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Hybrid Dynamic Variables-Dependent Event-Triggered Fuzzy Model Predictive Control 被引量:1
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作者 Xiongbo Wan Chaoling Zhang +2 位作者 Fan Wei Chuan-Ke Zhang Min Wu 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第3期723-733,共11页
This article focuses on dynamic event-triggered mechanism(DETM)-based model predictive control(MPC) for T-S fuzzy systems.A hybrid dynamic variables-dependent DETM is carefully devised,which includes a multiplicative ... This article focuses on dynamic event-triggered mechanism(DETM)-based model predictive control(MPC) for T-S fuzzy systems.A hybrid dynamic variables-dependent DETM is carefully devised,which includes a multiplicative dynamic variable and an additive dynamic variable.The addressed DETM-based fuzzy MPC issue is described as a “min-max” optimization problem(OP).To facilitate the co-design of the MPC controller and the weighting matrix of the DETM,an auxiliary OP is proposed based on a new Lyapunov function and a new robust positive invariant(RPI) set that contain the membership functions and the hybrid dynamic variables.A dynamic event-triggered fuzzy MPC algorithm is developed accordingly,whose recursive feasibility is analysed by employing the RPI set.With the designed controller,the involved fuzzy system is ensured to be asymptotically stable.Two examples show that the new DETM and DETM-based MPC algorithm have the advantages of reducing resource consumption while yielding the anticipated performance. 展开更多
关键词 Dynamic event-triggered mechanism(DETM) hybrid dynamic variables model predictive control(MPC) robust positive invariant(RPI)set T-S fuzzy systems
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Constructing Hopf Insulator from Geometric Perspective of Hopf Invariant
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作者 常治文 郝维昌 +1 位作者 Miguel Bustamante 刘鑫 《Chinese Physics Letters》 SCIE EI CAS CSCD 2024年第3期121-126,共6页
We propose a method to construct Hopf insulators based on the study of topological defects from the geometric perspective of Hopf invariant I.Firstly,we prove two types of topological defects naturally inhering in the... We propose a method to construct Hopf insulators based on the study of topological defects from the geometric perspective of Hopf invariant I.Firstly,we prove two types of topological defects naturally inhering in the inner differential structure of the Hopf mapping.One type is the four-dimensional point defects. 展开更多
关键词 HOPF TOPOLOGICAL INVARIANT
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The Ω(2012) as a Hadronic Molecule
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作者 Ju-Jun Xie Li-Sheng Geng 《Chinese Physics Letters》 SCIE EI CAS CSCD 2024年第8期13-16,共4页
Recently,a new excited baryon state,Ω(2012),was observed in the invariant mass spectra of𝐾K^(-)■^(0) and K_(S)^(0)■^(-)by the Belle collaboration.This state has a narrow width(∼6 MeV)compared to other bary... Recently,a new excited baryon state,Ω(2012),was observed in the invariant mass spectra of𝐾K^(-)■^(0) and K_(S)^(0)■^(-)by the Belle collaboration.This state has a narrow width(∼6 MeV)compared to other baryon states with a similar mass.Here,we provide a mini-review on the Ω(2012)state from the molecular perspective,where it appears to be a dynamically generated state with spin-parity 3/2^(−)from the coupled-channels interactions of the K■(1530)and ηΩ in s-wave and K■ in𝑑d-wave.Additionally,alternative explanations for the Ω(2012)resonance are also discussed. 展开更多
关键词 wave. INVARIANT STATE
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Accounting for Quadratic and Cubic Invariants in Continuum Mechanics–An Overview
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作者 Artur V.Dmitrenko Vladislav M.Ovsyannikov 《Fluid Dynamics & Materials Processing》 EI 2024年第9期1925-1939,共15页
The differential equations of continuum mechanics are the basis of an uncountable variety of phenomena and technological processes in fluid-dynamics and related fields.These equations contain derivatives of the first ... The differential equations of continuum mechanics are the basis of an uncountable variety of phenomena and technological processes in fluid-dynamics and related fields.These equations contain derivatives of the first order with respect to time.The derivation of the equations of continuum mechanics uses the limit transitions of the tendency of the volume increment and the time increment to zero.Derivatives are used to derive the wave equation.The differential wave equation is second order in time.Therefore,increments of volume and increments of time in continuum mechanics should be considered as small but finite quantities for problems of wave formation.This is important for calculating the generation of sound waves and water hammer waves.Therefore,the Euler continuity equation with finite time increments is of interest.The finiteness of the time increment makes it possible to take into account the quadratic and cubic invariants of the strain rate tensor.This is a new branch in hydrodynamics.Quadratic and cubic invariants will be used in differential wave equations of the second and third order in time. 展开更多
