Large amounts of carbon dioxide(CO2) should be injected in deep saline formations to mitigate climate change,implying geomechanical challenges that require further understanding.Pressure build-up induced by CO2injecti...Large amounts of carbon dioxide(CO2) should be injected in deep saline formations to mitigate climate change,implying geomechanical challenges that require further understanding.Pressure build-up induced by CO2injection will decrease the effective stresses and may affect fault stability.Geomechanical effects of overpressure induced by CO2injection either in the hanging wall or in the foot wall on fault stability are investigated.CO2injection in the presence of a low-permeable fault induces pressurization of the storage formation between the injection well and the fault.The low permeability of the fault hinders fluid flow across it and leads to smaller overpressure on the other side of the fault.This variability in the fluid pressure distribution gives rise to differential total stress changes around the fault that reduce its stability.Despite a significant pressure build-up induced by the fault,caprock stability around the injection well is not compromised and thus,CO2leakage across the caprock is unlikely to happen.The decrease in fault stability is similar regardless of the side of the fault where CO2is injected.Simulation results show that fault core permeability has a significant effect on fault stability,becoming less affected for high-permeable faults.An appropriate pressure management will allow storing large quantities of CO2without inducing fault reactivation.展开更多
Portal water injection sheet pile (PWISP), as a retaining wall, appeared in seashore engineering in 2000. Although there have been many systematic methods addressing the issue, there are very few focusing on the new s...Portal water injection sheet pile (PWISP), as a retaining wall, appeared in seashore engineering in 2000. Although there have been many systematic methods addressing the issue, there are very few focusing on the new structure because of the difficulties in defining the earth pressure between the two piles. A new method is proposed in this paper to obtain the earth pressure between the PWISPs. Stability analysis against overturning follows as a consequence. Using Finite Element Analysis (FEA) software ANSYS, both the nonlinear characteristics of the soil and those of the contact elements are taken into account to obtain the earth pressure distribution on the contact surface. Based on the results of the FEA, Rankin’s theory and the slip plane theory, the formula of the earth pressure on the inner surfaces between the piles is given. Assuming the PWISP as the analysis object and the earth pressure as an outside force acting upon it, the equation of stability against overturning of the PWISP is presented. Finally, some parameters are discussed about the stability of the PWISP against overturning, such as the embedded depth of the front pile, the distance between the two rows of piles, the internal friction angle and the cohesion of the earth. The results show that the increase of the cohesion and the internal friction angle will decrease the distance and the embedded depth, and therefore enhance the stability against overturning. Specifically, when the distance is 1/3-2/3 of the maximal excavation depth, the two rows of piles give the best performance in stability.展开更多
The change of drug quality of Yuxingcao injection after formulation is considered as one of the causes for adverse reactions. In this study, orthogonal experimental design was used to investigate the influencing facto...The change of drug quality of Yuxingcao injection after formulation is considered as one of the causes for adverse reactions. In this study, orthogonal experimental design was used to investigate the influencing factors on the pH stability of Yuxingcao injection. Two methods of accelerated tests were carried out in the experiments. The results showed that using Tween 80 as the solubilizer could significantly decrease the pH value of Yuxingcao injection after accelerated tests. There was no significant difference in the pH value after the accelerated tests when the other 6 factors varied, including the type of liquid processed, the dosage of activated carbon, heating temperature, reagents for pH adjustment, pH value range after adjustment, and sterilization conditions. In order to improve the quality stability of Yuxingcao injection, the quality of Tween 80 should be strictly controlled to minimize the change of pH value of Yuxingcao injection.展开更多
In recent years,China has attached great importance to the work of traditional Chinese medicine(TCM),more and more Chinese patent medicines are included in the national medical insurance catalogue,and the clinical app...In recent years,China has attached great importance to the work of traditional Chinese medicine(TCM),more and more Chinese patent medicines are included in the national medical insurance catalogue,and the clinical application of TCM injections is also increasing.This article reviews a total of 20 literature reports on the compatibility of fructose injections with TCM injections from 2005 to the present,and evaluates the stability based on the appearance,pH,insoluble particles and content changes after compatibility,and provides for the rational use of fructose injections.Theoretical evidence provides options for special patients with special solvent limit.展开更多
Objective:The clinical treatment of brain diseases is urgent. Xingnaojing (XNJ) injection is often used in combination with other injection drugs. Due to the possible interaction between the injections in vivo, the pa...Objective:The clinical treatment of brain diseases is urgent. Xingnaojing (XNJ) injection is often used in combination with other injection drugs. Due to the possible interaction between the injections in vivo, the particle size, osmotic pressure, pH value change and component stability decrease, that is one of the important factors causing various adverse reactions. Based on the above situation, this study investigated the physical properties and chemical composition changes of XNJ injection and its compatibility solvent and 13 kinds of clinical injection, speculated the possible interactions between the drugs in vivo from the perspective of in vitro compatibility stability, find out the safety risks of adverse reactions and provide guidance for the safe and rational use of XNJ injection. Methods:According to the clinical application, XNJ injection was mixed with 13 combination injections based on 250 mL 5% glucose injection, and placed at room temperature for 6 h. Then, the clarity, particle size, pH, osmolality, and the contents of camphor, d-borneol, and muscone of the compatible solutions were detected at 0, 1, 2, 4, and 6 h, respectively. Results:The results showed that the physical-chemical properties of compatibility solution were slightly influenced when XNJ was combined with Alprostadil injection and Danhong injection. The change of particle size and the degradation of muscone content were the main factors affecting the compatibility stability of XNJ injection, indicating that there are some problems in compatibility stability, which may be one of the causes of clinical adverse reactions. Conclusion:This study suggests that XNJ injection in combination with other injections during intravenous administration should be performed cautiously.展开更多
