This study aimed to investigate the effects of copper and manganese on hemocyte apoptosis and the antagonism of iron and zinc in Oreochromis niloticus The heavy metal contents in fish blood and feed were determined by...This study aimed to investigate the effects of copper and manganese on hemocyte apoptosis and the antagonism of iron and zinc in Oreochromis niloticus The heavy metal contents in fish blood and feed were determined by atomic absorption spectrophotometry, and the hemocyte apoptosis was determined by flow cytometry. A total of 360 tilapias were selected, and they were divided randomly and evenly into 12 groups. In the challenge groups, the tilapias were fed with con stant-level copper sulfate（0, 200 mg/kg） and manganese sulfate（0, 120 mg/kg）; in the antagonism groups, the tilapias were fed with constant-level zinc sulfate（20320 mg/kg） and iron sulfate（150, 350 mg/kg）. After 20-week aquaculture, the hemocyte apoptosis rates in the copper and manganese groups were significantly increased; with the increased addition levels of iron and zinc, the hemocyte apopto sis rates in the iron and zinc groups were significantly reduced, but they were stil higher than that in the control group. In conclusion, excessive copper and manganese can cause apoptosis in hemocytes of O. niloticus. However, the toxic effects of copper and manganese can be antagonized by iron and zinc.展开更多
Metals such as iron,manganese,copper,and zinc are recognized as essential trace elements.These trace metals play critical roles in development,growth,and metabolism,participating in various metabolic processes by acti...Metals such as iron,manganese,copper,and zinc are recognized as essential trace elements.These trace metals play critical roles in development,growth,and metabolism,participating in various metabolic processes by acting as cofactors of enzymes or providing structural support to proteins.Deficiency or toxicity of these metals can impact human and animal health,giving rise to a number of metabolic and neurological disorders.Proper breakdown,absorption,and elimination of these trace metals is a tightly regulated process that requires crosstalk between the host and these micronutrients.The gut is a complex system that serves as the interface between these components,but other factors that contribute to this delicate interaction are not well understood.The gut is home to trillions of microorganisms and microbial genes(the gut microbiome)that can regulate the metabolism and transport of micronutrients and contribute to the bioavailability of trace metals through their assimilation from food sources or by competing with the host.Furthermore,deficiency or toxicity of these metals can modulate the gut microenvironment,including microbiota,nutrient availability,stress,and immunity.Thus,understanding the role of the gut microbiota in the metabolism of manganese,iron,copper,and zinc,as well as in heavy metal deficiencies and toxicities,and vice versa,may provide insight into developing improved or alternative therapeutic strategies to address emerging health concerns.This review describes the current understanding of how the gut microbiome and trace metals interact and affect host health,particularly in pigs.展开更多
Micronutrients deficiency is a major limiting factor for increasing yield and productivity of major crops in India. Recent findings of multiple micronutrients interactions have evidenced the indispensable role played ...Micronutrients deficiency is a major limiting factor for increasing yield and productivity of major crops in India. Recent findings of multiple micronutrients interactions have evidenced the indispensable role played by micronutrients in plant nutrition. Though they are needed in smaller quantities, however, their availability in the Right amount, at the Right time, and for the Right crop has been a major limiting factor for improving the productivity and yield of Sugarcane in northern Karnataka state of India. This study was conducted to assess the level of Boron (B), Copper (Cu), Iron (Fe), Manganese (Mn) and Zinc (Zn) deficiencies in Sugarcane growing Vertisols of six micro-watersheds in northern Karnataka. The six selected micro-watersheds were intensively traversed and six representative pedons of standard dimensions were dug and horizon-wise soil samples collected and analyzed for various micronutrients using standard analytical procedures. Based on the optimum critical levels of micronutrients, B, Fe and Zn were deficient, ranging from 0.15 - 0.64, 1.23 - 5.92 and 0.11 - 0.64 mg⋅kg<sup>−1</sup> respectively while Cu and Mn were in excess, ranging from 1.54 - 7.62 and 1.22 - 7.03 mg⋅kg<sup>−1</sup> respectively. The distribution of B, Fe and Zn were inversely proportional to soil depth whereas that of Cu and Mn were irregular, which is an indication of the influence of pedoturbation in these soils. With the current rate of agricultural intensification, unbalanced fertilizer application, depletion of nutrients and no replenishment by smallholders, the results reveal that the current deficiency levels may increase further if appropriate and timely actions are not taken. We therefore recommend the use of site-specific nutrient management, balanced fertilizer application and good agronomic practices. These can enhance nutrient use efficiency in the study area.展开更多
Iron, manganese, zinc and copper in dark plum were determined by ICP-AES with microwave digestion. Under optimum conditions, the recoveries were in the rang of 102%-105%. The RSD is less than 4.0%. The method is simpl...Iron, manganese, zinc and copper in dark plum were determined by ICP-AES with microwave digestion. Under optimum conditions, the recoveries were in the rang of 102%-105%. The RSD is less than 4.0%. The method is simple, rapid and accurate.展开更多
基金Supported by Scientific Operating Expenses of Hainan Province(11-201410-0009)~~
文摘This study aimed to investigate the effects of copper and manganese on hemocyte apoptosis and the antagonism of iron and zinc in Oreochromis niloticus The heavy metal contents in fish blood and feed were determined by atomic absorption spectrophotometry, and the hemocyte apoptosis was determined by flow cytometry. A total of 360 tilapias were selected, and they were divided randomly and evenly into 12 groups. In the challenge groups, the tilapias were fed with con stant-level copper sulfate（0, 200 mg/kg） and manganese sulfate（0, 120 mg/kg）; in the antagonism groups, the tilapias were fed with constant-level zinc sulfate（20320 mg/kg） and iron sulfate（150, 350 mg/kg）. After 20-week aquaculture, the hemocyte apoptosis rates in the copper and manganese groups were significantly increased; with the increased addition levels of iron and zinc, the hemocyte apopto sis rates in the iron and zinc groups were significantly reduced, but they were stil higher than that in the control group. In conclusion, excessive copper and manganese can cause apoptosis in hemocytes of O. niloticus. However, the toxic effects of copper and manganese can be antagonized by iron and zinc.
