Effects of land-use patterns on soil microbial diversity and composition in the Loess Plateau,China

In the Loess Plateau of China,land-use pattern is a major factor in controlling underlying biological processes.Additionally,the process of land-use pattern was accompanied by abandoned lands,potentially impacting soil microbe.However,limited researches were conducted to study the impacts of land-use patterns on the diversity and community of soil microorganisms in this area.The study aimed to investigate soil microbial community diversity and composition using high-throughput deoxyribonucleic acid(DNA)sequencing under different land-use patterns(apricot tree land,apple tree land,peach tree land,corn land,and abandoned land).The results showed a substantial difference(P<0.050)in bacterial alpha-diversity and beta-diversity between abandoned land and other land-use patterns,with the exception of Shannon index.While fungal beta-diversity was not considerably impacted by land-use patterns,fungal alpha-diversity indices varied significantly.The relative abundance of Actinobacteriota(34.90%),Proteobacteria(20.65%),and Ascomycota(77.42%)varied in soils with different land-use patterns.Soil pH exerted a dominant impact on the soil bacterial communities'composition,whereas soil available phosphorus was the main factor shaping the soil fungal communities'composition.These findings suggest that variations in land-use pattern had resulted in changes to soil properties,subsequently impacting diversity and structure of microbial community in the Loess Plateau.Given the strong interdependence between soil and its microbiota,it is imperative to reclaim abandoned lands to maintain soil fertility and sustain its function,which will have significant ecological service implications,particularly with regards to soil conservation in ecologically vulnerable areas.

Contamination assessment,source apportionment and associated health risks of PTEs in agricultural soil under five land-use patterns in Sanya,China

To understand the levels of potentially toxic elements(PTEs)contamination in soils and their effects on human health from different agricultural land use in Sanya,China.128 soil samples(64 topsoil samples and corresponding subsoil samples)were collected from the five representative land-use patterns.Inductively coupled plasma mass spectrometry(ICP-MS),Atomic fluorescence spectrometry(AFS),and Inductively coupled plasma optical emission spectrometry(ICP-OES)were used to determine the content of PTEs(As,Cd,Hg,Cu,Cr,Ni,Pb,Zn,Co,Mo,Sb,and V).Correlation analysis and factor analysis were used to determine the source of PTEs.Geo-accumulation index(I_(geo)),hazard quotient(HQ),and total carcinogenic risk index(TR)were used to measure the PTEs contamination and its relative health impacts.Results showed that the average values of 12 PTEs in topsoil were higher than the Hainan soil geochemical baseline,showing different degrees of PTEs accumulation effect.The concentration of PTEs in the topsoil was lower than those in the subsoil except for Cd and Hg.The I_(geo)revealed that the major accumulated element in soils was As followed by Mo.Source apportionment suggested that parent materials and agricultural practices were the dominant factors for PTEs accumulation in the topsoil.Noncarcinogenic risks of soil samples from five land-use patterns presented a trend of paddy field>dry field>woodland>orchard>garden plot.However,the HQ values of 12 PTEs were less than the recommended limit of HQ=1,representing that there are no non-carcinogenic risks of PTEs for children and adults in the study area.The TR values are within 6.95×10^(-6)-1.38×10^(-5),which corresponds to the low level.Therefore the PTEs in the agricultural soil of the study area show little influence on the health status of the local population.

Using autologistic spatial models to simulate the distribution of land-use patterns in Zhangjiajie, Hunan Province