Safflower is a popular Chinese medicinal plant and Safflower injection is extensively used for the clinical treatment of cerebrovascular and cardiovascular diseases. In this study, HPLC-DAD-ESI-MSn was utilized to stu...Safflower is a popular Chinese medicinal plant and Safflower injection is extensively used for the clinical treatment of cerebrovascular and cardiovascular diseases. In this study, HPLC-DAD-ESI-MSn was utilized to study the stability and degradation of the two major but chemically unstable bioactive compounds hydroxysaffior yellow A and anhydrosaffior yellow B, in Safflower injection. The impact of light irradiation, temperature, and pH on the stability of these two compounds were studied. The results showed that hydroxysafflor yellow A and anhydrosafflor yellow B could degrade at high temperature (〉60 ℃) or extreme pHs (pH ≤ 3.0 or 〉7.0), but not under light irradiation. The common degradation product was p-coumaric acid. Chemical structures of the other degradation products were characterized by LC-MS. Hypothetical degradation pathways were proposed. In addition, ADP-induced platelet aggregation tests showed that the degradation of anhydrosaffior yellow B could reduce the anticoagulation activities of Safflower injection. Our results suggest that temperature and pH are critically important for the preparation and storage of Safflower injection.展开更多
Based on A356 aluminum alloy,aluminum foams were prepared by gas injection foaming process with pure nitrogen,air and some gas mixtures.The oxygen volume fraction of these gas mixtures varied from 0.2%to 8.0%.Optical ...Based on A356 aluminum alloy,aluminum foams were prepared by gas injection foaming process with pure nitrogen,air and some gas mixtures.The oxygen volume fraction of these gas mixtures varied from 0.2%to 8.0%.Optical microscopy,scanning electron microscopy(SEM) and Auger electron spectroscopy(AES) were used to analyze the influence of oxygen content on cell structure,relative density,macro and micro morphology of cell walls,coverage area fraction of oxide film,thickness of oxide film and other aspects.Results indicate that the coverage area fraction of oxide film on bubble surface increases with the increase of oxygen content when the oxygen volume is less than 1.2%.While when the oxygen volume fraction is larger than 1.6%,an oxide film covers the entire bubble surface and aluminum foams with good cell structure can be produced.The thicknesses of oxide films of aluminum foams produced by gas mixtures containing 1.6%-21%oxygen are almost the same.The reasons why the thickness of oxide film nearly does not change with the variation of oxygen content and the amount of oxygen needed to achieve 100%coverage of oxide film are both discussed.In addition,the role of oxide film on bubble surface in foam stability is also analyzed.展开更多
Here,this work presents an air-stable ultrabright inverted organic lightemitting device(OLED)by using zinc ionchelated polyethylenimine(PEI)as electron injection layer.The zinc chelation is demonstrated to increase th...Here,this work presents an air-stable ultrabright inverted organic lightemitting device(OLED)by using zinc ionchelated polyethylenimine(PEI)as electron injection layer.The zinc chelation is demonstrated to increase the conductivity of the PEI by three orders of magnitude and passivate the polar amine groups.With these physicochemical properties,the inverted OLED shows a record-high external quantum efficiency of 10.0% at a high brightness of 45,610 cd m^(-2) and can deliver a maximum brightness of 121,865 cd m^(-2).Besides,the inverted OLED is also demonstrated to possess an excellent air stability(humidity,35%)with a half-brightness operating time of 541 h@1000 cd m^(-2) without any protection nor encapsulation.展开更多
Carbon dots(CDs)show great potential as a new type of oil-displacing agent for unconventional oil and gas development.However,the instability and easy aggregation epitomize the challenges that accompany the applicatio...Carbon dots(CDs)show great potential as a new type of oil-displacing agent for unconventional oil and gas development.However,the instability and easy aggregation epitomize the challenges that accompany the application of CDs in high temperature and high salinity(HT/HS)reservoirs.In this research,novel benzene sulfonate-modified carbon dots(BS-CDs)with remarkable thermal stability and salt resistance were fabricated through an in-situ electrochemical exfoliation method.Molecular simulation verifies that the introduction of benzene sulfonate groups substantially strengthens the electrostatic repulsion between BS-CDs,leading to outstanding dispersibility and stability even at a temperature of 100℃ and salinity of 14×10^(4) mg/L.Core flooding tests show that 0.05 wt.%BS-CDs nanofluid can significantly reduce the water injection pressure by 50.00%and enhanced oil recovery(EOR)to 68.39%under HT/HS conditions.According to the atomic force microscopy(AFM)scanning results,the adhesion force between the core(after BS-CDs treatment)and oil decreased by 11.94 times,indicating that the hydrophilicity of the core surface was increased.In addition,the distribution of the adhesion force curve is more concentrated,which means that the micro-scale wettability of the core changes from oil-wet to more homogeneous water-wet.This study provides a feasible way for the development and application of good thermal stability and salt resistance CDs in unconventional reservoir development.展开更多
Purpose The high energy photon source(HEPS)uses the on-axial injection scheme.There are two designs in this injection scheme that are critical to the performance of the HEPS injection system.One is the strip line kick...Purpose The high energy photon source(HEPS)uses the on-axial injection scheme.There are two designs in this injection scheme that are critical to the performance of the HEPS injection system.One is the strip line kicker and another is the high voltage fast pulse power supply system.In the high voltage fast pulse power supply system,the design of high voltage power supply is very important.The output voltage stability of high voltage power supply directly affects the stability of the pulse amplitude of the injection system.Methods A high voltage power supply with high output voltage stability is designed in this paper,and the scheme is given.The correctness of the design scheme is verified by simulation experiments.Result A prototype is built for full test.The test results showed that the output voltage stability is lower than 58 ppm.The output voltage is 6.4 mV(f≤3 kHz)/113.2 mV(f>3 kHz).Conclusions The designed high voltage power supply can fully meet the requirements of the HEPS injection system.展开更多