基金Supported by the National Natural Science Foundation of China（30270924） Natural Science Foundation of Anhui Province （070411004） +1 种基金 the National Science Foundation of Education Department of Anhui Province（2006KJ184B） the Foundation of Provincial Key Lab of Biotic Environment and Ecological Safety in Anhui Province
基金supported by a grant from National Institute of Environmental Health Sciences(R01 ES024756)
文摘Metals such as iron,manganese,copper,and zinc are recognized as essential trace elements.These trace metals play critical roles in development,growth,and metabolism,participating in various metabolic processes by acting as cofactors of enzymes or providing structural support to proteins.Deficiency or toxicity of these metals can impact human and animal health,giving rise to a number of metabolic and neurological disorders.Proper breakdown,absorption,and elimination of these trace metals is a tightly regulated process that requires crosstalk between the host and these micronutrients.The gut is a complex system that serves as the interface between these components,but other factors that contribute to this delicate interaction are not well understood.The gut is home to trillions of microorganisms and microbial genes(the gut microbiome)that can regulate the metabolism and transport of micronutrients and contribute to the bioavailability of trace metals through their assimilation from food sources or by competing with the host.Furthermore,deficiency or toxicity of these metals can modulate the gut microenvironment,including microbiota,nutrient availability,stress,and immunity.Thus,understanding the role of the gut microbiota in the metabolism of manganese,iron,copper,and zinc,as well as in heavy metal deficiencies and toxicities,and vice versa,may provide insight into developing improved or alternative therapeutic strategies to address emerging health concerns.This review describes the current understanding of how the gut microbiome and trace metals interact and affect host health,particularly in pigs.
文摘Micronutrients deficiency is a major limiting factor for increasing yield and productivity of major crops in India. Recent findings of multiple micronutrients interactions have evidenced the indispensable role played by micronutrients in plant nutrition. Though they are needed in smaller quantities, however, their availability in the Right amount, at the Right time, and for the Right crop has been a major limiting factor for improving the productivity and yield of Sugarcane in northern Karnataka state of India. This study was conducted to assess the level of Boron (B), Copper (Cu), Iron (Fe), Manganese (Mn) and Zinc (Zn) deficiencies in Sugarcane growing Vertisols of six micro-watersheds in northern Karnataka. The six selected micro-watersheds were intensively traversed and six representative pedons of standard dimensions were dug and horizon-wise soil samples collected and analyzed for various micronutrients using standard analytical procedures. Based on the optimum critical levels of micronutrients, B, Fe and Zn were deficient, ranging from 0.15 - 0.64, 1.23 - 5.92 and 0.11 - 0.64 mg⋅kg<sup>−1</sup> respectively while Cu and Mn were in excess, ranging from 1.54 - 7.62 and 1.22 - 7.03 mg⋅kg<sup>−1</sup> respectively. The distribution of B, Fe and Zn were inversely proportional to soil depth whereas that of Cu and Mn were irregular, which is an indication of the influence of pedoturbation in these soils. With the current rate of agricultural intensification, unbalanced fertilizer application, depletion of nutrients and no replenishment by smallholders, the results reveal that the current deficiency levels may increase further if appropriate and timely actions are not taken. We therefore recommend the use of site-specific nutrient management, balanced fertilizer application and good agronomic practices. These can enhance nutrient use efficiency in the study area.
文摘Iron, manganese, zinc and copper in dark plum were determined by ICP-AES with microwave digestion. Under optimum conditions, the recoveries were in the rang of 102%-105%. The RSD is less than 4.0%. The method is simple, rapid and accurate.
