为探讨角蛋白关联蛋白6.2(keratin-associated protein 6.2,KAP6.2)基因遗传多态性与内蒙古绒山羊生长性状和绒细度性状的相关性,以期为内蒙古绒山羊遗传育种改良提供理论依据,本研究采集598只雌性内蒙古绒山羊耳组织,提取基因组DNA并进...为探讨角蛋白关联蛋白6.2(keratin-associated protein 6.2,KAP6.2)基因遗传多态性与内蒙古绒山羊生长性状和绒细度性状的相关性,以期为内蒙古绒山羊遗传育种改良提供理论依据,本研究采集598只雌性内蒙古绒山羊耳组织,提取基因组DNA并进行PCR扩增,检测KAP6.2基因的插入/缺失(Insertion/Deletion,InDel)突变,分析突变位点与生长性状和绒细度性状的相关性。结果显示,在育成羊中,该突变位点与胸围和十字部显著相关(P<0.05),与体长、胸宽和胸深极显著相关(P<0.01);在成年羊中,该突变位点与胸宽显著相关(P<0.05),与胸围、十字部高和胸深极显著相关(P<0.01);在育成羊和成年羊全部群体中,该突变位点与体长、胸围、十字部高、胸深和胸宽极显著相关(P<0.01),与绒细度显著相关(P<0.05)。上述结果提示,KAP6.2基因外显子区24 bp InDel突变位点与内蒙古绒山羊部分生长性状显著或极显著相关,与绒细度显著相关,可作为内蒙古绒山羊部分生长性状和绒细度性状选育的遗传标记,为内蒙古绒山羊的选育提供科学依据。展开更多
KRAB相关蛋白1(KRAB-associated protein 1,KAP1)是最早于1996年通过亲合色谱分离并克隆得到的一种转录辅因子,因能与含KRAB结构域的锌指蛋白家族(zinc family proteins,ZFPs)成员结合而得名。KAP1是一种具有多功能的蛋白质,它参与组蛋...KRAB相关蛋白1(KRAB-associated protein 1,KAP1)是最早于1996年通过亲合色谱分离并克隆得到的一种转录辅因子,因能与含KRAB结构域的锌指蛋白家族(zinc family proteins,ZFPs)成员结合而得名。KAP1是一种具有多功能的蛋白质,它参与组蛋白修饰与染色质重塑、调节DNA甲基化、作为转录共调控因子参与基因调控、参与DNA损伤反应等,并存在磷酸化、乙酰化等多种翻译后修饰。KAP1的表达水平与多种人类恶性肿瘤的发生发展密切相关,并影响肿瘤预后。因此,KAP1有望成为恶性肿瘤的诊断标志物或治疗新靶点。本文主要综述KAP1的结构、功能及其与人类恶性肿瘤发生发展的关系,并进一步探讨KAP1在恶性肿瘤研究中的应用前景,以期为恶性肿瘤的临床诊断和治疗提供参考依据。展开更多
Objective:To explore the impact of a continuous precision nursing model on patients’Knowledge,Attitudes,and Practices(KAP)and cardiac function during the nursing process of patients undergoing percutaneous coronary a...Objective:To explore the impact of a continuous precision nursing model on patients’Knowledge,Attitudes,and Practices(KAP)and cardiac function during the nursing process of patients undergoing percutaneous coronary angiography and stent implantation.Methods:Ninety patients who underwent percutaneous coronary angiography and stent implantation in our hospital from April 2022 to April 2023 were selected and randomly divided into the control group(45 cases),in which routine nursing support was carried out during the treatment process,and the observation group(45 cases),in which continuous precision nursing model was carried out during the treatment process.Comparisons were made between the two groups of patients on their KAP,cardiac function,and quality of life during recovery.Results:There was no difference in the left ventricular ejection fraction(LVEF),cardiac output(CO),and cardiac index(CI)levels before intervention.After the intervention,the levels of cardiac function in the observation group were higher than those of the control group(P<0.05).There was no difference in the Exercise of Self-Care Agency(ESCA)self-care ability scale scores before the intervention.After the intervention,the observation group had higher ESCA scores than the control group(P<0.05).Conclusion:Implementation of a continuous precision nursing model in the care of patients undergoing percutaneous coronary angiography and stent implantation improved the patient’s cardiac function,and KAP,and promoted recovery.展开更多
