Oxidative stress disturbs the balance between the production of reactive oxygen species(ROS)and the detoxification biological process.It plays an important role in the development and progression of many chronic disea...Oxidative stress disturbs the balance between the production of reactive oxygen species(ROS)and the detoxification biological process.It plays an important role in the development and progression of many chronic diseases.Upon exposure to oxidative stress or the inducers of ROS,the cellular nucleus undergoes some biological processes via different signaling pathways,such as stress adaption through the forkhead box O signaling pathway,inflammatory response through the IκB kinase/nuclear factor-κB signaling pathway,hypoxic response via the hypoxia-inducible factor/prolyl hydroxylase domain proteins pathway,DNA repair or apoptosis through the p53 signaling pathway,and antioxidant response through the Kelch-like ECH-associated protein 1/nuclear factor E2-related factor 2 signaling pathway.These processes are involved in many diseases.Therefore,oxidative stress has gained more attraction as a targeting process for disease treatment.Meanwhile,anti-oxidative stress agents have been widely explored in pre-clinical trials.However,only limited clinical trials are performed to evaluate the efficacy of anti-oxidative stress agents or antioxidants in diseases.In this letter,we further discuss the current clinical trials related to anti-oxidative stress treatment in different diseases.More pre-clinical studies and clinical trials are expected to use anti-oxidative stress strategies as disease treatment or dietary supplementation to improve disease treatment outcomes.展开更多
In the Freudian-Lacanian field,there is an important distinction between knowledge and truth.The truth,of an unconscious nature,is something that inhabits us,directs us,but that escapes us.Knowledge,in turn,is somethi...In the Freudian-Lacanian field,there is an important distinction between knowledge and truth.The truth,of an unconscious nature,is something that inhabits us,directs us,but that escapes us.Knowledge,in turn,is something to be invented,from the hole of the Real,the Unconscious truth,and the subjective experience.The relationships between playing,creating,and fantasizing;the dimension of the uncanny,fiction,and imagination in subjectivity;the invention of knowledge of oneself,derived from the pains and flavors of being who one is,are creative dimensions that inhabit the subject,permeate the analytical act,and transversalize psychoanalysis.In the practice,we listen to and witness processes of analysis that awaken an invention/reinvention of oneself,in the process of remembering,repeating,and elaborating,but also in what the transference relationship summons.Knowledge of oneself,does not guarantee a life without mishaps,sadness,and illusions,but allows the invention and recognition of knowledge and a style.The concept of Sinthome(2007),coined by Jacques Lacan,comes in the wake of the processes of self-invention and is a knowing-doing with the symptom,with the paradoxes of joyful suffering,producing,as a result,an art of saying.Therefore,in this communication,I will articulate elements of theory,practice,and psychoanalytic experience that allow us to expand knowledge of the themes of invention and imagination articulated with the concept of sinthome,their relationships with subjectivity,and the direction of psychoanalytic treatment.展开更多
1 History is a combination of events hidden in darkness.Archaeo⁃logical(考古学的)evidence and the written language were previously our only insights into what once hap⁃pened.The invention of the printing press was a m...1 History is a combination of events hidden in darkness.Archaeo⁃logical(考古学的)evidence and the written language were previously our only insights into what once hap⁃pened.The invention of the printing press was a major milestone in our ability to engage with history.The Internet,though,appears later,will provide a window into the past,consisting of tiny units of digital data.展开更多