Gasoline compression ignition (GCI) is one of the most promising combustion concepts to maintain low pollutant emissions and high efficiency. However, low load combustion stability and firing in cold-start operations ...Gasoline compression ignition (GCI) is one of the most promising combustion concepts to maintain low pollutant emissions and high efficiency. However, low load combustion stability and firing in cold-start operations are two major challenges for GCI combustion. Strategies including negative valve overlap (NVO), advanced injection strategies, fuel reforming, and intake preheating have been proposed in order to solve these difficulties;however, the cold start is still an obstacle. The objective of this work is to study effective methods to achieve GCI engine cold start-up. This work combines NVO, in-cylinder fuel reforming, and intake preheating to achieve quick firing under cold-start conditions and the subsequent warmup conditions. The results show that start of injection (SOI) during the intake stroke yields the best fuel economy, and injection during the compression stroke has the potential to extend the low load limit. Furthermore, SOI during the NVO period grants the ability to operate under engine conditions with cold intake air and coolant. With highly reactive products made by in-cylinder fuel reforming and fast heat accumulation in the combustion chamber, the NVO injection strategy is highly appropriate for GCI firing. An additional assisted technical method, such as intake preheating, is required to ignite the first firing cycle for a cold-start process. With the combination of NVO, in-cylinder fuel reforming, and intake preheating, the GCI engine successfully started within five combustion cycles in the experiment. After the firing process, the engine could stably operate without further intake preheating;thus, this method is appropriate for engine cold-start and warm-up.展开更多
A flat thin TiO2 film was employed as the photo-electrode of a dye sensitized solar cell (DSSC), on which only a geometrical mono-layer of dye was attached. The effect of sur- face protonation by HCI chemical treatm...A flat thin TiO2 film was employed as the photo-electrode of a dye sensitized solar cell (DSSC), on which only a geometrical mono-layer of dye was attached. The effect of sur- face protonation by HCI chemical treatment on the performance of DSSCs was studied. The results showed that the short-circuit current Jsc increased significantly upon the HCI treatment, while the open-circuit voltage Voc decreased slightly. Compared to the untreated DSSC, the Jsc and energy conversion efficiency was increased by 31% and 25%, respectively, for the 1 mol/L HCI treated cell. TiO2 surface protonation improved electronic coupling between the chemisorbed dye and the TiO2 surface, resulting in an enhanced electron in- jection. The decreased open-circuit voltage after TiO2 surface protonation was mainly due to the TiO2 conduction band edge downshift and was partially caused by increased electron recombination with the electrolyte. In situ Raman degradation study showed that the dye stability was improved after the TiO2 surface protonation. The increased dye stability was contributed by the increased electron injection and electron back reaction with the electrolyte under the open-circuit condition.展开更多
This paper analyses the effects of small injection/suction Reynolds number, Hartmann parameter, permeability parameter and wave number on a viscous incompressible electrically conducting fluid flow in a parallel porou...This paper analyses the effects of small injection/suction Reynolds number, Hartmann parameter, permeability parameter and wave number on a viscous incompressible electrically conducting fluid flow in a parallel porous plates forming a channel. The plates of the channel are parallel with the same constant temperature and subjected to a small injection/suction. The upper plate is allowed to move in flow direction and the lower plate is kept at rest. A uniform magnetic field is applied perpendicularly to the plates. The main objective of the paper is to study the effect of the above parameters on temporal linear stability analysis of the flow with a new approach based on modified Orr-Sommerfeld equation. It is obtained that the permeability parameter, the Hartmann parameter and the wave number contribute to the linear temporal stability while the small injection/suction Reynolds number has a negligible effect on the stability.展开更多
This paper mainly investigates the security problem of a networked control system based on a Kalman filter.A false data injection attack scheme is proposed to only tamper the measurement output,and its stealthiness an...This paper mainly investigates the security problem of a networked control system based on a Kalman filter.A false data injection attack scheme is proposed to only tamper the measurement output,and its stealthiness and effects on system performance are analyzed under three cases of system knowledge held by an attacker and a defender.Firstly,it is derived that the proposed attack scheme is stealthy for a residual-based detector when the attacker and the defender hold the same accurate system knowledge.Secondly,it is proven that the proposed attack scheme is still stealthy even if the defender actively modifies the Kalman filter gain so as to make it different from that of the attacker.Thirdly,the stealthiness condition of the proposed attack scheme based on an inaccurate model is given.Furthermore,for each case,the instability conditions of the closed-loop system under attack are derived.Finally,simulation results are provided to test the proposed attack scheme.展开更多
