Relationship between longitudinal changes in lipid composition and ischemic stroke among hypertensive patients

BACKGROUND Dyslipidemia was strongly linked to stroke,however the relationship between dyslipidemia and its components and ischemic stroke remained unexplained.AIM To investigate the link between longitudinal changes in lipid profiles and dyslipidemia and ischemic stroke in a hypertensive population.METHODS Between 2013 and 2014,6094 hypertension individuals were included in this,and ischemic stroke cases were documented to the end of 2018.Longitudinal changes of lipid were stratified into four groups:(1)Normal was transformed into normal group;(2)Abnormal was transformed into normal group;(3)Normal was transformed into abnormal group;and(4)Abnormal was transformed into abnormal group.To examine the link between longitudinal changes in dyslipidemia along with its components and the risk of ischemic stroke,we utilized multivariate Cox proportional hazards models with hazard ratio(HR)and 95%CI.RESULTS The average age of the participants was 62.32 years±13.00 years,with 329 women making up 54.0%of the sample.Over the course of a mean follow-up of 4.8 years,143 ischemic strokes happened.When normal was transformed into normal group was used as a reference,after full adjustments,the HR for dyslipidemia and ischemic stroke among abnormal was transformed into normal group,normal was transformed into abnormal group and abnormal was transformed into abnormal Wei CC et al.Dyslipidemia changed and ischemic stroke WJCC https://www.wjgnet.com 2 February 6,2025 Volume 13 Issue 4 group were 1.089(95%CI:0.598-1.982;P=0.779),2.369(95%CI:1.424-3.941;P<0.001)and 1.448(95%CI:1.002-2.298;P=0.047)(P for trend was 0.233),respectively.CONCLUSION In individuals with hypertension,longitudinal shifts from normal to abnormal in dyslipidemia-particularly in total and low-density lipoprotein cholesterol-were significantly associated with the risk of ischemic stroke.

Diffusion kurtosis imaging of microstructural changes in brain tissue affected by acute ischemic stroke in different locations

The location of an acute ischemic stroke is associated with its prognosis. The widely used Gaussian model-based parameter, apparent diffusion coefficient(ADC), cannot reveal microstructural changes in different locations or the degree of infarction. This prospective observational study was reviewed and approved by the Institutional Review Board of Xiamen Second Hospital, China(approval No. 2014002).Diffusion kurtosis imaging(DKI) was used to detect 199 lesions in 156 patients with acute ischemic stroke(61 males and 95 females), mean age 63.15 ± 12.34 years. A total of 199 lesions were located in the periventricular white matter(n = 52), corpus callosum(n = 14), cerebellum(n = 29), basal ganglia and thalamus(n = 21), brainstem(n = 21) and gray-white matter junctions(n = 62). Percentage changes of apparent diffusion coefficient(ΔADC) and DKI-derived indices(fractional anisotropy [ΔFA], mean diffusivity [ΔMD], axial diffusivity [ΔD_a], radial diffusivity ΔDr, mean kurtosis [ΔMK], axial kurtosis [ΔK_a], and radial kurtosis [ΔK_r]) of each lesion were computed relative to the normal contralateral region. The results showed that(1) there was no significant difference in ΔADC, ΔMD, ΔD_a or ΔD_r among almost all locations.(2) There was significant difference in ΔMK among almost all locations(except basal ganglia and thalamus vs. brain stem; basal ganglia and thalamus vs. gray-white matter junctions; and brainstem vs. gray-white matter junctions.(3) The degree of change in diffusional kurtosis in descending order was as follows: corpus callosum > periventricular white matter > brainstem > gray-white matter junctions > basal ganglia and thalamus > cerebellum. In conclusion, DKI could reveal the differences in microstructure changes among various locations affected by acute ischemic stroke, and performed better than diffusivity among all groups.

