The Xinjiang Geology and Mineral Resources Exploration and Development Bureau have conducted a detailed investigation project of the Xigobi soda-niter deposit in Hami, Xinjiang Province, which was completed at the end...The Xinjiang Geology and Mineral Resources Exploration and Development Bureau have conducted a detailed investigation project of the Xigobi soda-niter deposit in Hami, Xinjiang Province, which was completed at the end of 2011. The project put much emphasis on research of soda-niter mineralization rules, stratum classification, ore-forming展开更多
The pathways leading to synthesis and post-synthetic modification of DNA employed methionine as donor of atoms: the carbon that came from its –CH3 served for DNA replication and repair either in bacteria or humans;it...The pathways leading to synthesis and post-synthetic modification of DNA employed methionine as donor of atoms: the carbon that came from its –CH3 served for DNA replication and repair either in bacteria or humans;its entire –CH3 served instead for building N6-methyladenine and 5-methylcytosine on bacterial DNA and 5-methylcytosine alone on human DNA. In humans, although a slight extra-S asymmetric methylation appeared de novo yielding on parental DNA 5’-m5CpC-3’/ 3’-GpG-5’, 5’-m5CpT-3’/3’-GpA-5’ and 5’-m5CpA-3’/3’-GpT-5’ monomethylated dinucleotide pairs, a heavy symmetric methylation involved in S semiconservatively newly made DNA to guarantee genetic maintenance of –CH3 in 5’-m5CpG-3’/3’-Gpm5C-5’ dimethylated dinucleotide pairs. In this framework, an inverse correlation was found between bulk genomic DNA methylation occurring in S and bulk polyA-containing pre-mRNA transcription taking place in G1 and G2. Thus, probes of 1 × 106 Daltons (constructed using sheared by sonication newly made methylated DNA filaments) revealed a modular organization in genes: after the hypermethylated promoter, they exhibited an alternation of unmethylated coding and methylated uncoding sequences. This encouraged the search for a language that genes regulated by methylation should have in common. An initial deciphering of restriction minimaps with hypomethylatable exons vs. hypermethylatable promoters and introns was improved when the bisulfite technique allowed a direct sequencing of m5C. In lymphocytes, where the transglutaminase gene is inactive, its promoter exhibited two fully methylated CpG-rich domains at 5’ and one fully unmethylated CpG-rich domain at 3’, including the site +1 and a 5’-UTR. At variance, in HUVEC cells, where the transglutaminase gene is active, in the first CpG-rich domain of promoter few doublets lost their –CH3. Such an inverse correlation suggested new hypotheses especially in connection with repair-modification: UV radiation would cause demethylation in given loci of a promoter by chance, whilst even a partial demethylation in this promoter would be able to resume a previously silent pre-mRNA transcription.展开更多
We compared the numbers of nucleotide substitutions occurring in the non-coding regions and coding regions of Ebola virus genomes and found that non-coding regions contain indispensable phylogenetic and evolutionary i...We compared the numbers of nucleotide substitutions occurring in the non-coding regions and coding regions of Ebola virus genomes and found that non-coding regions contain indispensable phylogenetic and evolutionary information. The omission of genetic data from non-coding regions can lead to unreliable phylogenies and inaccurate estimates of evolutionary parameters.展开更多
针对锁相环同步的弱连接电压源变流器(weakgrid connected voltage source converter,WG-VSC)系统的暂态稳定问题,该文首先应用线性矩阵不等式优化法构建WG-VSC系统的最大估计吸引域(largest estimated domain of attraction,LEDA),并将...针对锁相环同步的弱连接电压源变流器(weakgrid connected voltage source converter,WG-VSC)系统的暂态稳定问题,该文首先应用线性矩阵不等式优化法构建WG-VSC系统的最大估计吸引域(largest estimated domain of attraction,LEDA),并将LEDA与基于LaSalle不变集定理的能量函数法和平方和规划法构建的LEDA进行详细对比,验证了所提方法在刻画LEDA方面具有更低的保守性。然后从保证故障穿越控制过程中的锁相环暂态同步稳定作为切入点,首次提出WG-VSC系统在电网对称故障大扰动下的有功/无功电流设定值可行域概念,并基于线性矩阵不等式方法刻画的LEDA,提出该可行域的求解算法,分析了典型参数对该电流设定值可行域的影响。该可行域为故障过程中的有功和无功电流设定值提供了切实可行的指导依据。最后在PSCAD/EMTDC中搭建了基于详细开关模型的WG-VSC系统仿真算例,通过多种暂态仿真工况验证了该文所构建的LEDA和电流设定值可行域的有效性和可行性。展开更多
The largest wire and cable production enterprise in the northwestern region-Qinghai Xingming Electric Power Material Co.,Ltd.has been officially put into production,meaning that Qinghai will be able to selfproduce med...The largest wire and cable production enterprise in the northwestern region-Qinghai Xingming Electric Power Material Co.,Ltd.has been officially put into production,meaning that Qinghai will be able to selfproduce medium and high voltage or even EHV crosslinked power cables and develop and produce differentiated new products such as high-altitude cold-resistant photovoltaic展开更多
By 2050,there will be 2.2 million centenarians[in the world,compared to 135,000 in 1998],that is one of every 5,000 people.The largest centenarian population in 2050 is projected to be in China.By 2050,Japan will have...By 2050,there will be 2.2 million centenarians[in the world,compared to 135,000 in 1998],that is one of every 5,000 people.The largest centenarian population in 2050 is projected to be in China.By 2050,Japan will have the highest proportion of centenarians,2.6 per 1,000 of the total population.展开更多
