Impact of body mass index on adverse kidney events in diabetes mellitus patients: A systematic-review and meta-analysis

BACKGROUND The incidence of chronic kidney disease among patients with diabetes mellitus(DM)remains a global concern.Long-term obesity is known to possibly influence the development of type 2 diabetes mellitus.However,no previous meta-analysis has assessed the effects of body mass index(BMI)on adverse kidney events in patients with DM.AIM To determine the impact of BMI on adverse kidney events in patients with DM.METHODS A systematic literature search was performed on the PubMed,ISI Web of Science,Scopus,Ovid,Google Scholar,EMBASE,and BMJ databases.We included trials with the following characteristics:(1)Type of study:Prospective,retrospective,randomized,and non-randomized in design;(2)participants:Restricted to patients with DM aged≥18 years;(3)intervention:No intervention;and(4)kidney adverse events:Onset of diabetic kidney disease[estimated glomerular filtration rate(eGFR)of<60 mL/min/1.73 m2 and/or microalbuminuria value of≥30 mg/g Cr],serum creatinine increase of more than double the baseline or end-stage renal disease(eGFR<15 mL/min/1.73 m2 or dialysis),or death.RESULTS Overall,11 studies involving 801 patients with DM were included.High BMI(≥25 kg/m2)was significantly associated with higher blood pressure(BP)[systolic BP by 0.20,95%confidence interval(CI):0.15–0.25,P<0.00001;diastolic BP by 0.21 mmHg,95%CI:0.04–0.37,P=0.010],serum albumin,triglycerides[standard mean difference(SMD)=0.35,95%CI:0.29–0.41,P<0.00001],low-density lipoprotein(SMD=0.12,95%CI:0.04–0.20,P=0.030),and lower high-density lipoprotein(SMD=–0.36,95%CI:–0.51 to–0.21,P<0.00001)in patients with DM compared with those with low BMIs(<25 kg/m2).Our analysis showed that high BMI was associated with a higher risk ratio of adverse kidney events than low BMI(RR:1.22,95%CI:1.01–1.43,P=0.036).CONCLUSION The present analysis suggested that high BMI was a risk factor for adverse kidney events in patients with DM.

Stratigraphical Time——Correlation and Mass Extinction Event Near Permian——Triassic Boundary in South China

Shaw's method used to correlate 40 sections across the Permo-Triassic boundary in South China is applied in the paper. Two steps are adopted to get an Integral Composite Section (ICS) by synthesizing these data : First , South China is divided into five areas and composite section developed for each area . Then the second step . the Changxing composite section is regarded as a composite standard (CSRS) while the ICS is produced by matching the CSRS with composite sections of the other areas. Three biozones in the Changxingian and two biozones in the Griesbachian can be discerned on the basis of computing Z values in the ICS. These biozones are marked by the Z values which quantitatively represent their time ranges ; therefore , they may increase accuracy of stratigraphic time correlation . The mass extinction at the end of the Permian is an abrupt event that is supported by the relative rate of extinction near the P/T boundary . About 90% of invertebrate species died out by the end of the Permian . The duration of the mass extinction is rather short ,approximately 0.018Ma .

Responses of Vertical Structures in Convective and Stratiform Regions to Large-Scale Forcing during the Landfall of Severe Tropical Storm Bilis (2006)

The responses of vertical structures, in convective and stratiform regions, to the large-scale forcing during the landfall of tropical storm Bilis （2006） are investigated using the data from a two-dimensional cloud-resolving model simulation. An imposed large-scale forcing with upward motion in the mid and upper troposphere and downward motion in the lower troposphere on 15 July suppresses convective clouds, which leads to -100% coverage of raining stratiform clouds over the entire model domain. The imposed forcing extends upward motion to the lower troposphere during 16-17 July, which leads to an enhancement of convective clouds and suppression of raining stratiform clouds. The switch of large-scale lower-tropospheric vertical velocity from weak downward motion on 15 July to moderate upward motion during 16-17 July produces a much broader distribution of the vertical velocity, water vapor and hydrometeor fluxes, perturbation specific humidity, and total hydrometeor mixing ratio during 16-17 July than those on 15 July in the analysis of contoured frequency-altitude diagrams. Further analysis of the water vapor budget reveals that local atmospheric moistening is mainly caused by the enhancement of evaporation of rain associated with downward motion on 15 July, whereas local atmospheric drying is mainly determined by the advective drying associated with downward motion over raining stratiform regions and by the net condensation associated with upward motion over convective regions during 16-17 July.

