The intensive care unit(ICU)is a complex setting by nature,and some have described it as bizarre due to its numerous sirens that sound when anything is dangerous,constant activity,equipment,bright lights,and high fata...The intensive care unit(ICU)is a complex setting by nature,and some have described it as bizarre due to its numerous sirens that sound when anything is dangerous,constant activity,equipment,bright lights,and high fatality rate.The demands placed on nurses to care for critically ill patients in this environment frequently prevent nurses and other health‑care professionals from acknowledging the feelings of patient’s relatives or family caregivers,resulting in a hostile environment from the patient’s relative’s perspective.When a patient’s family enters the ICU,they feel that hospital administrators do little to nothing to alleviate their discomfort and fear.Despite research demonstrating the importance of providing a homely environment for patients’families,In Nigeria ICU is still far behind how a conventional ICU environment should be structured to accommodate patient’s relations in the unit.The goal of this study was to look at the patient’s relative’s perspective on providing care for a critically ill patient in an ICU,with a focus on the unit’s complexity and overall experience.Based on the findings of this study,we recommend that hospital administrators ensure that the environment of the upcoming ICU is designed to meet the needs of patient’s relatives by addressing identified environmental concerns,like caring neglect,by providing a friendly and stress‑free environment.展开更多
We compare Newton’s force law of universal gravitation with a corrected simple approach based on Bhandari’s recently presented work, where the gravitation constant G is maintained. A reciprocity relation exists betw...We compare Newton’s force law of universal gravitation with a corrected simple approach based on Bhandari’s recently presented work, where the gravitation constant G is maintained. A reciprocity relation exists between both alternative gravity formulas with respect to the distances between mass centers. We conclude a one-to-one mapping of the two gravitational formulas. We don’t need Einstein’s construct of spacetime bending by matter.展开更多
AIM: To investigate the effect of vitamin D (VD) concentrations and VD supplementation on health related quality of life in inflammatory bowel disease (IBD) patients.
Due to global climate warming and natural and man-made land subsidence etc., relative sea level rise in the coastal plains of China will exceed 2-3 times over the golbal mean value during the first half part of the 21...Due to global climate warming and natural and man-made land subsidence etc., relative sea level rise in the coastal plains of China will exceed 2-3 times over the golbal mean value during the first half part of the 21st century. It will result in a series of adverse impacts on evolution of natural environment and socioeconomic development of the coastal area. This paper analyses environmental and resource effects induced by relative sea level rise in China's coastal areas on the basis of rough estimate of future relative sea level rise. These effects include inundating tidal flat and wetlands and increase in inundated risk of coastal habitable land,exacerbating storm surge. coastal erosion, flooding and salt water intrusion hazards.as well as endangering land. water. tourism and living resources and their utilization.展开更多
The Lie symmetry and Hojman conserved quantity of Nielsen equations in a dynamical system of relative motion with nonholonomic constraint of the Chetaev type are studied. The differential equations of motion of the Ni...The Lie symmetry and Hojman conserved quantity of Nielsen equations in a dynamical system of relative motion with nonholonomic constraint of the Chetaev type are studied. The differential equations of motion of the Nielsen equation for the system, the definition and the criterion of Lie symmetry, and the expression of the Hojman conserved quantity deduced directly from the Lie symmetry for the system are obtained. An example is given to illustrate the application of the results.展开更多
This paper presents an investigation of a DC glow discharge at low pressure in the normal mode and with Einstein＇s relation of electron diffusivity. Two-dimensional distributions in Cartesian geometry are presented i...This paper presents an investigation of a DC glow discharge at low pressure in the normal mode and with Einstein＇s relation of electron diffusivity. Two-dimensional distributions in Cartesian geometry are presented in the stationary state, including electric potential, electron and ion densities, longitudinal and transverse electrics fields as well as electron temperature. Our results are compared with those obtained in existing literature. The model used in this work is based on the first three moments of Boltzmann＇s equation. They serve as the continuity equation, the momentum transfer and the energy equations. The set of equations for charged particles presented in monatomic argon gas are coupled in a self-consistent way with Poisson＇s equation. A parametric study varying the cathode voltage, gas pressure, and secondary electron emission coefficient predicts many of the well-known features of DC discharges.展开更多
