Systems Theory-Driven Framework for AI Integration into the Holistic Material Basis Research of Traditional Chinese Medicine

This paper introduces a systems theory-driven framework to integration artificial intelligence(AI)into traditional Chinese medicine(TCM)research,enhancing the understanding of TCM’s holistic material basis while adhering to evidence-based principles.Utilizing the System Function Decoding Model(SFDM),the research progresses through define,quantify,infer,and validate phases to systematically explore TCM’s material basis.It employs a dual analytical approach that combines top-down,systems theory-guided perspectives with bottom-up,elements-structure-function methodologies,provides comprehensive insights into TCM’s holistic material basis.Moreover,the research examines AI’s role in quantitative assessment and predictive analysis of TCM’s material components,proposing two specific AIdriven technical applications.This interdisciplinary effort underscores AI’s potential to enhance our understanding of TCM’s holistic material basis and establishes a foundation for future research at the intersection of traditional wisdom and modern technology.

Antioxidant Activity of 50 Traditional Chinese Medicinal Materials Varies with Total Phenolics

This study was designed to determine the total phenolic content of 50 herbs and to examine their antioxidant potential. In the sample preparation, 60% ethanol was chosen as the extraction solvent for the subsequent experiments. Folin-Cicolteau phenol reagent and a colorimetric method were used to determine the total phenolic content of the selected herbs. The result showed that total phenolic content of those herbs ranged from 2 to 185 mg/g. In antioxidant assay, the ferric reducing/antioxidant power (FRAP) values ranged from 2 to 134 mg GAE/g;the IC50 values of DPPH?·, ·OH and ?scavenging were in the range of 0.06 - 5.50 mg/mL, 0.017 - 0.636 mg/mL and 0.050 - 0.681 mg/mL respectively. Flos caryophylli was the exceptant in the ?scavenging assay because there was no linear relation between the concentration and the scavenging percentage. Compared to gallic acid, ascorbic acid and butylated hydroxytoluene (BHT) in antioxidant assay as positive control, the most potential antioxidant herbs were Cacumen platycladi, Radix et Rhizoma rhei, Rhizoma rhodiolae crenulatae, and Rhizoma sanguisorbae with considerable content of phenolics. Especially, a positive and significant correlation was found between the total phenolic content and FRAP value or DPPH· scavenging percentage.

Reason Analysis and Risk Prevention of Soaring Price of Traditional Chinese Medicinal Materials

In recent years,the price of traditional Chinese medicinal materials soars continuously,and the resulting price risk increasingly looms large,which has critically affected midstream and downstream industries and peoples' demand for drug,and imperiled healthy and orderly development of traditional Chinese medicinal industries.Based on the status quo of continuous skyrocketing price of traditional Chinese medicinal materials at present,we winkle out the root cause of soaring price as follows:the supply and demand lose balance;the production costs hike up;there are other factors responsible for soaring price.This paper further analyses the impact of sharp increase in price of traditional Chinese medicinal materials on all links of industry chain as follows:the medicinal herb growers never benefit from soaring price;the counterfeiters and forgers in midstream industry increase;the gross profit rate of Chinese medicine enterprises declines.In accordance with the risk arising from abnormal fluctuation in price of traditional Chinese medicinal materials,corresponding precautionary measures are put forward as follows:promote the quality of traditional Chinese medicinal materials through management of value chain;curtail the production and management cost of traditional Chinese medicinal materials through management of organization chain;stabilize price of traditional Chinese medicinal materials through management of information chain;reduce transaction cost of traditional Chinese medicinal materials through management of logistics chain.

Problems in the Development of Traditional Chinese Medicinal Materials Planting Industry in Shiyan City and Countermeasures

Through the analysis on the cultivation advantages and development problems of traditional Chinese medicinal planting industry in Shiyan City, Hubei Province, some measures were proposed to enlarge and enhance the traditional Chinese medicinal planting industry, namely, large-scale, standardized, market-oriented and regionalized planting, thereby making it the pillar industry for farmers to increase income.