An Isentropic Mass Circulation View on the Extreme Cold Events in the 2020/21 Winter

Three extreme cold events successively occurred across East Asia and North America in the 2020/21 winter.This study investigates the underlying mechanisms of these record-breaking persistent cold events from the isentropic mass circulation(IMC)perspective.Results show that the midlatitude cold surface temperature anomalies always co-occurred with the high-latitude warm anomalies,and this was closely related to the strengthening of the low-level equatorward cold air branch of the IMC,particularly along the climatological cold air routes over East Asia and North America.Specifically,the two cold surges over East Asia in early winter were results of intensification of cold air transport there,influenced by the Arctic sea ice loss in autumn.The weakened cold air transport over North America associated with warmer northeastern Pacific sea surface temperatures(SSTs)explained the concurrent anomalous warmth there.This enhanced a wavenumber-1 pattern and upward wave propagation,inducing a simultaneous and long-lasting stronger poleward warm air branch(WB)of the IMC in the stratosphere and hence a displacement-type Stratospheric Sudden Warming(SSW)event on 4 January.The WB-induced increase in the air mass transported into the polar stratosphere was followed by intensification of the equatorward cold branch,hence promoting the occurrence of two extreme cold events respectively over East Asia in the beginning of January and over North America in February.Results do not yield a robust direct linkage from La Niña to the SSW event,IMC changes,and cold events,though the extratropical warm SSTs are found to contribute to the February cold surge in North America.

Relationship between the rock mass deformation and places of occurrence of seismological events

Static effort of rock mass very rarely causes of rock burst in polish coal mines. Rock bursts with source in the seismic tremor within the roof rock layers are prevailing. A seismic tremor is an effect of rupture or sliding in roof layers above the exploited panel in coal seam, sometime in a distance from actual exploitation. Sliding, as a rule occurs in fault zone and tremors in it are expected, but monolithic layer rupture is very hard to predict. In a past few years a practice of analyzing state of deformation in high energy seismic tremors zones has been employed. It let gathering experience thanks to witch determination of dangerous shape of reformatted roof is possible. In the paper some typical forms of roof rocks deformations leading to seismic tremor occurrence will be presented. In general these are various types of multidirectional rock layers bending. Real examples of seismic events and rock bursts will be shown.

Classification of wintertime large-scale tilted ridges over the Eurasian continent and their influences on surface air temperature

This study investigates the major patterns of large-scale tilted ridges(LSTRS)over the Eurasian continent and their connections with large-scale surface air temperature during boreal winter.A total number of 134 LSTR events with zonal extent exceeding 90°of longitude on the peak day are identified.Using self-organizing map(SOM),the LSTRs are classified into five clusters that are characterized by different spatial distributions and orientations.The leading two clusters are closely associated with extensive and persistent cold events over different places.Considering the first cluster,LSTRs extend from the Ural Mountains to Northeast Asia and are favorable for the amplification and southeastward extension of the Siberian high.Therefore,this cluster is closely associated with the occurrence of extensive and persistent cold events in china.In comparison with the first cluster,the LSTRs of second group are situated to the west,with starting points from the Kola Peninsula,and cause extensive and persistent cold events over Eastern Europe,central Asia,and central Siberia.The results suggest that the vertical coupling between LSTRs and the corresponding anomalous sea level pressure is crucial for the persistent cold temperature events associated with the leading two SOM clusters.