Parametric study of tip injection was implemented experimentally on a subsonic axial flow compressor to understand the underlying flow mechanisms of stability improvement of the compressor with discrete tip injection....Parametric study of tip injection was implemented experimentally on a subsonic axial flow compressor to understand the underlying flow mechanisms of stability improvement of the compressor with discrete tip injection.Injector throat height varied from 2 to 6 times the height of rotor tip clearance,and circumferential coverage percentage ranged from 8.3% to 25% of the annulus.Static pressure fluctuations over the rotor tip were measured with fast-response pressure transducers.Whole-passage time-accurate simulations were also carried out to help us understand the flow details.The combinations of tip injection with traditional casing treatments were experimentally studied to generate an engineering-acceptable method of compressor stall control.The results indicate that the maximum stability improvement is achieved when injectors are choked despite their different sizes.The effect of circumferential coverage percentage on compressor stability depends on the value of injector throat height for un-choked injectors,and vice versa.Tip blockage in the blade passage is greatly reduced by the choked injectors,which is the primary reason for stability enhancement.The accomplishment of blockage diminishment is maintained in the circumferential direction with the unsteady effect of tip injection,which manifests as a hysteresis between the recovery of tip blockage and the recovery of tip leakage vortex.The unsteady effect is primarily responsible for the effectiveness of tip injection with a partial circumferential coverage.Tip injection cannot enhance the stability of the rotor with axial slots significantly,but it can improve the stability of the rotor with circumferential grooves further.The combined structure of tip injection with circumferential grooves is an alternative for engineering application.展开更多
The power conversion efficiency(PCE)of polymer solar cells(PSCs)has exceeded 19%due to the rapid progress of photoactive organic materials,including conjugated polymer donors and the matched non-fullerene acceptors(NF...The power conversion efficiency(PCE)of polymer solar cells(PSCs)has exceeded 19%due to the rapid progress of photoactive organic materials,including conjugated polymer donors and the matched non-fullerene acceptors(NFAs).Due to the high density of oxygen vacancies and the consequent photocatalytic reactivity of ZnO,structure inverted polymer solar cells with the ZnO electron transport layer(ETL)usually suffer poor device photostability.In this work,the eco-friendly glucose(Glu)is found to simultaneously improve the efficiency and stability of polymer:NFA solar cells.Under the optimal conditions,we achieved improved PCEs from 14.77%to 15.86%for the PM6:Y6 solar cells.Such a PCE improvement was attributed to the improvement in J_(SC) and FF,which is ascribed to the smoother and more hydrophobic surface of the ZnO/Glu surface,thereby enhancing the charge extraction efficiency and inhibiting charge recombination.Besides,UV-Vis absorption spectra analysis revealed that glucose modification could significantly inhibit the photodegradation of Y6,resulting in a significant improvement in the stability of the device with 92%of its initial PCE after aging for 1250 h.The application of natural interface materials in this work brings hope for the commercial application of organic solar cells and provides new ideas for developing new interface materials.展开更多
The adaptive feedback control of stability with circumferential inlet distortion has been experimentally investigated in a low-speed,axial compressor.The flat-baffles with different span heights are used to simulate d...The adaptive feedback control of stability with circumferential inlet distortion has been experimentally investigated in a low-speed,axial compressor.The flat-baffles with different span heights are used to simulate different distorted inflow cases.Compared with auto-correlation and root-mean-square analysis,cross-correlation analysis used to predict early stall warning does not depend on the distortion position.Hence,the cross-correlation coefficient was used to monitor the stable status of the compressor and provide the feedback signal in the active control strategy when suffering from different distortions.Based on the stall margin improvement of tip air injection obtained under different distorted inflow cases and the sensitivity analysis of cross-correlation coefficients to injected momentum ratios,tip air injection was adopted as the actuator for adaptive feedback control.The digital signal processing controller was designed and applied to achieve adaptive feedback control in distorted inflow conditions.The results show that the adaptive feedback control of air injection nearly achieves the same stall margin improvement as steady air injection under different distortion intensities with a reduced injection mass flow.Thus,the proposed adaptive feedback control method is ideal for the engine operation with circumferential distorted inflow,which frequently occurs in flight.展开更多
High time-stability performance of the injection kicker system is important for the Beijing Electron Positron Collider Upgrade Project (BEPCⅡ),with jitter and drift less than±5ns.In order to compensate the delay...High time-stability performance of the injection kicker system is important for the Beijing Electron Positron Collider Upgrade Project (BEPCⅡ),with jitter and drift less than±5ns.In order to compensate the delay time drift of thyratron on the kicker pulsed power supply,a drift stabilizer is developed.The test results meet the demand of design by regulation resolution=1ns,jitter+drift<2ns in 8 hours.The detailed design of the time-drift stabilizer will be described in this paper.展开更多
Let X, Y be two real Banach spaces and ε≥0. A map f : X → Y is said to be a standard ε-isometry if│││f/(x) - f(y)││ - ]ix - Y││x-y││ ε for all x,y C X and with f(O) = O. We say that a pair of Ban...Let X, Y be two real Banach spaces and ε≥0. A map f : X → Y is said to be a standard ε-isometry if│││f/(x) - f(y)││ - ]ix - Y││x-y││ ε for all x,y C X and with f(O) = O. We say that a pair of Banach spaces (X, Y) is stable if there exists γ〉 0 such that, for every such ε and every standard v-isometry f : X → Y, there is a bounded linear operator T : L(f) → f(X) → X so that ││Tf(x) - x││ ≤γε for all x E X. X(Y) is said to be universally left-stable if (X, Y) is always stable for every Y(X). In this paper, we show that if a dual Banach space X is universally left-stable, then it is isometric to a complemented w*-closed subspace of ∞ (1) for some set F, hence, an injective space; and that a Banach space is universally left-stable if and only if it is a cardinality injective space; and universally left-stability spaces are invariant.展开更多
Let f∈C^1(R^2, R^2), f(0)=0. The Jacobian Conjecture states that if for any x∈R^2, the eigenvalues of the Jacobian matrix Df(x) have negative real parts, then the zero solution of the differential equation x=f(x) is...Let f∈C^1(R^2, R^2), f(0)=0. The Jacobian Conjecture states that if for any x∈R^2, the eigenvalues of the Jacobian matrix Df(x) have negative real parts, then the zero solution of the differential equation x=f(x) is globally asymptotically stable. In this paper we prove that the conjecture is true.展开更多
基金the support from the"EPFL Fellows"fellowship program co-funded by Marie Curie,FP7(Grant No.291771)partial support from the"TRUST"project of the European Community's Seventh Framework Programme FP7/2007-2013(Grant No.309607)+2 种基金the"FracRisk"project of the European Community's Horizon 2020 Framework Programme H2020-EU.3.3.2.3(Grant No.640979)sponsored by SCCER-SoE(Switzerland)(Grant No.KTI.2013.288)Swiss Federal Office of Energy(SFOE)project CAPROCK(Grant No.810008154)
