Enhanced recovery after surgery(ERAS)programs have been widely applied in liver surgery since the publication of the first ERAS guidelines in 2016 and the new recommendations in 2022.Liver surgery is usually performed...Enhanced recovery after surgery(ERAS)programs have been widely applied in liver surgery since the publication of the first ERAS guidelines in 2016 and the new recommendations in 2022.Liver surgery is usually performed in oncological patients(liver metastasis,hepatocellular carcinoma,cholangiocarcinoma,etc.),but the real impact of liver surgery ERAS programs in oncological outcomes is not clearly defined.Theoretical advantages of ERAS programs are:ERAS decreases postoperative complication rates and has been demonstrated a clear relationship between complications and oncological outcomes;a better and faster posto-perative recovery should let oncologic teams begin chemotherapeutic regimens on time;prehabilitation and nutrition actions before surgery should also improve the performance status of the patients receiving chemotherapy.So,ERAS could be another way to improve our oncological results.We will discuss the literature about liver surgery ERAS focusing on its oncological implications and future investigations projects.展开更多
The Chinese government has decided that the installed capacity of nuclear power plants(NPP)will reach 40 GW by the year of 2020,while other 18 GW under construction,and the electricity produced by NPPs will make up 4%...The Chinese government has decided that the installed capacity of nuclear power plants(NPP)will reach 40 GW by the year of 2020,while other 18 GW under construction,and the electricity produced by NPPs will make up 4%of the whole installed capacity. In such case,the spent fuel generated from those NPPs will reach 82630 tons by 2050.The Chinese policy is that,the spent fuel from light water reactors will be reprocessed first,followed by verification and展开更多
A primal-dual infeasible interior point algorithm for multiple objective linear programming (MOLP) problems was presented. In contrast to the current MOLP algorithm. moving through the interior of polytope but not con...A primal-dual infeasible interior point algorithm for multiple objective linear programming (MOLP) problems was presented. In contrast to the current MOLP algorithm. moving through the interior of polytope but not confining the iterates within the feasible region in our proposed algorithm result in a solution approach that is quite different and less sensitive to problem size, so providing the potential to dramatically improve the practical computation effectiveness.展开更多
Liaoning Dalmond Group （shorten for Dalmond）, established in 2001, is located on Yingkou City with abundant magnesia resource. Through several years struggle, Dalmond develops to an enterprise group holding several ...Liaoning Dalmond Group （shorten for Dalmond）, established in 2001, is located on Yingkou City with abundant magnesia resource. Through several years struggle, Dalmond develops to an enterprise group holding several company branches.展开更多
Key-recovery technology is often used by an adversary to attempt to recover the cryptographic key of an encryption scheme. The most obvious key-recovery attack is the exhaustive key-search attack. But modern ciphers o...Key-recovery technology is often used by an adversary to attempt to recover the cryptographic key of an encryption scheme. The most obvious key-recovery attack is the exhaustive key-search attack. But modern ciphers often have a key space of size 2128 or greater, making such attacks infeasible with current technology. Cache-based side channel attack is another way to get the cryptographic key of an encryption scheme, but there are random noises in side channel attack. In order to reduce random errors, it is advisable to repeat the key recovery process many times. This paper is focused on the way to improve the key recovery accuracy by dealing with the key sequences obtained from the repeated Cache-based side channel attacks. To get the real key, private key bits from side channel attack are collected firstly. And then the key sequences are aligned using sequence alignment algorithms based on dynamic programming. The provided method of key recovery is universal, which is not limited to any cryptographic algorithm. The experiment shows that the proposed method has a good performance and a high availability when the error rate of the collected key bit is within a reasonable range.展开更多
Over the past two decades,China has introduced significant changes to drug regulations through regulatory innovations to accelerate drug review and approvals,keeping in line with the rapidly growing scientific innovat...Over the past two decades,China has introduced significant changes to drug regulations through regulatory innovations to accelerate drug review and approvals,keeping in line with the rapidly growing scientific innovation in drug research and development(R&D).In this study,we outlined the revolution of drug regulation in China since the establishment of the State Drug Administration in 1998.More particularly,we performed a comprehensive analysis of newly approved anticancer drugs in China from the year 2005 to May 2021,as a powerful illustration of how the revolution has changed the drug R&D landscape.Innovative drug development in China has boomed,benefiting in particular from pro-innovation policies as well as expedited program designations by the authority.We found a significant increase in the number of both imported and domestic new anticancer drugs from 2005 to 2021,with the emergence of drugs with novel mechanisms of action,including immune checkpoint inhibitors and cell therapy products.Drug lag has also been dramatically shortened by more than 70%for imported drugs in years 2016-2020 compared to years 2006-2010.Furthermore,we provide an insight into the potential approaches to further optimize the science-based and clinical value-based regulatory and R&D drug ecosystem in China.This review provides evidence of significant impacts of regulations and policies on drug R&D and suggests that the constantly adapting regulatory ecosystem will speed up drug development in China and worldwide.展开更多
With the support by the National Key R&D Program of China,the National Natural Science Foundation of China,and the Chinese Academy of Sciences,the research team led by Prof.Wang JiangYun (王江云) at the Institute ...With the support by the National Key R&D Program of China,the National Natural Science Foundation of China,and the Chinese Academy of Sciences,the research team led by Prof.Wang JiangYun (王江云) at the Institute of Biophysics,CAS,rationally designed a genetically encoded photosensitizer protein (PSP)that facilitates photocatalytic CO2 reduction,which was published in Nature Chemistry (2018, DOI :10.1038/s41557-018-0150-4).展开更多
文摘Enhanced recovery after surgery(ERAS)programs have been widely applied in liver surgery since the publication of the first ERAS guidelines in 2016 and the new recommendations in 2022.Liver surgery is usually performed in oncological patients(liver metastasis,hepatocellular carcinoma,cholangiocarcinoma,etc.),but the real impact of liver surgery ERAS programs in oncological outcomes is not clearly defined.Theoretical advantages of ERAS programs are:ERAS decreases postoperative complication rates and has been demonstrated a clear relationship between complications and oncological outcomes;a better and faster posto-perative recovery should let oncologic teams begin chemotherapeutic regimens on time;prehabilitation and nutrition actions before surgery should also improve the performance status of the patients receiving chemotherapy.So,ERAS could be another way to improve our oncological results.We will discuss the literature about liver surgery ERAS focusing on its oncological implications and future investigations projects.
