Kalirin是一种胞质内蛋白,属于Dbl(Diffuse B lymphoma)癌基因家族的一员,由于其与PAM(一种对神经肽生物合成所必需的酶)相互作用而首次被发现。主要在成年大鼠的中枢神经系统中永久性高表达,在胚胎中的表达比在成年鼠更加普遍,既在神...Kalirin是一种胞质内蛋白,属于Dbl(Diffuse B lymphoma)癌基因家族的一员,由于其与PAM(一种对神经肽生物合成所必需的酶)相互作用而首次被发现。主要在成年大鼠的中枢神经系统中永久性高表达,在胚胎中的表达比在成年鼠更加普遍,既在神经组织中表达也在非神经组织中表达。Kalirin能够激发神经元突起的生长、提高树突棘的数量在协调内分泌、神经轴突的生长、突触的发育、大脑的成熟等过程中发挥极其重要的作用。Kalirin作为神经保护因子为中枢神经系统的退行性及急性损伤相关疾病提供新的治疗线索,有着非常广泛的应用前景。就Kalirin的发现、分子结构、亚基、分布、在神经系统保护等方面的应用前景进行综述。展开更多
Objective To investigate the roles of estrogen and kalirin-7 in chronic restraint stress （CRS）-induced depression and the pathophysiological mechanism of depression. Methods Healthy female mice from Institute of Can...Objective To investigate the roles of estrogen and kalirin-7 in chronic restraint stress （CRS）-induced depression and the pathophysiological mechanism of depression. Methods Healthy female mice from Institute of Cancer Research （ICR） were randomly divided into 3 groups： control group, CRS group, and estrogen ＋ CRS group. CRS was used to establish the animal model of depression. Forced swimming test and immunohistochemistry method were utilized to investigate the animal behavior and kalirin-7 expression in the hippocampus, respectively. Results Compared with the control group, the CRS mice displayed depression-like behaviors, including a significant reduction in body weight, a significant increase in immobility time in forced swimming test, and a dramatic decrease in kalirin-7 expression in the hippocampus. However, administration of estrogen attenuated the CRS-induced negative behaviors, and simultaneously increased kalirin-7 expression. Conclusion Estrogen replacement therapy （ERT） could prevent CRS-induced depression-like behaviors in female ICR mice. Besides, kalirin-7 also plays a role in preventing CRS-induced depression-like behaviors.展开更多
文摘Kalirin是一种胞质内蛋白,属于Dbl(Diffuse B lymphoma)癌基因家族的一员,由于其与PAM(一种对神经肽生物合成所必需的酶)相互作用而首次被发现。主要在成年大鼠的中枢神经系统中永久性高表达,在胚胎中的表达比在成年鼠更加普遍,既在神经组织中表达也在非神经组织中表达。Kalirin能够激发神经元突起的生长、提高树突棘的数量在协调内分泌、神经轴突的生长、突触的发育、大脑的成熟等过程中发挥极其重要的作用。Kalirin作为神经保护因子为中枢神经系统的退行性及急性损伤相关疾病提供新的治疗线索,有着非常广泛的应用前景。就Kalirin的发现、分子结构、亚基、分布、在神经系统保护等方面的应用前景进行综述。
基金supported by the Natural Science Foundation of Shaanxi Province, China (No.2006C240)
文摘Objective To investigate the roles of estrogen and kalirin-7 in chronic restraint stress （CRS）-induced depression and the pathophysiological mechanism of depression. Methods Healthy female mice from Institute of Cancer Research （ICR） were randomly divided into 3 groups： control group, CRS group, and estrogen ＋ CRS group. CRS was used to establish the animal model of depression. Forced swimming test and immunohistochemistry method were utilized to investigate the animal behavior and kalirin-7 expression in the hippocampus, respectively. Results Compared with the control group, the CRS mice displayed depression-like behaviors, including a significant reduction in body weight, a significant increase in immobility time in forced swimming test, and a dramatic decrease in kalirin-7 expression in the hippocampus. However, administration of estrogen attenuated the CRS-induced negative behaviors, and simultaneously increased kalirin-7 expression. Conclusion Estrogen replacement therapy （ERT） could prevent CRS-induced depression-like behaviors in female ICR mice. Besides, kalirin-7 also plays a role in preventing CRS-induced depression-like behaviors.
