In this work,we present an intravascular dual-mode endoscopic system capable of both intravascular photoacoustic imaging(IVPAI)and intravascular optical coherence tomography(IVOCT)for recognizing spontaneous coronary ...In this work,we present an intravascular dual-mode endoscopic system capable of both intravascular photoacoustic imaging(IVPAI)and intravascular optical coherence tomography(IVOCT)for recognizing spontaneous coronary artery dissection(SCAD)phantoms.IVPAI provides high-resolution and high-penetration images of intramural hematoma(IMH)at different depths,so it is especially useful for imaging deep blood clots associated with imaging phantoms.IVOCT can readily visualize the double-lumen morphology of blood vessel walls to identify intimal tears.We also demonstrate the capability of this dual-mode endoscopic system using mimicking phantoms and biological samples of blood clots in ex vivo porcine arteries.The results of the experiments indicate that the combined IVPAI and IVOCT technique has the potential to provide a more accurate SCAD assessment method for clinical applications.展开更多
The incidence and mortality of cardiovascular diseases and gastrointestinal cancer have gradually increased in recent years,and these diseases have become major social and public-health concerns.New requirements have ...The incidence and mortality of cardiovascular diseases and gastrointestinal cancer have gradually increased in recent years,and these diseases have become major social and public-health concerns.New requirements have been proposed for the clinical diagnosis of these diseases in the hope that,by accessing accurate structural information,to further grasp the functional information which closely related to the development of the diseases.Photoacoustic imaging is a new imaging method in which ultrasonic signals are generated from biological samples by laser-pulse irradiation.It has the advantages of high optical contrast,large ultrasound penetration depth,and high resolution.Additionally,it can acquire spectral information.The integration of a photoacoustic imaging system into a tiny imaging catheter can realize interventional imaging based on photoacoustic principles.The combination of structural imaging of cardiovascular and gastrointestinal lesion regions with photoacoustic spectroscopy to identify and quantify tissue components can realize highly sensitive functional imaging.After surveying the recent progress in the development of the photoacoustic imaging method for interventional application,with a particular emphasis on intravascular photoacoustic imaging,photoacoustic endoscopy,and photoacoustic spectroscopy,we summarize and identify future research directions for interventional photoacoustic imaging.展开更多
Early detection of vulnerable plaques is the critical step in the prevention of acute coronary events.Morphology,composition,and mechanical property of a coronary artery have been demonstrated to be the key characteri...Early detection of vulnerable plaques is the critical step in the prevention of acute coronary events.Morphology,composition,and mechanical property of a coronary artery have been demonstrated to be the key characteristics for the identification of vulnerable plaques.Several intravascular multimodal imaging technologies providing co-registered simultaneous images have been developed and applied in clinical studies to improve the characterization of atherosclerosis.In this paper,the authors review the present system and probe designs of representative intra-vascular multimodal techniques.In addition,the scientific innovations,potential limitations,and future directions of these technologies are also discussed.展开更多
基金funding from the National Natural Science Foundation of China(NSFC)under grants 61627827,61705068the Natural Science Foundation of Fujian Province 2021J01813the Fujian Medical University Research Foundation of Talented Scholars XRCZX2021004.
文摘In this work,we present an intravascular dual-mode endoscopic system capable of both intravascular photoacoustic imaging(IVPAI)and intravascular optical coherence tomography(IVOCT)for recognizing spontaneous coronary artery dissection(SCAD)phantoms.IVPAI provides high-resolution and high-penetration images of intramural hematoma(IMH)at different depths,so it is especially useful for imaging deep blood clots associated with imaging phantoms.IVOCT can readily visualize the double-lumen morphology of blood vessel walls to identify intimal tears.We also demonstrate the capability of this dual-mode endoscopic system using mimicking phantoms and biological samples of blood clots in ex vivo porcine arteries.The results of the experiments indicate that the combined IVPAI and IVOCT technique has the potential to provide a more accurate SCAD assessment method for clinical applications.
基金supported in part by the National Natural Science Foundation of China(No.61475182)the Scientific Research Project of Guangzhou University (No. ZJH3-2001)+2 种基金the Research Projects in Colleges and Universities of Guangzhou(No.1201610315)the Shenzhen Science and Technology Innovation Grant(Nos.JCYJ2015073 1154850923,JCYJ20160608214524052)the Science and Technology Department of Xuzhou city(No.KC16SY 158)
文摘The incidence and mortality of cardiovascular diseases and gastrointestinal cancer have gradually increased in recent years,and these diseases have become major social and public-health concerns.New requirements have been proposed for the clinical diagnosis of these diseases in the hope that,by accessing accurate structural information,to further grasp the functional information which closely related to the development of the diseases.Photoacoustic imaging is a new imaging method in which ultrasonic signals are generated from biological samples by laser-pulse irradiation.It has the advantages of high optical contrast,large ultrasound penetration depth,and high resolution.Additionally,it can acquire spectral information.The integration of a photoacoustic imaging system into a tiny imaging catheter can realize interventional imaging based on photoacoustic principles.The combination of structural imaging of cardiovascular and gastrointestinal lesion regions with photoacoustic spectroscopy to identify and quantify tissue components can realize highly sensitive functional imaging.After surveying the recent progress in the development of the photoacoustic imaging method for interventional application,with a particular emphasis on intravascular photoacoustic imaging,photoacoustic endoscopy,and photoacoustic spectroscopy,we summarize and identify future research directions for interventional photoacoustic imaging.
基金Theauthors acknowledge funding from National Institutes of Health(R01HL-125084.R01HL-127271,R01EY-026091,R01EY-028662)American Heart Association(18PRE34050021)the National Science Foundation(DGE-1839285).
文摘Early detection of vulnerable plaques is the critical step in the prevention of acute coronary events.Morphology,composition,and mechanical property of a coronary artery have been demonstrated to be the key characteristics for the identification of vulnerable plaques.Several intravascular multimodal imaging technologies providing co-registered simultaneous images have been developed and applied in clinical studies to improve the characterization of atherosclerosis.In this paper,the authors review the present system and probe designs of representative intra-vascular multimodal techniques.In addition,the scientific innovations,potential limitations,and future directions of these technologies are also discussed.