A reasonable classification of deposits holds great significance for identifying prospecting targets and deploying exploration. The world ’s keen demand for lithium resources has expedited the discovery of numerous n...A reasonable classification of deposits holds great significance for identifying prospecting targets and deploying exploration. The world ’s keen demand for lithium resources has expedited the discovery of numerous novel lithium resources. Given the presence of varied classification criteria for lithium resources presently, this study further ascertained and classified the lithium resources according to their occurrence modes, obtaining 10 types and 5 subtypes of lithium deposits(resources) based on endogenetic and exogenetic factors. As indicated by surveys of Cenozoic exogenetic lithium deposits in China and abroad,the formation and distribution of the deposits are primarily determined by plate collision zones, their primary material sources are linked to the anatectic magmas in the deep oceanic crust, and they were formed primarily during the Miocene and Late Paleogene. The researchers ascertained that these deposits,especially those of the salt lake, geothermal, and volcanic deposit types, are formed by unique slightly acidic magmas, tend to migrate and accumulate toward low-lying areas, and display supernormal enrichment. However, the material sources of lithium deposits(resources) of the Neopaleozoic clay subtype and the deep brine type are yet to be further identified. Given the various types and complex origins of lithium deposits(resources), which were formed due to the interactions of multiple spheres, it is recommended that the mineralization of exogenetic lithium deposits(resources) be investigated by integrating tectono-geochemistry, paleoatmospheric circulation, and salinology. So far, industrialized lithium extraction is primarily achieved in lithium deposits of the salt lake, clay, and hard rock types. The lithium extraction employs different processes, with lithium extraction from salt lake-type lithium deposits proving the most energy-saving and cost-effective.展开更多
One of the initiative’s prominent elemental achievements is the dynamic cultural interaction,evident in creativeness,vision,and exchanges that it has generated.THE ancient Silk Road made indelible contributions to sh...One of the initiative’s prominent elemental achievements is the dynamic cultural interaction,evident in creativeness,vision,and exchanges that it has generated.THE ancient Silk Road made indelible contributions to shaping civilizations,catalyzing inventions,and engendering literary and scientific treasures in history.Now,the Belt and Road Initiative is infusing new vitality into the ancient cultural exchange tradition.展开更多
Traditional Chinese woodblock printing is the ingenious creation of ancient Chinese laborers,whose invention facilitated cultural dissemination and information sharing,and greatly advanced the progress of world civili...Traditional Chinese woodblock printing is the ingenious creation of ancient Chinese laborers,whose invention facilitated cultural dissemination and information sharing,and greatly advanced the progress of world civilization.展开更多
Product innovation can be achieved by analyzing leading products patents in the market.Different methods have been proposed for design around patent,commonly using the elimination or replacement of a single patent ele...Product innovation can be achieved by analyzing leading products patents in the market.Different methods have been proposed for design around patent,commonly using the elimination or replacement of a single patent element However,the existing research fails to restore the position and function of the design around object in the original patent portfolio of enterprises,which often leads to the phenomenon of evading one patent and violating another.This paper proposes a method for design around patent through using the fusion of technologies of the evolution theory and bundle-type patent portfolio analysis in the initial stage of product development.The object system is analyzed to select technical opportunities through the evolutionary path of technologies and functional trimming methods to achieve circumvent barriers of bundle-type patents.The bundle patent portfolio is analyzed for the product evolution with a radar map.The technological evolution path is combined with the TRIZ innovation method to identify and solve the design problem.Patentability of the new design is evaluated using the patent system rules for innovative scheme difference from the original patent portfolio.The method is verified in a case study for the design of a glass-wiping robot.The design solution has been patented.展开更多
As a result of the fierceness of business competition, companies, to remaincompetitive, have to charm their customers by anticipating their needs and being able to rapidlydevelop exciting new products for them. To ove...As a result of the fierceness of business competition, companies, to remaincompetitive, have to charm their customers by anticipating their needs and being able to rapidlydevelop exciting new products for them. To overcome this challenge, technology forecasting isconsidered as a powerful tool in today's business environment, while there are as many successstories as there are failures, a good application of this method will give a good result. Amethodology of integration of patterns or lines of technology evolution in TRIZ parlance ispresented, which is also known as TRIZ technology forecasting, as input to the QFD process to designa new product. For this purpose, TRIZ technology forecasting, one of the TRIZ major tools, isdiscussed and some benefits compared to the traditional forecasting techniques are highlighted. Thena methodology to integrate TRIZ technology forecasting and QFD process is highlighted.展开更多
