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Preparative isolation of Heteroclitin D from Kadsurae Caulis using normal-phase flash chromatography 被引量:2
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作者 Xiao-Xue Yu Qian-Wen Wang +3 位作者 Xin-Jun Xu Wei-Jian Lv Ming-Qian Zhao Zhi-Kun Liang 《Journal of Pharmaceutical Analysis》 SCIE CAS 2013年第6期456-459,共4页
Heteroclitin D (H.D) was successfully isolated from Kadsurae Caulis by using flash chromatography and recrystalllzed by methanol, 10.2 mg of H.D was obtained from 4.86 g of crude extract, and the purity determined b... Heteroclitin D (H.D) was successfully isolated from Kadsurae Caulis by using flash chromatography and recrystalllzed by methanol, 10.2 mg of H.D was obtained from 4.86 g of crude extract, and the purity determined by HPLC was 99.4%. The structure was identified by UV, IR, MS, and NMR analysis. The fast, simple and efficient method can be applied to the preparation of reference substance of H. D. 展开更多
关键词 kadsurae caulis Heteroclitin D Normal-phase flashchromatography
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New Collection of Crude Drugs in Chinese Pharmacopoeia 2010 Ⅲ. Kadsurae Caulis 被引量:1
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作者 XU Li-jia, MA Pei, LI Li, WANG Wan-ying, XIAO Wei, PENG Yong, XIAO Pei-gen Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China 《Chinese Herbal Medicines》 CAS 2012年第3期177-182,共6页
The dried cane of Kadsura interior (Kadsurae Caulis) is recorded in Chinese Pharmacopoeia 2010 as Dian Jixueteng for the treatment of rheumatism, irregular menstruation, and deficiency of Qi and blood. In this paper, ... The dried cane of Kadsura interior (Kadsurae Caulis) is recorded in Chinese Pharmacopoeia 2010 as Dian Jixueteng for the treatment of rheumatism, irregular menstruation, and deficiency of Qi and blood. In this paper, morphological characteristics, chemical constituents, and pharmacological activities in the cane of K. interior were summarized. Moreover, some suggestions about application and quality control of Kadsurae Caulis were proposed in order to provide a theoretical basis for further scientific use. 展开更多
关键词 biological activities chemical constituents kadsurae caulis Kadsura interior morphological characteristics
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Based on Network Pharmacology to Explore the Action Mechanism of Caulis Sinomenii-Caulis Piperis Kadsurae Herb Pair in the Treatment of Rheumatoid Arthritis
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作者 Yuan Li Xiu-Juan Hou Hai-Yu Wang 《Medical Data Mining》 2021年第4期42-55,共14页
Objective:By using the method of network pharmacology to explore the mechanism of action of Caulis Sinomenii-Caulis Piperis Kadsurae herb pair in the treatment of rheumatoid arthritis.Methods:Search and screen the act... Objective:By using the method of network pharmacology to explore the mechanism of action of Caulis Sinomenii-Caulis Piperis Kadsurae herb pair in the treatment of rheumatoid arthritis.Methods:Search and screen the active ingredients and targets of Qingfengteng(Caulis Sinomenii)and Haifengteng(Caulis Piperis Kadsurae)through the TCMSP database,and predict and supplement the target points of the active ingredients through the Swiss Target Prediction platform;collect rheumatoid arthritis disease targets through GeneCards,OMIM database,and DRUGBANK database,construct a Venn diagram,and obtain the key target of Caulis Sinomenii-Caulis Piperis Kadsurae herb pairs in the treatment of rheumatoid arthritis;use Cytoscape 3.7.1 to establish the effect of Caysaceae sylvestris and Rhizoma sibirica in the treatment of rheumatoid arthritis"Drug-active ingredient-target"network diagram,submit key targets to STRING11.0 database to construct a protein interaction network model to obtain core targets;perform the GO and KEGG enrichment analysis of key targets on the Metascape platform,and draw the network diagram of"active pharmaceutical ingredients-targets-pathways".Results:After screening,discover a total of 27 active ingredients of Caulis Sinomenii-Caulis Piperis Kadsurae herb pairs,which can act on 229 targets,1269 related targets for rheumatoid arthritis diseases.And obtain a total of 95 common targets for drug active ingredients and diseases,including PTGS2,EGFR,MMP9,CASP3,JUN,etc.The common targets are mainly enriched in signaling pathways such as Pathways in cancer,Th17 cell differentiation and Endocrine resistance etc.Conclusion:This study preliminarily explored the potential mechanism of Caulis Sinomenii-Caulis Piperis Kadsurae herb pairs in the treatment of rheumatoid arthritis.The Caulis Sinomenii-Caulis Piperis Kadsurae herb pair may regulate cancer-related pathways,Th17 cell differentiation,endocrine resistance and other pathways to treat rheumatoid arthritis by regulating targets such as PTGS2,EGFR,and MMP9,providing clues and ideas for follow-up experimental research. 展开更多
关键词 caulis Sinomenii caulis Piperis kadsurae Network pharmacology Rheumatoid arthritis Signaling pathway MECHANISM
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