MRI Features and Site-specific Factors of Ischemic Changes in White Matter： A Retrospective Study

Brain magnetic resonance imaging （MRI） of the elderly often reveals white matter changes （WMCs） with substantial variability across individuals. Our study was designed to explore MRI features and site-specific factors of ischemic WMCs. Clinical data of consecutive patients diagnosed with ischemic cerebral vascular disease who had undergone brain MRI were collected and analyzed. Multi-logistic regression analysis comparing patients with mild versus severe WMCs was performed to detect independent associations. Analyses of variance （ANOVAs） were used to detect regionally specific differences in lesions. We found that lesion distribution differed significantly across five cerebral areas, with lesions being predominant in the frontal lobe and parieto-occipital area. To explore WMCs risk factors, after adjusting for gender, diabetes mellitus, and hypertension, only age （P〈0.01）, creatinine （P=0.01）, alkaline phosphatase （ALP） （P=0.01） and low-density lipoprotein cholesterol （LDL-C） （P=0.03） were found to be independently associated with severe WMCs. Age （P〈0.001） was strongly associated with WMCs in the frontal lobe while hypertension was independently related to lesions in the basal ganglia （P=0.048） or infratentorial area （P=0.016）. In conclusion, MRI of WMCs showed that ischemic WMCs occurred mostly in the frontal lobe and parieto-occipital area. The infratentorial area was least affected by WMCs. Typically, age-related WMCs were observed in the frontal lobes, while hypertension-related WMCs tended to occur in the basal ganglia and infratentorial area.

Changes of cTnI in myocardial ischemic and reperfusion injury during correction of cardiac defects in children

Objective The purpose of this study is to investgate changes of cTnI in myocardial ischemic and reperfusion injury during correction of cardiac defects in children. Methods From June, 1999 to May,2000,45 children (30 male, 15 female) undergoing correction of cardiac defects were divided into three groups randomly: group Ⅰ no myocardial ischemia,group Ⅱ myocardial ischemia less than 60 minutes, group Ⅲmyocardial ischemia 】 60 minutes. There were no significant differences in the three groups in age, sex ratio, C/T ratio, or left ventricular function. Blood samples for analysis were collected before skin incision and at time intervals up to 6 days postoperatively. Analysis of creatine kinase MB.LDH and cardiac-specific troponin I was used for the detection of myocardial damage. Meantime, the ECG was checked for myocardial infarction. After the reperfusion, myocardial tissue was obtained from the free wall of right ventricle myocardial structure studies. Results The level of cTnI was increased

Neuroprotective effects of ischemic adaptation on cognitive dysfunction in mice with cerebral ischemia-reperfusion injury

Objective: To observe the effects of remote ischemia on cognitive function and neuronal pathological damage in rats with cognitive impairment induced by bilateral common carotid artery occlusion(BCAO).Methods:Male SD rats were selected to establish the cognitive impairment model induced by cerebral ischemia reperfusion caused by BCAO.The tests included three groups of rats:a sham group,a model group with vascular cognitive impairment (VCI) , and a remote ischemic conditioning (RIC) group (VCI + RIC group). From 24 h after operation, both hind limbs of rats in VCI + RIC group were treated with RIC. After 28 d, Morris water maze test and HE staining was used to observe the pathological changes of white matter and hippocampus in each group.Results: After 3 d mice in VCI group began to improve gradually. The recovery of rats in the VCI + RIC group was relatively slow,but they started to recover rapidly 2 d after the operation.Morris water maze test showed that the escape latency of rats in VCI group and VCI+RIC group was longer than that in the sham group, and the score of VCI+RIC group was better than that of the VCI group, but there was a significant difference between the two groups(P<0.05).The space exploration experiment was performed at 7 d and 28 d after the operation;the VCI+RIC group outperformed the VCI group in both trials;the difference between the two groups was statistically significant (P<0.05).In the target quadrant exploration time, the difference between the VCI group (33.5±11.3 s) and the VCI+RIC group (41.2±9.7 s) was statistically significant (P<0.05).Results from the hematoxylin and eosin(HE)staining showed that compared with VCI group, cortical cells in VCI + RIC group had loose stroma, thinner nerve fibers, fewer broken cells, and slightly shrunken cells. Compared with VCI group, neurons in VCI + RIC group had a little vacuolar degenera-tion and slightly shrunken cell volume.Conclusion:Cerebral ischemia-reperfusion injury can cause learning and memory impairment in rats, leading to VCI. RIC can significantly improve VCI and play a neuroprotective role.