The 29th East China Fair,the largest regional trade fair in China,closed in Shanghai on March 5 with a trading volume of$2.3 billion.More than 3,500 Chinese companies and over 450 overseas companies took part in the f...The 29th East China Fair,the largest regional trade fair in China,closed in Shanghai on March 5 with a trading volume of$2.3 billion.More than 3,500 Chinese companies and over 450 overseas companies took part in the four-day event,which is regarded as an important barometer of China’s foreign trade.展开更多
文摘The Xinjiang Geology and Mineral Resources Exploration and Development Bureau have conducted a detailed investigation project of the Xigobi soda-niter deposit in Hami, Xinjiang Province, which was completed at the end of 2011. The project put much emphasis on research of soda-niter mineralization rules, stratum classification, ore-forming
文摘The pathways leading to synthesis and post-synthetic modification of DNA employed methionine as donor of atoms: the carbon that came from its –CH3 served for DNA replication and repair either in bacteria or humans;its entire –CH3 served instead for building N6-methyladenine and 5-methylcytosine on bacterial DNA and 5-methylcytosine alone on human DNA. In humans, although a slight extra-S asymmetric methylation appeared de novo yielding on parental DNA 5’-m5CpC-3’/ 3’-GpG-5’, 5’-m5CpT-3’/3’-GpA-5’ and 5’-m5CpA-3’/3’-GpT-5’ monomethylated dinucleotide pairs, a heavy symmetric methylation involved in S semiconservatively newly made DNA to guarantee genetic maintenance of –CH3 in 5’-m5CpG-3’/3’-Gpm5C-5’ dimethylated dinucleotide pairs. In this framework, an inverse correlation was found between bulk genomic DNA methylation occurring in S and bulk polyA-containing pre-mRNA transcription taking place in G1 and G2. Thus, probes of 1 × 106 Daltons (constructed using sheared by sonication newly made methylated DNA filaments) revealed a modular organization in genes: after the hypermethylated promoter, they exhibited an alternation of unmethylated coding and methylated uncoding sequences. This encouraged the search for a language that genes regulated by methylation should have in common. An initial deciphering of restriction minimaps with hypomethylatable exons vs. hypermethylatable promoters and introns was improved when the bisulfite technique allowed a direct sequencing of m5C. In lymphocytes, where the transglutaminase gene is inactive, its promoter exhibited two fully methylated CpG-rich domains at 5’ and one fully unmethylated CpG-rich domain at 3’, including the site +1 and a 5’-UTR. At variance, in HUVEC cells, where the transglutaminase gene is active, in the first CpG-rich domain of promoter few doublets lost their –CH3. Such an inverse correlation suggested new hypotheses especially in connection with repair-modification: UV radiation would cause demethylation in given loci of a promoter by chance, whilst even a partial demethylation in this promoter would be able to resume a previously silent pre-mRNA transcription.
基金supported by the National Natural Science Foundation of China(81470096)the Doctoral Starting up Foundation of Taishan Medical Collegesupported by a grant from the International Development Research Centre
文摘We compared the numbers of nucleotide substitutions occurring in the non-coding regions and coding regions of Ebola virus genomes and found that non-coding regions contain indispensable phylogenetic and evolutionary information. The omission of genetic data from non-coding regions can lead to unreliable phylogenies and inaccurate estimates of evolutionary parameters.
文摘针对锁相环同步的弱连接电压源变流器(weakgrid connected voltage source converter,WG-VSC)系统的暂态稳定问题,该文首先应用线性矩阵不等式优化法构建WG-VSC系统的最大估计吸引域(largest estimated domain of attraction,LEDA),并将LEDA与基于LaSalle不变集定理的能量函数法和平方和规划法构建的LEDA进行详细对比,验证了所提方法在刻画LEDA方面具有更低的保守性。然后从保证故障穿越控制过程中的锁相环暂态同步稳定作为切入点,首次提出WG-VSC系统在电网对称故障大扰动下的有功/无功电流设定值可行域概念,并基于线性矩阵不等式方法刻画的LEDA,提出该可行域的求解算法,分析了典型参数对该电流设定值可行域的影响。该可行域为故障过程中的有功和无功电流设定值提供了切实可行的指导依据。最后在PSCAD/EMTDC中搭建了基于详细开关模型的WG-VSC系统仿真算例,通过多种暂态仿真工况验证了该文所构建的LEDA和电流设定值可行域的有效性和可行性。
文摘The largest wire and cable production enterprise in the northwestern region-Qinghai Xingming Electric Power Material Co.,Ltd.has been officially put into production,meaning that Qinghai will be able to selfproduce medium and high voltage or even EHV crosslinked power cables and develop and produce differentiated new products such as high-altitude cold-resistant photovoltaic
文摘By 2050,there will be 2.2 million centenarians[in the world,compared to 135,000 in 1998],that is one of every 5,000 people.The largest centenarian population in 2050 is projected to be in China.By 2050,Japan will have the highest proportion of centenarians,2.6 per 1,000 of the total population.
文摘The 29th East China Fair,the largest regional trade fair in China,closed in Shanghai on March 5 with a trading volume of$2.3 billion.More than 3,500 Chinese companies and over 450 overseas companies took part in the four-day event,which is regarded as an important barometer of China’s foreign trade.