Nowadays, spatial simulation on land use patterns is one of the key contents of LUCC. Modeling is an important tool for simulating land use patterns due to its ability to integrate measurements of changes in land cover and the associated drivers. The conventional regression model can only analyze the correlation between land use types and driving factors but cannot depict the spatial autocorrelation characteristics. Land uses in Yongding County, which is located in the typical karst mountain areas in northwestern Hunan province, were investigated by means of modeling the spatial autocorrelation of land use types with the purpose of deriving better spatial land use patterns on the basis of terrain characteristics and infrastructural conditions. Through incorporating components describing the spatial autocorrelation into a conventional logistic model, we constructed a regression model （Autologistic model）, and used this model to simulate and analyze the spatial land use patterns in Yongding County. According to the comparison with the conventional logistic model without considering the spatial autocorrelation, this model showed better goodness and higher accuracy of fitting. The distribution of arable land, wood land, built-up land and unused land yielded areas under the ROC curves （AUC） was improved to 0.893, 0.940, 0.907 and 0.863 respectively with the autologistic model. It is argued that the improved model based on autologistic method was reasonable to a certain extent. Meanwhile, these analysis results could provide valuable information for modeling future land use change scenarios with actual conditions of local and regional land use, and the probability maps of land use types obtained from this study could also support government decision-making on land use management for Yongding County and other similar areas.

Sustainable land-use patterns for arid lands: A case study in the northern slope areas of the Tianshan Mountains

Sustainable land use patterns are ecological and economic prerequisites of regional sustainable development. This is especially true for arid lands, where the environment is wholly fragile thanks to extremely limited precipitation, and where human activities have greatly transformed natural desert system by clearing natural vegetation, expanding oases and even building dams on inland rivers. However, the current studies on land use patterns are still characterized by field investigations and case studies, with almost no solid scientific basis. This paper holds that land types and their combination patterns are the principal basis for designing sustainable land use patterns, and that GIS and RS-based large-scale land type mapping and the study of their spatial combination structures should be coordinated with the demand of social development. The existing environmental problems induced by irrational land use mostly result from their deviation from the natural properties of land types. Taking the northern slope of the Tianshan Mountains （NSTM） as an example and considering land type patterns as the basis of land use patterns, this paper improves the vertical oa- sis-and-mid-mountain two-belts development model and the sustainable mountain land use model for arid lands put forward in recent years; and in terms of oases patterns, it outlines oasis development models, including intensive land use pattern in alluvial-diluvial fans, moderate agricultural development pattern in alluvial plains, and ecological land use pattern in river-end oases.

Impact of Land-use Patterns on Distributed Groundwater Recharge and Discharge——A Case Study of Western Jilin,China

The impact of land-use on distributed groundwater recharge and discharge in the western Jilin (WJ) was analyzed in this study. WJ is a transitional, semi-arid zone with a fragile, hydrological closed ecosystem in the Songhua River Basin (SRB). The research tool includes a seamlessly linked MODFLOW, WetSpass, the Seepage packages, and ArcGIS. The model calibration showed good agreement between simulated water table elevation and measured water table depths, while predicted groundwater discharge zones showed strong correlations with field occurrences of drainage systems and wetlands. Simulated averages for distributed recharge, water table elevation and groundwater drawdown were 377.42mm/yr, 194.43m, and 0.18m respectively. Forest vegetation showed the highest recharge, followed by ag- ricultural farmlands, while open-water and other drainage systems constituted groundwater exit zones. When present land-use conditions were compared with the hypothetical natural pre-development scenario, an overall loss of ground- water recharge (24.09mm/yr) was observed, which for the project area is 18.05×108m3. Groundwater abstraction seemed to be the cause of water table drawdown, especially in the immediate vicinities of the supply wells. An important issue of the findings was the ability of the hypothetical forest vegetation to protect, and hence sustain aquifer reserves and dependent ecosystems. The profound data capture capability of ArcGIS makes it particularly useful in spa- tio-temporal hydroecological modeling.

Evaluation of land-use pattern change in West Bhanugach Reserved Forest,Bangladesh,using remote sensing and GIS techniques