Neuroimmunomodulatory effects of transcranial laser therapy combined with intravenous tPA administration for acute cerebral ischemic injury

At present, the only FDA approved treatment for ischemic strokes is intravenous administration of tissue plasminogen activator within 4.5 hours of stroke onset. Owing to this brief window only a small percentage of patients receive tissue plasminogen activator. Transcranial laser therapy has been shown to be effective in animal models of acute ischemic stroke, resulting in significant improvement in neurological score and function. NEST-1 and NEST-2 clinical trials in human patients have demonstrated the safety and positive trends in efficacy of transcranial laser therapy for the treatment of ischemic stroke when initiated close to the time of stroke onset. Combining intravenous tissue plasminogen activator treatment with transcranial laser therapy may provide better functional outcomes. Statins given within 4 weeks of stroke onset improve stroke outcomes at 90 days compared to patients not given statins, and giving statins following transcranial laser therapy may provide an effective treatment for patients not able to be given tissue plasminogen activator due to time constraints.

Is transesophageal echocardiography needed for evaluating tissue-based transient ischemic attack？

Transient ischemic attack（TIA） is a warning signal for stroke.A comprehensive evaluation of TIA may reduce the risk for subsequent stroke.Data on the findings of cardiac evaluation with transesophageal echocardiography（TEE） in patients with TIA are sparse.Our aims were to determine the frequency of TEE performance and to investigate the findings of TEE in patients with TIA based on the new definition of TIA（i.e.,transient neurological symptoms without evidence of infarction）.During a 4-year period（2011–2014）,1071 patients（mean age,70 ± 13 years;female,49.7%） with TIA were included in a prospective study and evaluated.Of 1071 consecutive patients suffering from TIA,288 patients（27%） underwent TEE.The median time between admission and TEE was 6 days.Patients with TIA who were evaluated by TEE were younger（67 vs.71 years,P 〈 0.001） than those who were not evaluated by TEE.They had a higher rate of sensibility disturbance as a TIA symptom（39% vs.31%,P = 0.012） but a lower rate of previous stroke（15% vs.25%,P = 0.001） and atrial fibrillation（2% vs.21%,P 〈 0.001） than those who did not.Foramen ovale was detected in 71 patients（25.7%）,atrial septal aneurysm in 13 patients（4.6%）,and severe atherosclerotic plaques（grade 4 and 5） in the aortic arch in 25 patients（8.7%）.One patient（0.3%） had a fibroma detected by TEE.In 17 of the 288 patients（6%） who underwent TEE,the indication for anticoagulation therapy was based on the TEE results,and 1 patient with fibroma underwent heart surgery.During hospitalization,7 patients experienced a subsequent stroke,and 27 patients had a recurrent TIA.At 3 months following discharge,the rates of readmission,stroke,recurrent TIA,and death were 19%,2.7%,4.2%,and 1.6%,respectively.The rates of mortality（0.9% vs.1.8%,P = 0.7）,stroke risk（1.9% vs.3.0%,P = 0.8）,and recurrent TIA（5.0% vs.3.9%,P = 0.8） were similar in patients who underwent TEE and in those who did not.Performing TEE in patients with tissue-based TIA is helpful in detecting cardiac sources for embolism and may indicate for anticoagulation.

