Re-examining Tropical Cyclone Fullness Using Aircraft Reconnaissance Data

We use FLIGHT+ aircraft reconnaissance data for tropical cyclones(TCs) in the North Atlantic and Eastern Pacific from 1997 to 2015 to re-examine TC fullness(TCF) characteristics at the flight level.The results show a strong positive correlation between the flight-level TCF and the intensity of TCs,with the flight-level TCF increasing much more rapidly than the near-surface TCF with increasing intensity of the TCs.The tangential wind in small-TCF hurricanes is statistically significantly stronger near the eye center than that in large-TCF hurricanes.Large-TCF hurricanes have a ring-like vorticity structure.No significant correlation is observed between the flight-level TCF and the comparative extent of the vorticityskirt region occupied in the outer core skirt.The proportion of the rapid filamentation zone in the outer core skirt increases with increasing flight-level TCF.The differences in entropy between the radius of the maximum wind and the outer boundary of the outer core skirt also increase with increasing flight-level TCF.

Clinical effects of injectable collagen in lower-lid pretarsal fullness rejuvenation

Background: Lower-lid pretarsal fullness rejuvenation is a popular surgery for Asian women. However, the current procedures have clinical complications and are not stable in the long-term. Here, we analyzed the effect of injectable collagen on lower-lid pretarsal fullness rejuvenation.Methods: To investigate the clinical effect of injectable collagen in lower-lid pretarsal fullness rejuvenation, we observed 32 Chinese Han female patients aged 18–55 years with non-distinctive lower-lid pretarsal fullness and no history of lower eyelid surgery or trauma. The injectable collagen products were used for local filling correction. After surgery, the patients were followed up for 12 months. A correction effect was evaluated through an analysis of volume changes using a visual analog scale. Adverse reactions were also recorded.Results: All patients achieved good aesthetic outcomes and strong stereoscopic impressions of lower-lid pretarsal fullness. Complications, such as edema and bruising, were not observed after the injection. Immediately after the operation, the average visual analog score was 2.65 ± 0.56. Six months after the operation, the average visual analog score was 2.96 ± 0.41. The patients reported high satisfaction levels. Immediately after the operation, the average lower-lid pretarsal fullness volume increase was 0.19 ± 0.04 m L on the left side and 0.21 ± 0.03 m L on the right side. After a 12-month follow-up, the average residual volume was 0.17 ± 0.06 m L on the left side and 0.19 ± 0.04 m L on the right side, suggesting that the injected collagen impact was stable.Conclusion: Injectable collagen promotes a vivid, natural appearance and is highly effective in rejuvenating lowerlid pretarsal fullness with low absorption rates in later stages. Therefore, injectable collagen should be considered in correcting congenital, non-distinctive, lower-lid pretarsal fullness in clinical practice.

Influence of Dilative Technology on Thickness and Fullness of Tussah Silk's Fiber and Fabric

In this paper, study objects are raw and dilative tussah silk. By means of measuring and analyzing the fiber's diameter, linear density, diameter coefficient, thickness and fullness, this paper focuses on the influence of dilative technology on tussah silk's fiber and fabric. The results include the following three aspects: the diameter coefficient of dilative tussah silk fiber is increased by 10.35%, dilative tussah heather silk is thicker and fabric fullness is improved by 9%.

Rare and lacking typical clinical symptoms of liver tumors:Four case reports

BACKGROUND Rare liver tumors(RLTs)have an extremely low likelihood of forming,and some have been recorded only in isolated cases.The lack of normal clinical symptoms in RLTs makes preoperative diagnosis extremely challenging,which results in frequent misinterpretation.The present case report helps enhance our ability to recognize and treat uncommon liver tumor disorders.CASE SUMMARY We describe four distinct examples of rare liver tumor diseases.These cases were all true cases with no conventional clinical signs or imaging findings.In all patients,hepatic occupancy was discovered on physical examination,which raised the preoperative suspicion of hepatic cancer.All tumors were surgically removed,and postoperative histology and immunohistochemistry were performed to confirm the diagnosis.The first patient had primary hepatic fibrosarcoma.The second case involved a primary hepatic neuroendocrine tumors.These two patients had malignant liver tumors,and both had extremely satisfactory surgical outcomes.The third case involved focal hepatic steatosis,and the fourth case involved a single necrotic nodule in the liver.These two patients had benign liver tumors,but they had already undergone surgery and did not require any postoperative care.CONCLUSION The number of patients with RLTs is small,and the clinical and imaging results are vague.Preoperative diagnosis is challenging,and patients are sometimes mistakenly diagnosed with liver cancer,which leads to unnecessary surgical therapy in certain individuals.