文摘Large amounts of carbon dioxide(CO2) should be injected in deep saline formations to mitigate climate change,implying geomechanical challenges that require further understanding.Pressure build-up induced by CO2injection will decrease the effective stresses and may affect fault stability.Geomechanical effects of overpressure induced by CO2injection either in the hanging wall or in the foot wall on fault stability are investigated.CO2injection in the presence of a low-permeable fault induces pressurization of the storage formation between the injection well and the fault.The low permeability of the fault hinders fluid flow across it and leads to smaller overpressure on the other side of the fault.This variability in the fluid pressure distribution gives rise to differential total stress changes around the fault that reduce its stability.Despite a significant pressure build-up induced by the fault,caprock stability around the injection well is not compromised and thus,CO2leakage across the caprock is unlikely to happen.The decrease in fault stability is similar regardless of the side of the fault where CO2is injected.Simulation results show that fault core permeability has a significant effect on fault stability,becoming less affected for high-permeable faults.An appropriate pressure management will allow storing large quantities of CO2without inducing fault reactivation.
文摘Portal water injection sheet pile (PWISP), as a retaining wall, appeared in seashore engineering in 2000. Although there have been many systematic methods addressing the issue, there are very few focusing on the new structure because of the difficulties in defining the earth pressure between the two piles. A new method is proposed in this paper to obtain the earth pressure between the PWISPs. Stability analysis against overturning follows as a consequence. Using Finite Element Analysis (FEA) software ANSYS, both the nonlinear characteristics of the soil and those of the contact elements are taken into account to obtain the earth pressure distribution on the contact surface. Based on the results of the FEA, Rankin’s theory and the slip plane theory, the formula of the earth pressure on the inner surfaces between the piles is given. Assuming the PWISP as the analysis object and the earth pressure as an outside force acting upon it, the equation of stability against overturning of the PWISP is presented. Finally, some parameters are discussed about the stability of the PWISP against overturning, such as the embedded depth of the front pile, the distance between the two rows of piles, the internal friction angle and the cohesion of the earth. The results show that the increase of the cohesion and the internal friction angle will decrease the distance and the embedded depth, and therefore enhance the stability against overturning. Specifically, when the distance is 1/3-2/3 of the maximal excavation depth, the two rows of piles give the best performance in stability.
文摘The change of drug quality of Yuxingcao injection after formulation is considered as one of the causes for adverse reactions. In this study, orthogonal experimental design was used to investigate the influencing factors on the pH stability of Yuxingcao injection. Two methods of accelerated tests were carried out in the experiments. The results showed that using Tween 80 as the solubilizer could significantly decrease the pH value of Yuxingcao injection after accelerated tests. There was no significant difference in the pH value after the accelerated tests when the other 6 factors varied, including the type of liquid processed, the dosage of activated carbon, heating temperature, reagents for pH adjustment, pH value range after adjustment, and sterilization conditions. In order to improve the quality stability of Yuxingcao injection, the quality of Tween 80 should be strictly controlled to minimize the change of pH value of Yuxingcao injection.
基金This study was supported by grants from the National Natural Science Foundation of China(Grant No.81801175)the China Postdoctoral Science Foundation(Grant No.2019M662179)+1 种基金the Anhui Province Postdoctoral Science Foundation(Grant No.2019B324)the Fundamental Research Funds for the Central Universities(Grant No.WK9110000044).
文摘In recent years,China has attached great importance to the work of traditional Chinese medicine(TCM),more and more Chinese patent medicines are included in the national medical insurance catalogue,and the clinical application of TCM injections is also increasing.This article reviews a total of 20 literature reports on the compatibility of fructose injections with TCM injections from 2005 to the present,and evaluates the stability based on the appearance,pH,insoluble particles and content changes after compatibility,and provides for the rational use of fructose injections.Theoretical evidence provides options for special patients with special solvent limit.
文摘Objective:The clinical treatment of brain diseases is urgent. Xingnaojing (XNJ) injection is often used in combination with other injection drugs. Due to the possible interaction between the injections in vivo, the particle size, osmotic pressure, pH value change and component stability decrease, that is one of the important factors causing various adverse reactions. Based on the above situation, this study investigated the physical properties and chemical composition changes of XNJ injection and its compatibility solvent and 13 kinds of clinical injection, speculated the possible interactions between the drugs in vivo from the perspective of in vitro compatibility stability, find out the safety risks of adverse reactions and provide guidance for the safe and rational use of XNJ injection. Methods:According to the clinical application, XNJ injection was mixed with 13 combination injections based on 250 mL 5% glucose injection, and placed at room temperature for 6 h. Then, the clarity, particle size, pH, osmolality, and the contents of camphor, d-borneol, and muscone of the compatible solutions were detected at 0, 1, 2, 4, and 6 h, respectively. Results:The results showed that the physical-chemical properties of compatibility solution were slightly influenced when XNJ was combined with Alprostadil injection and Danhong injection. The change of particle size and the degradation of muscone content were the main factors affecting the compatibility stability of XNJ injection, indicating that there are some problems in compatibility stability, which may be one of the causes of clinical adverse reactions. Conclusion:This study suggests that XNJ injection in combination with other injections during intravenous administration should be performed cautiously.