The most commonly used method for assessing the hydraulic erodibility of rock is Annandale's method.This method is based on a correlation between the erosive force of flowing water and the capacity of rock resista...The most commonly used method for assessing the hydraulic erodibility of rock is Annandale's method.This method is based on a correlation between the erosive force of flowing water and the capacity of rock resistance. This capacity is evaluated using Kirsten's index, which was initially developed to evaluate the excavatability of earth materials. For rocky material, this index is determined according to certain geomechanical factors related to intact rock and rock mass, such as compressive strength of intact rock, rock block size, discontinuity shear strength and relative block structure. To quantify the relative block structure, Kirsten(1982) developed a mathematical expression that accounts for the shape and orientation of the blocks relative to the direction of flow. Kirsten's initial concept for assessing the relative block structure considers that the geological formation is mainly fractured by two joint sets forming an orthogonally fractured system. An adjusted concept is proposed to determine the relative block structure when the fractured system is non-orthogonal where the angle between the planes of the two joint sets is greater or less than 90°. An analysis of the proposed relative block structure rating shows that considering a non-orthogonally fractured system has a significant effect on Kirsten's index and, as a consequence, on the assessment of the hydraulic erodibility of rock.展开更多
Green's relations and generalized Green's relations play a fundamental role in the study of semigroups.GV-semigroups are the generalizations of completely regular semigroups in the range of π-regular semigrou...Green's relations and generalized Green's relations play a fundamental role in the study of semigroups.GV-semigroups are the generalizations of completely regular semigroups in the range of π-regular semigroups.In this paper,Green's relations and generalized Green's relations on GV-semigroups are considered by the structure of GV-semigroups.D=j and D C D* on GV-semigroups will be proved.展开更多
Neurodegeneration is one of the biggest public health problems in modern society. Age-associated neurodegeneration, which is accelerated several-fold in Alzheimer＇s disease （AD） alone, is not only an enormous socia...Neurodegeneration is one of the biggest public health problems in modern society. Age-associated neurodegeneration, which is accelerated several-fold in Alzheimer＇s disease （AD） alone, is not only an enormous social and economic burden to the affected in- dividuals and their families, but is also a great scientific challenge. Currently 25-35 million people worldwide suffer from AD, the single largest cause of dementia in middle- to old-aged individuals. These numbers are projected to triple by 2050 if no treatment to prevent or reverse AD is developed.展开更多
In order to study rpp semigroups, in particular, some special cases, several facts on （l）-Green’s relations and strongly rpp semigroups are given as some remarks.
At present China-U.S.trade relations are in a state of confusion.Although both countries have gained tremendous benefits from the bilateral trade relationship,some Americans have intentionally distorted some basic fac...At present China-U.S.trade relations are in a state of confusion.Although both countries have gained tremendous benefits from the bilateral trade relationship,some Americans have intentionally distorted some basic facts regarding China-U.S.trade relations. Based on an analysis of some official and nonofficial research reports published in the United States,this article holds that the China-U.S.trade imbalance is the symptom of a bigger issue stemming from the contradiction between the United States as the world's sole superpower and China as an emerging power.Economic globalisation came about due to the needs of western developed countries represented by the United States to boost economic development.Only by seizing the opportunities of economic globalisation, has China gained strong economic growth. Such a development is changing the world political,economic,military and cultural landscape that have been shaped since the post-cold-war era,and has to some extent raised doubt or suspicion on the part of the United States and its western allies.This is a manifestation of how unprepared some people in the United States and other western countries are in the face of China's rapid development and rising status.So,their immediate reaction has been to seek protection for themselves,and try their utmost to prevent China's rapid growth from impacting on the international framework and their vested interests.展开更多