Draft of an Anthropometric Reference System for Full-Term Cameroonian Newborns: Prospective Study with Analytical Aim in the Maternity Wards of Douala

Introduction: Anthropometry applied to newborns is a reliable indicator of the quality of fetal growth. The latter is influenced by genetic, racial and nutritional factors varying from one population to another, explaining why a standard cannot be applied to all populations. Research question: should the Caucasian frame of reference be dogmatically applied in our African context? Multicenter studies are therefore necessary;hence the interest of this work, the main objective of which was to describe the anthropometric profile of full-term newborns in the city of Douala. Methodology: We carried out a cross-sectional study with an analytical aim and prospective data collection in the maternity wards of the Douala General Hospital, Laquintinie Hospital, District hospitals of Deido, Nylon and Bonassama over a period of 4 months (January to April 2020). We were interested in any newborn, born alive, vaginally or by cesarean section, seen in the first 24 hours from a full-term single-fetal pregnancy whose mother had given consent. We excluded newborns whose term was unclear and those with congenital malformations or signs of embryo-foetopathy. Data collection was done using structured and pre-tested survey sheets. The study variables were obstetric and anthropometric. Statistical analyzes were carried out with CS Pro 7.3 and SPSS version 25.0 software. The Student, Chi-square and Fischer tests were used to compare the means of the variables, the percentages with a significance threshold P value Results: During the study period, 305 full-term newborns were included, divided into 172 boys and 133 girls. The average anthropometric parameters of the full-term newborn in the city of Douala were: average weight: 3305 grams, average height: 49.8 centimeters, average head circumference: 34.6 centimeters, average upper arm circumference: 11.3 centimeters, circumference average thoracic: 32.8 centimeters. The percentile distribution showed a 10th percentile at 2656 grams and a 90th percentile at 3966 grams for weight defining the limits for small-for-gestational-age neonates and macrosomes. Conclusion: The anthropometric data of the full-term newborn in the city of Douala were: an average weight of 3305.4 grams, an average height of 49.8 centimeters, an average head circumference of 34.2 centimeters, an average upper arm circumference of 11.3 centimeters, and an average thoracic circumference of 32.8 centimeters with higher valuesin male newborns.

外源性碱性成纤维细胞生长因子促进大鼠创面愈合的机制

背景:深入揭示外源性碱性成纤维细胞生长因子促进创面愈合的分子机制。目的:探讨外源性碱性成纤维细胞生长因子对大鼠创面修复中巨噬细胞表型转换和肉芽再生的影响。方法:(1)体外细胞实验:分为正常对照组、低剂量碱性成纤维细胞生长因子组、高剂量碱性成纤维细胞生长因子组以及碱性成纤维细胞生长因子+丙戊酸组,其中低、高剂量碱性成纤维细胞生长因子组细胞培养基中分别添加100,200μg/L碱性成纤维细胞生长因子,碱性成纤维细胞生长因子+丙戊酸组细胞培养基中添加200μg/L碱性成纤维细胞生长因子和20 mmol/L Notch1/Jagged1激动剂丙戊酸。通过EdU实验、划痕实验、小管生成实验检测碱性成纤维细胞生长因子对人脐静脉内皮细胞增殖、迁移和血管新生的影响。(2)体内动物实验:SD大鼠按照随机数字表法分为模型组、低剂量碱性成纤维细胞生长因子组、高剂量碱性成纤维细胞生长因子组以及碱性成纤维细胞生长因子+丙戊酸组,构建大鼠全层皮肤缺损开放性创面模型,其中低、高剂量碱性成纤维细胞生长因子组皮下注射100,200μg/L碱性成纤维细胞生长因子,碱性成纤维细胞生长因子+丙戊酸组大鼠皮下注射200μg/L碱性成纤维细胞生长因子的同时腹腔注射10 mg/kg丙戊酸。给药7,14 d检测大鼠创面的愈合率;TUNEL检测创面组织中的细胞凋亡情况;酶联免疫吸附实验检测大鼠血清中丙二醛、超氧化物歧化酶、肿瘤坏死因子α和白细胞介素10水平;免疫荧光检测创面组织中巨噬细胞的表型转换情况;免疫组化检测创面组织中增殖细胞核抗原、CD31和血管内皮生长因子的表达;Western blot法检测创面组织中Notch1、Jagged1的表达。结果与结论:(1)与正常对照组相比,碱性成纤维细胞生长因子能明显促进人脐静脉内皮细胞的增殖、迁移和血管新生,并且具有剂量依赖性;(2)与模型组相比,碱性成纤维细胞生长因子能明显促进创面的愈合,下调创面组织中的细胞凋亡率;降低大鼠血清中丙二醛和肿瘤坏死因子α水平,升高超氧化物歧化酶和白细胞介素10水平;促使创面组织中巨噬细胞向M2型转换,上调创面组织中增殖细胞核抗原、CD31和血管内皮生长因子的表达;抑制创面组织中Notch1、Jagged1的表达,并且均具有剂量依赖性。丙戊酸可部分逆转碱性成纤维细胞生长因子对创面愈合的促进作用。结果表明,碱性成纤维细胞生长因子能明显促进创面愈合与肉芽再生以及诱导巨噬细胞向M2型转换,这可能与调控Notch1/Jagged1信号有关。

