To match nature’s prowess at using enzymes to make desired motifs in a regioselective fashion,we explore the use of visible light for the selective oxidation of the hydroxyl group to afford the corresponding ketosacc...To match nature’s prowess at using enzymes to make desired motifs in a regioselective fashion,we explore the use of visible light for the selective oxidation of the hydroxyl group to afford the corresponding ketosaccharide.This highly admirable approach offers several advantages over the enzymatic approach in terms of yields and the scope of substrates.Herein,we report the development of a simple visiblelight-promoted selective oxidation of unprotected glucosides that allows for inexpensive access to valuable keto-saccharide building blocks.The method is employed on a variety of different natural and artificial glucosides,is operationally simple and scalable,and can be used to access keto-saccharides rapidly and inexpensively.展开更多
基金Financial support for this work was provided by the National Science Foundation of China(grant no.22071087)the Fundamental Research Funds for the Central Universities(grant no.lzujbky-2021-ct05)the Open Projects Funds of Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology,Shandong University(grant no.2019CCG05).X.W.also thanks the Thousand Young Talents Program and Longyuan Talents Program for financial support.
文摘To match nature’s prowess at using enzymes to make desired motifs in a regioselective fashion,we explore the use of visible light for the selective oxidation of the hydroxyl group to afford the corresponding ketosaccharide.This highly admirable approach offers several advantages over the enzymatic approach in terms of yields and the scope of substrates.Herein,we report the development of a simple visiblelight-promoted selective oxidation of unprotected glucosides that allows for inexpensive access to valuable keto-saccharide building blocks.The method is employed on a variety of different natural and artificial glucosides,is operationally simple and scalable,and can be used to access keto-saccharides rapidly and inexpensively.