AIM： To analyze the DNA copy number of target genes NF2, TIMP3, ST13, TOB2, BIK, and TP and the reference microsatellite markers D22S283, D22S423, and D22S274 mapped on 22q12-qter in liver fluke related cholangiocarc...AIM： To analyze the DNA copy number of target genes NF2, TIMP3, ST13, TOB2, BIK, and TP and the reference microsatellite markers D22S283, D22S423, and D22S274 mapped on 22q12-qter in liver fluke related cholangiocarcinoma （CCA） and define its correlation with clinical parameters. METHODS： Quantitative real time PCR （qPCR） was used for determining allelic imbalances in 65 liver fluke related CCA tissues. Statistical correlations between allelic imbalances and clinicopathological parameters, i.e. age, sex, tumor stage, histological type, blood vessel invasion, nerve invasion and lymphatic invasion were evaluated by means of the X^2 test. Cox regression analysis was used for determining patient＇s survival. RESULTS： Amplifications of the TP （22q13.33）, TOB2 （22q13.2-13.31）, D22S283 （22q12.3）, TIMP3 （22q12.3） and NF2 （22q12.2） were found in 35 （53.8%）, 28 （43.1%）, 27 （41.5%）, 24 （36.9%）, and 24 （36.9%）, respectively. Losses at the D22S423 （22q13.1-13.2）and BIK （22q13.31） were detected in 26 （40%） and 23 （35.4%）, respectively. Significant correlations were observed between lymphatic invasion and allelic losses of BIK （P = 0.025） and D22S283 （P = 0.041）. Univariate and multivariate Cox regression analysis revealed D22S283 amplification as an independent predictor of good prognosis （P = 0.006, death hazard ratio = 0.411, 95% CI = 0.217-0.779） and blood vessel invasion as an independent poor prognostic factor （P = 0.042, death hazard ratio = 1.911, 95% CI = 1.022-3.571） in CCA patients. CONCLUSION： This study provides evidence for the involvement of gene amplification and deletion on chromosome 22q in liver fluke related CCA, This is the first report of D22S283 amplification as an independent indicator of favorable prognosis in liver fluke related CCA.展开更多
AIM：To identify the pathological role of amyloid beta（Aβ） deposition in retinal degeneration,and explore Aβ deposition on the retinal pigment epithelium cells（RPE） layer and the associated structural and functi...AIM：To identify the pathological role of amyloid beta（Aβ） deposition in retinal degeneration,and explore Aβ deposition on the retinal pigment epithelium cells（RPE） layer and the associated structural and functional changes in Alzheimer＇s disease transgenic mice.METHODS：RPE changes in the eyes of APPswe/PS1 transgenic and none transgenic（NTG） mice over 20 months old were examined.Histological changes were investigated via hematoxylin and eosin（H＆E） staining and transmission electron microscopy（TEM） examination,whereas the expression of amyloid precursor protein（APP）,Aβ,Zonula occludens-1（ZO-1） and Ionized calcium binding adaptor molecule-1（IBA-1） were investigated using immunohistochemistry and immunofluorescence techniques.All of the obtained results were quantitatively and statistically analyzed.RESULTS：In aged transgenic mice,an APP-positive immunoreaction and Aβ deposition were detected on the RPE layer but were undetectable in NTG mice.The RPE demonstrated some vacuole changes,shortened basal infoldings and basal deposition in histopathological examination and TEM tests,wherein irregular shapes were indicated by ZO-1 disorganization through fluorescence.Furthermore,IBA-1 positive cells were observed to have accumulated and infiltrated into the RPE layer and localized beneath the RPE/Bruch＇s membrane（Br M） complex,which was accompanied by an increase in BrM thickness in aged transgenic mice in comparison to NTG mice.The IBA-1 positive cells were found to be co-stained with Aβ deposition on the RPE flat mounts.CONCLUSION：The observed Aβ deposition in the RPE layer may cause RPE dysfunction,which is associated with microglia cells infiltration into the retina of aged transgenic mice,suggesting that Aβ deposition probably plays a significant role in RPE-related degenerative disease.展开更多
Geological storage of acid gas has been identified as a promising approach to reduce atmospheric carbon dioxide(CO_(2)),hydrogen sulfide(H_(2)S)and alleviate public concern resulting from the sour gas production.A goo...Geological storage of acid gas has been identified as a promising approach to reduce atmospheric carbon dioxide(CO_(2)),hydrogen sulfide(H_(2)S)and alleviate public concern resulting from the sour gas production.A good understanding of the relative permeability and capillary pressure characteristics is crucial to predict the process of acid gas injection and migration.The prediction of injection and redistribution of acid gas is important to determine storage capacity,formation pressure,plume extent,shape,and leakage potential.Herein,the existing experimental data and theoretical models were reviewed to gain a better understanding of the issue how the H_(2)S content affects gas density,gas viscosity,interfacial tension,wettability,relative permeability and capillary pressure characteristics of acid gas/brine/rock systems.The densities and viscosities of the acid gas with different H_(2)S mole fractions are both temperature-and pressure-dependent,which vary among the gas,liquid and supercritical phases.Water/acid gas interfacial tension decreases strongly with increasing H_(2)S content.For mica and clean quartz,water contact angle increases with increasing H_(2)S mole fraction.In particular,wettability reversal of mica to a H_(2)S-wet behavior occurs in the presence of dense H_(2)S.The capillary pressure increases with decreasing contact angle.At a given saturation,the relative permeability of a fluid is higher when the fluid is nonwetting.The capillary pressure decreases with decreasing interfacial tension at a given saturation.However,the existing datasets do not show a consistent link between capillary number and relative permeability.The capillary pressure decreases with increasing H_(2)S mole fraction.However,there is no consensus on the effect of the H_(2)S content on the relative permeability curves.This may be due to the limited availability of the relative permeability and capillary pressure data for acid gas/brine/rock systems;thus,more experimental measurements are required.展开更多