基于FullSubNet的单通道实时语音增强算法

针对语音实时通信场景,本文提出一种基于循环神经网络的单通道实时语音增强方案。通过模型层面融合全频带和子频带特征以同时捕获全频带信息和局部语谱特征,并且基于循环神经网络的内在时序性,实现了按帧推理实时输出的要求。实验结果显示,在DNS-Challenge InterSpeech 2020的测试集上,本文按帧输出方式的模型可以取得2.85的pesq值。在系统固定延时32 ms的情况下,使用NVidia GeForce RTX 3060 GPU处理16 ms一帧长度的数据耗时1.5 ms;如果将模型转为onnx格式,在Intel i7@2.7GHz CPU上处理一帧数据耗时3.8 ms。

两种雀形目鸟类的窝雏数处理实验:检验Lack假说

于 1 997～ 1 999年在位于青海省北部的中国科学院海北高寒草甸生态系统定位站进行。选择地面筑巢的小云雀 ( Alauda gulgula)和灌丛筑巢的黄嘴朱顶雀 ( Acanthis flavirostris)为代表进行窝雏数处理实验。根据 Lack假说的预报检验 ( 1 )常见窝卵数是否是最大生产力窝卵数 ;( 2 )窝雏数处理对雏鸟质量和亲鸟投入是否产生影响 ;( 3)两种鸟的响应方式是否相同。其结果如下 :1小云雀和黄嘴朱顶雀的常见窝卵数分别是 3和 5枚 ,年间变化不明显 ,用幼鸟出飞率作为生产力 ,两种鸟的扩增窝幼鸟出飞率下降 ,常见窝卵数 (分布频率最高 )等同于最大生产力窝卵数 ;2小云雀的幼鸟的生长参数不随窝雏数的改变而变化 ,而黄嘴朱顶雀有明显变化 ,说明窝雏数处理对后者幼鸟质量有明显影响。 3用递食率作为亲鸟投资指标 ,小云雀亲鸟的递食率随窝雏数的增加而增加 ,但雏期不变 ;而黄嘴朱顶雀递食率不变 ,但雏期延长。 4扩增窝雏数后 ,两种亲鸟表现出不同的响应方式 ,小云雀表现为提高单位时间递食次数 ,而黄嘴朱顶雀延长育幼时间。这两种方式不是通过影响雏鸟质量就是通过影响亲鸟存活率来降低子代和亲代的适合度。结果支持了自然选择将窝卵数调节到亲鸟能喂活最大数量子代的限度 ,即常见窝卵数就是最大生产力窝卵数的 Lack?

我国山丘疫区杜氏利什曼原虫LACK保护性抗原基因克隆和序列分析

利什曼原虫的LACK抗原是利什曼原虫的蛋白激酶C受体的同源物 ,是新发现的一种抗原蛋白。本实验用分子克隆的方法获得我国山丘疫区杜氏利什曼原虫编码LACK保护性抗原的基因片段 ,测序并对其序列分析比较。我国山丘疫区杜氏利什曼原虫 (L dSC10 )LACK抗原基因片段的大小为 94 2bp ,与GenBank中LACK的核苷酸序列一致性在 94 %以上 ,呈高度同源性 ;推导的氨基酸序列与GenBank中LACK的氨基酸序列一致性达 95 %以上 ,具有高度保守性 ;该蛋白质属于WD蛋白家族 ,有重要的生物学意义。

杜氏利什曼原虫LACK抗原基因的克隆和表达

目的 在大肠杆菌中高效表达纯化杜氏利什曼原虫的LACK抗原。方法 以本实验室的重组质粒T -LACK为模板 ,PCR扩增得到LACK抗原基因 ,与表达载体pQE31定向重组 ,转化到宿主菌M 15中进行表达和纯化 ,并以SDS -PAGE和Western -blotting进行鉴定。结果 1 SDS -PAGE电泳检测 ,重组质粒 pQE31-LACK的全菌蛋白没有出现明显的特异表达带 ,而纯化蛋白和包涵体溶解物在 36kDa处均出现了特异的表达带。 2 36kDa的纯化蛋白被抗利什曼原虫鼠血清清晰地识别。结论 得到了高效表达的LACK纯化蛋白 。