Ensemble prediction model of solar proton events associated with solar flares and coronal mass ejections

An ensemble prediction model of solar proton events （SPEs）, combining the information of solar flares and coronal mass ejections （CMEs）, is built. In this model, solar flares are parameterized by the peak flux, the duration and the longitude. In addition, CMEs are parameterized by the width, the speed and the measurement position angle. The importance of each parameter for the occurrence of SPEs is estimated by the information gain ratio. We find that the CME width and speed are more informative than the flare’s peak flux and duration. As the physical mechanism of SPEs is not very clear, a hidden naive Bayes approach, which is a probability-based calculation method from the field of machine learning, is used to build the prediction model from the observational data. As is known, SPEs originate from solar flares and/or shock waves associated with CMEs. Hence, we first build two base prediction models using the properties of solar flares and CMEs, respectively. Then the outputs of these models are combined to generate the ensemble prediction model of SPEs. The ensemble prediction model incorporating the complementary information of solar flares and CMEs achieves better performance than each base prediction model taken separately.

Unified Symmetry of Nonholonomic System of Non-Chetaev＇s Type with Variable Mass in Event Space

The unified symmetry of a nonholonomic system of non-Chetaev＇s type with variable mass in event space is studied. The differential equations of motion of the system are given. Then the definition and the criterion of the unified symmetry for the system are obtained. Finally, the Noether conserved quantity, the Hojman conserved quantity, and a new type of conserved quantity are deduced from the unified symmetry of the nonholonomic system of non-Chetaev＇s type with variable mass in event space at one time. An example is given to illustrate the application of the results.

The impact of climate changes on mass events in China

There is an increasing number of "mass events" in China's Mainland.My study extends the current studies to the context of China and tries to examine the potential impacts of climate changes on human conflias in China.The results suggest a strong linkage between the deviation of monthly mean temperature from the historical mean and the number of mass events in a province.If the current trend of warming persists,in the next 6-8 decades,the number of mass events in China will increase by over 8.8%.

Medical Care at Mass Gatherings: The Case of TIF-HELEXPO Trade Fairs and Events

The provision of medical care during major events is a significant issue,both for organisers and for the emergency services that support these events.Nevertheless,research on this matter is limited.This research attempts to approach the matter through the study of fairs and events held at TIF-HELEXPO during the 2015-2018 period(1,774 medical incidents).Result analysis indicated that there are no significant differentiations in the number of medical incidents with regard to gender,age,country of origin,status,type of illness,and outcome of incidents;however,there were differentiations in the frequency of incidents,with regards to the character of the fair and the event.

The efficacy and safety of endoscopic ultrasound-guided fine-needle biopsy in gallbladder masses

Background: Endoscopic ultrasound-guided fine-needle biopsy(EUS-FNB) is a widely used modality for acquiring various target samples, but its efficacy in gallbladder masses is unknown. The aim of this retrospective study was to evaluate the efficacy and safety of EUS-FNB in patients with gallbladder masses. Methods: The study samples were composed of patients from March 2015 to July 2019 who needed to identify the nature of gallbladder masses through EUS-FNB. The outcomes of this study were the adequacy of specimens, diagnostic yields, technical feasibility, and adverse events of the EUS-FNB in gallbladder masses. Results: A total of 27 consecutive patients with a median age of 58 years were included in this study. The 22-gauge FNB needle was feasible in all lesions. The median follow-up period of the patients was 294 days. The specimens sufficient for diagnosis account for 89%(24/27) and 93%(25/27) in cytology and histology, respectively. The overall diagnostic yields for malignancy showed the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 95.45% [95% confidence interval(CI): 75.12%-99.76%], 100%(95% CI: 46.29%-10 0%), 10 0%(95% CI: 80.76%-100%), 83.33%(95% CI: 36.48%-99.12%), and 96.30%(95% CI: 80.20%-99.99%), respectively. The subgroup analysis revealed that FNB could obtain sufficient specimens and high diagnostic yields in both gallbladder mass < 20.5 mm group and ≥20.5 mm group. One patient experienced mild abdominal pain after the procedure and recovered within one day. Conclusions: EUS-FNB is a reasonable diagnostic tool for the pretreatment diagnosis of patients with gallbladder masses, especially for patients who may miss the opportunity of surgery and need sufficient specimens to identify the pathological type so as to determine chemotherapy regimens. Further largescale studies are needed to confirm our conclusion.