基金Changjiang Scholar and Innovative Research Team in University (Grant No. 985-2-063-112)Youth Research Fellowship of Chinese Center for Disease Control and Prevention (Grant No. 2009A203)
文摘Safflower is a popular Chinese medicinal plant and Safflower injection is extensively used for the clinical treatment of cerebrovascular and cardiovascular diseases. In this study, HPLC-DAD-ESI-MSn was utilized to study the stability and degradation of the two major but chemically unstable bioactive compounds hydroxysaffior yellow A and anhydrosaffior yellow B, in Safflower injection. The impact of light irradiation, temperature, and pH on the stability of these two compounds were studied. The results showed that hydroxysafflor yellow A and anhydrosafflor yellow B could degrade at high temperature (〉60 ℃) or extreme pHs (pH ≤ 3.0 or 〉7.0), but not under light irradiation. The common degradation product was p-coumaric acid. Chemical structures of the other degradation products were characterized by LC-MS. Hypothetical degradation pathways were proposed. In addition, ADP-induced platelet aggregation tests showed that the degradation of anhydrosaffior yellow B could reduce the anticoagulation activities of Safflower injection. Our results suggest that temperature and pH are critically important for the preparation and storage of Safflower injection.
基金Project(51371104)supported by the National Natural Science Foundation of China
文摘Based on A356 aluminum alloy,aluminum foams were prepared by gas injection foaming process with pure nitrogen,air and some gas mixtures.The oxygen volume fraction of these gas mixtures varied from 0.2%to 8.0%.Optical microscopy,scanning electron microscopy(SEM) and Auger electron spectroscopy(AES) were used to analyze the influence of oxygen content on cell structure,relative density,macro and micro morphology of cell walls,coverage area fraction of oxide film,thickness of oxide film and other aspects.Results indicate that the coverage area fraction of oxide film on bubble surface increases with the increase of oxygen content when the oxygen volume is less than 1.2%.While when the oxygen volume fraction is larger than 1.6%,an oxide film covers the entire bubble surface and aluminum foams with good cell structure can be produced.The thicknesses of oxide films of aluminum foams produced by gas mixtures containing 1.6%-21%oxygen are almost the same.The reasons why the thickness of oxide film nearly does not change with the variation of oxygen content and the amount of oxygen needed to achieve 100%coverage of oxide film are both discussed.In addition,the role of oxide film on bubble surface in foam stability is also analyzed.
基金supported by the National Natural Science Foundation of China(Grant Nos.61905086,62174067,62175085)Science and Technology Development Planning of Jilin Province(Project Nos.20190101024JH,20200201296JC)+1 种基金the Hong Kong Scholars Program(Project No.XJ2020028)grants from the Research Grants Council of the Hong Kong Special Administrative Region,China(Project Nos.11300418 and 11300419).
文摘Here,this work presents an air-stable ultrabright inverted organic lightemitting device(OLED)by using zinc ionchelated polyethylenimine(PEI)as electron injection layer.The zinc chelation is demonstrated to increase the conductivity of the PEI by three orders of magnitude and passivate the polar amine groups.With these physicochemical properties,the inverted OLED shows a record-high external quantum efficiency of 10.0% at a high brightness of 45,610 cd m^(-2) and can deliver a maximum brightness of 121,865 cd m^(-2).Besides,the inverted OLED is also demonstrated to possess an excellent air stability(humidity,35%)with a half-brightness operating time of 541 h@1000 cd m^(-2) without any protection nor encapsulation.
基金the National Key Research and Development Program of China(No.2019YFA0708700)the Innovation fund project for graduate student of China University of Petroleum(East China)(No.22CX04050A)the Fundamental Research Funds for the Central Universities,the China National Petroleum Corporation Innovation Found(No.2021DQ02-0205).
文摘Carbon dots(CDs)show great potential as a new type of oil-displacing agent for unconventional oil and gas development.However,the instability and easy aggregation epitomize the challenges that accompany the application of CDs in high temperature and high salinity(HT/HS)reservoirs.In this research,novel benzene sulfonate-modified carbon dots(BS-CDs)with remarkable thermal stability and salt resistance were fabricated through an in-situ electrochemical exfoliation method.Molecular simulation verifies that the introduction of benzene sulfonate groups substantially strengthens the electrostatic repulsion between BS-CDs,leading to outstanding dispersibility and stability even at a temperature of 100℃ and salinity of 14×10^(4) mg/L.Core flooding tests show that 0.05 wt.%BS-CDs nanofluid can significantly reduce the water injection pressure by 50.00%and enhanced oil recovery(EOR)to 68.39%under HT/HS conditions.According to the atomic force microscopy(AFM)scanning results,the adhesion force between the core(after BS-CDs treatment)and oil decreased by 11.94 times,indicating that the hydrophilicity of the core surface was increased.In addition,the distribution of the adhesion force curve is more concentrated,which means that the micro-scale wettability of the core changes from oil-wet to more homogeneous water-wet.This study provides a feasible way for the development and application of good thermal stability and salt resistance CDs in unconventional reservoir development.
