AIM: To assess the efficacy and safety of a patientpositioning device(EZ-FIX) for endoscopic retrograde cholangiopancreatography(ERCP).METHODS: A total of 105 patients were randomized to the EZ-FIX(n = 53) or non-EZ-F...AIM: To assess the efficacy and safety of a patientpositioning device(EZ-FIX) for endoscopic retrograde cholangiopancreatography(ERCP).METHODS: A total of 105 patients were randomized to the EZ-FIX(n = 53) or non-EZ-FIX(n = 52) group in this prospective study. Midazolam and propofol,titrated to provide an adequate level of sedation during therapeutic ERCP, were administered by trained registered nurses under endoscopist supervision.Primary outcome measures were the total dose of propofol and sedative-related complications, including hypoxia and hypotension. Secondary outcome measures were recovery time and sedation satisfaction of the endoscopist, nurses, and patients.RESULTS: There was no significant difference in the rate of hypoxia, but there was a statistical trend(EX-FIX group; n = 4, 7.55%, control group; n = 6, 11.53%,P = 0.06). The mean total dose of propofol was lower in the EZ-FIX group than in the non-EZ-FIX group(89.43 ± 49.8 mg vs 112.4 ± 53.8 mg, P = 0.025).In addition, the EZ-FIX group had a shorter mean recovery time(11.23 ± 4.61 mg vs 14.96 ± 5.12 mg, P< 0.001). Sedation satisfaction of the endoscopist and nurses was higher in the EX.FIX group than in the nonEZ-FIX group. Technical success rates of the procedure were 96.23% and 96.15%, respectively(P = 0.856).Procedure-related complications did not differ by group(11.32% vs 13.46%, respectively, P = 0.735).CONCLUSION: Using EZ-FIX reduced the total dose of propofol and the recovery time, and increased the satisfaction of the endoscopist and nurses.展开更多
Dental biofilm is the initiating factor of oral diseases,such as periodontitis and caries.Orthodontic treatment could alter the microbiome structure balance,and increase the risk of such diseases.Furthermore,fixed app...Dental biofilm is the initiating factor of oral diseases,such as periodontitis and caries.Orthodontic treatment could alter the microbiome structure balance,and increase the risk of such diseases.Furthermore,fixed appliances can induce temporary changes in the microbiome community,and the changes that clear aligners bring are smaller by comparison.Temporary anchorage devices(TADs)are skeletal anchorages that are widely used in orthodontic treatment.Microorganisms affect the occurrence and development of inflammation surrounding TADs.At present,existing researches have verified the existence of plaque biofilm on the surface of TADs,but the formation of plaque biofilm and plaque composition under different stable conditions have not been fully understood.The development of high-throughput sequencing,molecular biology experiments,and metabonomics have provided new research ideas to solve this problem.They can become an effective means to explore the microbiome surrounding TADs.展开更多
基金Supported by Korea Healthcare Technology R and D Project,Ministry of Health and Welfare,South Korea(A100054)
文摘AIM: To assess the efficacy and safety of a patientpositioning device(EZ-FIX) for endoscopic retrograde cholangiopancreatography(ERCP).METHODS: A total of 105 patients were randomized to the EZ-FIX(n = 53) or non-EZ-FIX(n = 52) group in this prospective study. Midazolam and propofol,titrated to provide an adequate level of sedation during therapeutic ERCP, were administered by trained registered nurses under endoscopist supervision.Primary outcome measures were the total dose of propofol and sedative-related complications, including hypoxia and hypotension. Secondary outcome measures were recovery time and sedation satisfaction of the endoscopist, nurses, and patients.RESULTS: There was no significant difference in the rate of hypoxia, but there was a statistical trend(EX-FIX group; n = 4, 7.55%, control group; n = 6, 11.53%,P = 0.06). The mean total dose of propofol was lower in the EZ-FIX group than in the non-EZ-FIX group(89.43 ± 49.8 mg vs 112.4 ± 53.8 mg, P = 0.025).In addition, the EZ-FIX group had a shorter mean recovery time(11.23 ± 4.61 mg vs 14.96 ± 5.12 mg, P< 0.001). Sedation satisfaction of the endoscopist and nurses was higher in the EX.FIX group than in the nonEZ-FIX group. Technical success rates of the procedure were 96.23% and 96.15%, respectively(P = 0.856).Procedure-related complications did not differ by group(11.32% vs 13.46%, respectively, P = 0.735).CONCLUSION: Using EZ-FIX reduced the total dose of propofol and the recovery time, and increased the satisfaction of the endoscopist and nurses.
基金supported by the Beijing Municipal Science&Technology Commission(No.Z171100001017128)National Program for Multidisciplinary Cooperative Treatment on Major Diseases(No.PKUSSNMP-202013)+1 种基金National Natural Science Foundation of China(No.81671015)China Postdoctoral Science Foundation(No.2020M680263).
文摘Dental biofilm is the initiating factor of oral diseases,such as periodontitis and caries.Orthodontic treatment could alter the microbiome structure balance,and increase the risk of such diseases.Furthermore,fixed appliances can induce temporary changes in the microbiome community,and the changes that clear aligners bring are smaller by comparison.Temporary anchorage devices(TADs)are skeletal anchorages that are widely used in orthodontic treatment.Microorganisms affect the occurrence and development of inflammation surrounding TADs.At present,existing researches have verified the existence of plaque biofilm on the surface of TADs,but the formation of plaque biofilm and plaque composition under different stable conditions have not been fully understood.The development of high-throughput sequencing,molecular biology experiments,and metabonomics have provided new research ideas to solve this problem.They can become an effective means to explore the microbiome surrounding TADs.