我国乡村体育赛事发展经验及展望

运用文献资料、实地调研等方法,探讨我国乡村体育赛事的价值,总结其经验,并提出展望。价值:吸引群众广泛参与,形成全民健身发展热潮;激发体育消费潜力,助力乡村经济发展;搭建传统文化传承平台,丰富乡村体育赛事文化;推动办赛模式创新,提升乡村办赛能力。经验:紧密依托地方,推动赛事发展;鼓励全民参与,增强社会认同;创新传播方式,引发社会关注;融合地方特色,丰富赛事内容;多元主体合作,保障赛事开展。展望:推动办赛体制改革,构建协同化赛事保障;坚持村民共商共建,推动赛事生活化发展;加强赛事市场监管,树立规范化赛事形象;凸显地方文化内涵,打造个性化赛事IP;培养专业化人才队伍,促进赛事高质量发展。

我国群众性与竞技性赛事融合发展的机理、现实与策略

推动群众性与竞技性赛事融合发展对建设中国式现代化体育强国具有重要意义。在群众性与竞技性赛事融合发展中,以人民为中心和以运动项目为基本的共同基础是前提,边界逐渐模糊是加快融合的条件,以此构造全民参与的竞争型赛事样板的融合雏形。透过厘清“双赛”融合脉络探讨当前存在的根源性问题、主体性问题、内容性问题和体制性问题,表现为“双赛”融合认识不足制约互动关系、“双赛”地位竞争引致角色冲突、运动项目融入不深导致根基不稳和缺乏政策体系保障削弱融合动力。基于此,提出以体育强国建设为目标,强化“双赛”融合认识;以多元主体协同为抓手,促进“双赛”多方面融合;以运动项目为核心内容,推动“双赛”构建新发展形态;加强体制机制保障,促动政策资源向群众性赛事倾斜。

环境差异视角下我国高山滑雪运动的大众化培育

高山滑雪运动是大众冬季运动的重要形式,但由于我国滑雪产业起步较晚,项目开展环境存在地区差异,导致当前高山滑雪运动的大众参与率较低,普及发展并不均衡。通过分析国内外高山滑雪优势区域的综合环境,发现优越的自然环境、完善的雪场基础设施、舒适便捷的配套服务以及浓厚的滑雪文化是这些区域吸引大众、快速发展的保障。对此,提出宏观引领微观扶持,多元发展滑雪产业;完善雪场配套供给,优化滑雪消费环境;依托滑雪赛事活动,丰富大众休闲方式;厚植传播滑雪文化,增强大众参与意识等培育策略。旨在对照和借鉴高山滑雪优势区域的先进经验与举措,同步丰富高山滑雪运动的“硬件”供给和“软件”资源,加快我国高山滑雪运动的大众化培育,在后冬奥时代创造冰雪经济新的增长点。

我国群众体育赛事的演变特征与多维价值

群众体育赛事作为推动全民健身和促进体育产业发展的重要手段,在我国体育事业中占据着重要地位。分析我国群众体育赛事的演变特征,探讨其在促进体育消费、增强国民体质、传承体育文化、优化体育资源配置等方面的多维价值,为我国群众体育赛事的持续发展提供理论支持和实践指导。

Real-time arrival picking of rock microfracture signals based on convolutional-recurrent neural network and its engineering application