A study was conducted to investigate the land-use pattern change over a period of 18 years （1988-2006） by using remote sens- ing and Geographical Information System （GIS） technologies, in the West Bhanugach Reserved Forest, a hill forest, in Sylhet Forest Divi- sion of Bangladesh, The images were processed using ERDAS Imagine software. Both supervised and unsupervised approaches were ap- plied and ground control points were collected using a GPS. Maps were prepared using GIS software. Results showed that vegetation cover drastically decreased from the year 1988 to 1996 （l 826 ha to l 714.85 ha）, but increased gradually from the year 1996 to 2006 （l 714.85 ha to l 847.83 ha） due to the initiation of co-management practice involving local communities. Change in bare land was inversely proportionate to the amount of vegetation cover changes unless any other land-uses were converted into bare land. The area of water bodies increased from the year 1988 to 1996 （307.67 ha to 379.53 ha）, but decreased from the year 1996 to 1997, then remained invariabile from the year 1997 to 2006. Some recommendations were also made for applying the RS and GIS techniques to study the land-use pattern change in the Bhanugach Reserved Forest and to create a GIS data base for the study area.

Driving forces behind the spatiotemporal heterogeneity of land-use and land-cover change:A case study of the Weihe River Basin,China

The impact of socioeconomic development on land-use and land-cover change(LUCC)in river basins varies spatially and temporally.Exploring the spatiotemporal evolutionary trends and drivers of LUCC under regional disparities is the basis for the sustainable development and management of basins.In this study,the Weihe River Basin(WRB)in China was selected as a typical basin,and the WRB was divided into the upstream of the Weihe River Basin(UWRB),the midstream of the Weihe River Basin(MWRB),the downstream of the Weihe River Basin(DWRB),the Jinghe River Basin(JRB),and the Luohe River Basin(LRB).Based on land-use data(cultivated land,forestland,grassland,built-up land,bare land,and water body)from 1985 to 2020,we analyzed the spatiotemporal heterogeneity of LUCC in the WRB using a land-use transfer matrix and a dynamic change model.The driving forces of LUCC in the WRB in different periods were detected using the GeoDetector,and the selected influencing factors included meteorological factors(precipitation and temperature),natural factors(elevation,slope,soil,and distance to rivers),social factors(distance to national highway,distance to railway,distance to provincial highway,and distance to expressway),and human activity factors(population density and gross domestic product(GDP)).The results indicated that the types and intensities of LUCC conversions showed considerable disparities across different sub-basins,where complex conversions among cultivated land,forestland,and grassland occurred in the LRB,JRB,and UWRB,with higher dynamic change before 2000.The conversion of other land-use types to built-up land was concentrated in the UWRB,MWRB,and DWRB,with substantial increases after 2000.Additionally,the driving effects of the influencing factors on LUCC in each sub-basin also exhibited distinct diversity,with the LRB and JRB being influenced by the meteorological and social factors,and the UWRB,MWRB,and DWRB being driven by human activity factors.Moreover,the interaction of these influencing factors indicated an enhanced effect on LUCC.This study confirmed the spatiotemporal heterogeneity effects of socioeconomic status on LUCC in the WRB under regional differences,contributing to the sustainable development of the whole basin by managing sub-basins according to local conditions.