Analysis on the principles of differentiation and prescription of traditional Chinese medicine in the treatment of cancerous fever

To investigate the principles of differentiation and prescription of traditional Chinese medicine(TCM)treatment for cancerous fever by logistic stepwise regression and literature investigation,the following databases were searched(from inception to June 30th 2016):CNKI,CSPD,CBM,PubMed,MEDLINE,EMBASE.According to the inclusion and exclusion criteria,literatures about TCM in the treatment of cancerous fever were screened.The frequency about cancerous fever of differential syndrome types,formulas and herbs were analyzed by logistic multiple regression analysis.The model about syndrome types and formula application of cancerous fever was established.The result showed formula prescriptions used most frequently were Qing-Hao-Bie-Jia decoction,Xiao-Chai-Hu decoction,Xue-Fu-Zhu-Yu decoction,Bai-Hu decoction,San-Ren decoction.The main syndrome types of cancerous fever were as follows:Toxic heat flourishing type,Yin deficiency type,Stagnation of damp-heat type,Qi-Yin deficiency type,Liver meridian depressed-heat type,Blood stasis type and Yang deficiency type.Based on regression equation of the syndrome types,the corresponding herbs of this seven syndrome types were Radix Bupleuri,Radix Paeoniae Alba and Scutellaria Baicalensis Georgi;Radix Bupleuri and Cortex Moutan;Radix Paeoniae Rubra and Radix Angelicae Sinensis;Rhizoma Pinelliae,Cortex Lycii Radicis and Radix Paeoniae Alba;Herba Artemisiae Annuae,Gypsum Fibrosum and Poria Cocos;Rhizoma Anemarrhenae,Scutellaria Baicalensis Georgi and Radix Codonopsis;Radix Bupleuri respectively.The results of Logistic regression analysis and frequency of herbs statistics can provide reference for differentiation and treatment of cancerous fever in clinical.

An investigation on traditional Chinese medicine in Dublin Ireland

The traditional Chinese medicine chain arrived in Ireland in 2005. This study focused on the standardization and adaptation of TCM companies and the customer profile in Irish market. The objective of this research dissertation is to find that how TCM is learned in Irish market and how it faces different cultures.

Gaps and feasibility of fixed-dose combination strategy in the development of modern Chinese medicine

isTraditional Chinese medicine(TCM)is a highly complex chemical substance system,which not only reflected in the complexity of the chemical components and their interrelationships,but also in the intricacy of the prescription’s connection with the human body.Component compatibility strategy has been proposed for developing modern TCM since 2005 and established comprehensive relevant technologies and research approaches.Moreover,to meet the safety and efficacy of current pharmaceuticals,research on fixed-dose combination drugs is directed by modern scientific theories,conforms to TCM compatibility principles and clarifies material basis and pharmacological mechanisms and component-effect correlations.This review summarized gaps and feasibility of fixed-dose combination strategy in the development of modern TCM research and assessed their advantages and disadvantages in light of contemporary drug combination research practices.

辽宁省海城市中药资源调查与分析

目的 通过对辽宁省海城市中药资源的普查,掌握海城市药用植物资源现状及部分重点品种的蕴藏量,为海城市中药资源的保护及可持续开发利用提供理论参考。方法 以第四次《全国中药资源普查技术规范》要求为标准制定普查方案,采用传统野外调查与现代技术相结合的方法,对海城市药用植物资源进行调查及数据分析。结果研究共完成了36个样地、180个样方套、1080个样方的调查,调查到药用植物452种,涉及86科290属;其中2020版《中华人民共和国药典》收载的重点调查品种112种,辽宁省新纪录植物2种。结论 海城市药用植物资源较为丰富,县域内大部分中药物种种群处于稳定状态,少数种群呈减少趋势,政府应采取措施加强动态监测与保护,普查工作的开展有助于县域内中药文化知识的推广普及,亦为海城市中药资源的可持续发展及开发利用提供科学依据。

民国时期东北第一大药材集散地营口调查研究

全面收集清末、民国时期史志文献,民国出版图书、期刊、日报及日伪编纂汇编类文献,参考建国后出版文史资料中的口述文献,去伪存真,去粗取精,对民国时期东北地区起源最早、规模最大的中药材集散地营口发源、兴盛、凋敝、衰落之全过程加以调查研究;探究其成为东北第一大药材集散地的历史地理、交通、药材资源优势,重点讨论当地药材集散的种类、规模、变化规律和经营模式,了解其在民国独特社会进程和近代中医药学科发展影响下的时代特色,为尽可能全面客观认识民国中药产业史及民国药业探源溯流提供重要依据。

