王世荣教授益气活血消癥法治疗膜性肾病经验

益气活血消癥法是王世荣教授根据多年膜性肾病诊疗经验,基于气血津液理论、络病理论确立的治疗大法,并据此法研制了芪龙通肾方,临床疗效已得到证实。文章通过对膜性肾病的致病特点、芪龙通肾方方药探讨以及临床运用的心得体会进行综合分析,从中医药角度探讨益气活血消癥法治疗膜性肾病的病症理论,为临床治疗提供新思路。

Exploration of the effective components and mechanism of Alpinia oxyphylla-Saposhnikovia Radix in the treatment of diabetic kidney disease based on network pharmacology

Objective:Network pharmacology was used to predict the main targets and related mechanism pathways of the key compounds and active ingredients of the Alpinia oxyphylla-Saposhnikovia Radix based on the therapeutic strategy of tonifying kidney and dispelling pathogenic wind for the treatment of diabetic kidney disease(DKD).Methods:The effective components of Alpinia oxyphylla-Saposhnikovia Radix were screened through the data platform of Traditional Chinese Medicine(TCM).After screening effective targets,the disease target gene database was used to obtain targets for DKD,and then gene enrichment analysis to predict relevant signalling pathways after obtaining the key target genes through Venn analysis.Results:There were 324 active components of Alpinia oxyphylla-Saposhnikovia Radix through the data platform of TCM.In addition,Venn analysis showed that there were 48 key target genes for the treatment of DKD.The biological pathways for the action of Alpinia oxyphylla-Saposhnikovia Radix in DKD were closely related to many signaling pathways including NF-kappaB,classical MAP kinase,JNK and P38 MAP kinase,and ERK5.Conclusions:Treatment of DKD with Alpinia oxyphylla-Saposhnikovia Radix based on the therapeutic strategy of tonifying kidney and dispelling pathogenic wind has the characteristics of multi-components,multi-targets and multi-pathways,which could provide new ideas and methods for further researches on the treatment of DKD with Alpinia oxyphylla-Saposhnikovia Radix.

李东海运用脏腑风湿理论论治硬皮病经验介绍

介绍李东海教授运用脏腑风湿理论治疗硬皮病的临床经验。李东海教授认为硬皮病的病机关键是寒湿内伏、脏腑虚损、痰瘀胶着互结,治疗宜透散伏邪、补益虚损、消除痹阻。临证有升散、发汗、散寒、透表、清上、逐风等诸法透散伏邪,补肺、健脾、益肾、固精诸法补益虚损,行气、活血、祛瘀、通络诸法消除痹阻。透散伏邪常用葛根升散,麻黄发汗,附子散寒,香薷透表,升麻清上,荆芥逐风等时时透邪为要,补益虚损早期注重补肺健脾,后期注重益肾固精,酌加行气活血、祛瘀通络之品,起到协同增效的作用。