Summary： The hypoglycemic activity and its mechanism of Jatrorrhizine （Jat） were studied. The normal mice and alloxan-induced hyperglycemic mice were given with different doses of Jat. Blood glucose and liver glyco...Summary： The hypoglycemic activity and its mechanism of Jatrorrhizine （Jat） were studied. The normal mice and alloxan-induced hyperglycemic mice were given with different doses of Jat. Blood glucose and liver glycogen levels were determined by spectrophotometry with glucose-oxidase and iodine reagents respectively. The levels of blood lactic acid （LC） and liver lactate dehydrogenase （LDH） activity were measured to explore the effect of Jat on anaerobic glycolysis. Succinate dehydrogenase （SDH） activity in liver was measured to evaluate the effect of Jat on aerobic glycolysis in liver. It was found that Jat （50 mg/kg, 100 mg/kg） could significantly decrease blood glucose level in a dose- and time-dependent manner in both normal and alloxan-diabetic mice, increase the activity of SDH, but had no significant effects on the LC level and LDH activity. Jat could significantly reduce the content of liver glycogen in normal mice. Moreover, Jat could inhibit the platelet aggregation in rabbits in vitro in a dose-effect relationship. It was concluded that Jat induced the pronounced decrease in blood glucose in normal and hyperglycemic mice. The hypoglycemic activity of Jat may be attributed to the enhancement of aerobic glycolysis.展开更多
期刊论文结构化加工在期刊界已经逐步形成共识,国内期刊平台多采用新版期刊文章标签集(Journal Article Tag Suite,JATS)标准进行加工,但JATS标准仅对数据属性提出建议值,自行拓展空间较大,导致实际的数据加工结果千差万别,数据交换困...期刊论文结构化加工在期刊界已经逐步形成共识,国内期刊平台多采用新版期刊文章标签集(Journal Article Tag Suite,JATS)标准进行加工,但JATS标准仅对数据属性提出建议值,自行拓展空间较大,导致实际的数据加工结果千差万别,数据交换困难重重。本文分析了国内外数字化加工和标准进化的历程及我国在XML结构化数据加工中存在的问题,进一步分析了存档及交换标签集、出版标签集等不同子集的特点,提出既能完整保留论文原始信息,又便于提取各类结构化信息的数据加工及存储解决方案,可以根据需要通过减法转换生成符合各平台标准的数据加工存储格式,从而真正实现一次加工、多渠道投放和传播。展开更多
文摘Summary： The hypoglycemic activity and its mechanism of Jatrorrhizine （Jat） were studied. The normal mice and alloxan-induced hyperglycemic mice were given with different doses of Jat. Blood glucose and liver glycogen levels were determined by spectrophotometry with glucose-oxidase and iodine reagents respectively. The levels of blood lactic acid （LC） and liver lactate dehydrogenase （LDH） activity were measured to explore the effect of Jat on anaerobic glycolysis. Succinate dehydrogenase （SDH） activity in liver was measured to evaluate the effect of Jat on aerobic glycolysis in liver. It was found that Jat （50 mg/kg, 100 mg/kg） could significantly decrease blood glucose level in a dose- and time-dependent manner in both normal and alloxan-diabetic mice, increase the activity of SDH, but had no significant effects on the LC level and LDH activity. Jat could significantly reduce the content of liver glycogen in normal mice. Moreover, Jat could inhibit the platelet aggregation in rabbits in vitro in a dose-effect relationship. It was concluded that Jat induced the pronounced decrease in blood glucose in normal and hyperglycemic mice. The hypoglycemic activity of Jat may be attributed to the enhancement of aerobic glycolysis.
文摘期刊论文结构化加工在期刊界已经逐步形成共识,国内期刊平台多采用新版期刊文章标签集(Journal Article Tag Suite,JATS)标准进行加工,但JATS标准仅对数据属性提出建议值,自行拓展空间较大,导致实际的数据加工结果千差万别,数据交换困难重重。本文分析了国内外数字化加工和标准进化的历程及我国在XML结构化数据加工中存在的问题,进一步分析了存档及交换标签集、出版标签集等不同子集的特点,提出既能完整保留论文原始信息,又便于提取各类结构化信息的数据加工及存储解决方案,可以根据需要通过减法转换生成符合各平台标准的数据加工存储格式,从而真正实现一次加工、多渠道投放和传播。