Thermodynamics being among the most synthetic theories of physics and the mass-energy relation E = mc2 among the most general equations of science, it is somewhat surprising that this latter is not explicitly present ...Thermodynamics being among the most synthetic theories of physics and the mass-energy relation E = mc2 among the most general equations of science, it is somewhat surprising that this latter is not explicitly present in the laws of thermodynamics. Coupling this observation with the conceptual difficulties often felt in learning thermodynamics leads to the idea that both situations may have the same cause. On the basis of these clues, this paper is intended to provide complementary arguments to a hypothesis already presented. It consists of showing the existence of an imperfect compatibility between the conventional formulations of the first and second laws of thermodynamics and suggesting the need of the mass-energy relation to solving the problem.展开更多
Since the advent of relativity, it is widely accepted that the law of conservation of energy must include the energy created by disintegration of matter, or converted into matter. The aim of the present paper deals wi...Since the advent of relativity, it is widely accepted that the law of conservation of energy must include the energy created by disintegration of matter, or converted into matter. The aim of the present paper deals with the insertion of this concept into the basic equations of thermodynamics.展开更多
Crack growth rate curves are the fundamental material property for metal structures under fatigue loading. Although there are many crack growth rate curves available in the literature, few of them showed the capabilit...Crack growth rate curves are the fundamental material property for metal structures under fatigue loading. Although there are many crack growth rate curves available in the literature, few of them showed the capability to explain various special phenomena observed in tests. A modified constitutive relation recently proposed by McEvily and his co-workers showed very promising capability. This modified constitutive relation is further generalized by (1) introducing an unstable fracture condition; (2) defining a virtual strength to replace the yield stress; and (3) defining an overload and underload parameter. The performances of this general constitutive relation for fatigue crack growth is extensively studied and it is found that this general constitutive relation is able to explain various phenomena observed with particular strong capability on load sequence effect.展开更多
文摘The intensive care unit(ICU)is a complex setting by nature,and some have described it as bizarre due to its numerous sirens that sound when anything is dangerous,constant activity,equipment,bright lights,and high fatality rate.The demands placed on nurses to care for critically ill patients in this environment frequently prevent nurses and other health‑care professionals from acknowledging the feelings of patient’s relatives or family caregivers,resulting in a hostile environment from the patient’s relative’s perspective.When a patient’s family enters the ICU,they feel that hospital administrators do little to nothing to alleviate their discomfort and fear.Despite research demonstrating the importance of providing a homely environment for patients’families,In Nigeria ICU is still far behind how a conventional ICU environment should be structured to accommodate patient’s relations in the unit.The goal of this study was to look at the patient’s relative’s perspective on providing care for a critically ill patient in an ICU,with a focus on the unit’s complexity and overall experience.Based on the findings of this study,we recommend that hospital administrators ensure that the environment of the upcoming ICU is designed to meet the needs of patient’s relatives by addressing identified environmental concerns,like caring neglect,by providing a friendly and stress‑free environment.
文摘We compare Newton’s force law of universal gravitation with a corrected simple approach based on Bhandari’s recently presented work, where the gravitation constant G is maintained. A reciprocity relation exists between both alternative gravity formulas with respect to the distances between mass centers. We conclude a one-to-one mapping of the two gravitational formulas. We don’t need Einstein’s construct of spacetime bending by matter.
