Nowadays,it is possible to travel to distant parts of the globe in several hours.This can result in the traveler ending up in a part of the world where time is different from his or her own"body clock",which...Nowadays,it is possible to travel to distant parts of the globe in several hours.This can result in the traveler ending up in a part of the world where time is different from his or her own"body clock",which controls our sleep patterns.If we travel east or west by more than four time zones(hours)then we will usually be affected.In the past when people traveled by sea,there展开更多
Background:A long-haul flight across more than five time zones may produce a circadian rhythm sleep disorder known as jet lag.Little is known about the effect of jet lag on white matter(WM)functional connectivity(FC)....Background:A long-haul flight across more than five time zones may produce a circadian rhythm sleep disorder known as jet lag.Little is known about the effect of jet lag on white matter(WM)functional connectivity(FC).Objective:The present study is to investigate changes in WM FC in subjects due to recovery from jet lag after flying across six time zones.Methods:Here,resting-state functional magnetic resonance imaging was performed in 23 participants within 24 hours of flying and again 50 days later.Gray matter(GM)and WM networks were identified by k-means clustering.WM FC and functional covariance connectivity(FCC)were analyzed.Next,a sliding window method was used to establish dynamic WM FC.WM static and dynamic FC and FCC were compared between when participants had initially completed their journey and 50 days later.Emotion was assessed using the Positive and Negative Affect Schedule and the State Anxiety Inventory.Results:All participants were confirmed to have jet lag symptoms by the Columbian Jet Lag Scale.The static FC strengthes of cingulate network(WM7)-sensorimotor network and ventral frontal network-visual network were lower after the long-haul flight compared with recovery.Corresponding results were obtained for the dynamic FC analysis.The analysis of FCC revealed weakened connections between the WM7 and several other brain networks,especially the precentral/postcentral network.Moreover,a negative correlation was found between emotion scores and the FC between the WM7 and sensorimotor related regions.Conclusions:The results of this study provide further evidence for the existence of WM networks and show that jet lag is associated with alterations in static and dynamic WM FC and FCC,especially in sensorimotor networks.Jet lag is a complex problem that not only is related to sleep rhythm but also influences emotion.展开更多
白兰氏虫草鸡精(Brand’s Essence of Chicken with Cordyceps,BECC)是一种具有增强体质功效的功能性食品,因其能够改善睡眠状况、增强免疫力、缓解疲劳而得到人们的喜爱。为探索BECC在生物节律调节方面的功效,本实验以Wistar大鼠为研...白兰氏虫草鸡精(Brand’s Essence of Chicken with Cordyceps,BECC)是一种具有增强体质功效的功能性食品,因其能够改善睡眠状况、增强免疫力、缓解疲劳而得到人们的喜爱。为探索BECC在生物节律调节方面的功效,本实验以Wistar大鼠为研究对象,通过颠倒明暗光周期和喂食周期构建倒时差(jet-lag)模型,同时外源性补充BECC,采用红外探头监测大鼠每日行为活动,荧光定量PCR分析外周组织(肝脏和心脏)中生物钟基因转录水平。研究表明:倒时差大鼠服用BECC后,加快了外周组织肝脏和心脏中生物钟基因(Bmal1和Cry1)的重置和昼夜行为活动量的恢复,从而使机体更快地适应时差反应。由此可见,BECC对大鼠外周生物钟系统具有一定的调控作用。展开更多
At the 2022 Winter Olympics in Beijing,the XC skiing,biathlon and nordic combined events will be held at altitudes of~1700 m above sea level,possibly in cold environmental conditions and while requiring adjustment to ...At the 2022 Winter Olympics in Beijing,the XC skiing,biathlon and nordic combined events will be held at altitudes of~1700 m above sea level,possibly in cold environmental conditions and while requiring adjustment to several time zones.However,the ongoing COVID-19 pandemic may lead to sub-optimal preparations.The current commentary provides the following evidence-based recommendations for the Olympic preparations:make sure to have extensive experience of training(>60 days annually)and competition at or above the altitude of competition(~1700 m),to optimize and individualize your strategies for acclimatization and competition.In preparing for the Olympics,10-14 days at~1700 m seems to optimize performance at this altitude effectively.An alternative strategy involves two-three weeks of training at>2000 m,followed by 7-10 days of tapering off at~1700 m.During each of the last 3 or 4 days prior to departure,shift your sleeping and eating schedule by 0.5-1 h towards the time zone in Beijing.In addition,we recommend that you arrive in Beijing one day earlier for each hour change in time zone,followed by appropriate timing of exposure to daylight,meals,social contacts,and naps,in combination with a gradual increase in training load.Optimize your own individual procedures for warming-up,as well as for maintaining body temperature during the period between the warm-up and competition,effective treatment of asthma(if necessary)and pacing at~1700 m with cold ambient temperatures.Although we hope that these recommendations will be helpful in preparing for the Beijing Olympics in 2022,there is a clear need for more solid evidence gained through new sophisticated experiments and observational studies.展开更多
文摘Nowadays,it is possible to travel to distant parts of the globe in several hours.This can result in the traveler ending up in a part of the world where time is different from his or her own"body clock",which controls our sleep patterns.If we travel east or west by more than four time zones(hours)then we will usually be affected.In the past when people traveled by sea,there
基金supported by the National Natural Science Foundation(Grant Nos.81771812,81971595,81621003,81820108018,and 81901828)the Innovation Spark Project of Sichuan University(No.2019SCUH0003).