三全育人视域下中医学专业课程思政教学调查与探索

为了解中医学专业课程思政教学的开展情况,本文通过问卷调查广州中医药大学中医学专业课程思政开展的情况、教学效果、影响因素以及提升的方向。调查显示超过83%同学认为专业课程已经融入了课程思政教学,其教学效果得到了53%的同学肯定;不同课程之间,专业课课程思政对学生影响最大,课程思政教学效果受教师亲和力影响最大,其教学中还存在理论不能指导实践、教学方式单一等问题。提出从完善顶层设计,构建“大思政”格局、加强思政与中医药文化融合、丰富课程思政教学方式等方面进行提升。

中西医结合桥梁课程思政素材库的构建与实践

为落实立德树人根本任务,以中西医结合桥梁课程为例,系统介绍课程思政素材库构建思路,围绕政治素养、职业素养、科学素养、道德素养、文化素养5个素养挖掘思政元素,构建中西医结合桥梁课程思政素材库,以发挥出课程的育人功能,为培养高素质的中西医结合人才打下坚实基础。

葫芦岛地区中药材产业发展及装备需求分析

我国中药材种植业从播种到采收仍以传统的人工作业方式为主,劳动效率低下,会影响中药产业的长期健康稳定发展。阐述我国中药材产业发展及机械化配套现状,分析中药材机械化发展中存在的问题及其生产所需的配套装备,探讨中药材机械化的综合效益。

Bioactive constituents of animal-derived traditional Chinese medicinal materials for breast cancer:opportunities and challenges

Breast cancer is globally the most common invasive cancer in women and remains one of the leading causes of cancer-related deaths.Surgery,radiotherapy,chemotherapy,immunotherapy,and endocrine therapy are currently the main treatments for this cancer type.However,some breast cancer patients are prone to drug resistance related to chemotherapy or immunotherapy,resulting in limited treatment efficacy.Consequently,traditional Chinese medicinal materials(TCMMs)as natural products have become an attractive source of novel drugs.In this review,we summarized the current knowledge on the active components of animal-derived TCMMs,including Ophiocordyceps sinensis-derived cordycepin,the aqueous and ethanolic extracts of O.sinensis,norcantharidin(NCTD),Chansu,bee venom,deer antlers,Ostrea gigas,and scorpion venom,with reference to marked anti-breast cancer effects due to regulating cell cycle arrest,proliferation,apoptosis,metastasis,and drug resistance.In future studies,the underlying mechanisms for the antitumor effects of these components need to be further investigated by utilizing multi-omics technologies.Furthermore,large-scale clinical trials are necessary to validate the efficacy of bioactive constituents alone or in combination with chemotherapeutic drugs for breast cancer treatment.

山东省济南市钢城区中药资源现状调查及分析

为摸清山东省济南市钢城区中药资源分布现状,按照全国第四次中药资源普查的统一要求,通过野外调查、内业整理、数据分析等过程对钢城区野外药用植物资源的分布、中药材栽培等进行调查梳理。结果表明:钢城区现有野生中药资源180种,隶属于65科、151属,其中优势科有菊科、豆科、十字花科等,野生商陆、茜草、益母草的蕴藏量较大,野生中药资源中有69种被《中国药典》2020版收录;栽培品种丹参、黄芩、山楂、花椒、金银花、生姜的种植面积较大,其中白花丹参为地理标志性资源。本次资源普查对钢城区的野生药用植物资源种类和分布进行了全面了解,为区域性中药资源的开发利用以及中药产业可持续发展提供了科学依据。