基金Supported by Grant from the Slovak APVV agency,No.APVV-0672-11
文摘AIM: To investigate the effect of vitamin D (VD) concentrations and VD supplementation on health related quality of life in inflammatory bowel disease (IBD) patients.
文摘Due to global climate warming and natural and man-made land subsidence etc., relative sea level rise in the coastal plains of China will exceed 2-3 times over the golbal mean value during the first half part of the 21st century. It will result in a series of adverse impacts on evolution of natural environment and socioeconomic development of the coastal area. This paper analyses environmental and resource effects induced by relative sea level rise in China's coastal areas on the basis of rough estimate of future relative sea level rise. These effects include inundating tidal flat and wetlands and increase in inundated risk of coastal habitable land,exacerbating storm surge. coastal erosion, flooding and salt water intrusion hazards.as well as endangering land. water. tourism and living resources and their utilization.
文摘The Lie symmetry and Hojman conserved quantity of Nielsen equations in a dynamical system of relative motion with nonholonomic constraint of the Chetaev type are studied. The differential equations of motion of the Nielsen equation for the system, the definition and the criterion of Lie symmetry, and the expression of the Hojman conserved quantity deduced directly from the Lie symmetry for the system are obtained. An example is given to illustrate the application of the results.
文摘This paper presents an investigation of a DC glow discharge at low pressure in the normal mode and with Einstein＇s relation of electron diffusivity. Two-dimensional distributions in Cartesian geometry are presented in the stationary state, including electric potential, electron and ion densities, longitudinal and transverse electrics fields as well as electron temperature. Our results are compared with those obtained in existing literature. The model used in this work is based on the first three moments of Boltzmann＇s equation. They serve as the continuity equation, the momentum transfer and the energy equations. The set of equations for charged particles presented in monatomic argon gas are coupled in a self-consistent way with Poisson＇s equation. A parametric study varying the cathode voltage, gas pressure, and secondary electron emission coefficient predicts many of the well-known features of DC discharges.
基金the organizations that have funded this project:the Natural Sciences and Engineering Research Council of Canada(Grant No.498020-16)Hydro-Quebec(NC-525700)Mitacs Accelerate Program(Grant Ref.IT10008)
文摘The most commonly used method for assessing the hydraulic erodibility of rock is Annandale's method.This method is based on a correlation between the erosive force of flowing water and the capacity of rock resistance. This capacity is evaluated using Kirsten's index, which was initially developed to evaluate the excavatability of earth materials. For rocky material, this index is determined according to certain geomechanical factors related to intact rock and rock mass, such as compressive strength of intact rock, rock block size, discontinuity shear strength and relative block structure. To quantify the relative block structure, Kirsten(1982) developed a mathematical expression that accounts for the shape and orientation of the blocks relative to the direction of flow. Kirsten's initial concept for assessing the relative block structure considers that the geological formation is mainly fractured by two joint sets forming an orthogonally fractured system. An adjusted concept is proposed to determine the relative block structure when the fractured system is non-orthogonal where the angle between the planes of the two joint sets is greater or less than 90°. An analysis of the proposed relative block structure rating shows that considering a non-orthogonally fractured system has a significant effect on Kirsten's index and, as a consequence, on the assessment of the hydraulic erodibility of rock.
基金Leading Academic Discipline Project of SHNU,China (No.DZL803)Innovation Project of Shanghai Education Committee,China(No.12YZ081)+2 种基金General Scientific Research Project of SHNU,China (No.SK201121)National Natural Science Foundation of China(No.11001046)Fundamental Research Fundation for the Central Universities,China (No.11D10904)
文摘Green's relations and generalized Green's relations play a fundamental role in the study of semigroups.GV-semigroups are the generalizations of completely regular semigroups in the range of π-regular semigroups.In this paper,Green's relations and generalized Green's relations on GV-semigroups are considered by the structure of GV-semigroups.D=j and D C D* on GV-semigroups will be proved.
基金supported in part by the New York State Office of People with Developmental Disabilities(OPWDD)Zenith Award ZEN-12-241233 from Alzheimer’s Associationa research grant#20121203 from Alzheimer’s Drug Discovery Foundation,New York
文摘Neurodegeneration is one of the biggest public health problems in modern society. Age-associated neurodegeneration, which is accelerated several-fold in Alzheimer＇s disease （AD） alone, is not only an enormous social and economic burden to the affected in- dividuals and their families, but is also a great scientific challenge. Currently 25-35 million people worldwide suffer from AD, the single largest cause of dementia in middle- to old-aged individuals. These numbers are projected to triple by 2050 if no treatment to prevent or reverse AD is developed.