杜氏利什曼原虫平原和荒漠疫区分离株LACK基因克隆及序列分析

目的 测定我国平原疫区和荒漠疫区杜氏利什曼原虫分离株活性蛋白激酶 C受体同源物 (L ACK)基因序列 ,并与山丘疫区分离株及国外利什曼原虫分离株进行比较。 方法 应用 RT- PCR扩增 L ACK基因 ,将其克隆入p UC18载体后用双脱氧链末端终止法测序 ,并与 Gen Bank中相关数据进行比较。 结果 用 RT- PCR成功扩增出约95 0 bp的 L ACK基因片段 ,测序结果表明其片段大小均为 94 2 bp,与 Gen Bank中多种利什曼原虫 L ACK基因的核苷酸序列一致性达 97%以上。我国山丘、平原和荒漠 3个不同疫区杜氏利什曼原虫分离株的 L ACK基因序列的一致性达95 %以上。 结论 获得了我国平原和荒漠疫区杜氏利什曼原虫 L ACK基因序列。我国 3个不同疫区杜氏利什曼原虫分离株的 L ACK基因具有高度同源性。

α7烟碱型乙酰胆碱受体与阿尔茨海默病的关系

背景:α7烟碱型乙酰胆碱受体在大脑皮质和海马高度表达,并在阿尔茨海默病的病理发展过程中起重要调控作用,是阿尔茨海默病治疗的潜在靶点。目的:总结α7烟碱型乙酰胆碱受体和阿尔茨海默病的密切关系和相互作用机制。方法:检索中国知网、PubMed数据库中相关文献,中文检索词为“α7烟碱型乙酰胆碱受体,阿尔茨海默病,β-淀粉样蛋白,激动剂,正变构调节剂,拮抗剂”;英文检索词为“alpha 7 nicotinic acetylcholine receptor,Alzheimer’s disease,beta amyloid protein,agonist,positive allosteric modulator,antagonist”,文献检索时限为各数据库建库至2024年7月,依据入选标准对检索结果进行录用或排除,最终纳入符合标准的83篇文献进行综述。结果与结论:α7烟碱型乙酰胆碱受体通过与β-淀粉样蛋白的相互作用减轻β-淀粉样蛋白的神经毒性,如促进阿尔茨海默病的突触可塑性和胆碱能突触的快速传递、减轻β-淀粉样蛋白诱导的神经中枢炎症反应、抵抗神经细胞凋亡,从而对阿尔茨海默病患者的脑具有保护作用等。α7烟碱型乙酰胆碱受体作为阿尔茨海默病治疗靶标具有很大的潜能,但是又存在一系列问题有待解决,比如α7烟碱型乙酰胆碱受体的脱敏性、适度活性稳定性及基因多态性等问题。筛选高特异、安全性和以α7烟碱型乙酰胆碱受体为核心的多靶点结合作用的药物,将成为未来阿尔茨海默病治疗研究的一个方向。

杜氏利什曼原虫LACK基因真核表达重组质粒及其在真核细胞中的表达

利什曼原虫的 L ACK抗原是利什曼原虫活性蛋白激酶 C受体同源物 ,是一种新发现的抗原蛋白。我们以本实验室的重组质粒 T- L ACK为模板 ,PCR扩增获得 L ACK基因 ,与真核表达载体 pc DNA3.1(+)定向重组 ,重组质粒经酶切和 PCR分析 ,含有约 95 0 bp的 L ACK基因 ,成功构建含有 L ACK基因的真核表达重组质粒 pc D-NA3- L ACK。将此重组质粒转染 COS- 7细胞 ,通过 RT- PCR及免疫荧光检测 L ACK基因在真核细胞中的表达。实验结果显示转染了重组质粒的 COS- 7细胞 ,其 RT- PCR及免疫荧光检测均呈阳性反应 ,证实重组质粒 pc DNA3-L ACK能在 COS- 7细胞中有效表达 L ACK蛋白。

构建多PACS/RIS的FULL-PACS

总结了国内FULL-PACS建设的现状,提出不论从系统开发还是实施的复杂性方面,决定了FULL-PACS通常要由多PACS/RIS进行整合而成,而标准化、规范化和集成化是建设FULL-PACS的基础。提出了对标准化和规范化相对滞后的情况下如何建好医院的FULL-PACS的方法。

