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Efficacy and safety of traditional Chinese medicine kidney-nourishing formula for Alzheimer's disease in comparison with donepezil:a systematic review and meta-analysis 被引量:1
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作者 Fei-Zhou Li Yi-Ni Zhang +2 位作者 Tong Zhang Ling Liu Ping Wang 《Traditional Medicine Research》 2020年第5期337-354,共18页
Objective:Finding an effective therapy against Alzheimer’s disease(AD)has been associate increasingly pressing issue and traditional Chinese medicine(TCM)is widespread in the prevention and treatment of AD in China.T... Objective:Finding an effective therapy against Alzheimer’s disease(AD)has been associate increasingly pressing issue and traditional Chinese medicine(TCM)is widespread in the prevention and treatment of AD in China.The aim of this study was to judge the efficaciousness and safety of TCM kidney-nourishing(the changes of pathological state of kidney deficiency by means of TCM treatment and so on)formula(TKNF)for AD in comparison with donepezil.Methods:The retrieval period of seven databases was from the establishment of each database to April 2019.Two authors independently identified randomized controlled trials(RCTs),fetched data and assessed bias risk.Comprehensive analysis process was conducted with review manager for eligible and appropriate RCTs.Results:A complete of 981 AD patients from 13 studies were enclosed.Meta-analysis of RCTs showed that there was no significant difference in the improvement of Alzheimer's disease assessment scale-cognitive subscale score between 2 groups in short term,but the effect of long-term treatment may exceed donepezil;there was a significant difference in the improvement of activities of daily living score between 2 groups;there was a significant difference in TCM curative efficacy between 2 groups with long-term treatment.There was no significant difference in the incidence of adverse events between 2 groups.The quality of the evidence was high or moderate.Conclusion:Compared with donepezil,TKNF was an effective drug for AD patients and the clinical application of TKNF was safe.TKNF's long-term benefits need more evidence to verify. 展开更多
关键词 Alzheimer's disease Traditional Chinese medicine kidney-nourishing formula DONEPEZIL Systematic review META-ANALYSIS
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Observations on After-Effect Duration of Kidney-Nourishing and Marrow-Replenishing Therapy on 58 Cases of Mediterranean Anemia 被引量:4
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作者 王文娟 吴志奎 +8 位作者 张新华 王荣新 刘咏梅 方素萍 张冲 周天红 李平萍 罗瑞贵 段树民(翻译) 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2009年第4期258-262,共5页
To observe the after-effect duration of kidney-nourishing and marrow-replenishing therapy on Mediterranean anemia. Methods: To observe the kidney-nourishing and marrow-replenishing therapy on 58 cases of Mediterranea... To observe the after-effect duration of kidney-nourishing and marrow-replenishing therapy on Mediterranean anemia. Methods: To observe the kidney-nourishing and marrow-replenishing therapy on 58 cases of Mediterranean anemia and the influence of various relative factors on the after-effect duration. Results: The after-effect duration on 58 cases varied from 3-6 months, about 4 months on average, and was not influenced by sex, clinical types, genetic types, types of Mediterranean anemia and other factors. Conclusion: Kidney-nourishing and marrow-replenishing therapy used to treat Mediterranean anemia can not only produce good therapeutic effect during treatment but also keep after effect lasting for about 4 months, indicating that the therapy used to treat Mediterranean anemia has good clinical after effect. 展开更多
关键词 kidney-nourishing and marrow-replenishing therapy Mediterranean anemia FOLLOW-UP
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