基金The research of the second author was supported by the NSFC (10871161)
文摘In order to study rpp semigroups, in particular, some special cases, several facts on （l）-Green’s relations and strongly rpp semigroups are given as some remarks.
文摘At present China-U.S.trade relations are in a state of confusion.Although both countries have gained tremendous benefits from the bilateral trade relationship,some Americans have intentionally distorted some basic facts regarding China-U.S.trade relations. Based on an analysis of some official and nonofficial research reports published in the United States,this article holds that the China-U.S.trade imbalance is the symptom of a bigger issue stemming from the contradiction between the United States as the world's sole superpower and China as an emerging power.Economic globalisation came about due to the needs of western developed countries represented by the United States to boost economic development.Only by seizing the opportunities of economic globalisation, has China gained strong economic growth. Such a development is changing the world political,economic,military and cultural landscape that have been shaped since the post-cold-war era,and has to some extent raised doubt or suspicion on the part of the United States and its western allies.This is a manifestation of how unprepared some people in the United States and other western countries are in the face of China's rapid development and rising status.So,their immediate reaction has been to seek protection for themselves,and try their utmost to prevent China's rapid growth from impacting on the international framework and their vested interests.
基金Supported by The Thailand Research Fund through The Royal Golden Jubilee PhD Program, Grant No. PHD/0037/2544 for Thanasai J and Limpaiboon T
文摘AIM： To analyze the DNA copy number of target genes NF2, TIMP3, ST13, TOB2, BIK, and TP and the reference microsatellite markers D22S283, D22S423, and D22S274 mapped on 22q12-qter in liver fluke related cholangiocarcinoma （CCA） and define its correlation with clinical parameters. METHODS： Quantitative real time PCR （qPCR） was used for determining allelic imbalances in 65 liver fluke related CCA tissues. Statistical correlations between allelic imbalances and clinicopathological parameters, i.e. age, sex, tumor stage, histological type, blood vessel invasion, nerve invasion and lymphatic invasion were evaluated by means of the X^2 test. Cox regression analysis was used for determining patient＇s survival. RESULTS： Amplifications of the TP （22q13.33）, TOB2 （22q13.2-13.31）, D22S283 （22q12.3）, TIMP3 （22q12.3） and NF2 （22q12.2） were found in 35 （53.8%）, 28 （43.1%）, 27 （41.5%）, 24 （36.9%）, and 24 （36.9%）, respectively. Losses at the D22S423 （22q13.1-13.2）and BIK （22q13.31） were detected in 26 （40%） and 23 （35.4%）, respectively. Significant correlations were observed between lymphatic invasion and allelic losses of BIK （P = 0.025） and D22S283 （P = 0.041）. Univariate and multivariate Cox regression analysis revealed D22S283 amplification as an independent predictor of good prognosis （P = 0.006, death hazard ratio = 0.411, 95% CI = 0.217-0.779） and blood vessel invasion as an independent poor prognostic factor （P = 0.042, death hazard ratio = 1.911, 95% CI = 1.022-3.571） in CCA patients. CONCLUSION： This study provides evidence for the involvement of gene amplification and deletion on chromosome 22q in liver fluke related CCA, This is the first report of D22S283 amplification as an independent indicator of favorable prognosis in liver fluke related CCA.
