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Improvement of bone formation by bionic hydroxyapatite nanorod via the regulation of macrophage polarization 被引量:1
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作者 Da-Wang Zhao Ming-Zhi Yu +6 位作者 Yi-Xiang Zhao Rui Hu Peng-Cheng Xu Zhao-Yang Sun Kai Bian Chao Liu Lei Cheng 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2023年第5期109-120,共12页
Bone defects are common clinical problems in the world,and there are many biomaterials used for treat-ing them.However,there is still a paucity of bioactive materials capable of modulating the immune mi-croenvironment... Bone defects are common clinical problems in the world,and there are many biomaterials used for treat-ing them.However,there is still a paucity of bioactive materials capable of modulating the immune mi-croenvironment.Therefore,it is necessary to identify new therapeutic strategies to regulate the immune microenvironment of the bone defect to further promote osteogenesis.Hydroxyapatite(HAP)is an impor-tant mineral for the framework of the human body.Recently,HAP has become a key research object for bone tissue engineering applications due to its unique tailored properties and similarity to bone tissue.Here,we prepared rod-shaped HAP(rHAP)with different concentrations(0,100,200,and 300μg/mL).The slowly released Ca^(2+)of 200μg/mL rHAP can induce macrophage phenotype 2(M2)polarization to decrease inflammatory cytokine secretion via the PI3K-Akt and Wnt/β-catenin pathways.In addition,rHAP can induce osteogenesis through the osteogenic differentiation of rat bone marrow mesenchymal stem cells.In conclusion,the 200μg/mL rHAP shows the potential for osteoimmunomodulation in a bone defect in vitro and in vivo,which is beneficial to the treatment of bone defects. 展开更多
关键词 Hydroxyapatite nanorods Macrophage polarization Osteoimmunomodulation Calcium ions-related signaling pathway
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