Background and Objectives:Microneedling has been introduced as a new technique to address the growing concern of facial skin photoaging.Kangfuxin liquid has been found to promote the process of skin wound repair,inclu...Background and Objectives:Microneedling has been introduced as a new technique to address the growing concern of facial skin photoaging.Kangfuxin liquid has been found to promote the process of skin wound repair,including reducing inflammatory response,improving immunity and enhancing antioxidant levels.In this prospective randomized double-blinded study,we wanted to explore the clinical efficacy and safety of Kangfuxin liquid combined with microneedling in treating facial skin photoaging.Methods:57 patients with facial skin photoaging were randomly divided into two groups.The treatment group(28 cases)received microneedle therapy with Kangfuxin liquid,while the control group(29 cases)received microneedle therapy with physiological saline.The treatment interval was 4 weeks,and a total of 3 treatments were performed.Compare the VISIA scores of facial photoaging features such as wrinkles,texture,pores,spots and ultraviolet pigmentation between two groups of patients before and after treatment,Global Score for Photoaging,satisfaction evaluation,and record the occurrence of adverse reactions.Results:After treatment,the treatment group showed more significant improvement in wrinkles,texture,pores,spots and ultraviolet pigmentation,and the Global Score for Photoaging was better than the control group(P<0.05).The satisfaction rate with improving skin in the treatment group was 85.71%,which was higher than 75.86%in the control group(P<0.05).Both groups did not experience adverse reactions such as skin infection,pigmentation or hypopigmentation,scar formation,or worsening of melasma.Conclusion:Kangfuxin liquid combined with microneedling therapy has a good improvement effect on facial skin photoaging,with a low incidence of adverse reactions and high patient satisfaction.It is worthy of clinical promotion.展开更多
Through a meta-analysis,we comprehensively evaluated the clinical efficacy and safety of Kangfuxin liquid(KFXL)in patients with recurrent aphthous stomatitis(RAS).Randomized controlled clinical trials(RCTs)involving R...Through a meta-analysis,we comprehensively evaluated the clinical efficacy and safety of Kangfuxin liquid(KFXL)in patients with recurrent aphthous stomatitis(RAS).Randomized controlled clinical trials(RCTs)involving RAS patients treated with KFXL were systematically retrieved from several online databases from inception to December 2021.All the study selection,data extraction,and quality assessments were performed by two independent investigators using the Cochrane systematic review method.The total effective rate,VAS pain score,recurrence rate,and ulcer healing time were analyzed using Rev Man 5.3 software and Stata 16.0.A total of 17 studies consisting of 1703 patients were included in our investigation.The pooled result indicated that when compared with watermelon frost spray(WFS),KFXL had a significantly superior clinical effectiveness rate(logRR=0.19,95%CI:0.15 to 0.22,P<0.00001).Moreover,the ulcer healing time(MD=–1.63,95%CI=–2.32 to–0.93,P<0.00001),VAS pain score(MD=–1.81,95%CI:–2.65 to–0.97,P=0.00),and recurrence rate(logRR=–0.65,95%CI=–0.89 to 0.42,P<0.00001)of patients with RAS were also significantly improved after receiving the KFXL therapy.Our study revealed that KFXL was a more effective treatment for RAS than WFS,and it could significantly decrease the VAS pain score,recurrence rate,and ulcer healing time in patients.However,our study was limited by the quality of available literature,and further robust trials are needed for a more accurate analysis.展开更多
BACKGROUND The role of primary-level medical pharmacists in medical institutions in China is limited;therefore,it is necessary to explore the role of pharmacists in the process of drug treatment.CASE SUMMARY A Chinese...BACKGROUND The role of primary-level medical pharmacists in medical institutions in China is limited;therefore,it is necessary to explore the role of pharmacists in the process of drug treatment.CASE SUMMARY A Chinese pharmacist participated in the complete treatment of a patient with a duodenal ulcer.The rationale for drug treatment was evaluated,and adjustments were made to the antacid and anti-infective regimen,as well as the dose and frequency of administration.Body temperature,routine blood examination,and adverse drug reactions were strictly monitored.During treatment,the pharmacist recommended anti-infective therapy with ampicillin-sulbactam,which effectively controlled the infection.Additionally,the pharmacist suggested changing famotidine to lansoprazole for acid suppression and gastroprotective treatment,combined with Chinese patent medicine such as Kangfuxin Liquid.This is the first case report of a pharmacist in primary-level medical institutions adjusting drug use for patients with duodenal ulcer and pulmonary infection.CONCLUSION A pharmacist participated in the treatment process,provided individualized medication adjustment,and achieved good clinical results.展开更多
