The preparation of the key intermediate 4 of the methyl isosar-tortuoate is described. The macrocyclization was completed through an intramolecular [2,3]-Wittig ring contraction. The four necessary stereogenic carbons...The preparation of the key intermediate 4 of the methyl isosar-tortuoate is described. The macrocyclization was completed through an intramolecular [2,3]-Wittig ring contraction. The four necessary stereogenic carbons were established by Sharp-less asymmetric AE and AD reaction.展开更多
基金Project supported by Chinese Academy of Sciences and the National Natural Science Foundation of China.
文摘The preparation of the key intermediate 4 of the methyl isosar-tortuoate is described. The macrocyclization was completed through an intramolecular [2,3]-Wittig ring contraction. The four necessary stereogenic carbons were established by Sharp-less asymmetric AE and AD reaction.