关键词 Quadratic invariant cubic invariant continuity equation generation of periodic waves N.E.Zhukovsky’s hydraulic shock TURBULENCE
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Topological phases and edge modes of an uneven ladder
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作者 商文创 韩熠宁 +1 位作者 Shimpei Endo 高超 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第8期154-168,共15页
We investigate the topological properties of a two-chain quantum ladder with uneven legs,i.e.,the two chains differ in their periods by a factor of 2.Such an uneven ladder presents rich band structures classified by t... We investigate the topological properties of a two-chain quantum ladder with uneven legs,i.e.,the two chains differ in their periods by a factor of 2.Such an uneven ladder presents rich band structures classified by the closure of either direct or indirect bandgaps.It also provides opportunities to explore fundamental concepts concerning band topology and edge modes,including the difference of intracellular and intercellular Zak phases,and the role of the inversion symmetry(IS).We calculate the Zak phases of the two kinds and find excellent agreement with the dipole moment and extra charge accumulation.We also find that configurations with IS feature a pair of degenerate two-side edge modes emerging as the closure of the direct bandgap,while configurations without IS feature one-side edge modes emerging as not only the closure of both direct and indirect bandgaps but also within the band continuum.Furthermore,by projecting to the two sublattices,we find that the effective Bloch Hamiltonian corresponds to that of a generalized Su–Schrieffer–Heeger model or the Rice–Mele model whose hopping amplitudes depend on the quasimomentum.In this way,the topological phases can be efficiently extracted through winding numbers.We propose that uneven ladders can be realized by spin-dependent optical lattices and their rich topological characteristics can be examined by near future experiments. 展开更多
关键词 ladder model symmetry-protected topological phase topological invariant bulk-boundary correspondence
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Strong invariance principle for a counterbalanced random walk
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作者 TAN Hui-qun HU Zhi-shui DONG Liang 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2024年第2期370-380,共11页
We study a counterbalanced random walkS_(n)=X_(1)+…+X_(n),which is a discrete time non-Markovian process andX_(n) are given recursively as follows.For n≥2,X_(n) is a new independent sample from some fixed law̸=0 wit... We study a counterbalanced random walkS_(n)=X_(1)+…+X_(n),which is a discrete time non-Markovian process andX_(n) are given recursively as follows.For n≥2,X_(n) is a new independent sample from some fixed law̸=0 with a fixed probability p,andX_(n)=−X_(v(n))with probability 1−p,where v(n)is a uniform random variable on{1;…;n−1}.We apply martingale method to obtain a strong invariance principle forS_(n). 展开更多
关键词 random walk MARTINGALE invariance principle
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High-visibility ghost imaging with phase-controlled discrete classical light sources
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作者 仵雪滢 赵岳 李利明 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第7期328-334,共7页
We take phase modulation to create discrete phase-controlled sources and realize the super-bunching effect by a phasecorrelated method. From theoretical and numerical simulations, we find the space translation invaria... We take phase modulation to create discrete phase-controlled sources and realize the super-bunching effect by a phasecorrelated method. From theoretical and numerical simulations, we find the space translation invariance of the bunching effect is a key point for the ghost imaging realization. Experimentally, we create the orderly phase-correlated discrete sources which can realize high-visibility second-order ghost imaging than the result with chaotic sources. Moreover, some factors affecting the visibility of ghost image are discussed in detail. 展开更多
关键词 ghost imaging high visibility space translation invariance
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Factor Structure and Longitudinal Invariance of the CES-D across Diverse Residential Backgrounds in Chinese Adolescents
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作者 Yanjing Cao Chenchen Xu +2 位作者 Qi Li Shan Lu Jing Xiao 《International Journal of Mental Health Promotion》 2024年第4期261-269,共9页
