Structured Microgrids (SμGs) and Flexible Electronic Large Power Transformers (FeLPTs)

Structured microgrids(SμGs)and Flexible electronic large power transformers(FeLPTs)are emerging as two essential technologies for renewable energy integration,flexible power transmission,and active control.SμGs provide the integration of renewable energy and storage to balance the energy demand and supply as needed for a given system design.FeLPT’s flexibility for processing,control,and re-configurability offers the capability for flexible transmission for effective flow control and enable SμGs connectivity while still keeping multiscale system level control.Early adaptors for combined heat and power have demonstrated significant economic benefits while reducing environmental foot prints.They bring tremendous benefits to utility companies also.With storage and active control capabilities,a 300-percent increase in bulk transmission and distribution lines are possible without having to increase capacity.SμGs and FeLPTs will also enable the utility industry to be better prepared for the emerging large increase in base load demand from electric transportation and data centers.This is a win-win-win situation for the consumer,the utilities(grid operators),and the environment.SμGs and FeLPTs provide value in power substation,energy surety,reliability,resiliency,and security.It is also shown that the initial cost associated with SμG and FeLPTs deployment can be easily offset with reduced operating cost,which in turn reduces the total life-cycle cost by 33%to 67%.

Periodicities in the emplacement of large igneous provinces through the Phanerozoic:Relations to ocean chemistry and marine biodiversity evolution

Large igneous provinces （LIPs） are considered a relevant cause for mass extinctions of marine life throughout Earth＇s history. Their flood basalts and associated intrusions can cause significant release of SO4 and CO2 and consequently, cause major environmental disruptions. Here, we reconstruct the long-term periodic pattern of LIP emplacement and its impact on ocean chemistry and biodiversity from δ34Ssulfate of the last 520 Ma under particular consideration of the preservation limits of LIP records. A combination of cross-wavelet and other time-series analysis methods has been applied to quantify a potential chain of linkage between LIP emplacement periodicity, geochemical changes and the Phanerozoic marine genera record. We suggest a mantle plume cyclicity represented by LIP volumes （V） of V= （350-770） × 103km3sin（27πt/ 170 Ma）＋ （300-650）× 103 km3 sin（2πt/64.5 Ma ＋ 2.3） for t= time in Ma. A shift from the 64.5 Ma to a weaker -28-35 Ma LIP cyclicity during the Jurassic contributes together with probably independent changes in the marine sulfur cycle to less ocean anoxia, and a general stabilization of ocean chemistry and increasing marine biodiversity throughout the last -135 Ma. The LIP cycle pattern is coherent with marine biodiversity fluctuations corresponding to a reduction of marine biodiversity of -120 genera/Ma at 600 x 103 km3 LIP eruption volume. The 62-65 Ma LIP cycle pattern as well as excursion in -34Ssulfate and marine genera reduction suggest a not-vet identified found LIP event at - 440-450 Ma.

Clinical applicability of immunotherapy of cervical intraepithelial neoplasia

Immunotherapy for cervical intraepithelial neoplasia （CIN） has not yet reached clinical applicability, but seems sensible and shows promising preliminary results. One of the most promising forms of immunotherapy for CIN may currently be imiquimod, because of its established role in other human papillomavirus （HPV）-induced genital conditions, its promising treatment effcacy in high-grade CIN, and its off-label availability. Although imiquimod cannot yet replace the current gold standard treatment for CIN [ i.e. , large loop excision of the transformation zone （LLETZ）] in all patients, it may be considered in subgroups of patients; for example, young women who may wish to become pregnant in the future, or patients with recurrent CIN lesions in whom a second LLETZ is to be avoided. Immunotherapy of CIN could be extended to post-treatment vaccination, in order to prevent new HPV infections and disease recurrence.

Towards a (More) Electronic Transmission and Distribution (eT&D)

The challenges and the path towards a(more)electronic transmission and distribution(eT&D)is presented in this paper.The challenges are first identified together with key stakeholders in the drive for grid modernization.A fundamental question is then asked about the investment priority.Six basic characteristics are reviewed,leading to the composition of structured microgrids as the basic functional cell of a modern grid.One example of fractal radial structure and one fractal meshed structure are presented.The likely evolution path is then proposed together with basic technology sets.Specific foundation technologies are discussed in detail,including adiabatic power conversion,3MC technology,medium voltage conversion,distribution-level electronic power transformer and FACTs hardware integration,and back-to-back converters as a universal interconnect element.The rapidly emerging on-wire sensing technology is also discussed.It is pointed out that the distribution-level large electronic power transformer will provide a key component to enable hybrid ac/dc grid flow control and ancillary support for a flexible electronic transmission and distribution(eT&D)systems.

Transformation of Anaplastic Large Cell Lymphoma to High-grade Diffuse Large B-cell Ymphoma:Remission after Pegylated Liposomal Doxorubicin and Rituximab Immunotherapy

Summary:We demonstrate the usefulness of pegylated liposomal doxorubicin (PL-doxorubicin) combine with CD20 antibody Rituximab in a case of transformation of anaplastic large cell lymphoma (ALCL) to high-grade diffuse large B-cell lymphoma (B-DLCL).Case report:A 63-year-old woman suffering from anaplastic large cell lymphoma(stage Ⅳ a) since 2004 showed mediastinal relapse despite of 4 cyclesof chemotherapy following the