STUDY ON THE SPATIAL PATTERNS OF LAND-USE CHANGE AND ANALYSES OF DRIVING FORCES IN NORTHEASTERN CHINA DURING 1990-2000

Land-use change is an important aspect of global environment change. It is,in a sense, the direct result of human activities influencing our physical environment. Supported bythe dynamic serving system of national resources, including both the environment database and GIStechnology, this paper analyzed the land-use change in northeastern China in the past ten years(1990 ― 2000). It divides northeastern China into five land-use zones based on the dynamic degree(DD) of land-use: woodland/grassland ― arable land conversion zone, dry land ― paddy fieldconversion zone, urban expansion zone, interlocked zone of farming and pasturing, and reclamationand abandoned zone. In the past ten years, land-use change of northeastern China can be generalizedas follows: increase of cropland area was obvious, paddy field and dry land increased by 74. 9 and276. 0 thousand ha respectively; urban area expanded rapidly, area of town and rural residenceincreased by 76. 8 thousand ha; area of forest and grassland decreased sharply with the amount of1399. 0 and 1521. 3 thousand ha respectively; area of water body and unused land increased by 148. 4and 513. 9 thousand ha respectively. Besides a comprehensive analysis of the spatial patterns ofland use, this paper also discusses the driving forces in each land-use dynamic zones. The studyshows that some key biophysical factors affect conspicuously the conversion of different land-usetypes. In this paper, the relationships between land-use conversion and DEM, accumulated temperature(≥10℃) and precipitation were analysed and represented. We conclude that the land-use changes innortheast China resulted from the change of macro social and economic factors and local physicalelements. Rapid population growth and management changes, in some sense, can explain the shaping ofwoodland/grassland ― cropland conversion zone. The conversion from dry land to paddy field in thedry land ― paddy field conversion zone, apart from the physical elements change promoting theexpansion of paddy field, results from two reasons: one is that the implementation of market-economyin China has given fanners the right to decide what they plant and how they plant their crops, theother factor is originated partially from the change of dietary habit with the social and economicdevelopment. The conversion from paddy field to dry land is caused primarily by the shortfall ofirrigation water, which in turn is caused by poor water allocation managed by local governments. Theshaping of the reclamation and abandoned zone is partially due to the lack of environmentprotection consciousness among pioneer settlers. The reason for the conversion from grassland tocropland is the relatively higher profits of farming than that of pasturing in the interlocked zoneof farming and pasturing. In northeastern China, the rapid expansion of built-up areas results fromtwo factors: the first is its small number of towns; the second comes from the huge potential forexpansion of existing towns and cities. It is noticeable that urban expansion in the northeasternChina is characterized by gentle topographic relief and low population density. Physiognomy,transportation and economy exert great influences on the urban expansion.

Corrigendum to“Migration pattern of a population of Barn Swallows(Hirundo rustica)breeding in East Asian tropical region”[Avian Res.15(2024)100192]

The authors regret that the caption of Fig.4 should be replaced as below.

Clinical manifestation,lifestyle,and treatment patterns of chronic erosive gastritis:A multicenter real-world study in China

BACKGROUND Although chronic erosive gastritis(CEG)is common,its clinical characteristics have not been fully elucidated.The lack of consensus regarding its treatment has resulted in varied treatment regimens.AIM To explore the clinical characteristics,treatment patterns,and short-term outcomes in CEG patients in China.METHODS We recruited patients with chronic non-atrophic or mild-to-moderate atrophic gastritis with erosion based on endoscopy and pathology.Patients and treating physicians completed a questionnaire regarding history,endoscopic findings,and treatment plans as well as a follow-up questionnaire to investigate changes in symptoms after 4 wk of treatment.RESULTS Three thousand five hundred sixty-three patients from 42 centers across 24 cities in China were included.Epigastric pain(68.0%),abdominal distension(62.6%),and postprandial fullness(47.5%)were the most common presenting symptoms.Gastritis was classified as chronic non-atrophic in 69.9%of patients.Among those with erosive lesions,72.1%of patients had lesions in the antrum,51.0%had multiple lesions,and 67.3%had superficial flat lesions.In patients with epigastric pain,the combination of a mucosal protective agent(MPA)and proton pump inhibitor was more effective.For those with postprandial fullness,acid regurgitation,early satiety,or nausea,a MPA appeared more promising.CONCLUSION CEG is a multifactorial disease which is common in Asian patients and has non-specific symptoms.Gastroscopy may play a major role in its detection and diagnosis.Treatment should be individualized based on symptom profile.

Venous Doppler flow patterns,venous congestion,heart disease and renal dysfunction:A complex liaison

The World Journal of Cardiology published an article written by Kuwahara et al that we take the pleasure to comment on.We focused our attention on venous congestion.In intensive care settings,it is now widely accepted that venous congestion is an important clinical feature worthy of investigation.Evaluating venous Doppler profile abnormalities at multiple sites could suggest adequate treatment and monitor its efficacy.Renal dysfunction could trigger or worsen fluid overload in heart disease,and cardio-renal syndrome is a well-characterized spectrum of disorders describing the complex interactions between heart and kidney diseases.Fluid overload and venous congestion,including renal venous hypertension,are major determinants of acute and chronic renal dysfunction arising in heart disease.Organ congestion from venous hypertension could be involved in the development of organ injury in several clinical situations,such as critical diseases,congestive heart failure,and chronic kidney disease.Ultrasonography and abnormal Doppler flow patterns diagnose clinically significant systemic venous congestion.Cardiologists and nephrologists might use this valuable,noninvasive,bedside diagnostic tool to establish fluid status and guide clinical choices.