Background:Valid and reliable measures of depressive symptoms are crucial for understanding risk factors,outcomes,and interventions across rural and urban settings.Despite this need,the longitudinal invariance of thes... Background:Valid and reliable measures of depressive symptoms are crucial for understanding risk factors,outcomes,and interventions across rural and urban settings.Despite this need,the longitudinal invariance of these measures over time remains understudied.This research explores the structural components of the Center for Epidemiological Studies Depression Scale(CES-D)and examines its consistency across various living environments and temporal stability in a cohort of Chinese teenagers.Method:In the initial phase,1,042 adolescents furnished demographic details and undertook the CES-D assessment.After a three-month interval,967 of these participants repeated the CES-D evaluation.The study employed Confirmatory factor analysis(CFA)to scrutinize the scale’s structural integrity.We investigated factorial invariance by conducting a twopronged CFA:one comparing urban vs.rural backgrounds,and another contrasting the results from the initial assessment with those from the follow-up.Results:The CES-D demonstrated adequate reliability in both rural and urban high school student samples.The preliminary four-factor model applied to the CES-D demonstrated a good fit with the collected data.Invariance tests,including multigroup analyses comparing rural and urban samples and longitudinal assessments,confirmed the scale’s invariance.Conclusions:The results suggest that the CES-D serves as a reliable instrument for evaluating depressive symptoms among Chinese adolescents.Its applicability is consistent across different living environments and remains stable over time. 展开更多
关键词 DEPRESSION factor structure measurement invariance Chinese adolescent longitudinal invariance
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Abundant invariant solutions of extended(3+1)-dimensional KP-Boussinesq equation
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作者 Hengchun Hu Jiali Kang 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第11期167-174,共8页
Lie group analysis method is applied to the extended(3+1)-dimensional Kadomtsev–Petviashvili–Boussinesq equation and the corresponding similarity reduction equations are obtained with various infinitesimal generator... Lie group analysis method is applied to the extended(3+1)-dimensional Kadomtsev–Petviashvili–Boussinesq equation and the corresponding similarity reduction equations are obtained with various infinitesimal generators.By selecting suitable arbitrary functions in the similarity reduction solutions,we obtain abundant invariant solutions,including the trigonometric solution,the kink-lump interaction solution,the interaction solution between lump wave and triangular periodic wave,the two-kink solution,the lump solution,the interaction between a lump and two-kink and the periodic lump solution in different planes.These exact solutions are also given graphically to show the detailed structures of this high dimensional integrable system. 展开更多
关键词 extended(3+1)-dimensional KP-Boussinesq equation Lie group method similarity reduction invariant solution
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The Aharonov-Bohm Effect: An Exploration of Quantum Interference and Electromagnetic Potentials
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作者 Bahman Zohuri 《Journal of Energy and Power Engineering》 CAS 2024年第3期79-87,共9页
The AB(Aharonov-Bohm)effect is a pivotal quantum mechanical phenomenon that illustrates the fundamental role of the electromagnetic vector potential A in determining the phase of a charged particle’s wave function,ev... The AB(Aharonov-Bohm)effect is a pivotal quantum mechanical phenomenon that illustrates the fundamental role of the electromagnetic vector potential A in determining the phase of a charged particle’s wave function,even in regions where the magnetic field B is zero.This effect demonstrates that quantum particles are influenced not only by the fields directly present but also by the potentials associated with those fields.In the AB effect,an electron beam is split into two paths,with one path encircling a solenoid and the other bypassing it.Despite the absence of a magnetic field in the regions traversed by the beams,the vector potential A associated with the magnetic flux Φ through the solenoid induces a phase shift in the electron’s wave function.This phase shift,quantified by △φ=qΦ/hc,manifests as a change in the interference pattern observed in the detection screen.The phenomenon underscores the principle of gauge invariance in QED(quantum electrodynamics),where physical observables remain invariant under local gauge transformations of the vector and scalar potentials.This reinforces the notion that the vector potential A has a profound impact on quantum systems,beyond its classical role.This article outlines the AB effect,including its theoretical framework,experimental observations,and implications.The focus on the role of the vector potential in quantum mechanics provides a comprehensive understanding of this important phenomenon. 展开更多
关键词 AB effect vector potential(A) magnetic flux(Φ) quantum phase shift gauge invariance electromagnetic potentials interference pattern scalar fields longitudinal waves QED
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On Perron’s Formula and the Prime Numbers
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作者 Michael M. Anthony 《Advances in Pure Mathematics》 2024年第6期487-494,共8页