中药有效成分结合骨组织工程材料用于骨修复

背景:如何修复骨缺损一直以来是临床难题,中药有效成分在骨修复方面具有良好的生物活性与治疗效果,将中药有效成分与组织工程材料相结合在骨修复领域具有广阔的前景。不同中药有效成分与支架的组合在作用关系方面具有相似之处。目的:搜集常见的中药有效成分与支架材料组合的案例,基于七情配伍的启发将组织工程支架与中药有效成分类比为产生配伍关系的两类中药,以二者的作用关系为纲进行归纳总结。方法:检索1998年1月至2024年1月Pub Med和中国知网数据库中发表的相关文献,英文检索词:“traditional Chinese medicine,Chinese medicine,traditional Chinese medicine monomers,bone defect,bone repair,bone tissue engineering,tissue engineering,scaffold”,中文检索词:“中药,中药有效成分,中药单体,骨组织工程,骨组织工程支架,支架,组织工程,骨缺损,骨修复”,最终纳入88篇文献进行综述分析。结果与结论:(1)组织工程支架材料与中药有效成分各自均在骨修复领域有广泛的运用,二者在成骨方面优势明显但仍有许多缺陷,许多研究致力于将二者制备成复合材料,希望通过二者间的相互作用发挥减毒增效作用。(2)一些药物与材料在成骨、抗菌、促血管生成方面能互相促进,增强原有的效果,受到传统方剂配伍观念的启发,文章将其归纳为“相须”关系,并举实例佐证。(3)一些药物能提高材料的强度,而某些材料能对负载于其上的药物实现缓释控释效果、增加载药量与稳定性,或是进行靶向递送,文章将这种单方面的提升效果归纳为“相使”关系。(4)一些中药与材料搭配使用能减少对方的毒副反应,文章将这种减毒关系归纳为“相畏相杀”。(5)文章得出了一个由七情配伍关系启发、基于作用关系分类的关于中药复合支架的全新视角,将中药传统观念引入组织工程领域,为后续复合支架的研究者提供新的研究思路,并在选材搭配方面提供一定的便利。

中药物质基础新形式及其药动/药效研究

中药作为中华民族的瑰宝,拥有悠久的历史和丰富的文化内涵。过去几百年,大量结构明确、活性显著、机制清楚的活性化合物被发现,其研究初步明晰了中药的效应物质基础。然而,中药的天然成分具有骨架多样性和结构复杂性,除了单体小分子化合物,近年来越来越多的研究发现中药存在发挥药效的物质基础新形式,如活性单体化合物形成的超分子,以及具有药理活性的生物大分子等。聚焦中药物质基础新形式,通过新技术、新机制、新应用的分析,以期为中药药效物质基础、药动/药效相关性研究提供新思路。

医务人员及患儿家长对儿童使用中成药风险的KAP调查研究

目的 调查医务人员及患儿家长对儿童使用中成药风险的知识-态度-行为(KAP)现状,分析两类人群对中成药知识掌握程度、用药态度及用药行为的异同,并通过“医-患”两个角度分析中成药用药风险的影响因素,以期更好地指导临床工作。方法 2023年7月至2023年11月,以首都儿科研究所附属儿童医院(以下简称“我院”)及外院医务工作人员,以及在我院就诊过且服用过中成药的患儿家长为调查对象,通过问卷星发放并回收问卷,分析医务人员及患儿家长对儿童使用中成药风险KAP得分情况,采用Logistic回归对使用中成药KAP得分的影响因素进行分析,并通过Spearman分析探讨中成药用药知识、态度、行为之间的相关性。结果 医务人员版问卷共收集有效问卷339份(有效回收率98.83%),医务人员中成药用药知识、态度和行为评分优秀者分别占16.22%、7.08%和83.19%。患儿家长版共收集有效问卷336份(有效回收率98.82%),患儿家长中成药用药知识、态度和行为评分优秀者分别占25.87%、3.57%和30.65%。Logistic回归分析显示,不同医院所在地、受教育程度是医务人员KAP的重要影响因素,患儿家长的年龄、受教育程度、工作状况、职业和月收入是患儿家长KAP的重要影响因素(P<0.05)。Spearman相关分析结果显示用药知识、态度和行为3个维度之间呈显著正相关(P<0.01)。结论 医务人员和患儿家长的中成药用药知识和用药态度均有待进一步提高,患儿家长需特别注意规范用药行为,从而降低儿童使用中成药的风险。医师和药师可结合本研究结果针对患儿家长开展适宜的中成药知识普及和科普宣传工作。