目的系统评价康复新液治疗头颈部肿瘤放射性皮炎的效果。方法计算机检索PubMed、Co⁃chrane Library、Embase、Web of Science、中国生物医学文献服务系统、中国知网、维普、万方数据库自建库以来至2023年9月公开发表的与康复新液治疗头...目的系统评价康复新液治疗头颈部肿瘤放射性皮炎的效果。方法计算机检索PubMed、Co⁃chrane Library、Embase、Web of Science、中国生物医学文献服务系统、中国知网、维普、万方数据库自建库以来至2023年9月公开发表的与康复新液治疗头颈部肿瘤放射治疗所造成放射性皮炎相关的随机对照研究。由2人独立进行文献筛选、质量评价和资料提取,采用Revman 5.4软件进行数据分析。结果共纳入10篇中文文献,包括688例患者。Meta分析结果显示:康复新液组治疗头颈部肿瘤放射性皮炎的总体有效性优于对照组,差异有统计学意义[OR=4.04,95%CI(2.29,7.15),P<0.05];康复新液组Ⅱ级及以上放射性皮炎的发生率低于对照组,差异有统计学意义[OR=0.34,95%CI(0.19,0.63),P<0.05]。结论当前证据显示,康复新液治疗头颈部肿瘤放射性皮炎的效果显著,有助于降低Ⅱ级及以上头颈部肿瘤放射性皮炎的发生率。展开更多
文摘Background and Objectives:Microneedling has been introduced as a new technique to address the growing concern of facial skin photoaging.Kangfuxin liquid has been found to promote the process of skin wound repair,including reducing inflammatory response,improving immunity and enhancing antioxidant levels.In this prospective randomized double-blinded study,we wanted to explore the clinical efficacy and safety of Kangfuxin liquid combined with microneedling in treating facial skin photoaging.Methods:57 patients with facial skin photoaging were randomly divided into two groups.The treatment group(28 cases)received microneedle therapy with Kangfuxin liquid,while the control group(29 cases)received microneedle therapy with physiological saline.The treatment interval was 4 weeks,and a total of 3 treatments were performed.Compare the VISIA scores of facial photoaging features such as wrinkles,texture,pores,spots and ultraviolet pigmentation between two groups of patients before and after treatment,Global Score for Photoaging,satisfaction evaluation,and record the occurrence of adverse reactions.Results:After treatment,the treatment group showed more significant improvement in wrinkles,texture,pores,spots and ultraviolet pigmentation,and the Global Score for Photoaging was better than the control group(P<0.05).The satisfaction rate with improving skin in the treatment group was 85.71%,which was higher than 75.86%in the control group(P<0.05).Both groups did not experience adverse reactions such as skin infection,pigmentation or hypopigmentation,scar formation,or worsening of melasma.Conclusion:Kangfuxin liquid combined with microneedling therapy has a good improvement effect on facial skin photoaging,with a low incidence of adverse reactions and high patient satisfaction.It is worthy of clinical promotion.
基金Hebei province administration of traditional Chinese Me dicine(Grant No.2019141)。
文摘Through a meta-analysis,we comprehensively evaluated the clinical efficacy and safety of Kangfuxin liquid(KFXL)in patients with recurrent aphthous stomatitis(RAS).Randomized controlled clinical trials(RCTs)involving RAS patients treated with KFXL were systematically retrieved from several online databases from inception to December 2021.All the study selection,data extraction,and quality assessments were performed by two independent investigators using the Cochrane systematic review method.The total effective rate,VAS pain score,recurrence rate,and ulcer healing time were analyzed using Rev Man 5.3 software and Stata 16.0.A total of 17 studies consisting of 1703 patients were included in our investigation.The pooled result indicated that when compared with watermelon frost spray(WFS),KFXL had a significantly superior clinical effectiveness rate(logRR=0.19,95%CI:0.15 to 0.22,P<0.00001).Moreover,the ulcer healing time(MD=–1.63,95%CI=–2.32 to–0.93,P<0.00001),VAS pain score(MD=–1.81,95%CI:–2.65 to–0.97,P=0.00),and recurrence rate(logRR=–0.65,95%CI=–0.89 to 0.42,P<0.00001)of patients with RAS were also significantly improved after receiving the KFXL therapy.Our study revealed that KFXL was a more effective treatment for RAS than WFS,and it could significantly decrease the VAS pain score,recurrence rate,and ulcer healing time in patients.However,our study was limited by the quality of available literature,and further robust trials are needed for a more accurate analysis.
文摘BACKGROUND The role of primary-level medical pharmacists in medical institutions in China is limited;therefore,it is necessary to explore the role of pharmacists in the process of drug treatment.CASE SUMMARY A Chinese pharmacist participated in the complete treatment of a patient with a duodenal ulcer.The rationale for drug treatment was evaluated,and adjustments were made to the antacid and anti-infective regimen,as well as the dose and frequency of administration.Body temperature,routine blood examination,and adverse drug reactions were strictly monitored.During treatment,the pharmacist recommended anti-infective therapy with ampicillin-sulbactam,which effectively controlled the infection.Additionally,the pharmacist suggested changing famotidine to lansoprazole for acid suppression and gastroprotective treatment,combined with Chinese patent medicine such as Kangfuxin Liquid.This is the first case report of a pharmacist in primary-level medical institutions adjusting drug use for patients with duodenal ulcer and pulmonary infection.CONCLUSION A pharmacist participated in the treatment process,provided individualized medication adjustment,and achieved good clinical results.
文摘目的系统评价康复新液治疗头颈部肿瘤放射性皮炎的效果。方法计算机检索PubMed、Co⁃chrane Library、Embase、Web of Science、中国生物医学文献服务系统、中国知网、维普、万方数据库自建库以来至2023年9月公开发表的与康复新液治疗头颈部肿瘤放射治疗所造成放射性皮炎相关的随机对照研究。由2人独立进行文献筛选、质量评价和资料提取,采用Revman 5.4软件进行数据分析。结果共纳入10篇中文文献,包括688例患者。Meta分析结果显示:康复新液组治疗头颈部肿瘤放射性皮炎的总体有效性优于对照组,差异有统计学意义[OR=4.04,95%CI(2.29,7.15),P<0.05];康复新液组Ⅱ级及以上放射性皮炎的发生率低于对照组,差异有统计学意义[OR=0.34,95%CI(0.19,0.63),P<0.05]。结论当前证据显示,康复新液治疗头颈部肿瘤放射性皮炎的效果显著,有助于降低Ⅱ级及以上头颈部肿瘤放射性皮炎的发生率。