文摘Purpose The high energy photon source(HEPS)uses the on-axial injection scheme.There are two designs in this injection scheme that are critical to the performance of the HEPS injection system.One is the strip line kicker and another is the high voltage fast pulse power supply system.In the high voltage fast pulse power supply system,the design of high voltage power supply is very important.The output voltage stability of high voltage power supply directly affects the stability of the pulse amplitude of the injection system.Methods A high voltage power supply with high output voltage stability is designed in this paper,and the scheme is given.The correctness of the design scheme is verified by simulation experiments.Result A prototype is built for full test.The test results showed that the output voltage stability is lower than 58 ppm.The output voltage is 6.4 mV(f≤3 kHz)/113.2 mV(f>3 kHz).Conclusions The designed high voltage power supply can fully meet the requirements of the HEPS injection system.
基金the National Natural Science Foundation of China (91641203, 51476114, and 91741119)he National Key Research and Development Program of China (2017YFB0103400).
文摘Gasoline compression ignition (GCI) is one of the most promising combustion concepts to maintain low pollutant emissions and high efficiency. However, low load combustion stability and firing in cold-start operations are two major challenges for GCI combustion. Strategies including negative valve overlap (NVO), advanced injection strategies, fuel reforming, and intake preheating have been proposed in order to solve these difficulties;however, the cold start is still an obstacle. The objective of this work is to study effective methods to achieve GCI engine cold start-up. This work combines NVO, in-cylinder fuel reforming, and intake preheating to achieve quick firing under cold-start conditions and the subsequent warmup conditions. The results show that start of injection (SOI) during the intake stroke yields the best fuel economy, and injection during the compression stroke has the potential to extend the low load limit. Furthermore, SOI during the NVO period grants the ability to operate under engine conditions with cold intake air and coolant. With highly reactive products made by in-cylinder fuel reforming and fast heat accumulation in the combustion chamber, the NVO injection strategy is highly appropriate for GCI firing. An additional assisted technical method, such as intake preheating, is required to ignite the first firing cycle for a cold-start process. With the combination of NVO, in-cylinder fuel reforming, and intake preheating, the GCI engine successfully started within five combustion cycles in the experiment. After the firing process, the engine could stably operate without further intake preheating;thus, this method is appropriate for engine cold-start and warm-up.
文摘A flat thin TiO2 film was employed as the photo-electrode of a dye sensitized solar cell (DSSC), on which only a geometrical mono-layer of dye was attached. The effect of sur- face protonation by HCI chemical treatment on the performance of DSSCs was studied. The results showed that the short-circuit current Jsc increased significantly upon the HCI treatment, while the open-circuit voltage Voc decreased slightly. Compared to the untreated DSSC, the Jsc and energy conversion efficiency was increased by 31% and 25%, respectively, for the 1 mol/L HCI treated cell. TiO2 surface protonation improved electronic coupling between the chemisorbed dye and the TiO2 surface, resulting in an enhanced electron in- jection. The decreased open-circuit voltage after TiO2 surface protonation was mainly due to the TiO2 conduction band edge downshift and was partially caused by increased electron recombination with the electrolyte. In situ Raman degradation study showed that the dye stability was improved after the TiO2 surface protonation. The increased dye stability was contributed by the increased electron injection and electron back reaction with the electrolyte under the open-circuit condition.
文摘This paper analyses the effects of small injection/suction Reynolds number, Hartmann parameter, permeability parameter and wave number on a viscous incompressible electrically conducting fluid flow in a parallel porous plates forming a channel. The plates of the channel are parallel with the same constant temperature and subjected to a small injection/suction. The upper plate is allowed to move in flow direction and the lower plate is kept at rest. A uniform magnetic field is applied perpendicularly to the plates. The main objective of the paper is to study the effect of the above parameters on temporal linear stability analysis of the flow with a new approach based on modified Orr-Sommerfeld equation. It is obtained that the permeability parameter, the Hartmann parameter and the wave number contribute to the linear temporal stability while the small injection/suction Reynolds number has a negligible effect on the stability.
基金supported in part by the National Natural Science Foundation of China under Grant Nos.62173002, 61925303, 62088101, U20B2073, and 61720106011the Beijing Natural Science Foundation under Grant No. 4222045
文摘This paper mainly investigates the security problem of a networked control system based on a Kalman filter.A false data injection attack scheme is proposed to only tamper the measurement output,and its stealthiness and effects on system performance are analyzed under three cases of system knowledge held by an attacker and a defender.Firstly,it is derived that the proposed attack scheme is stealthy for a residual-based detector when the attacker and the defender hold the same accurate system knowledge.Secondly,it is proven that the proposed attack scheme is still stealthy even if the defender actively modifies the Kalman filter gain so as to make it different from that of the attacker.Thirdly,the stealthiness condition of the proposed attack scheme based on an inaccurate model is given.Furthermore,for each case,the instability conditions of the closed-loop system under attack are derived.Finally,simulation results are provided to test the proposed attack scheme.