Quality function deployment （QFD） is a quality system, that can help to design novel products that meet customers＇ needs. Theory of inventive problem solving （TRIZ） is a very powerful tool in helping to solve dif...Quality function deployment （QFD） is a quality system, that can help to design novel products that meet customers＇ needs. Theory of inventive problem solving （TRIZ） is a very powerful tool in helping to solve difficult technical problems encountered in the design process. Introducing QFD and TRIZ into the conceptual design of the pumping unit combines advantages of these two theories, therefore meeting different demands of different users. It can tell us “What should we do it” with QFD and “How should we do it” with TRIZ. The conceptual design method, which is based on QFD and TRIZ, is introduced andused to analyze and evaluate the conceptual design project of a pumping unit.展开更多
文摘Oxidative stress disturbs the balance between the production of reactive oxygen species(ROS)and the detoxification biological process.It plays an important role in the development and progression of many chronic diseases.Upon exposure to oxidative stress or the inducers of ROS,the cellular nucleus undergoes some biological processes via different signaling pathways,such as stress adaption through the forkhead box O signaling pathway,inflammatory response through the IκB kinase/nuclear factor-κB signaling pathway,hypoxic response via the hypoxia-inducible factor/prolyl hydroxylase domain proteins pathway,DNA repair or apoptosis through the p53 signaling pathway,and antioxidant response through the Kelch-like ECH-associated protein 1/nuclear factor E2-related factor 2 signaling pathway.These processes are involved in many diseases.Therefore,oxidative stress has gained more attraction as a targeting process for disease treatment.Meanwhile,anti-oxidative stress agents have been widely explored in pre-clinical trials.However,only limited clinical trials are performed to evaluate the efficacy of anti-oxidative stress agents or antioxidants in diseases.In this letter,we further discuss the current clinical trials related to anti-oxidative stress treatment in different diseases.More pre-clinical studies and clinical trials are expected to use anti-oxidative stress strategies as disease treatment or dietary supplementation to improve disease treatment outcomes.
文摘In the Freudian-Lacanian field,there is an important distinction between knowledge and truth.The truth,of an unconscious nature,is something that inhabits us,directs us,but that escapes us.Knowledge,in turn,is something to be invented,from the hole of the Real,the Unconscious truth,and the subjective experience.The relationships between playing,creating,and fantasizing;the dimension of the uncanny,fiction,and imagination in subjectivity;the invention of knowledge of oneself,derived from the pains and flavors of being who one is,are creative dimensions that inhabit the subject,permeate the analytical act,and transversalize psychoanalysis.In the practice,we listen to and witness processes of analysis that awaken an invention/reinvention of oneself,in the process of remembering,repeating,and elaborating,but also in what the transference relationship summons.Knowledge of oneself,does not guarantee a life without mishaps,sadness,and illusions,but allows the invention and recognition of knowledge and a style.The concept of Sinthome(2007),coined by Jacques Lacan,comes in the wake of the processes of self-invention and is a knowing-doing with the symptom,with the paradoxes of joyful suffering,producing,as a result,an art of saying.Therefore,in this communication,I will articulate elements of theory,practice,and psychoanalytic experience that allow us to expand knowledge of the themes of invention and imagination articulated with the concept of sinthome,their relationships with subjectivity,and the direction of psychoanalytic treatment.
文摘1 History is a combination of events hidden in darkness.Archaeo⁃logical(考古学的)evidence and the written language were previously our only insights into what once hap⁃pened.The invention of the printing press was a major milestone in our ability to engage with history.The Internet,though,appears later,will provide a window into the past,consisting of tiny units of digital data.