Effect of Shuxuetong injection on platelet function, hemorheology and cerebral blood flow in patients with ischemic stroke

Objective:To investigate the effect of Shuxuetong injection on platelet function, hemorheology and cerebral blood flow in patients with ischemic stroke.Methods: One hundred cases of ischemic stroke admitted in our hospital from February 2015 to January 2017 were randomly divided into control group and observation group. The control group was given routine treatment. The observation group was given Shuxuetong injection on the basis of the control group. The changes of platelet function, hemorheology and cerebral blood flow before and after treatment were detected in both groups.Results: After treatment, the whole blood viscosity, plasma viscosity and fibrinogen level in both groups were significantly lower than those before treatment. The whole blood viscosity, plasma viscosity and fibrinogen level in the observation group were (4.18±0.05) mPa?s, (1.66±0.12) mPa?s and (3.45±0.08) g/L, respectively, which were significantly lower than the control group;After treatment, the levels of MCA, ACA and PCA in both groups were significantly increased. MCA, ACA and PCA levels in the observation group were (70.82±4.13) cm/s, (60.62±3.55) cm/s and (54.11±2.36) cm/s, which were significantly higher than those in the control group;After treatment, the maximum platelet aggregation rate, PLT, MPV and PDW levels in the two groups significantly decreased. The maximum platelet aggregation rate, PLT, MPV and PDW levels in the observation group were (27.93±1.44)% and (155.32±13.46)×109/L, (9.42±0.32) fL and (9.12±0.24) fL, respectively, which were significantly lower than those in the control group. Conclusions: Shuxuetong injection can effectively improve the patient's hemorheology and platelet function, improve the level of cerebral blood flow in patients with significant effect, it is worth further clinical application.

急性脑梗死患者心电图缺血性ST-T改变与预后的关系

目的:探讨脑梗死急性期心电图缺血性ST-T改变与预后的关系。方法:77例急性脑梗死患者分别于入院时及7 d后做心电图检查,根据有无缺血性ST-T改变分为持续缺血性ST-T改变组、短暂缺血性ST-T改变组和无缺血性ST-T改变组。分析3组患者病情轻重、梗死灶大小及与预后的关系。结果:持续缺血性ST-T改变组病情重、梗死灶大、预后差,3组预后比较差异均有统计学意义(P<0.05～P<0.01)。结论:心电图缺血性ST-T改变可以反映急性脑梗死患者的病情轻重、梗死灶大小及预后,动态观察并及时治疗可改善预后。

缺血性脑卒中患者营养行为影响因素的质性研究

目的:通过质性研究,了解缺血性脑卒中患者营养行为影响因素,以期为制定更有效的营养干预措施提供参考。方法:采用便利抽样法,选取2023年9月玉林市第二人民医院经口进食的缺血性脑卒中患者作为研究对象,使用行为改变轮(BCW)理论模型拟定访谈提纲对患者进行半结构式访谈。结果:就缺血性脑卒中患者营养的行为影响因素提炼出3个主题:缺血性脑卒中患者自我管理能力缺乏;缺血性脑卒中患者知识受限导致自我管理动机不强;缺血性脑卒中患者自我管理支持缺乏。结论:医护人员和患者应该加强对营养饮食的重视度,医护人员帮助患者提高自我护理能力。

广州民警谷氨酰转肽酶与高血压和心电图缺血性ST-T改变关系的研究

目的：探讨谷氨酰转肽酶（GGT）与高血压及心电图缺血性ST段和（或）T波改变（ST-T改变）的关系，研究GGT对广州民警心血管事件的影响。方法对2120例广州民警四分位不同水平GGT的血压水平和心电图缺血性ST-T改变发生率进行分析。结果（1）受检者血压随GGT水平升高而升高。GGT水平与血压相关（β=0.006，P〈0.05），高血压与非高血压组间比率差异有显著统计学意义（P〈0.01）。（2）心电图缺血性ST-T改变发生率与GGT水平关系呈一近“V”形曲线图。发生率分别在GGT低水平组（〈18 U/L）和高水平组（〉39 U/L）出现高点，在中等较低水平组（18~26 U/L）出现波谷。心电图有、无缺血性ST-T改变的发生率之间差异有显著统计学意义（χ2=13.031，P〈0.01）。结论高血压病发病率随谷氨酰转肽酶水平升高而升高，谷氨酰转肽酶为高血压病独立的危险因素。谷氨酰转肽酶在低水平及高水平可能导致心电图缺血性ST-T改变发生率升高。

