The construction of advanced laboratories for precision instruments, such as electron microscopes, involves unique challenges that are influenced by the specific environmental conditions required for optimal functiona...The construction of advanced laboratories for precision instruments, such as electron microscopes, involves unique challenges that are influenced by the specific environmental conditions required for optimal functionality. These include mitigating interference from magnetic fields and vibrations, which are critical for maintaining the precision and accuracy of the instruments used. This study aims to offer enhanced project management strategies and detailed construction solutions that address the environmental and technical needs specific to electron microscopy labs, thereby facilitating effective lab operations and extending the lifecycle of high-end precision instruments. Case studies of existing laboratory constructions, onsite investigations, and comprehensive reviews of the technical and environmental requirements provide the basis for a best practice for constructing sophisticated electron microscopy labs. The approach integrates both pre-construction planning and post-construction adjustments to create optimal operational environments. The findings suggest that successful lab constructions are those that incorporate thorough onsite assessments, strategic location choices, and the use of advanced construction materials and techniques specifically designed to counteract environmental challenges like magnetic and vibration interferences. Actionable guidelines for both planning and executing the construction of electron microscope labs highlighted in this tutorial are intended as an important resource to troubleshoot or upgrade existing lab facilities and to consult in preparation of future lab construction projects.展开更多
With the advancements in technology and the evolution of forensic science,virtual autopsy techniques have gained increasing attention and promotion in China.Several provinces have established virtual autopsy laborator...With the advancements in technology and the evolution of forensic science,virtual autopsy techniques have gained increasing attention and promotion in China.Several provinces have established virtual autopsy laboratories within their public security system.However,these initiatives face challenges including equipment costs,the needs for technological updates,professional training,and the establishment of regulatory standards.This study utilized literature analysis,academic exchanges,surveys,and field investigations to examine the current state of virtual autopsy laboratory construction within the Chinese public security system.It identifies existing issues and explores future prospects when offering recommendations for improvement.The goal is to providing insights that may facilitate the development and enhancement of virtual autopsy laboratories in future.展开更多
In multiple areas such as science,technology,and economic activities,it is necessary to unify the management of repetitive tasks or concepts by standardization to obtain the best order and high efficiency.Organoids,as...In multiple areas such as science,technology,and economic activities,it is necessary to unify the management of repetitive tasks or concepts by standardization to obtain the best order and high efficiency.Organoids,as living tissue models,have rapidly developed in the past decade.Organoids can be used repetitively for in vitro culture,cryopreservation,and recovery for further utilization.Because organoids can recapitulate the parental tissues’morphological phenotypes,cell functions,biological behaviors,and genomic profiles,they are known as renewable“living biobanks”.Organoids cover two mainstream fields:Adult stem cell-derived organoids(also known as patient-derived organoids)and induced pluripotent stem cell-derived and/or embryonic stem cell-derived organoids.Given the increasing importance of organoids in the development of new drugs,standardized operation,and management in all steps of organoid construction is an important guarantee to ensure the high quality of products.In this review,we systematically introduce the standardization of organoid construction operation procedures,the standardization of laboratory construction,and available standardization documents related to organoid culture that have been published so far.We also proposed the challenges and prospects in this field.展开更多
The University of Applied Sciences in Vienna has offered university degree programs in the field of construction for more than twenty years and has thus gained great expertise in developing its curriculum. Founded in ...The University of Applied Sciences in Vienna has offered university degree programs in the field of construction for more than twenty years and has thus gained great expertise in developing its curriculum. Founded in 1996, the department of Building and Design consists of six university degree programs. A major strength of the department is the possibility to adapt to recent challenges in a timely manner. As shown in Figure 1, in the winter term 2008/2009, the master’s degree program, Sustainability in the Construction Industry, was held for the first time;it was transformed into the master’s degree program, Architecture-Green Building, in 2016. In 2013/14 the bachelor’s degree program, Architecture-Green Building, started with the first students graduating in 2016. For ten years the department has focused on sustainability within the building, planning and designing processes.展开更多
文摘The construction of advanced laboratories for precision instruments, such as electron microscopes, involves unique challenges that are influenced by the specific environmental conditions required for optimal functionality. These include mitigating interference from magnetic fields and vibrations, which are critical for maintaining the precision and accuracy of the instruments used. This study aims to offer enhanced project management strategies and detailed construction solutions that address the environmental and technical needs specific to electron microscopy labs, thereby facilitating effective lab operations and extending the lifecycle of high-end precision instruments. Case studies of existing laboratory constructions, onsite investigations, and comprehensive reviews of the technical and environmental requirements provide the basis for a best practice for constructing sophisticated electron microscopy labs. The approach integrates both pre-construction planning and post-construction adjustments to create optimal operational environments. The findings suggest that successful lab constructions are those that incorporate thorough onsite assessments, strategic location choices, and the use of advanced construction materials and techniques specifically designed to counteract environmental challenges like magnetic and vibration interferences. Actionable guidelines for both planning and executing the construction of electron microscope labs highlighted in this tutorial are intended as an important resource to troubleshoot or upgrade existing lab facilities and to consult in preparation of future lab construction projects.