基金funded by the major research program of the of National Natural Science Foundation of China entitled Metallogenic Mechanisms and Regularity of the Lithium Ore Concentration Area in the Zabuye Salt Lake, Tibet (91962219)Science and Technology Major Project of the Tibet Autonomous Region ’s Science and Techonlogy Plan (XZ202201ZD0004G01)a geological survey project of China Geological Survey (DD20230037)。
文摘A reasonable classification of deposits holds great significance for identifying prospecting targets and deploying exploration. The world ’s keen demand for lithium resources has expedited the discovery of numerous novel lithium resources. Given the presence of varied classification criteria for lithium resources presently, this study further ascertained and classified the lithium resources according to their occurrence modes, obtaining 10 types and 5 subtypes of lithium deposits(resources) based on endogenetic and exogenetic factors. As indicated by surveys of Cenozoic exogenetic lithium deposits in China and abroad,the formation and distribution of the deposits are primarily determined by plate collision zones, their primary material sources are linked to the anatectic magmas in the deep oceanic crust, and they were formed primarily during the Miocene and Late Paleogene. The researchers ascertained that these deposits,especially those of the salt lake, geothermal, and volcanic deposit types, are formed by unique slightly acidic magmas, tend to migrate and accumulate toward low-lying areas, and display supernormal enrichment. However, the material sources of lithium deposits(resources) of the Neopaleozoic clay subtype and the deep brine type are yet to be further identified. Given the various types and complex origins of lithium deposits(resources), which were formed due to the interactions of multiple spheres, it is recommended that the mineralization of exogenetic lithium deposits(resources) be investigated by integrating tectono-geochemistry, paleoatmospheric circulation, and salinology. So far, industrialized lithium extraction is primarily achieved in lithium deposits of the salt lake, clay, and hard rock types. The lithium extraction employs different processes, with lithium extraction from salt lake-type lithium deposits proving the most energy-saving and cost-effective.
文摘One of the initiative’s prominent elemental achievements is the dynamic cultural interaction,evident in creativeness,vision,and exchanges that it has generated.THE ancient Silk Road made indelible contributions to shaping civilizations,catalyzing inventions,and engendering literary and scientific treasures in history.Now,the Belt and Road Initiative is infusing new vitality into the ancient cultural exchange tradition.
文摘Traditional Chinese woodblock printing is the ingenious creation of ancient Chinese laborers,whose invention facilitated cultural dissemination and information sharing,and greatly advanced the progress of world civilization.
基金Supported by National Natural Science Foundation of China(Grant Nos.51675159,51605135)Central Guided Local Science and Technology Development Project(Grant No.1824-1837G)Ministry of Science and Technology(Grant No.2017IM040100)
文摘Product innovation can be achieved by analyzing leading products patents in the market.Different methods have been proposed for design around patent,commonly using the elimination or replacement of a single patent element However,the existing research fails to restore the position and function of the design around object in the original patent portfolio of enterprises,which often leads to the phenomenon of evading one patent and violating another.This paper proposes a method for design around patent through using the fusion of technologies of the evolution theory and bundle-type patent portfolio analysis in the initial stage of product development.The object system is analyzed to select technical opportunities through the evolutionary path of technologies and functional trimming methods to achieve circumvent barriers of bundle-type patents.The bundle patent portfolio is analyzed for the product evolution with a radar map.The technological evolution path is combined with the TRIZ innovation method to identify and solve the design problem.Patentability of the new design is evaluated using the patent system rules for innovative scheme difference from the original patent portfolio.The method is verified in a case study for the design of a glass-wiping robot.The design solution has been patented.
基金This project is supported by National Natural Science Foundation of China(No.20172041) and Provincial Science Foundation of Anhui, China (No.03042308).
文摘As a result of the fierceness of business competition, companies, to remaincompetitive, have to charm their customers by anticipating their needs and being able to rapidlydevelop exciting new products for them. To overcome this challenge, technology forecasting isconsidered as a powerful tool in today's business environment, while there are as many successstories as there are failures, a good application of this method will give a good result. Amethodology of integration of patterns or lines of technology evolution in TRIZ parlance ispresented, which is also known as TRIZ technology forecasting, as input to the QFD process to designa new product. For this purpose, TRIZ technology forecasting, one of the TRIZ major tools, isdiscussed and some benefits compared to the traditional forecasting techniques are highlighted. Thena methodology to integrate TRIZ technology forecasting and QFD process is highlighted.
文摘Quality function deployment （QFD） is a quality system, that can help to design novel products that meet customers＇ needs. Theory of inventive problem solving （TRIZ） is a very powerful tool in helping to solve difficult technical problems encountered in the design process. Introducing QFD and TRIZ into the conceptual design of the pumping unit combines advantages of these two theories, therefore meeting different demands of different users. It can tell us “What should we do it” with QFD and “How should we do it” with TRIZ. The conceptual design method, which is based on QFD and TRIZ, is introduced andused to analyze and evaluate the conceptual design project of a pumping unit.