Responses of Crop Yields and Soil Fertility to Long-term Nutrient Lacking

[Objective] Long-term （over 18 years） fertilization experiments were con- ducted to study the responses of crop yields and soil fertility to long-term nutrient lacking at Zhengzhou in China. [Method] The present study consisted of five treat- ments： 1 CK （no fertilizer or manure）, （2） NP （nitrogen and phosphorus fertilizer applied）, 31 NK （nitrogen and potassium fertilizer applied）, 4 PK （phosphorus and potassium fertilizer applied） and ：5 NPK （nitrogen, phosphorus and potassium fertil- izer applied）. [Result] Lacking of nitrogen or phosphorus led to a low yield; however, there was no significant difference in grain yields between the NP and NPK treat- ments which maintained a higher yield. Receiving no phosphorus, soil available phosphorus content declined to about 2.5 mg/kg. The concentration of soil ex- changeable potassium remained constant at a level of 60 mg/kg under the treat- ments without potassium fertilizer addition. Soil potassium spontaneous supply ca- pacity fluctuated around 100%.[Conclusion] In fluvo-aquic soil, nitrogen and phos- phorus were two key limiting factors to grain yields, biomass and yield component factors of wheat and maize, while potassium was not. However, potassium defi- ciency may occur in the future if there was still no potassium fertilizer applied.

地勘单位“Four Full”安全文化建设体系研究

为提升地勘单位安全文化建设水平,针对地勘单位的特点,总结归纳出安全文化建设中存在的管理不实、基础不牢、支撑不足、参与不够四个方面的突出问题,以制度规范、理念素养培养、措施投入、参与覆盖为主要内容,基于全天候推广、全过程管理、全方位建设、全员参与四个核心,提出了"Four Full"安全文化建设体系以及"TOVPCO安全文化理念系统"和"四步双向循环法"等特色安全文化建设方法,对地勘单位的安全文化建设具有重要的参考价值。

医院FULL PACS实现中的系统联动模式

FULL PACS系统需与诸多其它医院信息系统联动才能充分发挥优势。医院小规模PACS系统的研究已经相当广泛,而PACS系统与医院其他信息系统的联动(整合)方面的研究是医院真正实现FULL PACS所必须面临的课题:浙江大学医学院附属妇产科医院在FULL PACS的实施中提出了几种系统联动模式,经过近一年的系统运行,取得了良好的效果。

Camera Link Full至HD-SDI接口的高清传输显示系统

为实现远距离、高可靠性传输,并减小复杂度,对Camera Link Full接口数据的HD-SDI传输显示进行了深入研究。采用FPGA作为核心处理器,考虑相机输出具有多种帧频,采取帧频检测及充分降频策略,并通过3个SRAM进行缓存以实现帧频转换,以满足HD-SDI帧频25Hz的要求。考虑到SRAM数据宽度,采取FIFO行缓存策略将Camera Link Full80输出的10tap、80bits图像数据转换成单通道的8bits图像数据。最后,完成系统设计并进行实验验证。实验结果表明:系统实现了图像数据从50Hz、100Hz、500 Hz等多种帧频的Camera Link Full80到25帧HD-SDI接口1080i的格式转换及实时显示,且图像层次丰富,无失真。

Full-Heusler合金Ni_2MnSn力学性能和电子性能的第一性原理

Heusler合金,是有序的三元金属间化合物。围绕full-Heusler合金Ni_2MnSn力学性能和电子性能展开计算,利用基于密度泛函理论的第一性原理方法,从量子力学角度考虑了电子的电荷特性和自旋特性。建立full-Heusler合金Ni_2MnSn的结构模型,计算最优化晶格常数、能带结构和态密度;测试其体模量、剪切模量、杨氏模量和泊松比。计算得到总磁矩为-4.34μB,其中Mn原子的磁矩对总磁矩贡献最大,并通过对Ni_2MnSn态密度及各个原子态密度的分析,发现磁性来源于Mn原子的能级劈裂。在几何优化的基础上,进行了Ni_2MnSn的力学性能计算,发现Ni_2MnSn具有很好的延展性和塑性。

Full-Gauss分布束的束晕-混沌模拟控制

本工作基于束晕-混沌的非线性控制策略,对周期性聚焦磁场中初始分布满足Full-Gauss分布的离子束进行模拟研究,提出了控制其束晕-混沌的简单函数控制器,并给出具体的实施方案。数值模拟结果表明,运用这种方法不仅可消除束晕及其再生现象,达到对束晕-混沌的有效控制,而且可控制束流到高斯分布。