利用现代技术解析中医药防治脑病的机制及转化研究思考

脑病是严重危害人类身心健康的重大疾病,具有发病率高、致死致残率高、负担率高的特点。目前西医治疗脑病主要使用药物控制其症状,但存在副作用明显且易耐受等缺陷。中医药对于脑病的防治优势明显,基于“未病先防”“异病同治”等辨治理念已经形成了体现中医药优势的诊疗方案。虽然中医药对于一些优势病种具有较好的疗效,但由于相对匮乏的现代化机制阐释,使得中医药防治脑病的传承、创新和国际化仍面临着较大的挑战。本文结合现代科学研究的视角,分别从中医脑病理论的现代化机制阐释、“经典名方”的物质基础及效应机制解析、针灸治脑病的机制探索以及中药新药新疗法的转化开发几个维度,对中医药防治脑病现代化研究的潜在路径进行了思考和论述。

小檗碱促进骨再生的机制、安全性及在骨组织工程中的应用

背景:小檗碱具有诱导各种间充质干细胞在正常状态和高糖、感染及炎症等特殊状态下成骨分化的潜力,可替代生长因子诱导种子细胞成骨,是一种具有骨诱导潜力的天然小分子药物,在骨组织工程领域有着巨大的应用前景。目的:回顾和总结小檗碱成骨机制及效能,尤其是在高糖、感染及炎症环境下的成骨潜力,以及小檗碱生物安全性方面的研究进展,为其在骨组织工程中的发展应用提供理论依据。方法:在PubMed、万方及中国知网数据库,以英文检索词“berberine,bone defects,bone repair,bone regeneration,osteoinductive,osteoporosis,osteoblast,osteoclast,bone tissue engineering,bone,high glucose,diabetes,inflam*,infect*”,中文检索词“黄连素,小檗碱,骨缺损,骨修复,骨再生,骨诱导,骨质疏松,成骨细胞,破骨细胞,骨组织工程,骨,高糖,糖尿病,炎症,感染”进行文献检索,最终筛选后纳入105篇文献进行综述。结果与结论:(1)小檗碱能用于治疗包括骨病在内的多种疾病,其具有促进骨再生作用,文章系统综述了小檗碱对骨再生作用机制及体内外研究。(2)研究表明小檗碱能够通过促骨生成、抑制破骨细胞形成及其活性、抗骨质疏松等方面发挥骨修复作用,主要通过参与Wnt/β-catenin,PI3K/AKT,EGFR/MEK/p38MAPK,cAMP/PKA/CREB和ERK等信号通路,表现出优异的成骨诱导分化潜力。(3)小檗碱还可以解除因高糖、感染及炎症引起的细胞成骨分化抑制,这为治疗患有糖尿病的骨缺损患者或骨缺损部位有感染及炎症的患者提供了更多可能。(4)小檗碱还具有毒性小、价格低廉和易于获取(目前已经能够人工合成)等优点,是较为理想的骨诱导潜力药物。(5)近年来应用小檗碱治疗骨缺损趋于局部使用,主要通过与骨组织工程技术结合改善生物利用度,在动物实验中表现出良好的骨修复作用和生物安全性,而且临床前实验表明,小檗碱在糖尿病、局部感染及炎症状态下仍然表现出优秀的骨再生潜力。(6)未来还需要更多的研究完整地揭示小檗碱的成骨机制和生物安全性等问题,并寻求最合适的控释载体制作出机械强度、疗效及生物安全性均佳的人工骨替代材料。

天然产物抗肺癌作用及其机制的研究进展

目的总结天然产物抗肺癌的机制,为候选治疗肺癌新的前瞻性药物提供理论基础。方法利用肺癌、中药、药理学及其组合等关键词,收集中国知网、万方、维普、PubMed、Science Direct和Web of science等数据库有关天然产物抗肺癌作用研究的文章,并进行总结。结果中医药治疗肺癌优势明显,具有药理机制新颖、毒性低、不良反应小的特点,可增效减毒、提高患者生活质量。天然产物主要包括黄酮类、生物碱类、多糖类、萜类、皂苷类和酚类,具有抑制肿瘤细胞周期、抑制增殖、诱导凋亡、促进自噬、抑制肿瘤细胞侵袭和转移的作用;天然产物与细胞毒性药物联合使用,可以增强疗效或降低耐药性,延缓肺癌的进展,延长患者的生存时间。结论中药含有多种黄酮、生物碱、萜及其苷类、多酚和其他可有效对抗肺癌的活性化合物,适合作为治疗肺癌的候选药物。