基金Supported by the National Natural Science Foundation of China(No.81430009No.81400424)the Science and Technology Research and Development Project of Shaanxi Province(No.2014K11-03-07-04)
文摘AIM：To identify the pathological role of amyloid beta（Aβ） deposition in retinal degeneration,and explore Aβ deposition on the retinal pigment epithelium cells（RPE） layer and the associated structural and functional changes in Alzheimer＇s disease transgenic mice.METHODS：RPE changes in the eyes of APPswe/PS1 transgenic and none transgenic（NTG） mice over 20 months old were examined.Histological changes were investigated via hematoxylin and eosin（H＆E） staining and transmission electron microscopy（TEM） examination,whereas the expression of amyloid precursor protein（APP）,Aβ,Zonula occludens-1（ZO-1） and Ionized calcium binding adaptor molecule-1（IBA-1） were investigated using immunohistochemistry and immunofluorescence techniques.All of the obtained results were quantitatively and statistically analyzed.RESULTS：In aged transgenic mice,an APP-positive immunoreaction and Aβ deposition were detected on the RPE layer but were undetectable in NTG mice.The RPE demonstrated some vacuole changes,shortened basal infoldings and basal deposition in histopathological examination and TEM tests,wherein irregular shapes were indicated by ZO-1 disorganization through fluorescence.Furthermore,IBA-1 positive cells were observed to have accumulated and infiltrated into the RPE layer and localized beneath the RPE/Bruch＇s membrane（Br M） complex,which was accompanied by an increase in BrM thickness in aged transgenic mice in comparison to NTG mice.The IBA-1 positive cells were found to be co-stained with Aβ deposition on the RPE flat mounts.CONCLUSION：The observed Aβ deposition in the RPE layer may cause RPE dysfunction,which is associated with microglia cells infiltration into the retina of aged transgenic mice,suggesting that Aβ deposition probably plays a significant role in RPE-related degenerative disease.
基金the National Natural Science Foundation of China(Grant Nos.41872210 and 41274111)the Open Research Fund of State Key Laboratory of Geomechanics and Geotechnical Engineering(Grant No.Z018002)。
文摘Geological storage of acid gas has been identified as a promising approach to reduce atmospheric carbon dioxide(CO_(2)),hydrogen sulfide(H_(2)S)and alleviate public concern resulting from the sour gas production.A good understanding of the relative permeability and capillary pressure characteristics is crucial to predict the process of acid gas injection and migration.The prediction of injection and redistribution of acid gas is important to determine storage capacity,formation pressure,plume extent,shape,and leakage potential.Herein,the existing experimental data and theoretical models were reviewed to gain a better understanding of the issue how the H_(2)S content affects gas density,gas viscosity,interfacial tension,wettability,relative permeability and capillary pressure characteristics of acid gas/brine/rock systems.The densities and viscosities of the acid gas with different H_(2)S mole fractions are both temperature-and pressure-dependent,which vary among the gas,liquid and supercritical phases.Water/acid gas interfacial tension decreases strongly with increasing H_(2)S content.For mica and clean quartz,water contact angle increases with increasing H_(2)S mole fraction.In particular,wettability reversal of mica to a H_(2)S-wet behavior occurs in the presence of dense H_(2)S.The capillary pressure increases with decreasing contact angle.At a given saturation,the relative permeability of a fluid is higher when the fluid is nonwetting.The capillary pressure decreases with decreasing interfacial tension at a given saturation.However,the existing datasets do not show a consistent link between capillary number and relative permeability.The capillary pressure decreases with increasing H_(2)S mole fraction.However,there is no consensus on the effect of the H_(2)S content on the relative permeability curves.This may be due to the limited availability of the relative permeability and capillary pressure data for acid gas/brine/rock systems;thus,more experimental measurements are required.
文摘Thermodynamics being among the most synthetic theories of physics and the mass-energy relation E = mc2 among the most general equations of science, it is somewhat surprising that this latter is not explicitly present in the laws of thermodynamics. Coupling this observation with the conceptual difficulties often felt in learning thermodynamics leads to the idea that both situations may have the same cause. On the basis of these clues, this paper is intended to provide complementary arguments to a hypothesis already presented. It consists of showing the existence of an imperfect compatibility between the conventional formulations of the first and second laws of thermodynamics and suggesting the need of the mass-energy relation to solving the problem.
文摘Since the advent of relativity, it is widely accepted that the law of conservation of energy must include the energy created by disintegration of matter, or converted into matter. The aim of the present paper deals with the insertion of this concept into the basic equations of thermodynamics.
文摘Crack growth rate curves are the fundamental material property for metal structures under fatigue loading. Although there are many crack growth rate curves available in the literature, few of them showed the capability to explain various special phenomena observed in tests. A modified constitutive relation recently proposed by McEvily and his co-workers showed very promising capability. This modified constitutive relation is further generalized by (1) introducing an unstable fracture condition; (2) defining a virtual strength to replace the yield stress; and (3) defining an overload and underload parameter. The performances of this general constitutive relation for fatigue crack growth is extensively studied and it is found that this general constitutive relation is able to explain various phenomena observed with particular strong capability on load sequence effect.