广州民警血清尿酸水平与高血压和心电图缺血性ST-T改变的关系探讨

目的：探讨广州民警血清尿酸（ UA）水平与高血压及心电图缺血性ST-T改变的关系。方法广州市海珠区公安民警2120例，按照血清UA水平分为4个组：UA＜349μmol/L为低水平组，UA 349～408μmol/L为中等较低水平组，UA 409～472μmol/L为中等较高水平组，UA＞472μmol/L为高水平组。比较各组血压、心电图缺血性ST-T改变及TG、CHOL、LDL-C、HDL-C、空腹血糖（ FBG ）、ALT、AST、UA、肌酐（ CRE ）水平。结果高血压335例，UA水平为（445．6±99．2）μmol/L；非高血压1785例，UA水平为（406．6±93．5）μmol/L；P＜0．01。无心电图缺血性ST-T改变1938例，UA水平为（414．9±93．9）μmol/L；有缺血性ST-T改变182例，UA水平为（386．0±106．1）μmol/L；P＜0．01。多因素非条件性Logistic回归分析发现，年龄、Hb、RBC、ALT、TG、UA、ST-T改变、B超脂肪肝表现可能是高血压病的危险因素；DBP、GLU、AST可能是心电图缺血性ST-T改变的危险因素。结论广州市海珠区公安民警血压水平及高血压病发病率随UA水平升高而升高，UA可能是高血压病独立危险因素。 UA在低水平及高水平可能导致心电图缺血性ST-T改变发生率升高；但当UA达到一定高水平后，心电图缺血性ST-T改变发生率可能有所回落。

老年急性缺血性脑梗死患者心电图ST-T变化及其临床应用价值

目的:探讨老年急性缺血性脑梗死患者以缺血性ST-T改变为主的动态心电图特征及其与病情严重程度之间的相互关系,为病情诊断及预后提供理论依据。方法:选择2013年1月至2015年12月收治的老年急性缺血性脑梗死患者中筛查出83例ST-T改变者,均行头颅CT和常规心电图检查,并按心电图检查结果,分为持续性缺血ST-T改变组(16例)、短暂性缺血ST-T改变组(44例)和无缺血性ST-T改变组(23例),分析ST-T动态变化下的心电图特征并分别比较3组患者重度、中度、轻度病情下的心电图异常发生率,以及与梗死灶大小、预后之间的关系。结果:本组患者心电图特征以缺血性心电图ST-T改变为主,异常发生率为61.4%,其次为心律失常,异常发生率为49.4%,且患者可并发1项、2项或其它多项心电图异常;各组患者间病情严重程度、梗死灶大小及预后比较,差异均有统计学意义(P<0.05)。结论:缺血性ST-T改变在老年急性缺血性脑梗死的病情严重程度及预后判断中具有重要临床应用价值,可用于指导患者治疗。