文摘The Chinese government has decided that the installed capacity of nuclear power plants(NPP)will reach 40 GW by the year of 2020,while other 18 GW under construction,and the electricity produced by NPPs will make up 4%of the whole installed capacity. In such case,the spent fuel generated from those NPPs will reach 82630 tons by 2050.The Chinese policy is that,the spent fuel from light water reactors will be reprocessed first,followed by verification and
基金Supported by the Doctoral Educational Foundation of China of the Ministry of Education(20020486035)
文摘A primal-dual infeasible interior point algorithm for multiple objective linear programming (MOLP) problems was presented. In contrast to the current MOLP algorithm. moving through the interior of polytope but not confining the iterates within the feasible region in our proposed algorithm result in a solution approach that is quite different and less sensitive to problem size, so providing the potential to dramatically improve the practical computation effectiveness.
文摘Liaoning Dalmond Group （shorten for Dalmond）, established in 2001, is located on Yingkou City with abundant magnesia resource. Through several years struggle, Dalmond develops to an enterprise group holding several company branches.
基金Supported in part by the Fundamental Research Funds for the Central Universities of China(2015JBM034)
文摘Key-recovery technology is often used by an adversary to attempt to recover the cryptographic key of an encryption scheme. The most obvious key-recovery attack is the exhaustive key-search attack. But modern ciphers often have a key space of size 2128 or greater, making such attacks infeasible with current technology. Cache-based side channel attack is another way to get the cryptographic key of an encryption scheme, but there are random noises in side channel attack. In order to reduce random errors, it is advisable to repeat the key recovery process many times. This paper is focused on the way to improve the key recovery accuracy by dealing with the key sequences obtained from the repeated Cache-based side channel attacks. To get the real key, private key bits from side channel attack are collected firstly. And then the key sequences are aligned using sequence alignment algorithms based on dynamic programming. The provided method of key recovery is universal, which is not limited to any cryptographic algorithm. The experiment shows that the proposed method has a good performance and a high availability when the error rate of the collected key bit is within a reasonable range.
文摘Over the past two decades,China has introduced significant changes to drug regulations through regulatory innovations to accelerate drug review and approvals,keeping in line with the rapidly growing scientific innovation in drug research and development(R&D).In this study,we outlined the revolution of drug regulation in China since the establishment of the State Drug Administration in 1998.More particularly,we performed a comprehensive analysis of newly approved anticancer drugs in China from the year 2005 to May 2021,as a powerful illustration of how the revolution has changed the drug R&D landscape.Innovative drug development in China has boomed,benefiting in particular from pro-innovation policies as well as expedited program designations by the authority.We found a significant increase in the number of both imported and domestic new anticancer drugs from 2005 to 2021,with the emergence of drugs with novel mechanisms of action,including immune checkpoint inhibitors and cell therapy products.Drug lag has also been dramatically shortened by more than 70%for imported drugs in years 2016-2020 compared to years 2006-2010.Furthermore,we provide an insight into the potential approaches to further optimize the science-based and clinical value-based regulatory and R&D drug ecosystem in China.This review provides evidence of significant impacts of regulations and policies on drug R&D and suggests that the constantly adapting regulatory ecosystem will speed up drug development in China and worldwide.
文摘With the support by the National Key R&D Program of China,the National Natural Science Foundation of China,and the Chinese Academy of Sciences,the research team led by Prof.Wang JiangYun (王江云) at the Institute of Biophysics,CAS,rationally designed a genetically encoded photosensitizer protein (PSP)that facilitates photocatalytic CO2 reduction,which was published in Nature Chemistry (2018, DOI :10.1038/s41557-018-0150-4).