An Assessment and Geostatistics of Land-Use and Selected Physico-Chemical Properties of Soils in the Mount Cameroon Area

This work investigated the land-use/land-cover and some physico-chemical properties of the soils of Mt Cameroon and presented same in maps. ArcGIS Pro mapping software, Landsat images, Global Positioning Systems (GPS) coordinates collected from the field combined with updated shape files from competent services were used to produce the location and land-use/land-cover maps. Sixteen topsoil samples (0 - 20 cm) were collected, 4 from each land use/cover category: farmland, forest, plantation and settlement, and analysed for soil pH, cation exchange capacity (CEC), bulk density, moisture content and soil texture, in the laboratory using standard analytical procedures. This data was used to produce spatial distribution maps using ordinary kriging, in ArcGIS Pro. The main terrestrial land use/cover categories comprised of the forest (mangrove, lowland, montane and sub-montane), agroforestry, plantations, grassland, settlement, cropland, shrubby savannah, and bare lava. Bulk density showed the highest values in settlement areas and least values under forest land-use categories. Soil moisture content exhibited a reverse trend compared to that of soil bulk density. Forest soils were the sandiest while soils in plantation agricultural land were the most clayey. The soils were slightly acidic to neutral with soils from agricultural land being more acidic (pH(water) = 5.43). It is discernible from the results that the conversion from forest to other land use/cover classes enhances soil degradation and that soil physico-chemical properties adequately serve as indicators of soil quality in the Mt Cameroon area.

Pedestrian flow through exit:Study focused on evacuation pattern

Experiments are conducted on the evacuation rate of pedestrians through exits with queued evacuation pattern and random evacuation pattern. The experimental results show that the flow rate of pedestrians is larger with the random evacuation pattern than with the queued evacuation pattern. Therefore, the exit width calculated based on the minimum evacuation clear width for every 100 persons, which is on the assumption that the pedestrians pass through the exit in one queue or several queues, is conservative. The number of people crossing the exit simultaneously is greater in the random evacuation experiments than in the queued evacuation experiments, and the time interval between the front row and rear row of people is shortened in large-exit conditions when pedestrians evacuate randomly. The difference between the flow rate with a queued evacuation pattern and the flow rate with a random evacuation pattern is related to the surplus width of the exit, which is greater than the total width of all accommodated people streams. Two dimensionless quantities are defined to explore this relationship. It is found that the difference in flow rate between the two evacuation patterns is stable at a low level when the surplus width of the exit is no more than 45% of the width of a single pedestrian stream. There is a great difference between the flow rate with the queued evacuation pattern and the flow rate with the random evacuation pattern in a scenario with a larger surplus width of the exit. Meanwhile, the pedestrians crowd extraordinarily at the exit in these conditions as well, since the number of pedestrians who want to evacuate through exit simultaneously greatly exceeds the accommodated level. Therefore, the surplus width of exit should be limited especially in the narrow exit condition, and the relationship between the two dimensionless quantities mentioned above could provide the basis to some extent.

A divergent pattern in functional connectivity: a transdiagnostic perspective

Functional magnetic resonance imaging(fMRI)is a popular tool used to investigate not only how the brain responds to specific stimuli during sensorimotor or cognitive tasks,but also brain activity at rest.The physics beyond this approach is based on the analysis of the blood oxygenation level-dependent signal.

