The landscape of investigator‐initiated oncology trials conducted in China's Mainland during the past decade(2010–2019)

The number of clinical trials conducted in China's Mainland,including investigator‐initiated trials(IITs),has increased rapidly in recent years.However,there are few data on the characteristics of cancer‐related IITs.We performed a comprehensive analysis of the landscape of cancer‐related IITs in China's Mainland in the past decade.All cancer‐related IITs registered on two clinical trial registries in the United States(www.clinicaltrials.gov,CT.gov)and China's Mainland(www.chictr.org.cn,ChiCTR)from 2010 to 2019 were identified.IITs were reviewed manually to validate classification,subcategorized by cancer type,and stratified by design characteristics to facilitate comparison across cancer types and with other specialties.A total of 8199 cancer‐related IITs were identified.The number of trials registered annually increased over time,especially in the last 5 years.Although interventional studies were predominant,randomized double‐blind studies accounted for only 8%of IITs.In the past decade,the trend for interventional studies conducted with different drugs increased year on year,although the increase in hormonal therapy IITs was not significant.Additionally,cancerrelated IITs were unevenly geographically distributed,with half concentrated in the economically developed cities Shanghai,Beijing,and Guangdong.We also found an increase in registration before participant enrollment(64.9%for trials in conducted in 2015–2019 vs.40.2%in 2010–2014,p<0.001)and data monitoring committee use(44.5%vs.40.0%,p=0.001)and a decrease in randomization(51.5%vs.62.7%,p<0.001)and funding(36.4%vs.56.3%,p<0.001)between these periods.We also observed changes in intervention type(decrease in cytotoxic drug therapy[34.8%vs.48.9%,p<0.001];increase in targeted therapy[17.8%vs.14.2%,p=0.004],immune checkpoint inhibitor therapy[6.6%vs.0.0%,p<0.001],and immune cell therapy[9.6%vs.4.5%,p<0.001]).Details of cancer‐related IITs conducted during the past decade illustrate the merits of oncology research in China's Mainland.Although the increased quantity of IITs is encouraging,limitations remain regarding the quality of clinical trials,regional imbalances,and funding allocation.

Investigation on the Initial Stage of Film Growth in Situ

The initial stage of Ag film growth on Cu(100). Ta(100) and Ta(110) single crystals as well as YBaCuO on Si single crystal covered by Pd was investigated in situ by means of LAS 600 surface analysis system with a sputtering source in sample preparation chamber. The results show that the initial state for Ag / Cu(100) film growth is typical S-K model, for Ag / Ta(100) and Ag / Ta(110)they have the same S-K characteristics, but due to the different surface energies of two crystalline planes. there is some difference for Ag / Ta (100) and Ag / Ta(110). YBCO sputterjng process is rather complex and Cu is the first element appearing in the film.