左乙拉西坦联合丙戊酸钠治疗缺血性卒中后癫痫患者的临床效果

目的探讨左乙拉西坦联合丙戊酸钠对缺血性卒中(IS)后癫痫患者脑电图功率谱、神经功能、不良反应、癫痫发作及病情控制情况的影响。方法选择2021年10月至2022年10月江西省人民医院收治的50例IS后癫痫患者,按随机数字表法分为对照组与试验组,每组各25例。对照组采用丙戊酸钠治疗,试验组采用左乙拉西坦联合丙戊酸钠治疗,两组均治疗8周。比较分析两组脑电图功率谱变化、神经功能恢复情况、癫痫发作情况、病情控制率、不良反应。结果治疗后,试验组的α频段脑电相对功率、β频段脑电相对功率均高于对照组,δ频段脑电相对功率、θ频段脑电相对功率、美国国立卫生研究院卒中量表(NIHSS)评分均低于对照组,癫痫发作次数少于对照组,癫痫发作持续时间短于对照组,差异有统计学意义(P<0.05)。试验组的病情控制率为100.00%,高于对照组的76.00%,差异有统计学意义(P<0.05)。两组患者在用药期间均未发生不良反应。结论左乙拉西坦联合丙戊酸钠能够对IS后癫痫患者脑电图功率谱变化产生正性影响,提高α、β频段脑电相对功率,下调δ、θ频段脑电相对功率,改善癫痫发作与神经功能,积极控制病情,且安全性较高。

缺血性心脏病临床诊断中心电图QRS碎裂波与心电向量图T环改变的诊断价值分析

目的探讨在缺血性心脏病(IHD)临床诊断中心电图QRS碎裂波与心电向量图T环改变的诊断价值。方法前瞻性选取2017年1月至2019年1月泸州市中医医院收治的IHD患者134例(A组)作为研究对象,选取行健康体检的131名志愿者作为B组。诊断金标准为经皮冠状动脉造影,所有受试者均分别予以心电图QRS碎裂波与心电向量图T环改变及联合检测,分析2种检测方法的敏感度、准确性、异常检出率、T环改变率,并采用受试者工作特征(ROC)曲线比较诊断率。结果心电图碎裂QRS波、心电向量图T环改变联合诊断的敏感度为98.43%,显著高于单独诊断(84.87%、83.06%),差异有统计学意义(P<0.05)。联合诊断准确性为94.78%,显著高于心电图碎裂QRS波、心电向量图T环改变单独诊断(79.85%、79.10%),差异均有统计学意义(P<0.05)。心电图碎裂QRS波、心电向量图T环改变联合诊断的异常检出率为5.22%,显著低于单独检测(20.15%、20.90%),差异均有统计学意义(P<0.05)。A组的QRS/T值、QRS-T夹角、T环(L/W)、T环转位等的F、H、F+H、S等全部发生了T环改变,且除T环(L/W)中的F+H与B组相比无显著差异之外,其他的各T环改变率均高于B组,差异有统计学意义(P<0.05)。经ROC曲线发现,联合诊断的AUC值(0.801)显著高于心电图碎裂QRS波和心电向量图T环改变(0.703、0.657)。结论心电图QRS碎裂波与心电向量图T环改变均对IHD有较好的检测价值,联合诊断可更全面的获取IHD诊断数据,值得临床推广。

基于整合行为转变模型的护理干预对缺血性脑卒中病人自我管理及康复效果的影响

目的:探讨基于整合行为转变模型的护理干预对缺血性脑卒中病人自我管理及康复效果的影响。方法:便利选取2020年12月—2022年12月收治的100例缺血性脑卒中病人为研究对象,采用抽签法分为对照组和观察组,各50例。对照组实施常规护理,观察组实施基于整合行为转变模型的护理干预,干预前后比较两组病人自我管理行为、肢体运动功能及日常生活能力。结果:两组病人干预后自我管理行为、上肢及下肢运动功能、日常生活能力评分比较,差异均有统计学意义(P<0.05)。结论:基于整合行为转变模型的护理干预有助于提升病人自我管理能力,改善肢体功能与日常生活能力。