The Riemann hypothesis is intimately connected to the counting functions for the primes. In particular, Perron’s explicit formula relates the prime counting function to fixed points of iterations of the explicit form... The Riemann hypothesis is intimately connected to the counting functions for the primes. In particular, Perron’s explicit formula relates the prime counting function to fixed points of iterations of the explicit formula with particular relations involving the trivial and non-trivial roots of the Riemann Zeta function and the Primes. The aim of the paper is to demonstrate this relation at the fixed points of iterations of explicit formula, defined by functions of the form limT∈Ν→∞fT(zw)=zw,where, zwis a real number. 展开更多
关键词 Perron Fixed Points ITERATIONS Number Theory Riemann Hypothesis ITERATIONS INVARIANCE PRIMES
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The Equation for the CP Violating Phase for Quarks: The Rule for the Sum of Quark Oscillation Probabilities
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作者 Zoran B. Todorovic 《Journal of High Energy Physics, Gravitation and Cosmology》 CAS 2024年第4期1835-1865,共31页
By applying the rules for the sum of quark oscillation probabilities for the original CKM matrix and for Wolfenstein’s parameterization, equations were derived in which the CP violating phase for quarks appears as an... By applying the rules for the sum of quark oscillation probabilities for the original CKM matrix and for Wolfenstein’s parameterization, equations were derived in which the CP violating phase for quarks appears as an unknown quantity. Quark oscillations occur in spaces that are on the femtometer scale and they are unmeasurable from the point of view of experiments. However, the consequence of those oscillations is the CP violating phase for quarks, which is measured through unitary triangles in Wolfenstein’s parameterization. Through the mathematical model presented in this paper, the equation in Wolfenstein’s parameterization was derived, the root of which is consistent with measurements in today’s quark physics. 展开更多
关键词 QUARKS CKM Matrix PMNS Matrix Wolfenstein Parameterization CP Violation Phase Jarlskog Invariant
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Solving Invariant Problem of Cauchy Means Based on Wronskian Determinant
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作者 Yingjun Ni Fen Wang 《Advances in Pure Mathematics》 2024年第7期515-522,共8页
This paper studied the invariance of the Cauchy mean with respect to the arithmetic mean when the denominator functions satisfy certain conditions. The partial derivatives of Cauchy’s mean on the diagonal are obtaine... This paper studied the invariance of the Cauchy mean with respect to the arithmetic mean when the denominator functions satisfy certain conditions. The partial derivatives of Cauchy’s mean on the diagonal are obtained by using the method of Wronskian determinant in the process of solving. Then the invariant equation is solved by using the obtained partial derivatives. Finally, the solutions of invariant equations when the denominator functions satisfy the same simple harmonic oscillator equation or the denominator functions are power functions that have been obtained. 展开更多
关键词 Cauchy Mean Wronskian Determinant Arithmetic Mean Invariant Equation
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Solving the Three-Neutrino Problem as One of the Three-Body Problems in Physics
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作者 Zoran B. Todorovic 《Journal of High Energy Physics, Gravitation and Cosmology》 CAS 2024年第1期197-227,共31页
By using the standard PMNS (Pontecorvo-Maki-Nakagawa-Sakata) mixing matrix and applying the rule for the sum of the oscillation probabilities of three neutrinos, the equations of motion were derived in which the Dirac... By using the standard PMNS (Pontecorvo-Maki-Nakagawa-Sakata) mixing matrix and applying the rule for the sum of the oscillation probabilities of three neutrinos, the equations of motion were derived in which the Dirac CP violating phase appeared as an unknown quantity. The equations of motion were separately derived for each of the three possible transitions for flavor-neutrino oscillations. Two roots of those equations were obtained in the form of two formulas for the Dirac CP violating phase with opposite signs. In the mathematical sense, the connection between those formulas was established in order to maintain the continuous process of oscillation of three neutrinos. This made it possible to calculate the numerical value for the Dirac CP violating phase, the Jarlskog invariant and to write the general form of the PMNS mixing matrix in the final form in which all its elements are defined with explicit numerical values. 展开更多
关键词 Ordinary Neutrino PMNS Matrix Dirac CPV Phase Jarlskog Invariant
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From Dirac’s Aether to the Dirac Equation
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作者 Richard D. Bateson 《Journal of High Energy Physics, Gravitation and Cosmology》 CAS 2024年第4期1450-1466,共17页