文摘为探讨角蛋白关联蛋白6.2(keratin-associated protein 6.2,KAP6.2)基因遗传多态性与内蒙古绒山羊生长性状和绒细度性状的相关性,以期为内蒙古绒山羊遗传育种改良提供理论依据,本研究采集598只雌性内蒙古绒山羊耳组织,提取基因组DNA并进行PCR扩增,检测KAP6.2基因的插入/缺失(Insertion/Deletion,InDel)突变,分析突变位点与生长性状和绒细度性状的相关性。结果显示,在育成羊中,该突变位点与胸围和十字部显著相关(P<0.05),与体长、胸宽和胸深极显著相关(P<0.01);在成年羊中,该突变位点与胸宽显著相关(P<0.05),与胸围、十字部高和胸深极显著相关(P<0.01);在育成羊和成年羊全部群体中,该突变位点与体长、胸围、十字部高、胸深和胸宽极显著相关(P<0.01),与绒细度显著相关(P<0.05)。上述结果提示,KAP6.2基因外显子区24 bp InDel突变位点与内蒙古绒山羊部分生长性状显著或极显著相关,与绒细度显著相关,可作为内蒙古绒山羊部分生长性状和绒细度性状选育的遗传标记,为内蒙古绒山羊的选育提供科学依据。
文摘KRAB相关蛋白1(KRAB-associated protein 1,KAP1)是最早于1996年通过亲合色谱分离并克隆得到的一种转录辅因子,因能与含KRAB结构域的锌指蛋白家族(zinc family proteins,ZFPs)成员结合而得名。KAP1是一种具有多功能的蛋白质,它参与组蛋白修饰与染色质重塑、调节DNA甲基化、作为转录共调控因子参与基因调控、参与DNA损伤反应等,并存在磷酸化、乙酰化等多种翻译后修饰。KAP1的表达水平与多种人类恶性肿瘤的发生发展密切相关,并影响肿瘤预后。因此,KAP1有望成为恶性肿瘤的诊断标志物或治疗新靶点。本文主要综述KAP1的结构、功能及其与人类恶性肿瘤发生发展的关系,并进一步探讨KAP1在恶性肿瘤研究中的应用前景,以期为恶性肿瘤的临床诊断和治疗提供参考依据。
文摘Objective:To explore the impact of a continuous precision nursing model on patients’Knowledge,Attitudes,and Practices(KAP)and cardiac function during the nursing process of patients undergoing percutaneous coronary angiography and stent implantation.Methods:Ninety patients who underwent percutaneous coronary angiography and stent implantation in our hospital from April 2022 to April 2023 were selected and randomly divided into the control group(45 cases),in which routine nursing support was carried out during the treatment process,and the observation group(45 cases),in which continuous precision nursing model was carried out during the treatment process.Comparisons were made between the two groups of patients on their KAP,cardiac function,and quality of life during recovery.Results:There was no difference in the left ventricular ejection fraction(LVEF),cardiac output(CO),and cardiac index(CI)levels before intervention.After the intervention,the levels of cardiac function in the observation group were higher than those of the control group(P<0.05).There was no difference in the Exercise of Self-Care Agency(ESCA)self-care ability scale scores before the intervention.After the intervention,the observation group had higher ESCA scores than the control group(P<0.05).Conclusion:Implementation of a continuous precision nursing model in the care of patients undergoing percutaneous coronary angiography and stent implantation improved the patient’s cardiac function,and KAP,and promoted recovery.