对缺血性中风“风痰”证变化规律的探讨

目的:探讨缺血性中风急性期风痰证的演变规律。方法:对400例72h内入院的缺血性中风患者的组合证侯发生频次及风痰证演变过程中证素加减情况进行统计描述与分析,运用聚类分析方法对风痰证患者与NIHSS分值的关系进行研究。结果:证侯发生的概率是动态演变的,具有规律性,且无论在急性期还是恢复期,风痰证都占有很高的比例。结论:风痰证在中风患者证候分布中占有重要地位,风痰阻络是缺血性中风病急性期的基本病机。这一结论为临床确立风痰同治的基本治疗提供了有力的依据。

蛭龙活血通瘀胶囊对短暂性脑缺血患者血流动力学的影响

目的:观察蛭龙活血通瘀胶囊对短暂性脑缺血患者TCD、血流变学及血脂的影响。方法:将60例短暂性脑缺血患者,随机分为治疗组30例,对照组30例。治疗组采用基础治疗加蛭龙活血通瘀胶囊4粒每天3次,对照组采用基础治疗,2周为1个疗程。观察对比TCD、血脂、血流变改变情况。结果:治疗后治疗组总有效率93.33%,对照组总有效率76.67%,两组有着显著差异(P<0.01);治疗后治疗组TC、TG和LDL-C显著降低(P<0.01),且疗效显著优于对照组(P<0.05);治疗组全血黏度(高切、低切值)、红细胞聚集指数、血沉、血小板聚集率和纤维蛋白原明显下降(P<0.01),疗效显著优于对照组(P<0.01);两组经治疗后大脑中动脉(MCA)、椎动脉(VA)和基底动脉(BA)平均峰流速(Vm)以及血管搏动指数(PI)均有不同程度改善,其中两组患者的BA、VA及治疗组MCA的VM改善较为明显,有统计学差异(P<0.05)。治疗后,蛭龙活血通瘀胶囊组基底动脉的VM、椎动脉和大脑中动脉的PI与对照组比较均有显著性差异(P<0.01)。结论:蛭龙活血通瘀胶囊治疗短暂性脑缺血疗效较为满意,能有效降低血脂、改善血液流变学指标和改善大脑主要动脉的供血情况。

重型颅脑损伤合并缺血缺氧后氨基酸谱改变

目的 :研究重型颅脑损伤 (SHI)合并缺血、缺氧时脑组织谷氨酸 (Glu)及环核苷酸代谢的改变及临床意义。方法 :在 SD大鼠弥漫性脑损伤模型基础上 ,制成 SHI合并低血压及脑缺血模型。通过氨基酸分析仪与放射免疫法测定伤后不同时间脑组织 Glu、c AMP和 c GMP含量。结果 :SHI后 10分钟 ,Glu明显增加〔(19.0±0 .9)μmol/ g(P<0 .0 1)〕,随后逐渐下降 ,并于 2 4小时达最低点〔 (6 .5± 1.0 )μmol/ g〕,72小时组出现回升趋势 ,但仍维持低水平 ;SHI后 2 4小时 c AMP下降至 (5 .7± 1.9) nm ol/ g(P <0 .0 5 ) ,c GMP则升高到 (1.1±0 .3) nm ol/ g(P<0 .0 1) ,c AMP/ c GMP比值下降到 (5 .0± 1.0 ,P<0 .0 5 ) ;SHI合并缺血、缺氧后 ,上述指标变化更加明显。结论 :在 SHI合并缺血、缺氧后 ,脑组织 Glu、c AMP和 c GMP含量发生显著变化 ,上述氨基酸谱的改变所引起的神经细胞兴奋毒性和代谢性应激反应是加重继发性脑损害的关键因素。

续命汤对大鼠脑缺血模型脑血管通透性和脑组织病理改变的影响

续命汤２．３、７．１、２３ｇ／ｋｇ给大鼠灌胃２周，能明显降低脑缺血大鼠脑组织含水量与脑血管通透性，使脑缺血大鼠脑组织病理变化明显减轻。表明续命汤能改善脑部血液供应，对缺血脑组织有明显保护作用。