In 1951, Dirac proposed a formalism for a Lorentz invariant Aether with a vacuum state that contains all possible velocity states at each space-time point. Dirac showed no explicit path from the Aether towards the Qua... In 1951, Dirac proposed a formalism for a Lorentz invariant Aether with a vacuum state that contains all possible velocity states at each space-time point. Dirac showed no explicit path from the Aether towards the Quantum Mechanics. In this paper, we demonstrate that Dirac’s proposed Aether can be described by a lattice of possible events in space-time built in the local Lorentz frame. The idealised case of single velocity state leads to the famous Dirac equation for a plane wave state and is compatible with quantum statistics. On the lattice, possible space-time events are connected by the Dirac spinors which provide the probability of observing an event. The inertial mass of a particle is shown to be equivalent to the density of possible events on the lattice. Variation of the lattice density of events modifies the metric and provides a space-time curvature leading to the Hilbert action associated with general relativity. In classical limit, the perturbation in the density of possible events of the Aether is proportional to the Newtonian gravitational potential. 展开更多
关键词 Dirac Aether Lorentz Invariance Dirac Equation Quantum Mechanics Space-Time Lattice Dirac Spinors Inertial Mass Metric Modification Space-Time Curvature General Relativity
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A New Kind of Pre-Mean-Type Mappings and Its Gauss Iteration
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作者 Yingjun Ni Yuli Fan 《Journal of Applied Mathematics and Physics》 2024年第7期2574-2581,共8页
A function which is reflexive is called by pre-mean, a more generalized definition of a mean. In this paper, we define a new pre-mean and study its properties, and then using the given invariant curve we consider the ... A function which is reflexive is called by pre-mean, a more generalized definition of a mean. In this paper, we define a new pre-mean and study its properties, and then using the given invariant curve we consider the problem of convergence of Gauss iteration of a kind of pre-mean type mappings generated by the exponential and logarithmic functions. 展开更多
关键词 Pre-Mean-Type Mapping Invariant Equation Invariant Curves
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Binding Energy, Root Mean Square Radius and Magnetic Dipole Moment of the Triton Nucleus
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作者 Khadija Abdelhassan Kharroube 《Open Journal of Microphysics》 2024年第2期24-39,共16页
The basis functions of the translation invariant shell model are used to construct the ground state nuclear wave functions of <sup>3</sup>H. The used residual two-body interactions consist of central, tens... The basis functions of the translation invariant shell model are used to construct the ground state nuclear wave functions of <sup>3</sup>H. The used residual two-body interactions consist of central, tensor, spin orbit and quadratic spin orbit terms with Gaussian radial dependence. The parameters of these interactions are so chosen in such a way that they represent the long-range attraction and the short-range repulsion of the nucleon-nucleon interactions. These parameters are so chosen to reproduce good agreement between the calculated values of the binding energy, the root mean-square radius, the D-state probability, the magnetic dipole moment and the electric quadrupole moment of the deuteron nucleus. The variation method is then used to calculate the binding energy of triton by varying the oscillator parameter which exists in the nuclear wave function. The obtained nuclear wave functions are then used to calculate the root mean-square radius and the magnetic dipole moment of the triton. 展开更多
关键词 Translation Invariant Shell Model Residual Two-Body Interactions Nucleon-Nucleon Interactions Binding Energy Nuclear Wave Functions
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Heteroclinic Cycles in a Class of 3-Dimensional Piecewise Affine Systems
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作者 Minghao Liu Ruimin Liu 《Journal of Applied Mathematics and Physics》 2024年第2期488-508,共21页
This paper explores the existence of heteroclinic cycles and corresponding chaotic dynamics in a class of 3-dimensional two-zone piecewise affine systems. Moreover, the heteroclinic cycles connect two saddle foci and ... This paper explores the existence of heteroclinic cycles and corresponding chaotic dynamics in a class of 3-dimensional two-zone piecewise affine systems. Moreover, the heteroclinic cycles connect two saddle foci and intersect the switching manifold at two points and the switching manifold is composed of two perpendicular planes. 展开更多
关键词 Piecewise Affine System Heteroclinic Cycle Chaotic Invariant Set
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Mathematical Wave Functions and 3D Finite Element Modelling of the Electron and Positron
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作者 Declan Traill 《Journal of Applied Mathematics and Physics》 2024年第4期1134-1162,共29页