基金the support of the National Natural Science Foundation of China(Nos.51576162 and51236006)The Doctorate Foundation of Northwestern Polytechnical University(No.CX201422)
文摘Parametric study of tip injection was implemented experimentally on a subsonic axial flow compressor to understand the underlying flow mechanisms of stability improvement of the compressor with discrete tip injection.Injector throat height varied from 2 to 6 times the height of rotor tip clearance,and circumferential coverage percentage ranged from 8.3% to 25% of the annulus.Static pressure fluctuations over the rotor tip were measured with fast-response pressure transducers.Whole-passage time-accurate simulations were also carried out to help us understand the flow details.The combinations of tip injection with traditional casing treatments were experimentally studied to generate an engineering-acceptable method of compressor stall control.The results indicate that the maximum stability improvement is achieved when injectors are choked despite their different sizes.The effect of circumferential coverage percentage on compressor stability depends on the value of injector throat height for un-choked injectors,and vice versa.Tip blockage in the blade passage is greatly reduced by the choked injectors,which is the primary reason for stability enhancement.The accomplishment of blockage diminishment is maintained in the circumferential direction with the unsteady effect of tip injection,which manifests as a hysteresis between the recovery of tip blockage and the recovery of tip leakage vortex.The unsteady effect is primarily responsible for the effectiveness of tip injection with a partial circumferential coverage.Tip injection cannot enhance the stability of the rotor with axial slots significantly,but it can improve the stability of the rotor with circumferential grooves further.The combined structure of tip injection with circumferential grooves is an alternative for engineering application.
基金financially supported by the National Natural Science Foundation of China (No.22075315)the Chinese Academy of Science (Nos.YJKYYQ20180029 and GJHZ2092-019)the Youth Innovation Promotion Association,CAS (No.2019317)。
文摘The power conversion efficiency(PCE)of polymer solar cells(PSCs)has exceeded 19%due to the rapid progress of photoactive organic materials,including conjugated polymer donors and the matched non-fullerene acceptors(NFAs).Due to the high density of oxygen vacancies and the consequent photocatalytic reactivity of ZnO,structure inverted polymer solar cells with the ZnO electron transport layer(ETL)usually suffer poor device photostability.In this work,the eco-friendly glucose(Glu)is found to simultaneously improve the efficiency and stability of polymer:NFA solar cells.Under the optimal conditions,we achieved improved PCEs from 14.77%to 15.86%for the PM6:Y6 solar cells.Such a PCE improvement was attributed to the improvement in J_(SC) and FF,which is ascribed to the smoother and more hydrophobic surface of the ZnO/Glu surface,thereby enhancing the charge extraction efficiency and inhibiting charge recombination.Besides,UV-Vis absorption spectra analysis revealed that glucose modification could significantly inhibit the photodegradation of Y6,resulting in a significant improvement in the stability of the device with 92%of its initial PCE after aging for 1250 h.The application of natural interface materials in this work brings hope for the commercial application of organic solar cells and provides new ideas for developing new interface materials.
基金co-supported by the National Natural Science Foundation of China(No.51922098)the National Science and Technology Major Project of China(No.2017-Ⅱ-0004-0017)the Special Fund for the Member of Youth Innovation Promotion Association of CAS(No.2018173).
文摘The adaptive feedback control of stability with circumferential inlet distortion has been experimentally investigated in a low-speed,axial compressor.The flat-baffles with different span heights are used to simulate different distorted inflow cases.Compared with auto-correlation and root-mean-square analysis,cross-correlation analysis used to predict early stall warning does not depend on the distortion position.Hence,the cross-correlation coefficient was used to monitor the stable status of the compressor and provide the feedback signal in the active control strategy when suffering from different distortions.Based on the stall margin improvement of tip air injection obtained under different distorted inflow cases and the sensitivity analysis of cross-correlation coefficients to injected momentum ratios,tip air injection was adopted as the actuator for adaptive feedback control.The digital signal processing controller was designed and applied to achieve adaptive feedback control in distorted inflow conditions.The results show that the adaptive feedback control of air injection nearly achieves the same stall margin improvement as steady air injection under different distortion intensities with a reduced injection mass flow.Thus,the proposed adaptive feedback control method is ideal for the engine operation with circumferential distorted inflow,which frequently occurs in flight.
文摘High time-stability performance of the injection kicker system is important for the Beijing Electron Positron Collider Upgrade Project (BEPCⅡ),with jitter and drift less than±5ns.In order to compensate the delay time drift of thyratron on the kicker pulsed power supply,a drift stabilizer is developed.The test results meet the demand of design by regulation resolution=1ns,jitter+drift<2ns in 8 hours.The detailed design of the time-drift stabilizer will be described in this paper.
基金Supported by National Natural Science Foundation of China(Grant Nos.11071201 and 11001231)
文摘Let X, Y be two real Banach spaces and ε≥0. A map f : X → Y is said to be a standard ε-isometry if│││f/(x) - f(y)││ - ]ix - Y││x-y││ ε for all x,y C X and with f(O) = O. We say that a pair of Banach spaces (X, Y) is stable if there exists γ〉 0 such that, for every such ε and every standard v-isometry f : X → Y, there is a bounded linear operator T : L(f) → f(X) → X so that ││Tf(x) - x││ ≤γε for all x E X. X(Y) is said to be universally left-stable if (X, Y) is always stable for every Y(X). In this paper, we show that if a dual Banach space X is universally left-stable, then it is isometric to a complemented w*-closed subspace of ∞ (1) for some set F, hence, an injective space; and that a Banach space is universally left-stable if and only if it is a cardinality injective space; and universally left-stability spaces are invariant.
基金supported by the National Natural Science Foundation of China
文摘Let f∈C^1(R^2, R^2), f(0)=0. The Jacobian Conjecture states that if for any x∈R^2, the eigenvalues of the Jacobian matrix Df(x) have negative real parts, then the zero solution of the differential equation x=f(x) is globally asymptotically stable. In this paper we prove that the conjecture is true.