Pig Reproductive and Respiratory Syndrome Virus (PRRSV) Does Not Attach to Boar Sperm;It Affects Only the Velocity Pattern and the Mobility Pattern

The purpose of the study was to evaluate the sperm viability of semen infected with PRRSV viral particles, observing the effect of the Virus on the motility of boar sperm. The work was carried out at the FMVZ-BUAP Genetics and Reproduction Laboratory. 5 stallions were used. Each sample contained 1 × 106 sperm, the PRRS virus strain was ATCC-VR-2332 (0, 102, 104 and 106 copies of RNA/mL in triplicate), it was observed daily at the CASA;Hamilton Thorne®. Cells with MT (P < 0.05) on days 1, 3, 5, 7 and 10 of evaluation with 201 ± 7.3, 167 ± 10.1, 165 ± 14.6, 134 ± 8.2 and 120 ± 8.8, respectively. The % MP between control and virus concentrations (P ≥ 0.05). The LCV on day 1 and 7 PI at 10X2 and 10X6 (P < 0.05) vs control. In the Correlation Matrix, where it is observed that there is a correlation between VSL and VAP, VSL and VCL, VCL and ALH, VAP with ALH. There is a correlation of VSL and ALH, STR and ALH. In this study there were (P ≤ 0.01) in the VCL, in the concentrations (102) 162.81 ± 10.65 and (106) 177.12 ± 5.77 vs 193.04 ± 4.62 of control. This indicates that altering these parameters would be related to fertility and the PRRS virus affects the LCV. Regarding the VSL, it was observed that the sperm infected with viruses 102, 104 and 106 of 48.00 ± 3.38, 49.88 ± 1.83 and 50.55 ± 2.24 Vs. 56.66 ± 1.68 of control respectively, the control would have greater possibilities of fertilizing the oocyte. In this study, it was found (P ≤ 0.01) in the VAP with 102 of 77.26 ± 5.16, 104 with 83.35 ± 2.41 and 106 with 81.29 ± 3.14 vs the control with 90.56 ± 2.07. Regarding the ALH there is (P < 0.05) a 104 with 8.70 ± .26 and 106 with 9.64 ± 0.23 vs control 8.50 ± 0.27. The presence of different concentrations of PRRSV in boar semen induces changes in different types of sperm motility. Infection of ejaculates with the PRRS virus affects sperm motility on days 1, 3, 5, 7, and 10 post-infections.

A Portfolio Selection Method Based on Pattern Matching with Dual Information of Direction and Distance

Pattern matching method is one of the classic classifications of existing online portfolio selection strategies. This article aims to study the key aspects of this method—measurement of similarity and selection of similarity sets, and proposes a Portfolio Selection Method based on Pattern Matching with Dual Information of Direction and Distance (PMDI). By studying different combination methods of indicators such as Euclidean distance, Chebyshev distance, and correlation coefficient, important information such as direction and distance in stock historical price information is extracted, thereby filtering out the similarity set required for pattern matching based investment portfolio selection algorithms. A large number of experiments conducted on two datasets of real stock markets have shown that PMDI outperforms other algorithms in balancing income and risk. Therefore, it is suitable for the financial environment in the real world.

Pattern of Referral of Obstetric Patients at a Tertiary Care Hospital in Southern Nigeria

Background: Health challenges that are difficult to manage at primary health centres should be referred to secondary health facilities, and if untreated, to the tertiary hospitals. A good referral should include the patient’s biography, such as age, gender, tribe, religion, occupation, medical history, the reason for the referral, treatments received, and clinical diagnosis. Objectives: To evaluate the referral patterns, indications for referrals, and feto-maternal outcomes for obstetric patients who were referred to the University of Port Harcourt Teaching Hospital. Materials and Methods: A prospective study of patients admitted to the Obstetric unit from January 1, 2021, to December 31, 2022. Data was collected from patients while on admission or clinic visits and recorded in an excel spread sheet. Data was analyzed with the Statistical Package for Social Sciences (SPSS) version 25. Results: Of the 3469 patients were admitted to the obstetric unit, 1476 and 1993 were admitted in 2021 and 2022, respectively. Most (70.35%) of the patients were in the 20-34 years age group, parity 1-4 was the most frequent (66.49%), while 85.39% of patients were booked. 10.46% of the booked patients were referred from other facilities, whereas 89.54% of patients were booked at our facility from the onset. Most common indications of referrals were previous caesarean section (CS) at term (40.09%) and hypertensive disorders of pregnancy (17.59%). The outcome for 2021 indicated 17 maternal deaths, 132 fetal deaths and 1010 live births, giving maternal mortality ratio (MMR) as 1810.44 per 100,000 live births and perinatal mortality ratio (PMR) of 130.7 per 1000 births respectively. In 2022, there were 17 maternal deaths, 130 fetal deaths and 1297 deliveries, giving a MMR of 1399 per 100,000 live births and a PMR of 100.2 per 1000 births. Conclusion: The pattern of referral among obstetric patients in this study shows that a lot of the patients do not get adequate care at the lower cadre of the referral system, hence adequate facilities should be made available in primary and secondary health centres to tackle obstetric emergencies.