文摘Background:A long-haul flight across more than five time zones may produce a circadian rhythm sleep disorder known as jet lag.Little is known about the effect of jet lag on white matter(WM)functional connectivity(FC).Objective:The present study is to investigate changes in WM FC in subjects due to recovery from jet lag after flying across six time zones.Methods:Here,resting-state functional magnetic resonance imaging was performed in 23 participants within 24 hours of flying and again 50 days later.Gray matter(GM)and WM networks were identified by k-means clustering.WM FC and functional covariance connectivity(FCC)were analyzed.Next,a sliding window method was used to establish dynamic WM FC.WM static and dynamic FC and FCC were compared between when participants had initially completed their journey and 50 days later.Emotion was assessed using the Positive and Negative Affect Schedule and the State Anxiety Inventory.Results:All participants were confirmed to have jet lag symptoms by the Columbian Jet Lag Scale.The static FC strengthes of cingulate network(WM7)-sensorimotor network and ventral frontal network-visual network were lower after the long-haul flight compared with recovery.Corresponding results were obtained for the dynamic FC analysis.The analysis of FCC revealed weakened connections between the WM7 and several other brain networks,especially the precentral/postcentral network.Moreover,a negative correlation was found between emotion scores and the FC between the WM7 and sensorimotor related regions.Conclusions:The results of this study provide further evidence for the existence of WM networks and show that jet lag is associated with alterations in static and dynamic WM FC and FCC,especially in sensorimotor networks.Jet lag is a complex problem that not only is related to sleep rhythm but also influences emotion.
文摘白兰氏虫草鸡精(Brand’s Essence of Chicken with Cordyceps,BECC)是一种具有增强体质功效的功能性食品,因其能够改善睡眠状况、增强免疫力、缓解疲劳而得到人们的喜爱。为探索BECC在生物节律调节方面的功效,本实验以Wistar大鼠为研究对象,通过颠倒明暗光周期和喂食周期构建倒时差(jet-lag)模型,同时外源性补充BECC,采用红外探头监测大鼠每日行为活动,荧光定量PCR分析外周组织(肝脏和心脏)中生物钟基因转录水平。研究表明:倒时差大鼠服用BECC后,加快了外周组织肝脏和心脏中生物钟基因(Bmal1和Cry1)的重置和昼夜行为活动量的恢复,从而使机体更快地适应时差反应。由此可见,BECC对大鼠外周生物钟系统具有一定的调控作用。
文摘At the 2022 Winter Olympics in Beijing,the XC skiing,biathlon and nordic combined events will be held at altitudes of~1700 m above sea level,possibly in cold environmental conditions and while requiring adjustment to several time zones.However,the ongoing COVID-19 pandemic may lead to sub-optimal preparations.The current commentary provides the following evidence-based recommendations for the Olympic preparations:make sure to have extensive experience of training(>60 days annually)and competition at or above the altitude of competition(~1700 m),to optimize and individualize your strategies for acclimatization and competition.In preparing for the Olympics,10-14 days at~1700 m seems to optimize performance at this altitude effectively.An alternative strategy involves two-three weeks of training at>2000 m,followed by 7-10 days of tapering off at~1700 m.During each of the last 3 or 4 days prior to departure,shift your sleeping and eating schedule by 0.5-1 h towards the time zone in Beijing.In addition,we recommend that you arrive in Beijing one day earlier for each hour change in time zone,followed by appropriate timing of exposure to daylight,meals,social contacts,and naps,in combination with a gradual increase in training load.Optimize your own individual procedures for warming-up,as well as for maintaining body temperature during the period between the warm-up and competition,effective treatment of asthma(if necessary)and pacing at~1700 m with cold ambient temperatures.Although we hope that these recommendations will be helpful in preparing for the Beijing Olympics in 2022,there is a clear need for more solid evidence gained through new sophisticated experiments and observational studies.