基金supported by the 2023 National Key Research and Development Program Project“Research on Cause of Death Diagnosis Technology and Equipment for Virtual Autopsy Fusion with Minimally Invasive Examination(2023YFC3303901)”.
文摘With the advancements in technology and the evolution of forensic science,virtual autopsy techniques have gained increasing attention and promotion in China.Several provinces have established virtual autopsy laboratories within their public security system.However,these initiatives face challenges including equipment costs,the needs for technological updates,professional training,and the establishment of regulatory standards.This study utilized literature analysis,academic exchanges,surveys,and field investigations to examine the current state of virtual autopsy laboratory construction within the Chinese public security system.It identifies existing issues and explores future prospects when offering recommendations for improvement.The goal is to providing insights that may facilitate the development and enhancement of virtual autopsy laboratories in future.
基金supported by grants from the National Natural Science Foundation of China(Nos.82473013 and 82072602)the Shanghai Science and Technology Committee(No.20DZ2201900)+1 种基金the Innovation Foundation of Translational Medicine of Shanghai Jiao Tong University School of Medicine(No.TM202001)the Collaborative Innovation Center for Clinical and Translational Science by Chinese Ministry of Education&Shanghai Municipal Government(Nos.CCTS-2022202 and CCTS-202302).
文摘In multiple areas such as science,technology,and economic activities,it is necessary to unify the management of repetitive tasks or concepts by standardization to obtain the best order and high efficiency.Organoids,as living tissue models,have rapidly developed in the past decade.Organoids can be used repetitively for in vitro culture,cryopreservation,and recovery for further utilization.Because organoids can recapitulate the parental tissues’morphological phenotypes,cell functions,biological behaviors,and genomic profiles,they are known as renewable“living biobanks”.Organoids cover two mainstream fields:Adult stem cell-derived organoids(also known as patient-derived organoids)and induced pluripotent stem cell-derived and/or embryonic stem cell-derived organoids.Given the increasing importance of organoids in the development of new drugs,standardized operation,and management in all steps of organoid construction is an important guarantee to ensure the high quality of products.In this review,we systematically introduce the standardization of organoid construction operation procedures,the standardization of laboratory construction,and available standardization documents related to organoid culture that have been published so far.We also proposed the challenges and prospects in this field.
文摘The University of Applied Sciences in Vienna has offered university degree programs in the field of construction for more than twenty years and has thus gained great expertise in developing its curriculum. Founded in 1996, the department of Building and Design consists of six university degree programs. A major strength of the department is the possibility to adapt to recent challenges in a timely manner. As shown in Figure 1, in the winter term 2008/2009, the master’s degree program, Sustainability in the Construction Industry, was held for the first time;it was transformed into the master’s degree program, Architecture-Green Building, in 2016. In 2013/14 the bachelor’s degree program, Architecture-Green Building, started with the first students graduating in 2016. For ten years the department has focused on sustainability within the building, planning and designing processes.