Tuning the diffusion constant to optimize the readout of positional information of spatial concentration patterns

Positional information encoded in spatial concentration patterns is crucial for the development of multicellular organisms.However,it is still unclear how such information is affected by the physically dissipative diffusion process.Here we study one-dimensional patterning systems with analytical derivation and numerical simulations.We find that the diffusion constant of the patterning molecules exhibits a nonmonotonic effect on the readout of the positional information from the concentration patterns.Specifically,there exists an optimal diffusion constant that maximizes the positional information.Moreover,we find that the energy dissipation due to the physical diffusion imposes a fundamental upper limit on the positional information.

Temporal and spatial evolution of global major grain trade patterns

The complex and volatile international landscape has significantly impacted global grain supply security. This study uses a complex network analysis model to examine the evolution and trends of the global major grain trade from 1990 to 2020, focusing on network topology, centrality ranking, and community structure. There are three major findings. First, the global major grain trade network has expanded in scale, with a growing emphasis on diversification and balance. During the study period, the United States, Canada, China, and Brazil were the core nodes of the network. Grain-exporting countries were mainly situated in Asia, the Americas, and Europe, and importing countries in Asia, Africa, and Europe. Second, a significant increase in the number of high centrality countries with high export capacity occurred, benefiting from natural advantages such as fertile land and favorable climates. Third, the main global grain trade network is divided into four communities, with the Americas-Europe community being the largest and most widespread. The formation of the community pattern was influenced by geographic proximity, driven by the core exporting countries. Therefore, the world needs to enhance the existing trade model, promote the multi-polarization of the grain trade network, and establish a global vision for the future community. Countries and regions should participate actively in global grain trade security governance and institutional reform, expand trade links with other countries, and optimize import and export policies to reduce trade risks.

Dissolvable temporary barrier:a novel paradigm for flexible hydrogel patterning in organ-on-a-chip models

A combination of hydrogels and microfluidics allows the construction of biomimetic three-dimensional(3D)tissue models in vitro,which are also known as organ-on-a-chipmodels.The hydrogel patterningwith awell-controlled spatial distribution is typically achieved by embedding sophisticated microstructures to act as a boundary.However,these physical barriers inevitably expose cells/tissues to a less physiologically relevant microenvironment than in vivo conditions.Herein,we present a novel dissolvable temporary barrier(DTB)strategy that allows robust and flexible hydrogel patterning with great freedom of design and desirable flow stimuli for cellular hydrogels.The key aspect of this approach is the patterning of a water-soluble rigid barrier as a guiding path for the hydrogel using stencil printing technology,followed by a barrier-free medium perfusion after the dissolution of the DTB.Single and multiple tissue compartments with different geometries can be established using either straight or curved DTB structures.The effectiveness of this strategy is further validated by generating a 3D vascular network through vasculogenesis and angiogenesis using a vascularized microtumor model.As a new proof-of-concept in vasculature-on-a-chip,DTB enables seamless contact between the hydrogel and the culture medium in closed microdevices,which is an improved protocol for the fabrication ofmultiorgan chips.Therefore,we expect it to serve as a promising paradigm for organ-on-a-chip devices for the development of tumor vascularization and drug evaluation in the future preclinical studies.