Accurately picking P-and S-wave arrivals of microseismic(MS)signals in real-time directly influences the early warning of rock mass failure.A common contradiction between accuracy and computation exists in the current arrival picking methods.Thus,a real-time arrival picking method of MS signals is constructed based on a convolutional-recurrent neural network(CRNN).This method fully utilizes the advantages of convolutional layers and gated recurrent units(GRU)in extracting short-and long-term features,in order to create a precise and lightweight arrival picking structure.Then,the synthetic signals with field noises are used to evaluate the hyperparameters of the CRNN model and obtain an optimal CRNN model.The actual operation on various devices indicates that compared with the U-Net method,the CRNN method achieves faster arrival picking with less performance consumption.An application of large underground caverns in the Yebatan hydropower station(YBT)project shows that compared with the short-term average/long-term average(STA/LTA),Akaike information criterion(AIC)and U-Net methods,the CRNN method has the highest accuracy within four sampling points,which is 87.44%for P-wave and 91.29%for S-wave,respectively.The sum of mean absolute errors(MAESUM)of the CRNN method is 4.22 sampling points,which is lower than that of the other methods.Among the four methods,the MS sources location calculated based on the CRNN method shows the best consistency with the actual failure,which occurs at the junction of the shaft and the second gallery.Thus,the proposed method can pick up P-and S-arrival accurately and rapidly,providing a reference for rock failure analysis and evaluation in engineering applications.

融合事理知识的群体性事件演化预测

[研究目的]当前,由社会矛盾和冲突所引发的网络群体性事件对公共安全构成了严重威胁,预测群体性事件的演化趋势对提升社会危机的防范与治理能力至关重要。[研究方法]提出了一种融合事理知识的群体性事件演化预测方法。该方法首先利用大语言模型蕴含的丰富事件知识及模型强大的生成能力来构建初始的事理图谱,通过结合真实新闻报道来验证图谱内容;其次,将事理图谱与图神经网络模型相结合,以获得更充分的事件语义表示;最后,基于上下文事件与候选事件间的语义相似度来预测未来可能发生的事件。[研究结论]研究表明,所提方法在事件演化预测的准确性和可解释性方面均显著优于参与比较的其他方法,验证了事理知识融合对揭示群体性事件演化模式的可行性和有效性。

群众体育赛事赋能乡村振兴研究

运用文献资料、案例分析等方法,深入探究群众体育赛事赋能乡村振兴的价值、困境,并提出路径。价值:健全乡村产业体系,促进产业兴旺;提升乡村生态效益,促进生态宜居;繁荣乡村文体事业,促进乡风文明;优化乡村基层治理,促进治理有效;拓宽就业增收渠道,促进生活富裕。困境:组织体系需要完善,融合发展亟待深化,资源配置亟须优化。路径:完善组织体系建设,建立健全长效工作机制;创新融合发展业态,因地制宜打造乡村特色活动;加大资源供给力度,持续优化乡村资源均衡配置。

数字化背景下群众性体育赛事破圈传播研究

采用文献资料法,探讨数字化背景下群众性体育赛事破圈传播的理论基础、现实影响与优化策略.研究认为:群众性体育赛事的破圈传播是通过创新、多样化的方式将传统的群众性体育赛事的影响力扩展到更广泛的社会群体和领域.其积极影响在于带动群众性体育赛事传播效率的提高、助力市场规模的扩大、并促进相关体育产业结构的优化;与此同时,其消极影响也不可忽视,主要表现在造成广泛的消极话语、隐私问题的不断加剧、导致伴生的社会隔阂.若要对数字化背景下群众性体育赛事破圈传播进行优化,就必须克服相关责任主体监管不严、同类体育赛事内容单一、线下体育热情仍然有限等掣肘,有必要通过多方协同完善机制,来加强优质内容供给,并反哺线下体育活动.

乡村振兴战略背景下乡村体育赛事品牌的生成机理与培育路径研究——以贵州“村BA”为例

运用文献资料法和案例分析法,以贵州“村BA”篮球赛为典型案例,探析乡村体育赛事品牌促进乡村振兴的时代价值、生成机理及培育路径。指出,乡村体育赛事品牌具有促进乡村产业、生态、文化、人才、组织振兴的多重价值。乡村体育赛事品牌的生成需要依赖政策规划做好顶层设计,依赖全民参与形成路径保障,依赖因地制宜凝练独特优势,依赖品牌策略提供有力支撑。在此基础上提出,通过系统培育赛事环境,夯实品牌发展基础;推动多元主体协同合作,凝聚品牌发展合力;利用资源驱动产业融合,拓展品牌发展模式;实施有效的品牌策略,扩大品牌影响。旨在为乡村体育赛事健康发展、促进乡村振兴提供参考借鉴。