The present work revealed that the praseodymium()complex of 2carboxyethylgermanium sesquioxide(Ge132)promotes the hydrolysis of the phosphodiester linkages of 3,5cyclic adenosine monophosphate(cAMP),3,5cyclic deoxyade...The present work revealed that the praseodymium()complex of 2carboxyethylgermanium sesquioxide(Ge132)promotes the hydrolysis of the phosphodiester linkages of 3,5cyclic adenosine monophosphate(cAMP),3,5cyclic deoxyadenosine monophosphate(dcAMP),5adenosine monophosphate(5AMP)and 5deoxyadenosine monophosphate(5dAMP)under mild conditions.Both cAMP and dcAMP were hydrolyzed sitespecifically,yielding predominantly 3monophosphates,the main products of the cleavage of 5AMP and 5dAMP included adenosine(Ado),deoxyadenosine(dAdo)and free phosphates respectively.A hydrolytic mechanism was proposed for cAMP,dcAMP,5AMP and 5dAMP.展开更多
文摘The present work revealed that the praseodymium()complex of 2carboxyethylgermanium sesquioxide(Ge132)promotes the hydrolysis of the phosphodiester linkages of 3,5cyclic adenosine monophosphate(cAMP),3,5cyclic deoxyadenosine monophosphate(dcAMP),5adenosine monophosphate(5AMP)and 5deoxyadenosine monophosphate(5dAMP)under mild conditions.Both cAMP and dcAMP were hydrolyzed sitespecifically,yielding predominantly 3monophosphates,the main products of the cleavage of 5AMP and 5dAMP included adenosine(Ado),deoxyadenosine(dAdo)and free phosphates respectively.A hydrolytic mechanism was proposed for cAMP,dcAMP,5AMP and 5dAMP.
