A new isobenzofuran derivative( 1) was isolated from the marine Streptomyces sp. W007 and its structure was determined through extensive spectroscopic analyses, including 1D-NMR, 2D-NMR, and ESI-MS. The absolute confi...A new isobenzofuran derivative( 1) was isolated from the marine Streptomyces sp. W007 and its structure was determined through extensive spectroscopic analyses, including 1D-NMR, 2D-NMR, and ESI-MS. The absolute configuration of compound 1 was determined by a combination of experimental analyses and comparison with reported data, including biogenetic reasoning, J-coupling analysis, NOESY, and 1 H- 1 HCOSY. Compound 1 exhibited no cytotoxicity against human cells of gastric cancer BGC-823, lung cancer A549, and breast cancer MCF7.展开更多
An efficient synthesis of substituted 1,3-dihydroisobenzofurans is developed. In this novel route, oaroylbenzaldehydes, as key intermediates, can be obtained by lead tetraacetate oxidation of Naroylhydrazones of salic...An efficient synthesis of substituted 1,3-dihydroisobenzofurans is developed. In this novel route, oaroylbenzaldehydes, as key intermediates, can be obtained by lead tetraacetate oxidation of Naroylhydrazones of salicylaldehydes. The mild and general strategy enables the synthesis of various substituted 1,3-dihydroisobenzofurans in high yields. Moreover, this method can be applied to efficiently synthesize escitalopram.展开更多
An efficient method for preparation of substituted 1,2-phenylenedimethanols and aliphatic 1,4-diols that are valuable intermediates in organic synthesis, has been developed by the base-promoted reduction of isobenzofu...An efficient method for preparation of substituted 1,2-phenylenedimethanols and aliphatic 1,4-diols that are valuable intermediates in organic synthesis, has been developed by the base-promoted reduction of isobenzofuran-1(3H)-ones and y-lactones with silane under mild conditions. Compared with traditional procedures using stoichiometric amounts of metal hydrides and alkyl reductants, the present method avoids the use of sensitive reagents and is operationally simple and a broad variety of functional groups are tolerated.展开更多
基金Supported by the Open Fund of Key Laboratory of Experimental Marine Biology,Chinese Academy of Sciences(No.KF2015No07)the Innovative and Entrepreneurial Training Program of College Students,Tianjin University of Commerce(No.2015052)
文摘A new isobenzofuran derivative( 1) was isolated from the marine Streptomyces sp. W007 and its structure was determined through extensive spectroscopic analyses, including 1D-NMR, 2D-NMR, and ESI-MS. The absolute configuration of compound 1 was determined by a combination of experimental analyses and comparison with reported data, including biogenetic reasoning, J-coupling analysis, NOESY, and 1 H- 1 HCOSY. Compound 1 exhibited no cytotoxicity against human cells of gastric cancer BGC-823, lung cancer A549, and breast cancer MCF7.
基金supported by the National Basic Research Program of China(No.2011CB933503)Technology Supporting Program of Jiangsu Province(Nos.BE2009639 and BE2012657)
文摘An efficient synthesis of substituted 1,3-dihydroisobenzofurans is developed. In this novel route, oaroylbenzaldehydes, as key intermediates, can be obtained by lead tetraacetate oxidation of Naroylhydrazones of salicylaldehydes. The mild and general strategy enables the synthesis of various substituted 1,3-dihydroisobenzofurans in high yields. Moreover, this method can be applied to efficiently synthesize escitalopram.
基金the National Natural Science Foundation of China (Nos. 21572034, 21732007, 21871054) for financial support
文摘An efficient method for preparation of substituted 1,2-phenylenedimethanols and aliphatic 1,4-diols that are valuable intermediates in organic synthesis, has been developed by the base-promoted reduction of isobenzofuran-1(3H)-ones and y-lactones with silane under mild conditions. Compared with traditional procedures using stoichiometric amounts of metal hydrides and alkyl reductants, the present method avoids the use of sensitive reagents and is operationally simple and a broad variety of functional groups are tolerated.