with recurrent lower urinary symptoms (LUTS) and urinary tract infection since 2 years earlier. The IUD had been inserted 12 years earlier and 3 years after placement of the IUD, the patient experienced an uneventful pregnancy and a successful delivery. Sonographic images and later on the cystoscopic procedure confirmed the diagnosis of transvesical migration of the IUD. The IUD was removed using cystoscopic procedure, leaving no complication. 展开更多
关键词 BLADDER Stone intrauterine CONTRACEPTIVE device INTRAVESICAL MIGRATION
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Characteristics of High-Speed Copper Plating Films Using a Jet Flow Device
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作者 Yohei Suzuki Yushi Miyashita +4 位作者 Yasushi Umeda Christpher E.J.Cordonier Hideo Honma Osamu Takai Joo-Hyong Noh 《材料科学与工程(中英文A版)》 2019年第3期91-97,共7页
Since copper has excellent properties such as malleability and conductivity,it is widely used in the electronics field.Copper sulfate plating is expanding further in fields requiring thick deposits such as for heat di... Since copper has excellent properties such as malleability and conductivity,it is widely used in the electronics field.Copper sulfate plating is expanding further in fields requiring thick deposits such as for heat dissipation boards and bumps for stress relaxation during semiconductor packaging.In this study,high-speed copper plating at 50 A/dm2 or more was achieved using a jet flow device.In addition,as a result of comparison with the low current density film,the current density had little effect on electrical conductivity and film surface structure.On the other hand,it was confirmed that the etching rate of the high current density film was greatly increased as the crystallites on the film surface became smaller than low current density film.Increase in productivity is expected due to shorter plating time enabled by film deposition at high current density.Furthermore,the increase of etching rate is expected to contribute to the suppression of undercuts that occur when removing the seed layer during wiring and bump fabrication. 展开更多
关键词 ELECTRO copper PLATING high current density film CHARACTERISTICS JET flow device
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Role of IL-6 in the contraceptive mechanism of intrauterine device
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作者 Zhu Dan Wang Liyan +1 位作者 Fu Li Jia Ruiying 《白求恩医科大学学报》 CSCD 2000年第6期597-599,共3页
目的 :探讨血清中白细胞介素 - 6(IL- 6)水平与宫内节育器 (IUD)存在的关系。方法 :采用酶联免疫吸附试验测定 64例置器妇女 (试验组 ,试验组又分为置器出血组和无出血组 ) ,以及60例健康妇女 (对照组 )血清中 IL- 6水平 ,同时测定两组... 目的 :探讨血清中白细胞介素 - 6(IL- 6)水平与宫内节育器 (IUD)存在的关系。方法 :采用酶联免疫吸附试验测定 64例置器妇女 (试验组 ,试验组又分为置器出血组和无出血组 ) ,以及60例健康妇女 (对照组 )血清中 IL- 6水平 ,同时测定两组血清中 C-反应蛋白 (CRP)水平。结果 :试验组 64例中有 31例血中 IL- 6水平升高 ,与对照组相比差异显著 (P<0 .0 1 )。但其中置器出血组与不出血组中 IL- 6水平无统计学差异 (P>0 .0 5)。试验组及对照组血清中 CRP检验结果均为阴性。结论 :宫内节育器引起子宫内膜无菌性炎症反应 ,导致部分妇女血清中 IL- 6水平升高。IL- 展开更多
关键词 intrauterine contraceptive devices INTERLEUKIN-6 C-reactive protein
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A Comparative Study on the Contraception Efficacy and Safety of the Progesterone Releasing Contraceptive Vaginal Ring and the Copper T 380A IUD Inserted during the Lactation Period
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作者 杜明昆 郑怀美 +1 位作者 郑苏华 陈帼君 《Journal of Reproduction and Contraception》 CAS 1996年第1期40-47,共8页
A comparative study was made on the contraception efficacy and safety of the vaginal ring releasing 10mg/day Of progesterone in 160 cases and an intrauterine device,the cOPPer T 380A in 100 cases during lactation.It w... A comparative study was made on the contraception efficacy and safety of the vaginal ring releasing 10mg/day Of progesterone in 160 cases and an intrauterine device,the cOPPer T 380A in 100 cases during lactation.It was found that the contraceptive method is acceptable from 42 to 60 days postpartum.No pregnancy occurred in the copper T 380A IUD users during lactation.Those methods are worth to be recommended because of their contraceptive efficacy and no adverse effects on breastfeeding children.Prenatal care and Family Planning Programe are administered together to raise lactation performance rate,and to decrease induced abortion rate,the health of mothers and children were protected. 展开更多
关键词 Vaginal ring intrauterine device POSTPARTUM Lactating copper T 380A IUD
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Level of Copper Ion in Cervical Mucus of Various Duration after Inserting VCu200IUD
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作者 刘庆喜 黄祝 潘琢如 《Journal of Reproduction and Contraception》 CAS 1996年第1期25-31,共7页
The purpose of the study was to test the effective period of VCu200 IUD.The concentration of copper ion was measured with non-flame atomic absorption spectrophotometer HITACHI-180.The average concentration of coPPer i... The purpose of the study was to test the effective period of VCu200 IUD.The concentration of copper ion was measured with non-flame atomic absorption spectrophotometer HITACHI-180.The average concentration of coPPer ion(x±s.)was 2.66±0.58μg/g cervical mucus wet weight(μg/g·M·W·W) in the first year,then gradually decreasing to 0.91±0.16μg/g·M·W·W in the fifteenth-year group of VCu200 IUD.There was an average of 0.35±0.08~0.56±0.14 μg/g·M·W·W in the control group.It showed that the concentration of copper ion was decreasing with prolongation of use of VCu200 IUD and there was statistically significant difference between VCu200 IUD group,on the one hand,and the stainless steel ring group and the control group(P<0.05~0.01)on the other hand.No difference was found between the stainless steel ring group and the control group(P>0.05).It was reported in the literature that the concentration Of copper ion in 1.0μg/ml had the action of antifertility,and it was found that the concentration of copper ion was higher than 1.0μg/ml in the tenth year after insertion of VCu200 IUD.It suggested that effective period of VCu200 IUD was at least ten years. 展开更多
关键词 Intrautering device copper ion Cervical mucus
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Uterine Artery Rupture After Induced Abortion and Extraction of an Intrauterine Device 被引量:1
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作者 Xiao-Ming Yu Jing Guan Ting-Ting Sun 《Chinese Medical Journal》 SCIE CAS CSCD 2016年第4期484-486,共3页
An intrauterine device (IUD) is a safe, effective, simple, and reversible method tbr birth control, but some women with IUD may still become pregnant. Induced abortion is the main method for termination of pregnancy... An intrauterine device (IUD) is a safe, effective, simple, and reversible method tbr birth control, but some women with IUD may still become pregnant. Induced abortion is the main method for termination of pregnancy. If induced abortion is not well-managed in these patients, it may result in serious vaginal bleeding and uterine rupture. We report a case of uterine artery rupture after induced abortion combined with extraction of an IUD. This case highlights the necessity of a standard operation for complicated induced abortion, and the value of interventional therapy, such as uterine artery embolization (UAE), for controlling serious vaginal bleedit3g. 展开更多
关键词 Induced Abortion intrauterine device RUPTURE Uterine Arterial Embolization: Uterine Artery
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