The wave/particle duality of particles in Physics is well known. Particles have properties that uniquely characterize them from one another, such as mass, charge and spin. Charged particles have associated Electric an... The wave/particle duality of particles in Physics is well known. Particles have properties that uniquely characterize them from one another, such as mass, charge and spin. Charged particles have associated Electric and Magnetic fields. Also, every moving particle has a De Broglie wavelength determined by its mass and velocity. This paper shows that all of these properties of a particle can be derived from a single wave function equation for that particle. Wave functions for the Electron and the Positron are presented and principles are provided that can be used to calculate the wave functions of all the fundamental particles in Physics. Fundamental particles such as electrons and positrons are considered to be point particles in the Standard Model of Physics and are not considered to have a structure. This paper demonstrates that they do indeed have structure and that this structure extends into the space around the particle’s center (in fact, they have infinite extent), but with rapidly diminishing energy density with the distance from that center. The particles are formed from Electromagnetic standing waves, which are stable solutions to the Schrödinger and Classical wave equations. This stable structure therefore accounts for both the wave and particle nature of these particles. In fact, all of their properties such as mass, spin and electric charge, can be accounted for from this structure. These particle properties appear to originate from a single point at the center of the wave function structure, in the same sort of way that the Shell theorem of gravity causes the gravity of a body to appear to all originate from a central point. This paper represents the first two fully characterized fundamental particles, with a complete description of their structure and properties, built up from the underlying Electromagnetic waves that comprise these and all fundamental particles. 展开更多
关键词 ELECTRON POSITRON Wave Function Solution Electromagnetic Spin Mass Charge Proof Fundamental Particle Properties Quantum Mechanics Classical Physics Computer 3D Model Schrödinger Equation RMS KLEIN GORDON Electric Magnetic Lorentz Invariant Hertzian Vector Point Potential Field Density Phase Flow Attraction REPULSION Shell Theorem Ehrenfest VIRIAL Normalization Harmonic Oscillator
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Activation-induced pyroptosis contributes to the loss of MAIT cells in chronic HIV-1 infected patients 被引量:1
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作者 Peng Xia Xu-Dong Xing +14 位作者 Cui-Xian Yang Xue-Jiao Liao Fu-Hua Liu Hui-Huang Huang Chao Zhang Jin-Wen Song Yan-Mei Jiao Ming Shi Tian-Jun Jiang Chun-Bao Zhou Xi-Cheng Wang Qing He Qing-Lei Zeng Fu-Sheng Wang Ji-Yuan Zhang 《Military Medical Research》 SCIE CAS CSCD 2023年第1期45-63,共19页
Background: Mucosal-associated invariant T(MAIT) cells are systemically depleted in human immunodeficiency virus type 1(HIV-1) infected patients and are not replenished even after successful combined antiretroviral th... Background: Mucosal-associated invariant T(MAIT) cells are systemically depleted in human immunodeficiency virus type 1(HIV-1) infected patients and are not replenished even after successful combined antiretroviral therapy(cART).This study aimed to identify the mechanism underlying MAIT cell depletion.Methods: In the present study, we applied flow cytometry, single-cell RNA sequencing and immunohistochemical staining to evaluate the characteristics of pyroptotic MAIT cells in a total of 127 HIV-1 infected individuals, including 69 treatment-naive patients, 28 complete responders, 15 immunological non-responders, and 15 elite controllers, at the Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.Results: Single-cell transcriptomic profiles revealed that circulating MAIT cells from HIV-1 infected subjects were highly activated, with upregulation of pyroptosis-related genes. Further analysis revealed that increased frequencies of pyroptotic MAIT cells correlated with markers of systemic T-cell activation, microbial translocation, and intestinal damage in cART-naive patients and poor CD4+ T-cell recovery in long-term cART patients. Immunohistochemical staining revealed that MAIT cells in the gut mucosa of HIV-1 infected patients exhibited a strong active gasdermin-D(GSDMD, marker of pyroptosis) signal near the cavity side, suggesting that these MAIT cells underwent active pyroptosis in the colorectal mucosa. Increased levels of the proinflammatory cytokines interleukin-12(IL-12) and IL-18 were observed in HIV-1 infected patients. In addition, activated MAIT cells exhibited an increased pyroptotic phenotype after being triggered by HIV-1 virions, T-cell receptor signals, IL-12 plus IL-18, and combinations of these factors, in vitro.Conclusions: Activation-induced MAIT cell pyroptosis contributes to the loss of MAIT cells in HIV-1 infected patients,which could potentiate disease progression and poor immune reconstitution. 展开更多
关键词 Acquired immune deficiency syndrome Human immunodeficiency virus Mucosal-associated invariant T cells PYROPTOSIS Immune reconstitution
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